Objective:To study the clinical efficacy of applying the Meridian Flow Low-Frequency Therapy Device combined with Chinese herbal enema for patients with acute and chronic pelvic inflammatory disease(PID).Methods:Sixty...Objective:To study the clinical efficacy of applying the Meridian Flow Low-Frequency Therapy Device combined with Chinese herbal enema for patients with acute and chronic pelvic inflammatory disease(PID).Methods:Sixty-two patients with acute and chronic PID admitted from January 2024 to October 2025 were selected and randomly divided into a standard group(n=31)and an experimental group(n=31).The standard group received conventional medication+Chinese herbal enema treatment.The experimental group received the Meridian Flow Low-Frequency Therapy Device in addition to the standard group’s treatment.The clinical efficacy,changes in inflammatory markers,and pelvic improvement were compared between the two groups.Results:The excellent-good rate of treatment in the experimental group was higher than that in the standard group(p<0.05).The levels of various inflammatory factors in the experimental group were lower than those in the standard group(all p<0.05).The improvement in pelvic mass diameter and pelvic effusion depth in the experimental group was superior to that in the standard group(both p<0.05).Conclusion:The Meridian Flow Low-Frequency Therapy Device combined with Chinese herbal enema has a definite curative effect in treating pelvic inflammatory disease.It can effectively alleviate clinical symptoms,reduce inflammatory response,and promote the improvement of the pelvic environment.展开更多
OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Trad...OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 d.They continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ultrasound.RESULTS: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P < 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P = 0.0369). No significant differences were found between the two groups on the Physicochemical indexes(all P >0.05). No adverse events or reactions occurred in the experimental groups.CONCLUSION: Jinying capsule can reduce the dosage of antibiotics needed for PID treatment, and improve the symptoms in PID patients.展开更多
Chronic pelvic inflammatory disease is a highly common gynecological disease.It is often caused by the failure to completely treat acute pelvic inflammatory disease or persistent disease due to the poor physique of pa...Chronic pelvic inflammatory disease is a highly common gynecological disease.It is often caused by the failure to completely treat acute pelvic inflammatory disease or persistent disease due to the poor physique of patients.This paper provides a summary of the recent research studies on chronic pelvic inflammatory disease.展开更多
Objective Pelvic inflammatory disease(PID)is one of the most common gynaecological diseases.Here,this thesis aims to investigate the therapeutic effects of Prunella vulgaris L.oil on the PID by using metabolomics base...Objective Pelvic inflammatory disease(PID)is one of the most common gynaecological diseases.Here,this thesis aims to investigate the therapeutic effects of Prunella vulgaris L.oil on the PID by using metabolomics based on gas chromatographymass spectrometry(GC-MS)to address this challenge.Methods First,measurements of pro-inflammatory cytokines and histological analysis of the uterus were conducted to validate the successful generation of a PID rat model.Furthermore,the volatile oil from Prunella vulgaris L.was administered to treat PID rats.Serum samples were collected before and after treatment and analyzed by GC-MS to generate metabolite profiles for each sample.The information generated from the qualitative and quantitative analysis of these metabolites was applied to distinguish between the PID model and normal control groups.Results Some metabolites,such as acetic acid,succinic acid,glyceric acid,(R*,S*)-3,4-dihydroxybutanoic acid,3-hydroxyphenylacetic acid,D-ribose and myo-inositol showed a higher contribution in the classification model;thus,they can be considered as potential biomarkers.Furthermore,the therapeutic effect of the volatile oil extracted from Prunella vulgaris L.could also be visualized using GC-MS-based metabolomics.Conclusions The results show that metabolomics studies are invaluable for disease diagnosis and therapeutic effect estimation.展开更多
BACKGROUND We report a case of ruptured ovarian teratoma mimicking pelvic inflammatory disease(PID)and ovarian malignancy.The case indicates the need for reviewing the information on ovarian teratomas,as the symptoms ...BACKGROUND We report a case of ruptured ovarian teratoma mimicking pelvic inflammatory disease(PID)and ovarian malignancy.The case indicates the need for reviewing the information on ovarian teratomas,as the symptoms are vague,and,therefore,diagnosis and treatment had to be structured accordingly.CASE SUMMARY A 60-year-old woman was admitted to the emergency department with acute lower abdominal pain.She experienced weight loss and increased abdominal girth.Pelvic ultrasound and computed tomography revealed a 14-cm pelvic tumor.Laboratory examination revealed leukocytosis(white blood cell count:12620/μL,segment:87.7%)and high levels of C-reactive protein(18.2 mg/dL).Elevated levels of the tumor marker cancer antigen 19-9(367.8 U/mL,normal value<35 U/mL)were also noted.Due to the impression of a ruptured tuboovarian abscess or a tumor with malignancy,she immediately underwent an exploratory laparotomy.A ruptured ovarian tumor with fat balls,hair strands,cartilage,and yellowish fluid was observed on the right side.Right salpingooophorectomy was performed.A pathological examination revealed a mature cystic teratoma.The patient recovered after surgery and was discharged on postoperative day three.No antibiotics were administered.CONCLUSION This case illustrates the differential diagnosis of an ovarian tumor.Therefore,surgery is the mainstay for treating a ruptured teratoma.展开更多
[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randoml...[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.展开更多
