In this paper we define higher order (F,α,β,ρ,d,E)-convex function with respect to E-differentiable function K and obtain optimality conditions for nonlinear programming problem (NP) from the concept of higher orde...In this paper we define higher order (F,α,β,ρ,d,E)-convex function with respect to E-differentiable function K and obtain optimality conditions for nonlinear programming problem (NP) from the concept of higher order (F,α,β,ρ,d)-convexity. Here, we establish Mond-Weir and Wolfe duality for (NP) and utilize these duality in nonlinear fractional programming problem.展开更多
Chang'E-1, the first lunar mission in China, was successfully launched on October 24,2007, which opened the prelude of China's Lunar Exploration Program. Later on, the Chang'E-2 and Chang'E-3 satellite...Chang'E-1, the first lunar mission in China, was successfully launched on October 24,2007, which opened the prelude of China's Lunar Exploration Program. Later on, the Chang'E-2 and Chang'E-3 satellites were successfully launched in 2010 and 2013, respectively. In order to achieve the science objectives, various payloads boarded the spacecraft. The scientific data from these instruments were received by Beijing and Kunming ground stations simultaneously. Up to now, about 5.628 Terabytes of raw data were received totally. A series of research results has been achieved. This paper presents a brief introduction to the main scientific results and latest progress from Chang'E-3 mission.展开更多
Developing countries face a number of unique problems related to the hazards of chemicals. The WHO International Program on Chemical Safety may play a useful role by working jointly with Member Nations and such intern...Developing countries face a number of unique problems related to the hazards of chemicals. The WHO International Program on Chemical Safety may play a useful role by working jointly with Member Nations and such international organizations as FAO, UNEP. and ILO. (c)1990 Academic Press. Inc.展开更多
In this paper our studies about the sequential testing program for predicting and identificating carcinogens, sequential discriminant method and cost- effectiveness analysis are summarized. The analysis of our databas...In this paper our studies about the sequential testing program for predicting and identificating carcinogens, sequential discriminant method and cost- effectiveness analysis are summarized. The analysis of our database of carcinogeniclty and genotoxicity of chemicals demonstrates the uncertainty . of short- term tests ( STTs ) to predict carcinogens and the results of most routine STTs are statistically dependent. We recommend the sequential testing program combining STTs and carclnogenicity assay, the optimal STT batteries, the rules of the sequential discrimination and the preferal choices of STTs tor specific chemical class. For illustrative pmposes the carclnogenicity prediction of several sample chamicals is presented. The results of cost-effectiveness analysis suggest that this program has vast social-economic effectiveness.展开更多
BACKGROUND Hepatitis B surface antigen(HBsAg)loss,a functional cure in patients with chronic hepatitis B(CHB)undergoing antiviral therapy,might be an ideal endpoint of antiviral treatment in clinical practice.The fact...BACKGROUND Hepatitis B surface antigen(HBsAg)loss,a functional cure in patients with chronic hepatitis B(CHB)undergoing antiviral therapy,might be an ideal endpoint of antiviral treatment in clinical practice.The factors that contribute to the functional cure remain unclear,and the predictors of functional cure are worth exploring.The concentration and kinetics of soluble programmed death-1(sPD-1)in patients with CHB may play an important role in elucidating the immune response associated with functional cure after nucleos(t)ide analogs therapy.AIM To investigate the factors associated with HBsAg loss and explore the influence of sPD-1 Levels.METHODS This study analyzed the data and samples from patients with CHB who underwent antiviral treatment in a non-interventional observational study conducted at Peking University First Hospital in Beijing(between 2007 and 2019).All patients were followed up:Serum samples were collected every 3 mo during the first year of antiviral treatment and every 6 mo thereafter.Patients with positive hepatitis B e antigen levels at baseline and with available sequential samples who achieved HBsAg loss during antiviral treatment served as the case group.This case group(n=11)was further matched to 44 positive hepatitis B e anti patients without HBsAg loss as controls.The Spearman’s rank correlation test and receiver operating characteristic curves analysis were performed.RESULTS The sPD-1 Levels were higher in patients with HBsAg loss than in those without HBsAg loss from baseline to month 96,and the differences were significant between the groups at baseline(P=0.0136),months 6(P=0.0003),12(P<0.0001),24(P=0.0007),48(P<0.0001),and 96(P=0.0142).After 6 mo of antiviral treatment,the sPD-1 levels were positively correlated with alanine transaminase(ALT)levels(r=0.5103,P=0.0017),and the sPD-1 levels showed apparent correlation with ALT(r=0.6883,P=0.0192)and HBV DNA(r=0.5601,P=0.0703)levels in patients with HBsAg loss.After 12 mo of antiviral treatment,the sPD-1 levels also showed apparent correlation with ALT(r=0.8134,P=0.0042)and HBV DNA(r=0.6832,P=0.0205)levels in patients with HBsAg loss.The sPD-1 levels were negatively correlated with HBsAg levels in all patients after 12 mo of antiviral treatment,especially at 24(r=-0.356,P=0.0497)and 48(r=-0.4783,P=0.0037)mo.After 6 mo of antiviral treatment,the AUC of sPD-1 for HBsAg loss was 0.898(P=0.000),whereas that of HBsAg was 0.617(P=0.419).The cut-off value of sPD-1 was set at 2.34 log pg/mL;the sensitivity and specificity were 100%and 66.7%,respectively.CONCLUSION The sPD-1 levels at 6 mo can predict HBsAg loss after 144 mo of antiviral treatment.展开更多
