This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute cour...Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.展开更多
The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:tho...The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR domains.Functionally,various LRR proteins are primarily involved in plant development and responses to environmental stress.Notably,the LRR protein family plays a central role in signal transduction pathways related to stress adaptation.In this review,we classify and analyze the functions of LRR proteins in plants.While extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress responses.This review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic stresses.Building upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.展开更多
River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by gen...River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by generations of water resources professionals.Rooted in river ecology,it offers a framework for advancing modern water governance systems and capabilities.This paper examines eight dimensions of river ethics to provide actionable recommendations:enhancing knowledge systems on water,rivers,and lakes;addressing critical challenges in water governance to strengthen the foundational role of water authorities in ensuring water security,resource management,ecological sustainability and environmental protection;optimizing water project planning to mitigate ecological impacts;ensuring high standards in the lifecycle management of water projects;refining water diversion strategies for precise scheduling;utilizing ecosystem complexity for river and lake restoration;implementing tiered management of water-related disasters;and driving reforms to modernize water governance systems and mechanisms.展开更多
Cardiotoxicity is a critical issue in drug development that poses serious health risks,including potentially fatal arrhythmias.The human ether-à-go-go related gene(hERG)potassium channel,as one of the primary tar...Cardiotoxicity is a critical issue in drug development that poses serious health risks,including potentially fatal arrhythmias.The human ether-à-go-go related gene(hERG)potassium channel,as one of the primary targets of cardiotoxicity,has garnered widespread attention.Traditional cardiotoxicity testing methods are expensive and time-consuming,making computational virtual screening a suitable alternative.In this study,we employed machine learning techniques utilizing molecular fingerprints and descriptors to predict the cardiotoxicity of compounds,with the aim of improving prediction accuracy and efficiency.We used four types of molecular fingerprints and descriptors combined with machine learning and deep learning algorithms,including Gaussian naive Bayes(NB),random forest(RF),support vector machine(SVM),K-nearest neighbors(KNN),eXtreme gradient boosting(XGBoost),and Transformer models,to build predictive models.Our models demonstrated advanced predictive performance.The best machine learning model,XGBoost Morgan,achieved an accuracy(ACC)value of 0.84,and the deep learning model,Transformer_Morgan,achieved the best ACC value of 0.85,showing a high ability to distinguish between toxic and non-toxic compounds.On an external independent validation set,it achieved the best area under the curve(AUC)value of 0.93,surpassing ADMETlab3.0,Cardpred,and CardioDPi.In addition,we explored the integration of molecular descriptors and fingerprints to enhance model performance and found that ensemble methods,such as voting and stacking,provided slight improvements in model stability.Furthermore,the SHapley Additive exPlanations(SHAP)explanations revealed the relationship between benzene rings,fluorine-containing groups,NH groups,oxygen in ether groups,and cardiotoxicity,highlighting the importance of these features.This study not only improved the predictive accuracy of cardiotoxicity models but also promoted a more reliable and scientifically interpretable method for drug safety assessment.Using computational methods,this study facilitates a more efficient drug development process,reduces costs,and improves the safety of new drug candidates,ultimately benefiting medical and public health.展开更多
Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institut...Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.展开更多
Investigation and analysis of the current status of farmers'livelihood capital and promptly discovering and solving problems in farmers'livelihood development are of great practical significance for optimizing...Investigation and analysis of the current status of farmers'livelihood capital and promptly discovering and solving problems in farmers'livelihood development are of great practical significance for optimizing farmers'livelihood strategies and enhancing farmers'livelihood sustainable development capability.Based on the framework of sustainable livelihood analysis,taking Yangshan County as an example,this paper uses field surveys,questionnaires and interviews to summarize and analyze the current status and characteristics and main problems of local farmers'livelihood capitals on the basis of the data of 628 farmer samples.It proposes countermeasures for future development of farmers'livelihoods.Implementing these strategies will be helpful for improving the livelihoods capital structure of farmers'and enhancing their sustainable development capability.展开更多
Against the background of energy conservation and emission reduction,green construction and intelligent buildings have become an inevitable trend in the transformation of the construction industry.They effectively red...Against the background of energy conservation and emission reduction,green construction and intelligent buildings have become an inevitable trend in the transformation of the construction industry.They effectively reduce environmental damage and pollution caused by construction projects during the construction process,improve the comfort and health of buildings,and are conducive to promoting the sustainable development of China’s construction industry.This paper analyzes the relationship between green construction and intelligent buildings,examines the dilemmas faced by the integrated development of green construction and intelligent buildings,and proposes measures such as optimizing architectural design schemes,advancing technological innovation,improving energy utilization efficiency,actively applying BIM technology,and strengthening building lifecycle management,so as to promote the sustainable development of China’s construction industry.展开更多