Sequelae of Pelvic Inflammatory Diseases (SPID) is a common and frequent disease in gynecology, which adversely affects women’s reproductive health and quality of life due to its prolonged course. In recent years, tr...Sequelae of Pelvic Inflammatory Diseases (SPID) is a common and frequent disease in gynecology, which adversely affects women’s reproductive health and quality of life due to its prolonged course. In recent years, traditional Chinese medicine (TCM) in China has gradually shown its clinical advantages in the treatment of SPID. Therefore, the present review summarizes the etiology and pathogenesis of SPID, the evidence typology, and the clinical application effects of moxibustion, herbal retention enema, acupoint compresses, external application of traditional Chinese medicine, auricular pressure beans, tuina massage, traditional Chinese medicine gongfu, and other commonly used Chinese medicine nursing techniques, with the aim of providing references and experiences for the subsequent related studies.展开更多
Objecrive:To investigate the expression of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory disease(CPID)model rats.Methods:40 female rats that adaptive fed for 5 days were randomly divided into normal gr...Objecrive:To investigate the expression of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory disease(CPID)model rats.Methods:40 female rats that adaptive fed for 5 days were randomly divided into normal group,model group,high dose group,medium dose group and low dosegroup.In addition to the normal group:the rats in each group were made chronic pelvic inflammatory model by mechanical injuuy combined with implantation of bacteria.The rats in each group were administrated by gavage for 20days.After the last administration,the level of TNF-αand NF-κB in serum was measured by ELASA method.Results:(1)after the establishment of the model,the uterus of the chronic pelvic inflammatory model rats showed the pathological damage of chroic infilammation;the levels of lNF-αand NF-κB inserum were higher than those in the normal group,the difference was statistically significant(P<0.05).(2)After the drug intervention,the uterine tissue morphology of the rats in the Zhuang Yi Liu Fang Teng Fang Group was basically restored to normal,with only a small amount of inflammatory cell infiltration and other pathological changes;compared with the rats in the model group,the TNF-αin serum of the rats in each treatment group was lower,the difference was statistically significant(P<0.05).The expression of NF-κB in serum of each treatment group was lower fthan that of the model group(P<0.05).Conclusion:Zhuang Yi Liu Teng Fang can efectively improve the endometrial histomorphology of CPID model rats,and regulate the levels of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory model rats.展开更多
With a history of more than two thousand years, the theory of preventative treatment has been closely followed by the development of modern medical theories on the basis of inheritance by medical experts in the past d...With a history of more than two thousand years, the theory of preventative treatment has been closely followed by the development of modern medical theories on the basis of inheritance by medical experts in the past dynasties, which has been constantly improved and enriched, and deeply applied in the prevention and treatment of serious and multiple diseases. It has achieved great benefits. For women with gynecological diseases, pelvic inflammatory disease patients accounted for a large proportion. Due to the lack of specificity in diagnosis and treatment, the condition is lingering and difficult to cure, so it seriously reduces the quality of life of women, thus affecting the harmony of family and society. From the perspective of prevention, according to the characteristics of each stage of the disease, this paper put forward substantive prevention suggestions and targeted treatment methods, ensuring preventing before disease, preventing progress after disease, and preventing reoccurring after recovery. It has important practical significance for the prevention and treatment of pelvic inflammatory diseases, as well as the development and inheritance of traditional Chinese medicine.展开更多
Objective: to investigate the clinical value of azithromycin and pelvic inflammatory medicine in the treatment of pelvic inflammatory disease. Methods: 98 cases of pelvic inflammatory disease in our hospital were divi...Objective: to investigate the clinical value of azithromycin and pelvic inflammatory medicine in the treatment of pelvic inflammatory disease. Methods: 98 cases of pelvic inflammatory disease in our hospital were divided into double blind groups, including 49 cases of observation group and 49 cases of control group. In the relevant treatment, the control group was selected azithromycin alone, and the observation group was added with pelvic inflammatory medicine. The clinical efficacy between the groups was compared, and the hemodynamics and adverse side effects were comprehensively analyzed. Results: after related treatment, the clinical efficacy of the observation group was better than that of the control group, the hemodynamics was significantly optimized, the incidence of adverse side effects was lower, and there was a certain difference in p-value data. Conclusion: for the related treatment of pelvic inflammatory disease, azithromycin drug therapy and the selection of pelvic inflammatory disease preparation for adjuvant treatment can promote the significant optimization of hemodynamics, reduce the chance of adverse side effects, and should be vigorously promoted.展开更多
Objective: to explore the clinical efficacy of levofloxacin hydrochloride in the treatment of pelvic inflammatory disease. Methods: 110 patients with pelvic inflammatory disease were randomly divided into the control ...Objective: to explore the clinical efficacy of levofloxacin hydrochloride in the treatment of pelvic inflammatory disease. Methods: 110 patients with pelvic inflammatory disease were randomly divided into the control group and the observation group. The control group was treated with levofloxacin, and the observation group was treated with levofloxacin hydrochloride combined with Fule tablets. The therapeutic effects of the two groups were statistically analyzed. Results: The therapeutic effect of the observation group was better than that of the control group (P<0.05). Conclusion: pelvic inflammatory disease is inflammation of pelvic tissues. At this time, anti-inflammatory treatment should be adopted to reduce the clinical features of the patients and further improve the clinical symptoms. Levofloxacin hydrochloride combined with Fule tablets can treat