Efficient anti-jamming rateless coding based on cognitive Orthogonal Frequency Division Multiplexing (OFDM) modulation in Cognitive Radio Network (CRN) is mainly discussed. Rateless coding with small redundancy and lo...Efficient anti-jamming rateless coding based on cognitive Orthogonal Frequency Division Multiplexing (OFDM) modulation in Cognitive Radio Network (CRN) is mainly discussed. Rateless coding with small redundancy and low complexity is presented, and the optimal design methods of building rateless codes are also proposed. In CRN, anti-jamming rateless coding could recover the lost packets in parallel channels of cognitive OFDM, thus it protects Secondary Users (SUs) from the in-terference by Primary Users (PUs) efficiently. Frame Error Rate (FER) and throughput performance of SU employing anti-jamming rateless coding are analyzed in detail. Performance comparison between rateless coding and piecewise coding are also presented. It is shown that, anti-jamming rateless coding provides low FER and Word Error Rate (WER) performance with uniform sub-channel selection. Meanwhile, it is also verified that, in higher jamming rate and longer code redundancy scenario, rateless coding method could achieve better FER and throughput performance than another anti-jamming coding schemes.展开更多
TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing enzymes.As impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule dynamics.We therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to microtubules.To investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic littermates.In sum,P301L-TAU results in changes in microtubule PTMs,suggestive of impairment of microtubule stability.This is accompanied by missorting and aggregation of TAU in mice but not in i Neurons.Microtubule PTMs/impairment may be of key importance in tauopathies.展开更多
Unbalanced multi-stage logistics systems are optimized using an improved genetic algorithm based on the Prüfer number and the effective capacity coding. The improved decoding procedure uses the node capacity of t...Unbalanced multi-stage logistics systems are optimized using an improved genetic algorithm based on the Prüfer number and the effective capacity coding. The improved decoding procedure uses the node capacity of the logistics system as an important factor, which influences the decoding procedure. As a result, any Prüfer number produced stochastically can be decoded to a feasible logistics pattern, which matchs the node capacities of the logistics system. With effective capacity coding, an unbalanced logistics system can be converted to a set of balanced systems. The effective capacity coding was combined with the Prefer number to construct the chromosome for the new method to search the whole solution space of the unbalanced multi-stage logistics system. Simulation results show that the new method finds a better solution with less computational time than st-GA. Although using a little more memory, the new method is still an efficient and robust method for optimizing unbalanced multi-stage logistics systems.展开更多
基金Supported by the National Natural Science Foundation of China (No. 60972039)the Scientific Planning Project of Zhejiang Province entitled "Research and Development of Smart Antenna for the Next Generation Mobile Com-munications Based on TDD"the Young Staff Startup Research Foundation of Hangzhou Dianzi University entitled "Research on Key Technologies of Resource Allocation in Cognitive Radio Networks Based on Multicarrier Modulation"
文摘Efficient anti-jamming rateless coding based on cognitive Orthogonal Frequency Division Multiplexing (OFDM) modulation in Cognitive Radio Network (CRN) is mainly discussed. Rateless coding with small redundancy and low complexity is presented, and the optimal design methods of building rateless codes are also proposed. In CRN, anti-jamming rateless coding could recover the lost packets in parallel channels of cognitive OFDM, thus it protects Secondary Users (SUs) from the in-terference by Primary Users (PUs) efficiently. Frame Error Rate (FER) and throughput performance of SU employing anti-jamming rateless coding are analyzed in detail. Performance comparison between rateless coding and piecewise coding are also presented. It is shown that, anti-jamming rateless coding provides low FER and Word Error Rate (WER) performance with uniform sub-channel selection. Meanwhile, it is also verified that, in higher jamming rate and longer code redundancy scenario, rateless coding method could achieve better FER and throughput performance than another anti-jamming coding schemes.
基金supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ)open-access funding from the DFG/GRC issued to the University of CologneAlzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。
文摘TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing enzymes.As impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule dynamics.We therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to microtubules.To investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic littermates.In sum,P301L-TAU results in changes in microtubule PTMs,suggestive of impairment of microtubule stability.This is accompanied by missorting and aggregation of TAU in mice but not in i Neurons.Microtubule PTMs/impairment may be of key importance in tauopathies.
文摘Unbalanced multi-stage logistics systems are optimized using an improved genetic algorithm based on the Prüfer number and the effective capacity coding. The improved decoding procedure uses the node capacity of the logistics system as an important factor, which influences the decoding procedure. As a result, any Prüfer number produced stochastically can be decoded to a feasible logistics pattern, which matchs the node capacities of the logistics system. With effective capacity coding, an unbalanced logistics system can be converted to a set of balanced systems. The effective capacity coding was combined with the Prefer number to construct the chromosome for the new method to search the whole solution space of the unbalanced multi-stage logistics system. Simulation results show that the new method finds a better solution with less computational time than st-GA. Although using a little more memory, the new method is still an efficient and robust method for optimizing unbalanced multi-stage logistics systems.