The Chinese government promises to reach the carbon emission peak by 2030 and achieve the carbon neutrality by 2060.Renewable energy development is important for achieving this target.Local governments’behaviors and ...The Chinese government promises to reach the carbon emission peak by 2030 and achieve the carbon neutrality by 2060.Renewable energy development is important for achieving this target.Local governments’behaviors and attitudes might be influenced by neighbors.Therefore,this study uses simultaneous autoregressive models(SAR)to examine the peer effects on renewable energy development across China’s provinces and explain the imbalanced renewable energy developments across regions in China.The results exemplified:①The peer effects exist in China and the endogenous interaction is the main cause.②The interaction between geographically adjacent provinces have greatest peer effects.③Both competition mechanism and learning mechanism induce the peer effects and the imbalanced development.This research introduces energy-related peer effects at the provincial level to reflect the preferences of governments and reveal the underlying mechanisms involved.It also provides suggestions to policy makers:①Select developed provinces as the frontrunner to promote the renewable energy development in neighboring areas.②Regional renewable energy development policies need to be considered.③Central government should consider adding“green growth indicators”into evaluation system to avoid the asymmetrical incentives policies between economic growth and environmental protection.展开更多
Integrated urban-rural development is an inevitable choice for promoting Chinese modernization.High-quality integrated urban-rural development is essentially a practical response to the current multi-factor and multi-...Integrated urban-rural development is an inevitable choice for promoting Chinese modernization.High-quality integrated urban-rural development is essentially a practical response to the current multi-factor and multi-sectoral challenges in urban-rural relations,and plays an important role in implementing the new development philosophy,which promotes Chinese modernization.The theoretical logic supporting the function it plays in enabling Chinese modernization lies in the following aspects:it leverages the free flow of population and resources between urban and rural areas and thus facilitates the balanced development of China’s modernization;it advances the common prosperity of all people through its new type of urban-rural and industrial-agricultural relations;it fosters the coordinated development of the material and spiritual civilizations through the integration of urban and rural cultures;it promotes steering the modernization toward green development through the joint building and managing of the overall urban-rural ecosystem;and it drives modernization in a harmonious and stable direction through integrated urban-rural development.Currently,integrated urban-rural development still faces challenges such as restrictions on the two-way flow of factors,the low efficiency of industrial coordination and support,unequal access to public service facilities,and the insufficient use of land.Therefore,based on the strategic framework of urban-rural integrated development,it is necessary to continuously promote Chinese modernization through high-quality integrated urban-rural development from the perspectives of deepening institutional coordination,expanding the application of digital intelligence in urban and rural industries,optimizing public services,and improving land management.展开更多
Taking its advantages as a state-owned financial institution,the Bank of China Shanghai Branch has formulated the action plan for the high-quality development of AI,which includes ten aspects.First,it will invest no l...Taking its advantages as a state-owned financial institution,the Bank of China Shanghai Branch has formulated the action plan for the high-quality development of AI,which includes ten aspects.First,it will invest no less than 100 billion yuan in the next five years to provide strong comprehensive financial support for various entities in Shanghai’s entire AI industry chain.展开更多
Rural tourism has emerged as a key strategy for sustainable development in underdeveloped regions,offering vital opportunities for economic and social revitalization.This study examines the impact and prospects of rur...Rural tourism has emerged as a key strategy for sustainable development in underdeveloped regions,offering vital opportunities for economic and social revitalization.This study examines the impact and prospects of rural tourism in Jezerc village,Kosovo,using a mixed-methods approach that integrates both quantitative and qualitative data.Quantitative analysis of survey responses from 120 residents and 72 tourists reveals that 57% of residents believe tourism increases household income,while 62% see it as a means of preserving local traditions.However,only 21% report sufficient institutional support,and 74% call for stronger promotion efforts.The findings also show that tourists are primarily drawn to the natural environment(72%)and to peace and relaxation(61%),but express dissatisfaction with infrastructure,particularly signage and roads.A Chi-square test confirmed significant differences in stakeholder views on tourism development strategies(p<0.001),underscoring the need for inclusive planning.While rural tourism’s general benefits,such as job creation,income diversification,and infrastructure improvement,are well known,this study provides new insights by highlighting the disconnect between community potential and institutional support,and by revealing specific demographic and perceptual trends among domestic tourists.The research concludes by advocating for policy frameworks that prioritize local engagement,targeted investment,and strategic promotion to ensure the sustainable and inclusive development of rural tourism in Kosovo.展开更多