pelvic inflammation, and on the basis of adjusting the score of inflammatory factors in patients, improve the clinical symptoms of patients such as abdominal pain, abnormal leucorrhea, menstrual disorders or dysmenorrhea, and further reduce the pain of the patients. It can provide high-quality clinical services for patients and achieve the fundamental purpose of treatment. The invention avoids the adverse events such as pain and the like repeatedly occurring in the body. During the treatment period, levofloxacin hydrochloride can carry out antibody on the related bacteria causing the disease of the patient, and inhibit the generation of the related bacterial DNA after reaching the body of the patient, thereby helping the patient to kill the related infectious bacteria. The invention has high clinical use value, and the Fule tablet has the effects of clearing heat, cooling blood, reducing swelling and relieving pain. The combination of the two has higher safety and effectiveness, and is recommended to be popularized in clinical application.展开更多
Objective: to select patients with chronic pelvic inflammatory disease, explore their nursing situation, and clarify the feasibility and effectiveness of nursing intervention. Methods: 60 patients with chronic pelvic ...Objective: to select patients with chronic pelvic inflammatory disease, explore their nursing situation, and clarify the feasibility and effectiveness of nursing intervention. Methods: 60 patients with chronic pelvic inflammatory disease were included in our gynecology department from January 2020 to January 2021. The patients who received routine care were set as Group A (30 cases) and the patients who received targeted care were set as Group B (30 cases). The intervention effects were compared, including resilience level, health belief, relapse rate and compliance behavior. The resilience level and health belief were evaluated by resilience scale (CD-RISC) and health belief scale respectively. Results: after the intervention, ① The level of psychological elasticity (CD-RISC score): Group B was lower than Group A (p < 0.05);② Health belief: Group B was higher than Group A (p < 0.05);③ Compliance behavior: 96.67% in Group B was higher than 80.0% in Group A ((2= 4.043, p < 0.05);④ Relapse rate: 3.33% in Group B was lower than 23.33% in Group A ((2 = 5.192, p < 0.05). Conclusion: the effect of targeted nursing is relatively high. For this research object, it can improve the level of psychological elasticity, strengthen health belief, improve compliance behavior, and reduce recurrence rate, which is worthy of optimization.展开更多
Objective: the fundamental purpose of this special medical research in our hospital is to understand the actual therapeutic effect of obstetrics and gynecology in the treatment of chronic pelvic inflammatory disease. ...Objective: the fundamental purpose of this special medical research in our hospital is to understand the actual therapeutic effect of obstetrics and gynecology in the treatment of chronic pelvic inflammatory disease. Methods: the total course of this special medical research was 12 months, starting from May 2021 and ending from May 2022. A total of 86 patients were included in the study. The study completely followed the principle of linear development of time to group patients, i.e. the patients were grouped according to the order in which the patients went to the hospital. 1-43 patients were classified as Group Z in the study, all received routine treatment, and 44-86 patients were classified as Group F, all received comprehensive gynecologic and obstetric drug treatment. After the completion of this special medical study, the data generated by the two groups of patients during the study period will be collected and analyzed, and the actual therapeutic effect of clinical treatment in obstetrics and gynecology department will be determined based on the presented data differences. Results: after the completion of this special medical research and the analysis of various data, it can be seen that after the patients in Group Z and Group F received different treatment measures, the performance of Group F was significantly better than that of Group Z in all aspects. Conclusion: according to the actual results of this special medical research, it can be preliminarily determined that comprehensive medication aiming at the actual situation of patients with pelvic inflammatory disease in the clinical treatment stage of obstetrics and gynecology has the application value of optimizing the treatment effect.展开更多
Chronic pelvic inflammatory disease is more common gynecological diseases in clinic, is often seen in production at the end of women, most of patients with acute pelvic inflammatory disease, and chronic tubal inflamma...Chronic pelvic inflammatory disease is more common gynecological diseases in clinic, is often seen in production at the end of women, most of patients with acute pelvic inflammatory disease, and chronic tubal inflammation did not cure, then gradually develop into chronic pelvic inflammatory disease, if he can't give timely and effective in patients with early in disease intervention, patient can appear repeatedly, And patients are more likely to develop more severe disease later in life. With the increasing incidence of chronic pelvic inflammatory disease, treatment and treatment effect of this kind of disease also has received the widespread attention, is aimed at this kind of disease is more commonly used clinical treatment including antibiotic therapy, surgical treatment, physical therapy and traditional Chinese medicine treatment, etc., in order to further analyze the therapeutic effect of the several treatment measures, This paper analyzes the pathogenesis of chronic pelvic inflammatory disease from the perspective of traditional Chinese medicine and western medicine, and further analyzes the pathogenesis characteristics of chronic pelvic inflammatory disease and the current treatment progress, in order to be conducive to the future treatment of chronic pelvic inflammatory disease patients, to help improve the work efficiency of clinicians.展开更多
