Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particu...Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particularly young children,may have different immunological responses to infection.Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.The characteristics of CV-A10 infection,replication,and shedding in humans remain unknown.In this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in humans.The clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in humans.Substantial inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and kidney.During the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery period.In addition,there were no significant differences between respiratory and digestive tract infected animals.Overall,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies.展开更多
Enterococci bacteria are important in environmental, food and clinical microbiology. Enterococcus faecium is a nosocomial pathogen that causes bacteremia, endocarditis and other infections. It is among the most preval...Enterococci bacteria are important in environmental, food and clinical microbiology. Enterococcus faecium is a nosocomial pathogen that causes bacteremia, endocarditis and other infections. It is among the most prevalent organisms encountered in hospital-associated infections accounting for approximately 12% of nosocomial infections in the USA （Linden and Miller, 1999）. However, certain strains of E. faecium are not only non-pathogenic but also have beneficial effects on human health with probiotic potential. For example, E. faecium T-110 is a consortium member in several probiotic products including BIO-THREE~ which is widely prescribed for human, animal and aqua-cultural use. This strain was originally developed by TOA Pharmaceuticals in Japan, and later used in the probiotic products of several other companies.展开更多
Objective: investigate the pathogenesis of acute coronary syndrome (ACS) with paroxysmal atrial fibrillation, and to provide theoretical basis for subsequent treatment and prevention. Methods: A 72-year-old female pat...Objective: investigate the pathogenesis of acute coronary syndrome (ACS) with paroxysmal atrial fibrillation, and to provide theoretical basis for subsequent treatment and prevention. Methods: A 72-year-old female patient with persistent "paroxysm chest pain" who was admitted to hospital at 15:00, 2020.03.17.00, was given physical examination immediately after admission, and performed routine blood, urine, stool, liver function, kidney function, electrolyte, coagulation series, D-dimer and other laboratory tests, followed by electrocardiogram, cardiac ultrasonography and coronary angiography. Results: the laboratory examination showed no obvious abnormality. ECG showed sinus rhythm, heart rate 76 beats/min. The color ultrasonography of the heart showed aorta sclerosis with no abnormal color blood flow. The coronary artery presented the dominant type of right coronary artery, with different degrees of stenosis at the opening, the middle segment, the proximal segment of the left ventricular posterior branch, the proximal segment of the anterior descending branch and the distal segment. Conclusion: the patient had coronary heart disease with unstable angina pectoris, type-2 diabetes mellitus and grade 3-level hypertension. The whole course of the patient's disease was consistent with the acute coronary syndrome (ACS) induced by paroxysmal atrial fibrillation (AF) and the specific clinical presentation was unstable angina pectoris.展开更多
supported by the China Animal Disease Prevention and Control Center;the China Agriculture Research System Poultry-Related Science and Technology Innovation Team of Peking, China （CARS-PSTP）
基金the Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences(CIFMS,2016-I2M-2-001)National Resource Center for Non-Human Primates,Major Science and Technology Special Projects in Yunnan ProvinceKunming Science and Technology Innovation and Service Capacity Enhancement Program Key Projects(2016-2-R-07674)。
文摘Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particularly young children,may have different immunological responses to infection.Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.The characteristics of CV-A10 infection,replication,and shedding in humans remain unknown.In this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in humans.The clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in humans.Substantial inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and kidney.During the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery period.In addition,there were no significant differences between respiratory and digestive tract infected animals.Overall,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies.
文摘Enterococci bacteria are important in environmental, food and clinical microbiology. Enterococcus faecium is a nosocomial pathogen that causes bacteremia, endocarditis and other infections. It is among the most prevalent organisms encountered in hospital-associated infections accounting for approximately 12% of nosocomial infections in the USA （Linden and Miller, 1999）. However, certain strains of E. faecium are not only non-pathogenic but also have beneficial effects on human health with probiotic potential. For example, E. faecium T-110 is a consortium member in several probiotic products including BIO-THREE~ which is widely prescribed for human, animal and aqua-cultural use. This strain was originally developed by TOA Pharmaceuticals in Japan, and later used in the probiotic products of several other companies.
文摘Objective: investigate the pathogenesis of acute coronary syndrome (ACS) with paroxysmal atrial fibrillation, and to provide theoretical basis for subsequent treatment and prevention. Methods: A 72-year-old female patient with persistent "paroxysm chest pain" who was admitted to hospital at 15:00, 2020.03.17.00, was given physical examination immediately after admission, and performed routine blood, urine, stool, liver function, kidney function, electrolyte, coagulation series, D-dimer and other laboratory tests, followed by electrocardiogram, cardiac ultrasonography and coronary angiography. Results: the laboratory examination showed no obvious abnormality. ECG showed sinus rhythm, heart rate 76 beats/min. The color ultrasonography of the heart showed aorta sclerosis with no abnormal color blood flow. The coronary artery presented the dominant type of right coronary artery, with different degrees of stenosis at the opening, the middle segment, the proximal segment of the left ventricular posterior branch, the proximal segment of the anterior descending branch and the distal segment. Conclusion: the patient had coronary heart disease with unstable angina pectoris, type-2 diabetes mellitus and grade 3-level hypertension. The whole course of the patient's disease was consistent with the acute coronary syndrome (ACS) induced by paroxysmal atrial fibrillation (AF) and the specific clinical presentation was unstable angina pectoris.
基金supported by the China Animal Disease Prevention and Control Centerthe China Agriculture Research System Poultry-Related Science and Technology Innovation Team of Peking, China (CARS-PSTP)
文摘supported by the China Animal Disease Prevention and Control Center;the China Agriculture Research System Poultry-Related Science and Technology Innovation Team of Peking, China （CARS-PSTP）