In order to train nurses to perform disease management and telenursing, we developed an e-learning education program, and assessed the efficacy. A single-group pre-test and post-test design was used. Nurses who worked...In order to train nurses to perform disease management and telenursing, we developed an e-learning education program, and assessed the efficacy. A single-group pre-test and post-test design was used. Nurses who worked at a medical institution or a disease management company were included, and the duration of the program was set 2 months. We developed the program so that it could grow attitude and improve knowledge and skills in disease management and patient education. Of 55 subjects, 48 who completed the program were analyzed. After the program, subjects increased knowledge and interests in disease management and patient education. Almost of the subjects answered that e-learning was a good learning method. Our program was effective at enhancing subject’s interests in disease management and patient education, and considered to improve their skills in the future.展开更多
Jointly published by 14 Department headed by Standardization Administraion ofChina(SAC) Subtitle: China will formulate and reformulate 926 standards for energy conservation andcomprehensive u-tilization during 2005 an...Jointly published by 14 Department headed by Standardization Administraion ofChina(SAC) Subtitle: China will formulate and reformulate 926 standards for energy conservation andcomprehensive u-tilization during 2005 and 2007. In the past few days, 14 departments jointlypublished the Development Program of Energy Conservation and Comprehensive Utilization 2005-2007,(Program for short). They are Standardization Administration of China, National Development andReform Commission, Ministry of Land and Resources, Ministry of Establishment, Ministry ofCommunications, Ministry of Information Industry, Ministry of Waster Resources, Ministry ofAgriculture, Ministry of Commerce, General Administration of Quality Supervision, Inspection andQuarantine of the PRC, State Environmental Protection Administration, State Forestry Bureau, StateOceanic Administration and China Meteorological Bureau.展开更多
Murong Feng, a 31-year-old activist from Hebei Province in northern China, had attended several training workshops for non-governmental organizations （NGOs） related to HIV/AIDS prevention before he came to Beijing ...Murong Feng, a 31-year-old activist from Hebei Province in northern China, had attended several training workshops for non-governmental organizations （NGOs） related to HIV/AIDS prevention before he came to Beijing last October for another one.展开更多
Ⅰ. REVIEW The Institute of Theoretical Physics (ITP) of the CAS was founded in 1978 with the personal approval of Comrade Deng Xiaoping, in the same year when the Third Plenary Session of the Central Committee of the...Ⅰ. REVIEW The Institute of Theoretical Physics (ITP) of the CAS was founded in 1978 with the personal approval of Comrade Deng Xiaoping, in the same year when the Third Plenary Session of the Central Committee of the CPC (Communist Party of China) was convened. Over the past 20 years, the Institute has been striving to explore a road for sound development in a bid to achieve the following targets: In regard to research, the institute strives展开更多
文摘In this paper we define higher order (F,α,β,ρ,d,E)-convex function with respect to E-differentiable function K and obtain optimality conditions for nonlinear programming problem (NP) from the concept of higher order (F,α,β,ρ,d)-convexity. Here, we establish Mond-Weir and Wolfe duality for (NP) and utilize these duality in nonlinear fractional programming problem.
基金Supported by the NSFC under Grant(41073053)the Key Research Program of the Chinese Academy of Sciencesunder Grant(KGZD-EW-603)
文摘Chang'E-1, the first lunar mission in China, was successfully launched on October 24,2007, which opened the prelude of China's Lunar Exploration Program. Later on, the Chang'E-2 and Chang'E-3 satellites were successfully launched in 2010 and 2013, respectively. In order to achieve the science objectives, various payloads boarded the spacecraft. The scientific data from these instruments were received by Beijing and Kunming ground stations simultaneously. Up to now, about 5.628 Terabytes of raw data were received totally. A series of research results has been achieved. This paper presents a brief introduction to the main scientific results and latest progress from Chang'E-3 mission.
文摘Developing countries face a number of unique problems related to the hazards of chemicals. The WHO International Program on Chemical Safety may play a useful role by working jointly with Member Nations and such international organizations as FAO, UNEP. and ILO. (c)1990 Academic Press. Inc.
文摘In this paper our studies about the sequential testing program for predicting and identificating carcinogens, sequential discriminant method and cost- effectiveness analysis are summarized. The analysis of our database of carcinogeniclty and genotoxicity of chemicals demonstrates the uncertainty . of short- term tests ( STTs ) to predict carcinogens and the results of most routine STTs are statistically dependent. We recommend the sequential testing program combining STTs and carclnogenicity assay, the optimal STT batteries, the rules of the sequential discrimination and the preferal choices of STTs tor specific chemical class. For illustrative pmposes the carclnogenicity prediction of several sample chamicals is presented. The results of cost-effectiveness analysis suggest that this program has vast social-economic effectiveness.
