Human genetic variants have long been known to play an important role in both Mendelian disorders and common diseases. Notably, pathogenic variants are not limited to single-nucleotide variants. It has become apparent...Human genetic variants have long been known to play an important role in both Mendelian disorders and common diseases. Notably, pathogenic variants are not limited to single-nucleotide variants. It has become apparent that human diseases can also be caused by copy number variations （CNVs）, especially patient- specific novel CNVs （lafrate et al., 2004; Sebat et al., 2004; Redon et al., 2006; LuDski, 2007; Zhan~ et al.. 2009： Wu et al.. 2015）.展开更多
National Population Health Data Center(NPHDC)is one of China's 20 national-level science data centers,jointly designated by the Ministry of Science and Technology and the Ministry of Finance.Operated by the Chines...National Population Health Data Center(NPHDC)is one of China's 20 national-level science data centers,jointly designated by the Ministry of Science and Technology and the Ministry of Finance.Operated by the Chinese Academy of Medical Sciences under the oversight of the National Health Commission,NPHDC adheres to national regulations including the Scientific Data Management Measures and the National Science and Technology Infrastructure Service Platform Management Measures,and is committed to collecting,integrating,managing,and sharing biomedical and health data through openaccess platform,fostering open sharing and engaging in international cooperation.展开更多
Cell population data(CPD)is regarded as the fingerprint of a blood cell at a given moment.CPD parameters harbor information associated with cell morphology and can be automatically generated using modern hematological...Cell population data(CPD)is regarded as the fingerprint of a blood cell at a given moment.CPD parameters harbor information associated with cell morphology and can be automatically generated using modern hematological analyzers.Various studies have revealed many unique clinical applications for CPD,especially for infectious diseases,such as sepsis.For example,one monocyte-related CPD parameter is the monocyte distribution width(MDW),which can be generated using a Beckman Coulter hematological analyzer.MDW has received FDA and CE approval for aiding in sepsis diagnosis in adult patients in the emergency department.Additionally,MDW can serve as a diagnostic biomarker in patients infected with SARS-CoV-2.CPD has also been widely explored for possible clinical applications beyond infectious dis-eases,such as for predicting myelodysplastic syndromes,screening for he-matological malignancies,and detecting sterile inflammation.CPD parameter measurements are easily obtained and quite cost-effective,making them practical for clinical use.However,there are some potential drawbacks of CPD parameters.Some pre-analytical conditions can affect CPD values.Further-more,CPD are specific to certain hematological analyzers and the result cannot be transferred between different analyzers.The practical usefulness of CPD reference intervals is also still questionable.In this review,wesummarize the current studies related to CPD and its clinical applications.Additional well-designed clinical studies related to CPD are still expected.展开更多
Data User Service(DUS)offers you any data on China's population and rclated socioec onomic data--total population,age-sex composition,population density,labour force and more--to help you do demographic research,m...Data User Service(DUS)offers you any data on China's population and rclated socioec onomic data--total population,age-sex composition,population density,labour force and more--to help you do demographic research,make investments in China and so on.展开更多
This is a very attractive article. It combines fascinating new methodology with a most interesting dataset, and a highly motivating presentation. However, despite the many
The authors are to be congratulated for an innovative paper in terms of both modelling methodology and subject matter significance. The analysis of short time series is known to be
OpenStreetMap(OSM)is an essential source for acquiring building data,although such data may suffer from quality issues.Many studies have focused on assessing OSM building data quality but few have been carried out on ...OpenStreetMap(OSM)is an essential source for acquiring building data,although such data may suffer from quality issues.Many studies have focused on assessing OSM building data quality but few have been carried out on a global scale.This study aims to assess OSM building completeness(a quality measure)for 12,975 cities across the globe.This was achieved by employing population grid data as a proxy for reference building data.Not only the completeness of each city but also that of the grids within that city was assessed.The assessment results were evaluated based on calculating the overall accuracy and the r-square value between estimated and reference OSM building completeness values.Results showed that for 75%of cities,the completeness is lower than 20%;no more than 9%of cities have an estimated completeness higher than 80%.The overall accuracies of most countries were higher than 80%.The estimated completeness was also highly correlated with the reference completeness,which verifies the effectiveness of our approach.These results may be useful for acquiring and updating building data in OSM.A global and open dataset related to OSM building completeness has been made available for public use.展开更多
基金supported by the National Basic Research Program of China(No.2012CB944600)the National Key Research and Development Program of China(No.2016YFC0905100)+1 种基金the National Natural Science Foundation of China(Nos.31521003,31625015,31571297,31601046,31525014 and 91331204)the Science and Technology Commission of Shanghai Municipality(No.16YF1413900)
文摘Human genetic variants have long been known to play an important role in both Mendelian disorders and common diseases. Notably, pathogenic variants are not limited to single-nucleotide variants. It has become apparent that human diseases can also be caused by copy number variations （CNVs）, especially patient- specific novel CNVs （lafrate et al., 2004; Sebat et al., 2004; Redon et al., 2006; LuDski, 2007; Zhan~ et al.. 2009： Wu et al.. 2015）.