Objective: to observe and analyze the nursing effect of staging nursing measures for chronic pelvic inflammatory disease. Methods: 80 patients with chronic pelvic inflammatory disease admitted to our hospital from Jun...Objective: to observe and analyze the nursing effect of staging nursing measures for chronic pelvic inflammatory disease. Methods: 80 patients with chronic pelvic inflammatory disease admitted to our hospital from June 2017 to June 2019 were selected as the research object, and the patients were given staged nursing. Results: after nursing, the patient's body index tended to be normal and the inflammation disappeared. Conclusion: in the process of nursing the patients with chronic pelvic inflammatory disease, the nursing effect of stage nursing is remarkable. After nursing, the inflammation of the patients has obvious improvement trend, the quality of life has been significantly improved, and the anxiety, depression and panic degree of the patients have been reduced. Therefore, the stage nursing measures have application value in the process of nursing the patients with chronic pelvic inflammatory disease.展开更多
In order to investigate the clinical value of clarithromycin combined with Guizhi Poria capsule in the treatment of chronic pelvic inflammatory disease. Methods: a "double-blind number" study was conducted i...In order to investigate the clinical value of clarithromycin combined with Guizhi Poria capsule in the treatment of chronic pelvic inflammatory disease. Methods: a "double-blind number" study was conducted in 60 patients with chronic pelvic inflammatory disease (study group and control group). The treatment period was from January 2020 to April 2021, and the total number of patients in each group was 30. In the clinical treatment, clarithromycin was used in the control group and Guigzhi Tuckahoe capsule was used in the observation group. Results: through clinical intensive treatment, the study group was significantly lower in the data analysis of treatment response rate. At the same time, for the improvement of inflammatory cells, the study group was more optimized in the stability comparison. In addition, in the analysis of adverse side effects, the study group had a lower chance of adverse side effects, and the treatment effect of the study group was superior through the comparison of relevant data differences. Conclusion: in the chronic pelvic inflammatory disease clinical drug research, comprehensive treatment comprehensive function, take a combination of western medicine, Chinese medicine treatment, can achieve organic improvement of inflammation level, promote the incidence of adverse side effects significantly reduced, to achieve the effective improvement of the treatment level, clinical can be vigorously promoted and used.展开更多
Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who wer...Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.展开更多
Objective: to explore the nursing experience of treating chronic pelvic inflammatory disease with traditional Chinese medicine traditional Chinese medicine hot compress bag. Methods: 80 patients with chronic pelvic in...Objective: to explore the nursing experience of treating chronic pelvic inflammatory disease with traditional Chinese medicine traditional Chinese medicine hot compress bag. Methods: 80 patients with chronic pelvic inflammatory disease in our hospital were selected and randomly divided into the control group and the observation group. The control group received routine treatment and routine nursing care, while the observation group received traditional Chinese medicine hot election package treatment and nursing intervention. The therapeutic effect and nursing effect of the two groups of patients were counted. Results: the patients in the observation group were better than those in the control group (P<0.05). Conclusion: the traditional Chinese medicine traditional Chinese medicine hot compress bag is quite different from the need in the traditional treatment process. It does not need to enter the patients body, and can help patients to reduce their own clinical symptoms. In the process of treating chronic pelvic inflammatory disease, it can improve the patients leucorrhea increase and abdominal pain, effectively reduce the permeability of capillary vessels, help patients to maintain the circulation of self-immune mechanism, so as to achieve the best clinical treatment effect, avoid adhesion of patients pelvic tissues, and adopt multidisciplinary comprehensive and effective care to help patients to improve the clinical symptoms of the disease as soon as possible and restore normal life.展开更多
Objective: to explore the clinical application of postpartum pelvic floor rehabilitation therapy in postpartum pelvic floor dysfunction diseases. Methods: a total of 120 patients with postpartum pelvic floor dysfuncti...Objective: to explore the clinical application of postpartum pelvic floor rehabilitation therapy in postpartum pelvic floor dysfunction diseases. Methods: a total of 120 patients with postpartum pelvic floor dysfunction in our hospital from January 2019 to June 2021 were selected as the research object. They were divided into research group and reference group with 60 patients in each group by random number table method. The reference group received pelvic floor rehabilitation training, and the research group received pelvic floor rehabilitation therapy instrument on the basis of the reference group. Vaginal systolic blood pressure and pelvic floor muscle strength were compared between the two groups before and after treatment. Results: after comparative analysis, uterine prolapse and urinary incontinence accounted for 8.3% and 6.7% respectively in the study group, and 15.0% and 16.7% respectively in the reference group, the differences were statistically significant (P < 0.05). Compared with pelvic floor muscle strength, the qualified rate of the study group was 96.7%, and that of the reference group was 81.7%, the difference was statistically significant (P < 0.05). Before the treatment, there was no significant difference in vaginal systolic blood pressure between the study group and the reference group (P > 0.05). After the implementation of treatment, the levels of both groups were improved, and the index level of the study group was more advantageous, the difference was statistically significant (P < 0.05). Conclusion: the combination of pelvic floor rehabilitation training and pelvic floor rehabilitation therapy instrument has significant effect on postpartum patients with pelvic floor dysfunction disease, which can improve the level of pelvic floor muscle of patients, and suggest clinical promotion.展开更多