基金Supported by The 13^(th)Five-Year Plan of Ministry of Science and Technology of the People’s Republic of China,No.2017ZX10302201-004-009,and No.2017ZX10203202-003Beijing Municipal Science and Technology Commission of Major Projects,No.D161100002716002,and No.D161100002716003.
文摘BACKGROUND Hepatitis B surface antigen(HBsAg)loss,a functional cure in patients with chronic hepatitis B(CHB)undergoing antiviral therapy,might be an ideal endpoint of antiviral treatment in clinical practice.The factors that contribute to the functional cure remain unclear,and the predictors of functional cure are worth exploring.The concentration and kinetics of soluble programmed death-1(sPD-1)in patients with CHB may play an important role in elucidating the immune response associated with functional cure after nucleos(t)ide analogs therapy.AIM To investigate the factors associated with HBsAg loss and explore the influence of sPD-1 Levels.METHODS This study analyzed the data and samples from patients with CHB who underwent antiviral treatment in a non-interventional observational study conducted at Peking University First Hospital in Beijing(between 2007 and 2019).All patients were followed up:Serum samples were collected every 3 mo during the first year of antiviral treatment and every 6 mo thereafter.Patients with positive hepatitis B e antigen levels at baseline and with available sequential samples who achieved HBsAg loss during antiviral treatment served as the case group.This case group(n=11)was further matched to 44 positive hepatitis B e anti patients without HBsAg loss as controls.The Spearman’s rank correlation test and receiver operating characteristic curves analysis were performed.RESULTS The sPD-1 Levels were higher in patients with HBsAg loss than in those without HBsAg loss from baseline to month 96,and the differences were significant between the groups at baseline(P=0.0136),months 6(P=0.0003),12(P<0.0001),24(P=0.0007),48(P<0.0001),and 96(P=0.0142).After 6 mo of antiviral treatment,the sPD-1 levels were positively correlated with alanine transaminase(ALT)levels(r=0.5103,P=0.0017),and the sPD-1 levels showed apparent correlation with ALT(r=0.6883,P=0.0192)and HBV DNA(r=0.5601,P=0.0703)levels in patients with HBsAg loss.After 12 mo of antiviral treatment,the sPD-1 levels also showed apparent correlation with ALT(r=0.8134,P=0.0042)and HBV DNA(r=0.6832,P=0.0205)levels in patients with HBsAg loss.The sPD-1 levels were negatively correlated with HBsAg levels in all patients after 12 mo of antiviral treatment,especially at 24(r=-0.356,P=0.0497)and 48(r=-0.4783,P=0.0037)mo.After 6 mo of antiviral treatment,the AUC of sPD-1 for HBsAg loss was 0.898(P=0.000),whereas that of HBsAg was 0.617(P=0.419).The cut-off value of sPD-1 was set at 2.34 log pg/mL;the sensitivity and specificity were 100%and 66.7%,respectively.CONCLUSION The sPD-1 levels at 6 mo can predict HBsAg loss after 144 mo of antiviral treatment.
文摘In order to train nurses to perform disease management and telenursing, we developed an e-learning education program, and assessed the efficacy. A single-group pre-test and post-test design was used. Nurses who worked at a medical institution or a disease management company were included, and the duration of the program was set 2 months. We developed the program so that it could grow attitude and improve knowledge and skills in disease management and patient education. Of 55 subjects, 48 who completed the program were analyzed. After the program, subjects increased knowledge and interests in disease management and patient education. Almost of the subjects answered that e-learning was a good learning method. Our program was effective at enhancing subject’s interests in disease management and patient education, and considered to improve their skills in the future.
文摘Jointly published by 14 Department headed by Standardization Administraion ofChina(SAC) Subtitle: China will formulate and reformulate 926 standards for energy conservation andcomprehensive u-tilization during 2005 and 2007. In the past few days, 14 departments jointlypublished the Development Program of Energy Conservation and Comprehensive Utilization 2005-2007,(Program for short). They are Standardization Administration of China, National Development andReform Commission, Ministry of Land and Resources, Ministry of Establishment, Ministry ofCommunications, Ministry of Information Industry, Ministry of Waster Resources, Ministry ofAgriculture, Ministry of Commerce, General Administration of Quality Supervision, Inspection andQuarantine of the PRC, State Environmental Protection Administration, State Forestry Bureau, StateOceanic Administration and China Meteorological Bureau.
文摘Murong Feng, a 31-year-old activist from Hebei Province in northern China, had attended several training workshops for non-governmental organizations （NGOs） related to HIV/AIDS prevention before he came to Beijing last October for another one.
文摘Ⅰ. REVIEW The Institute of Theoretical Physics (ITP) of the CAS was founded in 1978 with the personal approval of Comrade Deng Xiaoping, in the same year when the Third Plenary Session of the Central Committee of the CPC (Communist Party of China) was convened. Over the past 20 years, the Institute has been striving to explore a road for sound development in a bid to achieve the following targets: In regard to research, the institute strives