In today’s rapidly evolving digital landscape,web application security has become paramount as organizations face increasingly sophisticated cyber threats.This work presents a comprehensive methodology for implementi...In today’s rapidly evolving digital landscape,web application security has become paramount as organizations face increasingly sophisticated cyber threats.This work presents a comprehensive methodology for implementing robust security measures in modern web applications and the proof of the Methodology applied to Vue.js,Spring Boot,and MySQL architecture.The proposed approach addresses critical security challenges through a multi-layered framework that encompasses essential security dimensions including multi-factor authentication,fine-grained authorization controls,sophisticated session management,data confidentiality and integrity protection,secure logging mechanisms,comprehensive error handling,high availability strategies,advanced input validation,and security headers implementation.Significant contributions are made to the field of web application security.First,a detailed catalogue of security requirements specifically tailored to protect web applications against contemporary threats,backed by rigorous analysis and industry best practices.Second,the methodology is validated through a carefully designed proof-of-concept implementation in a controlled environment,demonstrating the practical effectiveness of the security measures.The validation process employs cutting-edge static and dynamic analysis tools for comprehensive dependency validation and vulnerability detection,ensuring robust security coverage.The validation results confirm the prevention and avoidance of security vulnerabilities of the methodology.A key innovation of this work is the seamless integration of DevSecOps practices throughout the secure Software Development Life Cycle(SSDLC),creating a security-first mindset from initial design to deployment.By combining proactive secure coding practices with defensive security approaches,a framework is established that not only strengthens application security but also fosters a culture of security awareness within development teams.This hybrid approach ensures that security considerations are woven into every aspect of the development process,rather than being treated as an afterthought.展开更多
This study investigates the critical intersection of cyberpsychology and cybersecurity policy development in small and medium-sized enterprises (SMEs). Through a mixed-methods approach incorporating surveys of 523 emp...This study investigates the critical intersection of cyberpsychology and cybersecurity policy development in small and medium-sized enterprises (SMEs). Through a mixed-methods approach incorporating surveys of 523 employees across 78 SMEs, qualitative interviews, and case studies, the research examines how psychological factors influence cybersecurity behaviors and policy effectiveness. Key findings reveal significant correlations between psychological factors and security outcomes, including the relationship between self-efficacy and policy compliance (r = 0.42, p β = 0.37, p < 0.001). The study identifies critical challenges in risk perception, policy complexity, and organizational culture affecting SME cybersecurity implementation. Results demonstrate that successful cybersecurity initiatives require the integration of psychological principles with technical solutions. The research provides a framework for developing human-centric security policies that address both behavioral and technical aspects of cybersecurity in resource-constrained environments.展开更多
In this paper,the research status of industrial ecology abroad is briefly introduced,and the development status of industrial ecology in China is summarized and evaluated,including research content,methods,application...In this paper,the research status of industrial ecology abroad is briefly introduced,and the development status of industrial ecology in China is summarized and evaluated,including research content,methods,applications,etc.At the same time,combined with the current needs of China s economic-social development,it looks forward to the future development direction and application prospects of industrial ecology.In the coming period,research on green transformation technologies for industrial structure and production methods,carbon peak routes and carbon reduction implementation paths for industrial systems,key technologies for adapting to climate change and achieving carbon peak and carbon neutrality in priority areas,cross regional collaborative technologies for industrial chains,regional energy resource optimization and allocation technologies,efficient industrial agglomeration and collaboration technologies,multimedia composite pollution collaborative governance technologies,collaborative governance technologies for pollution and carbon reduction,multimedia comprehensive governance of multiple pollutants,and empirical theoretical systems of industrial ecology with Chinese characteristics will be the direction of industrial ecology research in China.展开更多
Nowadays,with the continuous deepening of quality-oriented education in China and the increasing demands of parents,especially the implementation of the new curriculum design concept,tremendous changes have taken plac...Nowadays,with the continuous deepening of quality-oriented education in China and the increasing demands of parents,especially the implementation of the new curriculum design concept,tremendous changes have taken place in teaching methods,teaching contents,teaching means,and learning approaches,which pose new challenges to the professional growth of preschool teachers.At present,preschool teachers are not only required to have a sense of responsibility and love,but also to have rich professional knowledge and skills,as well as new creative thinking and research ability.Even if the preschool teachers who have performed very well in traditional education are now struggling to adapt to the actual needs of educational development,which requires preschool teachers to continuously develop in the direction of specialization.This article will focus on how to promote the professional growth and development of preschool teachers to analyze and elaborate.展开更多
The application of digital technology in prosthodontics not only improves the accuracy of restoration and the efficiency of diagnosis and treatment,but also brings more comfortable and convenient diagnosis and treatme...The application of digital technology in prosthodontics not only improves the accuracy of restoration and the efficiency of diagnosis and treatment,but also brings more comfortable and convenient diagnosis and treatment experience to patients.It effectively promotes the rapid development of the prosthodontic aesthetics industry and leads prosthodontic technology to gradually enter a new digital era.Combining the advantages of digital technology in prosthodontics,this paper focuses on the specific applications of digital impression technology,CAD/CAM technology,network-based integrated cloud service technology,and CBCT technology in prosthodontics.On this basis,it prospects the development trend of digital technology in the field of prosthodontics,aiming to provide solid theoretical and practical support for clinical practice of prosthodontics and promote the gradual integration of the prosthodontic industry with the digital era.展开更多