As a Chinese medicinal plant,Smilax china is traditionally used in the treatment of pelvic inflammatory disease(PID).Flavonoids have been identified as the anti-inflammatory bioactive fraction.However,the high content...As a Chinese medicinal plant,Smilax china is traditionally used in the treatment of pelvic inflammatory disease(PID).Flavonoids have been identified as the anti-inflammatory bioactive fraction.However,the high content of total flavonoids has not been extracted from S.china.The therapeutic effects and mechanisms of total flavonoids are still unknown.In the present study,we aimed to obtain the effective parts of flavonoids in S.china,and elucidate the mechanism of action on PID.The anti-inflammatory effect was evaluated on phenol mucilage-induced pelvic inflammation in rats.This was the first time that total flavonoids in high concentration(up to 55.6%)were obtained in S.china.A total of 15 compounds were separated and identified by NMR,and the total flavonoids were detected with HPLC.TFSC caused a reduction in serum levels of IL-6 and IL-1β.These results suggested that TFSC had a significant anti-PID effect,probably due to inhibition of the inflammatory reaction.展开更多
文摘Objective:To study the clinical efficacy of applying the Meridian Flow Low-Frequency Therapy Device combined with Chinese herbal enema for patients with acute and chronic pelvic inflammatory disease(PID).Methods:Sixty-two patients with acute and chronic PID admitted from January 2024 to October 2025 were selected and randomly divided into a standard group(n=31)and an experimental group(n=31).The standard group received conventional medication+Chinese herbal enema treatment.The experimental group received the Meridian Flow Low-Frequency Therapy Device in addition to the standard group’s treatment.The clinical efficacy,changes in inflammatory markers,and pelvic improvement were compared between the two groups.Results:The excellent-good rate of treatment in the experimental group was higher than that in the standard group(p<0.05).The levels of various inflammatory factors in the experimental group were lower than those in the standard group(all p<0.05).The improvement in pelvic mass diameter and pelvic effusion depth in the experimental group was superior to that in the standard group(both p<0.05).Conclusion:The Meridian Flow Low-Frequency Therapy Device combined with Chinese herbal enema has a definite curative effect in treating pelvic inflammatory disease.It can effectively alleviate clinical symptoms,reduce inflammatory response,and promote the improvement of the pelvic environment.
文摘OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 d.They continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ultrasound.RESULTS: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P < 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P = 0.0369). No significant differences were found between the two groups on the Physicochemical indexes(all P >0.05). No adverse events or reactions occurred in the experimental groups.CONCLUSION: Jinying capsule can reduce the dosage of antibiotics needed for PID treatment, and improve the symptoms in PID patients.
文摘Chronic pelvic inflammatory disease is a highly common gynecological disease.It is often caused by the failure to completely treat acute pelvic inflammatory disease or persistent disease due to the poor physique of patients.This paper provides a summary of the recent research studies on chronic pelvic inflammatory disease.
基金We thank for the funding support from the National Natural Science Foundation of China(No.81503041)Natural Science Foundation of Hunan Province(No.2017JJ4045)Changsha Science and Technology Project(No.kq1701073).
文摘Objective Pelvic inflammatory disease(PID)is one of the most common gynaecological diseases.Here,this thesis aims to investigate the therapeutic effects of Prunella vulgaris L.oil on the PID by using metabolomics based on gas chromatographymass spectrometry(GC-MS)to address this challenge.Methods First,measurements of pro-inflammatory cytokines and histological analysis of the uterus were conducted to validate the successful generation of a PID rat model.Furthermore,the volatile oil from Prunella vulgaris L.was administered to treat PID rats.Serum samples were collected before and after treatment and analyzed by GC-MS to generate metabolite profiles for each sample.The information generated from the qualitative and quantitative analysis of these metabolites was applied to distinguish between the PID model and normal control groups.Results Some metabolites,such as acetic acid,succinic acid,glyceric acid,(R*,S*)-3,4-dihydroxybutanoic acid,3-hydroxyphenylacetic acid,D-ribose and myo-inositol showed a higher contribution in the classification model;thus,they can be considered as potential biomarkers.Furthermore,the therapeutic effect of the volatile oil extracted from Prunella vulgaris L.could also be visualized using GC-MS-based metabolomics.Conclusions The results show that metabolomics studies are invaluable for disease diagnosis and therapeutic effect estimation.
文摘BACKGROUND We report a case of ruptured ovarian teratoma mimicking pelvic inflammatory disease(PID)and ovarian malignancy.The case indicates the need for reviewing the information on ovarian teratomas,as the symptoms are vague,and,therefore,diagnosis and treatment had to be structured accordingly.CASE SUMMARY A 60-year-old woman was admitted to the emergency department with acute lower abdominal pain.She experienced weight loss and increased abdominal girth.Pelvic ultrasound and computed tomography revealed a 14-cm pelvic tumor.Laboratory examination revealed leukocytosis(white blood cell count:12620/μL,segment:87.7%)and high levels of C-reactive protein(18.2 mg/dL).Elevated levels of the tumor marker cancer antigen 19-9(367.8 U/mL,normal value<35 U/mL)were also noted.Due to the impression of a ruptured tuboovarian abscess or a tumor with malignancy,she immediately underwent an exploratory laparotomy.A ruptured ovarian tumor with fat balls,hair strands,cartilage,and yellowish fluid was observed on the right side.Right salpingooophorectomy was performed.A pathological examination revealed a mature cystic teratoma.The patient recovered after surgery and was discharged on postoperative day three.No antibiotics were administered.CONCLUSION This case illustrates the differential diagnosis of an ovarian tumor.Therefore,surgery is the mainstay for treating a ruptured teratoma.