文摘National Population Health Data Center(NPHDC)is one of China's 20 national-level science data centers,jointly designated by the Ministry of Science and Technology and the Ministry of Finance.Operated by the Chinese Academy of Medical Sciences under the oversight of the National Health Commission,NPHDC adheres to national regulations including the Scientific Data Management Measures and the National Science and Technology Infrastructure Service Platform Management Measures,and is committed to collecting,integrating,managing,and sharing biomedical and health data through openaccess platform,fostering open sharing and engaging in international cooperation.
基金the basic and applied basic research projects of Guangdong Province,Grant/Award Number:2021A1515220040。
文摘Cell population data(CPD)is regarded as the fingerprint of a blood cell at a given moment.CPD parameters harbor information associated with cell morphology and can be automatically generated using modern hematological analyzers.Various studies have revealed many unique clinical applications for CPD,especially for infectious diseases,such as sepsis.For example,one monocyte-related CPD parameter is the monocyte distribution width(MDW),which can be generated using a Beckman Coulter hematological analyzer.MDW has received FDA and CE approval for aiding in sepsis diagnosis in adult patients in the emergency department.Additionally,MDW can serve as a diagnostic biomarker in patients infected with SARS-CoV-2.CPD has also been widely explored for possible clinical applications beyond infectious dis-eases,such as for predicting myelodysplastic syndromes,screening for he-matological malignancies,and detecting sterile inflammation.CPD parameter measurements are easily obtained and quite cost-effective,making them practical for clinical use.However,there are some potential drawbacks of CPD parameters.Some pre-analytical conditions can affect CPD values.Further-more,CPD are specific to certain hematological analyzers and the result cannot be transferred between different analyzers.The practical usefulness of CPD reference intervals is also still questionable.In this review,wesummarize the current studies related to CPD and its clinical applications.Additional well-designed clinical studies related to CPD are still expected.
文摘Data User Service(DUS)offers you any data on China's population and rclated socioec onomic data--total population,age-sex composition,population density,labour force and more--to help you do demographic research,make investments in China and so on.
文摘This is a very attractive article. It combines fascinating new methodology with a most interesting dataset, and a highly motivating presentation. However, despite the many
文摘The authors are to be congratulated for an innovative paper in terms of both modelling methodology and subject matter significance. The analysis of short time series is known to be
基金supported by National Natural Science Foundation of China(Grant No.41771428)the Director Fund of the International Research Center of Big Data for Sustainable Development Goals(Grant No.CBAS2022DF010).
文摘OpenStreetMap(OSM)is an essential source for acquiring building data,although such data may suffer from quality issues.Many studies have focused on assessing OSM building data quality but few have been carried out on a global scale.This study aims to assess OSM building completeness(a quality measure)for 12,975 cities across the globe.This was achieved by employing population grid data as a proxy for reference building data.Not only the completeness of each city but also that of the grids within that city was assessed.The assessment results were evaluated based on calculating the overall accuracy and the r-square value between estimated and reference OSM building completeness values.Results showed that for 75%of cities,the completeness is lower than 20%;no more than 9%of cities have an estimated completeness higher than 80%.The overall accuracies of most countries were higher than 80%.The estimated completeness was also highly correlated with the reference completeness,which verifies the effectiveness of our approach.These results may be useful for acquiring and updating building data in OSM.A global and open dataset related to OSM building completeness has been made available for public use.