Pentatricopeptide repeat(PPR)proteins perform essential functions in post-transcriptional regulation of gene expression,particularly RNA editing and RNA splicing,in plant organelles.Although research on chloroplast bi...Pentatricopeptide repeat(PPR)proteins perform essential functions in post-transcriptional regulation of gene expression,particularly RNA editing and RNA splicing,in plant organelles.Although research on chloroplast biogenesis and development has been extensive,the functions of most PPR genes in this process in rice(Oryza sativa)remain incompletely understood.This study identifies a novel P-type PPR protein,YELLOW-GREEN LEAF AND SEEDLING LETHALITY(YGS),which localizes to rice chloroplasts.YGS shows predominant expression in leaves.The ygs mutants,generated through CRISPR/Cas9-mediated genome editing of the YGS gene,displayed yellow-green leaves and seedling lethality.These phenotypes corresponded with reduced pigment levels and disrupted chloroplast ultrastructure compared to wild-type plants.Furthermore,the expression of genes associated with chloroplast development and chlorophyll biosynthesis showed significant alterations in the ygs mutants.The absence of YGS function affected RNA editing of rpl2 and intron splicing of ycf3-1 in the plastid genome.Additionally,YGS demonstrated interaction with the chloroplast signal recognition particle protein Oscp SRP54b in yeast two-hybrid and bimolecular fluorescence complementation analyses.These results indicate that YGS participates in RNA editing and RNA splicing in chloroplasts,thus serving a vital role in rice chloroplast development.展开更多
Antarctic krill(Euphausia superba)is a keystone species in the Southern Ocean;however,seasonal variations in reproductive development for krill are complex and remains unknown.A histological investigation with observa...Antarctic krill(Euphausia superba)is a keystone species in the Southern Ocean;however,seasonal variations in reproductive development for krill are complex and remains unknown.A histological investigation with observations of external secondary sex features of krill in the south Scotia Sea region was carried out using a multi-seasonal dataset for detail reproductive descriptions for this commercially important species.The monthly development of secondary sexual characteristics,the thelycum,as well as of oocytes over a period of two years were described.It was observed that krill have diverse reproductive development characteristics within the ovary,and that this function differently between the juvenile,sub-adult,and adult stages.During the summer,adult krill ovaries are large and ripe with oocytes rich in yolk ready for release in late summer.Post spawning,the ovaries resorb,fragment,and regress throughout the autumn and winter.During reproductive diapause period,krill focus on absorbing nutrients.Un-released eggs are reabsorbed by the ovary,the permanent germinal zone is active,and early oocytes begin to develop in preparation for the egg production phase.Krill that are about to spawn have an ovary that fills the space between the digestive gland and muscle.The ovarian development of krill is divided into 10 sexual developmental stages.As a part of this study,data on the carapace thickness with similar development patterns in krill size and carapace width,was investigated for the first time to help understand krill growth and development.展开更多
Inferior grains exhibit delayed developmental processes and reduced metabolic activities compared to superior grains,leading to unstable rice yield and quality.While significant advancements have been achieved in eluc...Inferior grains exhibit delayed developmental processes and reduced metabolic activities compared to superior grains,leading to unstable rice yield and quality.While significant advancements have been achieved in elucidating the physiology of endosperm filling in inferior grains,the role of the embryo remains underexplored and warrants comprehensive investigation.Two Wuyujing 3 mutants,DW024(relatively synchronous;syn-DW024)and DW179(significantly asynchronous;asyn-DW179),with different grain-filling patterns were used in this study.Samples of superior and inferior grains were collected at intervals from 5 to 60 d after fertilization and subsequently dissected into subsamples of the embryo and endosperm.Histochemical staining,biochemical analysis,and RNA sequencing(RNA-seq)were combined to systematically compare developmental and physiological traits between superior and inferior grains.Combining hierarchical clustering of mRNA datasets revealed three developmental phases of the endosperm and embryo:morphogenesis,endosperm filling/embryo enlargement,and maturation.In both syn-DW024 and asyn-DW179,the duration of the endosperm/embryo morphogenesis phase was identical in superior and inferior grains.The inferior grains of asyn-DW179 exhibited a 10-day prolongation in the endosperm filling phase and a 20-day extension in the embryo enlargement phase compared to the superior grains.The endosperm of inferior grains exhibited higher contents of sugars and free amino acids,along with slower accumulation of storage compounds,which was associated with the down-regulation of genes for starch synthesis and ABA signaling.In addition,transporters for nutrient exchanges between endosperm and embryo were down-regulated,suggesting a potential role of the embryo in adjusting the endosperm filling process.Collectively,our results reveal that the prolonged phases of endosperm filling and embryo enlargement may underlie the impaired development of inferior grains,offering a new perspective for breeding or cultivating rice with uniform grain quality.展开更多
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
基金supported by the National Key Research and Development Program of China,No.2022YFC2703101(to YC)the National Natural Science Fundation of China,No.82371422(to YC)+1 种基金the National Innovation and Entrepreneurship Training Program for College Students,No.202310611408(to XW)the 1·3·5 Project for Disciplines of Excellence Clinical Research Fund,West China Hospital,Sichuan University,No.2023HXFH032(to YC)。
文摘Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.