文摘[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.
文摘Sequelae of Pelvic Inflammatory Diseases (SPID) is a common and frequent disease in gynecology, which adversely affects women’s reproductive health and quality of life due to its prolonged course. In recent years, traditional Chinese medicine (TCM) in China has gradually shown its clinical advantages in the treatment of SPID. Therefore, the present review summarizes the etiology and pathogenesis of SPID, the evidence typology, and the clinical application effects of moxibustion, herbal retention enema, acupoint compresses, external application of traditional Chinese medicine, auricular pressure beans, tuina massage, traditional Chinese medicine gongfu, and other commonly used Chinese medicine nursing techniques, with the aim of providing references and experiences for the subsequent related studies.
基金Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,No.:Gui Jiao Ke Yan〔2013〕20Guangxi first-class discipline construction project(No.Gui Jiao Ke Yan[2018]12)+1 种基金Open Project for Guangxi First-class Discipline Constuction of GuangxiUniversity of Chinese Medicine(No.2019XK038)Funded by Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine(No.2018005).
文摘Objecrive:To investigate the expression of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory disease(CPID)model rats.Methods:40 female rats that adaptive fed for 5 days were randomly divided into normal group,model group,high dose group,medium dose group and low dosegroup.In addition to the normal group:the rats in each group were made chronic pelvic inflammatory model by mechanical injuuy combined with implantation of bacteria.The rats in each group were administrated by gavage for 20days.After the last administration,the level of TNF-αand NF-κB in serum was measured by ELASA method.Results:(1)after the establishment of the model,the uterus of the chronic pelvic inflammatory model rats showed the pathological damage of chroic infilammation;the levels of lNF-αand NF-κB inserum were higher than those in the normal group,the difference was statistically significant(P<0.05).(2)After the drug intervention,the uterine tissue morphology of the rats in the Zhuang Yi Liu Fang Teng Fang Group was basically restored to normal,with only a small amount of inflammatory cell infiltration and other pathological changes;compared with the rats in the model group,the TNF-αin serum of the rats in each treatment group was lower,the difference was statistically significant(P<0.05).The expression of NF-κB in serum of each treatment group was lower fthan that of the model group(P<0.05).Conclusion:Zhuang Yi Liu Teng Fang can efectively improve the endometrial histomorphology of CPID model rats,and regulate the levels of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory model rats.
基金National Natural Science Foundation of China Youth Science Fund Project (81904245, 81903998)Jiangsu Province Key Research and Development Project (BE2019766)Jiangsu Province Science and Technology Project Basic Research Program (Natural Science Foundation) General Project (BK20171511)。
文摘With a history of more than two thousand years, the theory of preventative treatment has been closely followed by the development of modern medical theories on the basis of inheritance by medical experts in the past dynasties, which has been constantly improved and enriched, and deeply applied in the prevention and treatment of serious and multiple diseases. It has achieved great benefits. For women with gynecological diseases, pelvic inflammatory disease patients accounted for a large proportion. Due to the lack of specificity in diagnosis and treatment, the condition is lingering and difficult to cure, so it seriously reduces the quality of life of women, thus affecting the harmony of family and society. From the perspective of prevention, according to the characteristics of each stage of the disease, this paper put forward substantive prevention suggestions and targeted treatment methods, ensuring preventing before disease, preventing progress after disease, and preventing reoccurring after recovery. It has important practical significance for the prevention and treatment of pelvic inflammatory diseases, as well as the development and inheritance of traditional Chinese medicine.
文摘Objective: to investigate the clinical value of azithromycin and pelvic inflammatory medicine in the treatment of pelvic inflammatory disease. Methods: 98 cases of pelvic inflammatory disease in our hospital were divided into double blind groups, including 49 cases of observation group and 49 cases of control group. In the relevant treatment, the control group was selected azithromycin alone, and the observation group was added with pelvic inflammatory medicine. The clinical efficacy between the groups was compared, and the hemodynamics and adverse side effects were comprehensively analyzed. Results: after related treatment, the clinical efficacy of the observation group was better than that of the control group, the hemodynamics was significantly optimized, the incidence of adverse side effects was lower, and there was a certain difference in p-value data. Conclusion: for the related treatment of pelvic inflammatory disease, azithromycin drug therapy and the selection of pelvic inflammatory disease preparation for adjuvant treatment can promote the significant optimization of hemodynamics, reduce the chance of adverse side effects, and should be vigorously promoted.
文摘Objective: to explore the clinical efficacy of levofloxacin hydrochloride in the treatment of pelvic inflammatory disease. Methods: 110 patients with pelvic inflammatory disease were randomly divided into the control group and the observation group. The control group was treated with levofloxacin, and the observation group was treated with levofloxacin hydrochloride combined with Fule tablets. The therapeutic effects of the two groups were statistically analyzed. Results: The therapeutic effect of the observation group was better than that of the control group (P<0.05). Conclusion: pelvic inflammatory disease is inflammation of pelvic tissues. At this time, anti-inflammatory treatment should be adopted to reduce the clinical features of the patients and further improve the clinical symptoms. Levofloxacin hydrochloride combined with Fule tablets can treat pelvic inflammation, and on the basis of adjusting the score of inflammatory factors in patients, improve the clinical symptoms of patients such as abdominal pain, abnormal leucorrhea, menstrual disorders or dysmenorrhea, and further reduce the pain of the patients. It can provide high-quality clinical services for patients and achieve the fundamental purpose of treatment. The invention avoids the adverse events such as pain and the like repeatedly occurring in the body. During the treatment period, levofloxacin hydrochloride can carry out antibody on the related bacteria causing the disease of the patient, and inhibit the generation of the related bacterial DNA after reaching the body of the patient, thereby helping the patient to kill the related infectious bacteria. The invention has high clinical use value, and the Fule tablet has the effects of clearing heat, cooling blood, reducing swelling and relieving pain. The combination of the two has higher safety and effectiveness, and is recommended to be popularized in clinical application.
文摘Objective: to select patients with chronic pelvic inflammatory disease, explore their nursing situation, and clarify the feasibility and effectiveness of nursing intervention. Methods: 60 patients with chronic pelvic inflammatory disease were included in our gynecology department from January 2020 to January 2021. The patients who received routine care were set as Group A (30 cases) and the patients who received targeted care were set as Group B (30 cases). The intervention effects were compared, including resilience level, health belief, relapse rate and compliance behavior. The resilience level and health belief were evaluated by resilience scale (CD-RISC) and health belief scale respectively. Results: after the intervention, ① The level of psychological elasticity (CD-RISC score): Group B was lower than Group A (p < 0.05);② Health belief: Group B was higher than Group A (p < 0.05);③ Compliance behavior: 96.67% in Group B was higher than 80.0% in Group A ((2= 4.043, p < 0.05);④ Relapse rate: 3.33% in Group B was lower than 23.33% in Group A ((2 = 5.192, p < 0.05). Conclusion: the effect of targeted nursing is relatively high. For this research object, it can improve the level of psychological elasticity, strengthen health belief, improve compliance behavior, and reduce recurrence rate, which is worthy of optimization.
文摘Objective: the fundamental purpose of this special medical research in our hospital is to understand the actual therapeutic effect of obstetrics and gynecology in the treatment of chronic pelvic inflammatory disease. Methods: the total course of this special medical research was 12 months, starting from May 2021 and ending from May 2022. A total of 86 patients were included in the study. The study completely followed the principle of linear development of time to group patients, i.e. the patients were grouped according to the order in which the patients went to the hospital. 1-43 patients were classified as Group Z in the study, all received routine treatment, and 44-86 patients were classified as Group F, all received comprehensive gynecologic and obstetric drug treatment. After the completion of this special medical study, the data generated by the two groups of patients during the study period will be collected and analyzed, and the actual therapeutic effect of clinical treatment in obstetrics and gynecology department will be determined based on the presented data differences. Results: after the completion of this special medical research and the analysis of various data, it can be seen that after the patients in Group Z and Group F received different treatment measures, the performance of Group F was significantly better than that of Group Z in all aspects. Conclusion: according to the actual results of this special medical research, it can be preliminarily determined that comprehensive medication aiming at the actual situation of patients with pelvic inflammatory disease in the clinical treatment stage of obstetrics and gynecology has the application value of optimizing the treatment effect.
文摘Chronic pelvic inflammatory disease is more common gynecological diseases in clinic, is often seen in production at the end of women, most of patients with acute pelvic inflammatory disease, and chronic tubal inflammation did not cure, then gradually develop into chronic pelvic inflammatory disease, if he can't give timely and effective in patients with early in disease intervention, patient can appear repeatedly, And patients are more likely to develop more severe disease later in life. With the increasing incidence of chronic pelvic inflammatory disease, treatment and treatment effect of this kind of disease also has received the widespread attention, is aimed at this kind of disease is more commonly used clinical treatment including antibiotic therapy, surgical treatment, physical therapy and traditional Chinese medicine treatment, etc., in order to further analyze the therapeutic effect of the several treatment measures, This paper analyzes the pathogenesis of chronic pelvic inflammatory disease from the perspective of traditional Chinese medicine and western medicine, and further analyzes the pathogenesis characteristics of chronic pelvic inflammatory disease and the current treatment progress, in order to be conducive to the future treatment of chronic pelvic inflammatory disease patients, to help improve the work efficiency of clinicians.
文摘Objective: to observe and analyze the nursing effect of staging nursing measures for chronic pelvic inflammatory disease. Methods: 80 patients with chronic pelvic inflammatory disease admitted to our hospital from June 2017 to June 2019 were selected as the research object, and the patients were given staged nursing. Results: after nursing, the patient's body index tended to be normal and the inflammation disappeared. Conclusion: in the process of nursing the patients with chronic pelvic inflammatory disease, the nursing effect of stage nursing is remarkable. After nursing, the inflammation of the patients has obvious improvement trend, the quality of life has been significantly improved, and the anxiety, depression and panic degree of the patients have been reduced. Therefore, the stage nursing measures have application value in the process of nursing the patients with chronic pelvic inflammatory disease.