基金supported by the National Natural Science Foundation of China(Grant Nos.32072048 and U2004204)National Key Research and Development Program of China(Grant No.2023YFF1001200)+2 种基金China Rice Research Institute Basal Research Fund(Grant No.CPSIBRF-CNRRI-202404)Academician Workstation of National Nanfan Research Institute(Sanya),Chinese Agricultural Academic Science(CAAS),(Grant Nos.YBXM2422 and YBXM2423)Agricultural Science and Technology Innovation Program of CAAS,China.
文摘The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR domains.Functionally,various LRR proteins are primarily involved in plant development and responses to environmental stress.Notably,the LRR protein family plays a central role in signal transduction pathways related to stress adaptation.In this review,we classify and analyze the functions of LRR proteins in plants.While extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress responses.This review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic stresses.Building upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.
基金Three Gorges Follow-up Work Fund,Grant/Award Number:WE0161A042024National Key Research Program of China,Grant/Award Number:2024YFC3210900。
文摘River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by generations of water resources professionals.Rooted in river ecology,it offers a framework for advancing modern water governance systems and capabilities.This paper examines eight dimensions of river ethics to provide actionable recommendations:enhancing knowledge systems on water,rivers,and lakes;addressing critical challenges in water governance to strengthen the foundational role of water authorities in ensuring water security,resource management,ecological sustainability and environmental protection;optimizing water project planning to mitigate ecological impacts;ensuring high standards in the lifecycle management of water projects;refining water diversion strategies for precise scheduling;utilizing ecosystem complexity for river and lake restoration;implementing tiered management of water-related disasters;and driving reforms to modernize water governance systems and mechanisms.
基金supported by National Key Research and Development Project,China(Grant No.:2021YFA1500403).
文摘Cardiotoxicity is a critical issue in drug development that poses serious health risks,including potentially fatal arrhythmias.The human ether-à-go-go related gene(hERG)potassium channel,as one of the primary targets of cardiotoxicity,has garnered widespread attention.Traditional cardiotoxicity testing methods are expensive and time-consuming,making computational virtual screening a suitable alternative.In this study,we employed machine learning techniques utilizing molecular fingerprints and descriptors to predict the cardiotoxicity of compounds,with the aim of improving prediction accuracy and efficiency.We used four types of molecular fingerprints and descriptors combined with machine learning and deep learning algorithms,including Gaussian naive Bayes(NB),random forest(RF),support vector machine(SVM),K-nearest neighbors(KNN),eXtreme gradient boosting(XGBoost),and Transformer models,to build predictive models.Our models demonstrated advanced predictive performance.The best machine learning model,XGBoost Morgan,achieved an accuracy(ACC)value of 0.84,and the deep learning model,Transformer_Morgan,achieved the best ACC value of 0.85,showing a high ability to distinguish between toxic and non-toxic compounds.On an external independent validation set,it achieved the best area under the curve(AUC)value of 0.93,surpassing ADMETlab3.0,Cardpred,and CardioDPi.In addition,we explored the integration of molecular descriptors and fingerprints to enhance model performance and found that ensemble methods,such as voting and stacking,provided slight improvements in model stability.Furthermore,the SHapley Additive exPlanations(SHAP)explanations revealed the relationship between benzene rings,fluorine-containing groups,NH groups,oxygen in ether groups,and cardiotoxicity,highlighting the importance of these features.This study not only improved the predictive accuracy of cardiotoxicity models but also promoted a more reliable and scientifically interpretable method for drug safety assessment.Using computational methods,this study facilitates a more efficient drug development process,reduces costs,and improves the safety of new drug candidates,ultimately benefiting medical and public health.
文摘Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.
基金Supported by Guangdong Province Philosophy and Social Science Planning Project(GD24CGL18&GD23CGL02).
文摘Investigation and analysis of the current status of farmers'livelihood capital and promptly discovering and solving problems in farmers'livelihood development are of great practical significance for optimizing farmers'livelihood strategies and enhancing farmers'livelihood sustainable development capability.Based on the framework of sustainable livelihood analysis,taking Yangshan County as an example,this paper uses field surveys,questionnaires and interviews to summarize and analyze the current status and characteristics and main problems of local farmers'livelihood capitals on the basis of the data of 628 farmer samples.It proposes countermeasures for future development of farmers'livelihoods.Implementing these strategies will be helpful for improving the livelihoods capital structure of farmers'and enhancing their sustainable development capability.