文摘In order to investigate the clinical value of clarithromycin combined with Guizhi Poria capsule in the treatment of chronic pelvic inflammatory disease. Methods: a "double-blind number" study was conducted in 60 patients with chronic pelvic inflammatory disease (study group and control group). The treatment period was from January 2020 to April 2021, and the total number of patients in each group was 30. In the clinical treatment, clarithromycin was used in the control group and Guigzhi Tuckahoe capsule was used in the observation group. Results: through clinical intensive treatment, the study group was significantly lower in the data analysis of treatment response rate. At the same time, for the improvement of inflammatory cells, the study group was more optimized in the stability comparison. In addition, in the analysis of adverse side effects, the study group had a lower chance of adverse side effects, and the treatment effect of the study group was superior through the comparison of relevant data differences. Conclusion: in the chronic pelvic inflammatory disease clinical drug research, comprehensive treatment comprehensive function, take a combination of western medicine, Chinese medicine treatment, can achieve organic improvement of inflammation level, promote the incidence of adverse side effects significantly reduced, to achieve the effective improvement of the treatment level, clinical can be vigorously promoted and used.
文摘Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.
文摘Objective: to explore the nursing experience of treating chronic pelvic inflammatory disease with traditional Chinese medicine traditional Chinese medicine hot compress bag. Methods: 80 patients with chronic pelvic inflammatory disease in our hospital were selected and randomly divided into the control group and the observation group. The control group received routine treatment and routine nursing care, while the observation group received traditional Chinese medicine hot election package treatment and nursing intervention. The therapeutic effect and nursing effect of the two groups of patients were counted. Results: the patients in the observation group were better than those in the control group (P<0.05). Conclusion: the traditional Chinese medicine traditional Chinese medicine hot compress bag is quite different from the need in the traditional treatment process. It does not need to enter the patients body, and can help patients to reduce their own clinical symptoms. In the process of treating chronic pelvic inflammatory disease, it can improve the patients leucorrhea increase and abdominal pain, effectively reduce the permeability of capillary vessels, help patients to maintain the circulation of self-immune mechanism, so as to achieve the best clinical treatment effect, avoid adhesion of patients pelvic tissues, and adopt multidisciplinary comprehensive and effective care to help patients to improve the clinical symptoms of the disease as soon as possible and restore normal life.
文摘Objective: to explore the clinical application of postpartum pelvic floor rehabilitation therapy in postpartum pelvic floor dysfunction diseases. Methods: a total of 120 patients with postpartum pelvic floor dysfunction in our hospital from January 2019 to June 2021 were selected as the research object. They were divided into research group and reference group with 60 patients in each group by random number table method. The reference group received pelvic floor rehabilitation training, and the research group received pelvic floor rehabilitation therapy instrument on the basis of the reference group. Vaginal systolic blood pressure and pelvic floor muscle strength were compared between the two groups before and after treatment. Results: after comparative analysis, uterine prolapse and urinary incontinence accounted for 8.3% and 6.7% respectively in the study group, and 15.0% and 16.7% respectively in the reference group, the differences were statistically significant (P < 0.05). Compared with pelvic floor muscle strength, the qualified rate of the study group was 96.7%, and that of the reference group was 81.7%, the difference was statistically significant (P < 0.05). Before the treatment, there was no significant difference in vaginal systolic blood pressure between the study group and the reference group (P > 0.05). After the implementation of treatment, the levels of both groups were improved, and the index level of the study group was more advantageous, the difference was statistically significant (P < 0.05). Conclusion: the combination of pelvic floor rehabilitation training and pelvic floor rehabilitation therapy instrument has significant effect on postpartum patients with pelvic floor dysfunction disease, which can improve the level of pelvic floor muscle of patients, and suggest clinical promotion.
基金The Science and Technology Department of Jiangxi Province(Grant No.20192ACB20016,20165BCB18006,20172BCB22010,GJJ201214)the National Natural Science Foundation of China(NSFC,Grant No.8150640)。
文摘As a Chinese medicinal plant,Smilax china is traditionally used in the treatment of pelvic inflammatory disease(PID).Flavonoids have been identified as the anti-inflammatory bioactive fraction.However,the high content of total flavonoids has not been extracted from S.china.The therapeutic effects and mechanisms of total flavonoids are still unknown.In the present study,we aimed to obtain the effective parts of flavonoids in S.china,and elucidate the mechanism of action on PID.The anti-inflammatory effect was evaluated on phenol mucilage-induced pelvic inflammation in rats.This was the first time that total flavonoids in high concentration(up to 55.6%)were obtained in S.china.A total of 15 compounds were separated and identified by NMR,and the total flavonoids were detected with HPLC.TFSC caused a reduction in serum levels of IL-6 and IL-1β.These results suggested that TFSC had a significant anti-PID effect,probably due to inhibition of the inflammatory reaction.