文摘Against the background of energy conservation and emission reduction,green construction and intelligent buildings have become an inevitable trend in the transformation of the construction industry.They effectively reduce environmental damage and pollution caused by construction projects during the construction process,improve the comfort and health of buildings,and are conducive to promoting the sustainable development of China’s construction industry.This paper analyzes the relationship between green construction and intelligent buildings,examines the dilemmas faced by the integrated development of green construction and intelligent buildings,and proposes measures such as optimizing architectural design schemes,advancing technological innovation,improving energy utilization efficiency,actively applying BIM technology,and strengthening building lifecycle management,so as to promote the sustainable development of China’s construction industry.
基金supported by the National Natural Science Foundation of China[Grant No.71834003,72204111]the Major Program of National Social Science Foundation of China[Grant No.21&ZD110,22ZDA113].
文摘The Chinese government promises to reach the carbon emission peak by 2030 and achieve the carbon neutrality by 2060.Renewable energy development is important for achieving this target.Local governments’behaviors and attitudes might be influenced by neighbors.Therefore,this study uses simultaneous autoregressive models(SAR)to examine the peer effects on renewable energy development across China’s provinces and explain the imbalanced renewable energy developments across regions in China.The results exemplified:①The peer effects exist in China and the endogenous interaction is the main cause.②The interaction between geographically adjacent provinces have greatest peer effects.③Both competition mechanism and learning mechanism induce the peer effects and the imbalanced development.This research introduces energy-related peer effects at the provincial level to reflect the preferences of governments and reveal the underlying mechanisms involved.It also provides suggestions to policy makers:①Select developed provinces as the frontrunner to promote the renewable energy development in neighboring areas.②Regional renewable energy development policies need to be considered.③Central government should consider adding“green growth indicators”into evaluation system to avoid the asymmetrical incentives policies between economic growth and environmental protection.
基金the Research on the Original Contribution and Global Significance of the Concept of Community with a Shared Future for Mankind from a Historical Materialist Perspective(Project No.:20&ZD026)a major project of the National Social Science Foundation of China.
文摘Integrated urban-rural development is an inevitable choice for promoting Chinese modernization.High-quality integrated urban-rural development is essentially a practical response to the current multi-factor and multi-sectoral challenges in urban-rural relations,and plays an important role in implementing the new development philosophy,which promotes Chinese modernization.The theoretical logic supporting the function it plays in enabling Chinese modernization lies in the following aspects:it leverages the free flow of population and resources between urban and rural areas and thus facilitates the balanced development of China’s modernization;it advances the common prosperity of all people through its new type of urban-rural and industrial-agricultural relations;it fosters the coordinated development of the material and spiritual civilizations through the integration of urban and rural cultures;it promotes steering the modernization toward green development through the joint building and managing of the overall urban-rural ecosystem;and it drives modernization in a harmonious and stable direction through integrated urban-rural development.Currently,integrated urban-rural development still faces challenges such as restrictions on the two-way flow of factors,the low efficiency of industrial coordination and support,unequal access to public service facilities,and the insufficient use of land.Therefore,based on the strategic framework of urban-rural integrated development,it is necessary to continuously promote Chinese modernization through high-quality integrated urban-rural development from the perspectives of deepening institutional coordination,expanding the application of digital intelligence in urban and rural industries,optimizing public services,and improving land management.
文摘Taking its advantages as a state-owned financial institution,the Bank of China Shanghai Branch has formulated the action plan for the high-quality development of AI,which includes ten aspects.First,it will invest no less than 100 billion yuan in the next five years to provide strong comprehensive financial support for various entities in Shanghai’s entire AI industry chain.
文摘Rural tourism has emerged as a key strategy for sustainable development in underdeveloped regions,offering vital opportunities for economic and social revitalization.This study examines the impact and prospects of rural tourism in Jezerc village,Kosovo,using a mixed-methods approach that integrates both quantitative and qualitative data.Quantitative analysis of survey responses from 120 residents and 72 tourists reveals that 57% of residents believe tourism increases household income,while 62% see it as a means of preserving local traditions.However,only 21% report sufficient institutional support,and 74% call for stronger promotion efforts.The findings also show that tourists are primarily drawn to the natural environment(72%)and to peace and relaxation(61%),but express dissatisfaction with infrastructure,particularly signage and roads.A Chi-square test confirmed significant differences in stakeholder views on tourism development strategies(p<0.001),underscoring the need for inclusive planning.While rural tourism’s general benefits,such as job creation,income diversification,and infrastructure improvement,are well known,this study provides new insights by highlighting the disconnect between community potential and institutional support,and by revealing specific demographic and perceptual trends among domestic tourists.The research concludes by advocating for policy frameworks that prioritize local engagement,targeted investment,and strategic promotion to ensure the sustainable and inclusive development of rural tourism in Kosovo.
文摘In today’s rapidly evolving digital landscape,web application security has become paramount as organizations face increasingly sophisticated cyber threats.This work presents a comprehensive methodology for implementing robust security measures in modern web applications and the proof of the Methodology applied to Vue.js,Spring Boot,and MySQL architecture.The proposed approach addresses critical security challenges through a multi-layered framework that encompasses essential security dimensions including multi-factor authentication,fine-grained authorization controls,sophisticated session management,data confidentiality and integrity protection,secure logging mechanisms,comprehensive error handling,high availability strategies,advanced input validation,and security headers implementation.Significant contributions are made to the field of web application security.First,a detailed catalogue of security requirements specifically tailored to protect web applications against contemporary threats,backed by rigorous analysis and industry best practices.Second,the methodology is validated through a carefully designed proof-of-concept implementation in a controlled environment,demonstrating the practical effectiveness of the security measures.The validation process employs cutting-edge static and dynamic analysis tools for comprehensive dependency validation and vulnerability detection,ensuring robust security coverage.The validation results confirm the prevention and avoidance of security vulnerabilities of the methodology.A key innovation of this work is the seamless integration of DevSecOps practices throughout the secure Software Development Life Cycle(SSDLC),creating a security-first mindset from initial design to deployment.By combining proactive secure coding practices with defensive security approaches,a framework is established that not only strengthens application security but also fosters a culture of security awareness within development teams.This hybrid approach ensures that security considerations are woven into every aspect of the development process,rather than being treated as an afterthought.
文摘This study investigates the critical intersection of cyberpsychology and cybersecurity policy development in small and medium-sized enterprises (SMEs). Through a mixed-methods approach incorporating surveys of 523 employees across 78 SMEs, qualitative interviews, and case studies, the research examines how psychological factors influence cybersecurity behaviors and policy effectiveness. Key findings reveal significant correlations between psychological factors and security outcomes, including the relationship between self-efficacy and policy compliance (r = 0.42, p β = 0.37, p < 0.001). The study identifies critical challenges in risk perception, policy complexity, and organizational culture affecting SME cybersecurity implementation. Results demonstrate that successful cybersecurity initiatives require the integration of psychological principles with technical solutions. The research provides a framework for developing human-centric security policies that address both behavioral and technical aspects of cybersecurity in resource-constrained environments.
基金Supported by the National Natural Science Foundation of China(42477521).
文摘In this paper,the research status of industrial ecology abroad is briefly introduced,and the development status of industrial ecology in China is summarized and evaluated,including research content,methods,applications,etc.At the same time,combined with the current needs of China s economic-social development,it looks forward to the future development direction and application prospects of industrial ecology.In the coming period,research on green transformation technologies for industrial structure and production methods,carbon peak routes and carbon reduction implementation paths for industrial systems,key technologies for adapting to climate change and achieving carbon peak and carbon neutrality in priority areas,cross regional collaborative technologies for industrial chains,regional energy resource optimization and allocation technologies,efficient industrial agglomeration and collaboration technologies,multimedia composite pollution collaborative governance technologies,collaborative governance technologies for pollution and carbon reduction,multimedia comprehensive governance of multiple pollutants,and empirical theoretical systems of industrial ecology with Chinese characteristics will be the direction of industrial ecology research in China.
文摘Nowadays,with the continuous deepening of quality-oriented education in China and the increasing demands of parents,especially the implementation of the new curriculum design concept,tremendous changes have taken place in teaching methods,teaching contents,teaching means,and learning approaches,which pose new challenges to the professional growth of preschool teachers.At present,preschool teachers are not only required to have a sense of responsibility and love,but also to have rich professional knowledge and skills,as well as new creative thinking and research ability.Even if the preschool teachers who have performed very well in traditional education are now struggling to adapt to the actual needs of educational development,which requires preschool teachers to continuously develop in the direction of specialization.This article will focus on how to promote the professional growth and development of preschool teachers to analyze and elaborate.
基金Wuhan University of Arts and Science 2023 University-Level Scientific Research(Project No.:2023xk33)。
文摘The application of digital technology in prosthodontics not only improves the accuracy of restoration and the efficiency of diagnosis and treatment,but also brings more comfortable and convenient diagnosis and treatment experience to patients.It effectively promotes the rapid development of the prosthodontic aesthetics industry and leads prosthodontic technology to gradually enter a new digital era.Combining the advantages of digital technology in prosthodontics,this paper focuses on the specific applications of digital impression technology,CAD/CAM technology,network-based integrated cloud service technology,and CBCT technology in prosthodontics.On this basis,it prospects the development trend of digital technology in the field of prosthodontics,aiming to provide solid theoretical and practical support for clinical practice of prosthodontics and promote the gradual integration of the prosthodontic industry with the digital era.
基金supported by the National Natural Science Foundation of China(32201784,32072048,and U2004204)the Natural Science Foundation of Shandong Province,China(ZR2020QC111 and ZR2022QC176)the Talent Introduction Project of Dezhou University,China(2020xjrc207)。
文摘Pentatricopeptide repeat(PPR)proteins perform essential functions in post-transcriptional regulation of gene expression,particularly RNA editing and RNA splicing,in plant organelles.Although research on chloroplast biogenesis and development has been extensive,the functions of most PPR genes in this process in rice(Oryza sativa)remain incompletely understood.This study identifies a novel P-type PPR protein,YELLOW-GREEN LEAF AND SEEDLING LETHALITY(YGS),which localizes to rice chloroplasts.YGS shows predominant expression in leaves.The ygs mutants,generated through CRISPR/Cas9-mediated genome editing of the YGS gene,displayed yellow-green leaves and seedling lethality.These phenotypes corresponded with reduced pigment levels and disrupted chloroplast ultrastructure compared to wild-type plants.Furthermore,the expression of genes associated with chloroplast development and chlorophyll biosynthesis showed significant alterations in the ygs mutants.The absence of YGS function affected RNA editing of rpl2 and intron splicing of ycf3-1 in the plastid genome.Additionally,YGS demonstrated interaction with the chloroplast signal recognition particle protein Oscp SRP54b in yeast two-hybrid and bimolecular fluorescence complementation analyses.These results indicate that YGS participates in RNA editing and RNA splicing in chloroplasts,thus serving a vital role in rice chloroplast development.
基金Supported by the Inter-governmental Science and Technology Innovation(STI)Cooperation Special Program of the National Key Research and Development Program of China(No.2023YFE0104500)the NIWA-SHOU-Otago Joint Research Center on Antarctic Marine Science。
文摘Antarctic krill(Euphausia superba)is a keystone species in the Southern Ocean;however,seasonal variations in reproductive development for krill are complex and remains unknown.A histological investigation with observations of external secondary sex features of krill in the south Scotia Sea region was carried out using a multi-seasonal dataset for detail reproductive descriptions for this commercially important species.The monthly development of secondary sexual characteristics,the thelycum,as well as of oocytes over a period of two years were described.It was observed that krill have diverse reproductive development characteristics within the ovary,and that this function differently between the juvenile,sub-adult,and adult stages.During the summer,adult krill ovaries are large and ripe with oocytes rich in yolk ready for release in late summer.Post spawning,the ovaries resorb,fragment,and regress throughout the autumn and winter.During reproductive diapause period,krill focus on absorbing nutrients.Un-released eggs are reabsorbed by the ovary,the permanent germinal zone is active,and early oocytes begin to develop in preparation for the egg production phase.Krill that are about to spawn have an ovary that fills the space between the digestive gland and muscle.The ovarian development of krill is divided into 10 sexual developmental stages.As a part of this study,data on the carapace thickness with similar development patterns in krill size and carapace width,was investigated for the first time to help understand krill growth and development.
基金supported by the National Key Research and Development Program of China(2022YFD2300700)the National Natural Science Foundation of China(32201894)+1 种基金Hainan Provincial Natural Science Foundation of China(323QN193)Rothamsted Research receives strategic funding from the Biotechnological and Biological Sciences Research Council of the UK.Matthew J.Paul acknowledges funding from the Delivering Sustainable Wheat(BB/X011003/1)Strategic Program.
文摘Inferior grains exhibit delayed developmental processes and reduced metabolic activities compared to superior grains,leading to unstable rice yield and quality.While significant advancements have been achieved in elucidating the physiology of endosperm filling in inferior grains,the role of the embryo remains underexplored and warrants comprehensive investigation.Two Wuyujing 3 mutants,DW024(relatively synchronous;syn-DW024)and DW179(significantly asynchronous;asyn-DW179),with different grain-filling patterns were used in this study.Samples of superior and inferior grains were collected at intervals from 5 to 60 d after fertilization and subsequently dissected into subsamples of the embryo and endosperm.Histochemical staining,biochemical analysis,and RNA sequencing(RNA-seq)were combined to systematically compare developmental and physiological traits between superior and inferior grains.Combining hierarchical clustering of mRNA datasets revealed three developmental phases of the endosperm and embryo:morphogenesis,endosperm filling/embryo enlargement,and maturation.In both syn-DW024 and asyn-DW179,the duration of the endosperm/embryo morphogenesis phase was identical in superior and inferior grains.The inferior grains of asyn-DW179 exhibited a 10-day prolongation in the endosperm filling phase and a 20-day extension in the embryo enlargement phase compared to the superior grains.The endosperm of inferior grains exhibited higher contents of sugars and free amino acids,along with slower accumulation of storage compounds,which was associated with the down-regulation of genes for starch synthesis and ABA signaling.In addition,transporters for nutrient exchanges between endosperm and embryo were down-regulated,suggesting a potential role of the embryo in adjusting the endosperm filling process.Collectively,our results reveal that the prolonged phases of endosperm filling and embryo enlargement may underlie the impaired development of inferior grains,offering a new perspective for breeding or cultivating rice with uniform grain quality.
