PV （photovoltaic） solar panels generally produce electricity in the 6% to 12% efficiency range, the rest is being dissipated in thermal losses. To recover this amount, hybrid photovoltaic thermal systems （PV/T） ha...PV （photovoltaic） solar panels generally produce electricity in the 6% to 12% efficiency range, the rest is being dissipated in thermal losses. To recover this amount, hybrid photovoltaic thermal systems （PV/T） have been devised. These are devices that simultaneously convert solar energy into electricity and heat. It is thus interesting to study the PV/T system as part of a closed loop single phase water CDU （coolant distribution unit） in laminar forced convection. In particular, the analysis was conducted on the optimal cooling performance of the thermal part, testing polynomial channel profiles of varying order （from zero to fourth） for channels of a real industrial module heat sink, under the following conditions： ideal flux of 1,000 W/m2 on one side, insulation on the opposite side, periodic conditions on the remaining sides, fully developed thermal and velocity profile in laminar flow of water. Through the use of a genetic algorithm, we have optimized the shape of the channel＇s sidewalls in terms of heat transfer maximization. In terms of Nusselt number, results show that fourth order profiles are the most efficient. When limits to allowable pressure loss and module weight are introduced, these bring generally to a lower efficiency of the system than the unconstrained case.展开更多
目的:探索上皮性卵巢癌(EOC)中lncRNA PVT1调控上皮-间皮质转化(EMT)的关键通路和枢纽基因。方法:收集EOC相关基因,通过疾病富集分析验证其可靠性。然后,通过通路富集分析,发现EOC显著富集的通路,筛选出与EMT过程相关的通路。通过整合Me...目的:探索上皮性卵巢癌(EOC)中lncRNA PVT1调控上皮-间皮质转化(EMT)的关键通路和枢纽基因。方法:收集EOC相关基因,通过疾病富集分析验证其可靠性。然后,通过通路富集分析,发现EOC显著富集的通路,筛选出与EMT过程相关的通路。通过整合MetaCore数据库中四种算法构建的子网络,得到lncRNA PVT1的调控网络。最后,通过构建EOC相关EMT通路-基因网络,综合分析EMT通路和lncRNA PVT1调控网络,确定上皮性卵巢癌EMT过程中lncRNA PVT1调控的关键信号通路和核心节点。结果:共收集到EOC相关基因1138个。获得了77条与EOC相关的显著富集通路,其中6条通路与EMT过程相关。lncRNA PVT1的调控网络包含377个节点和1182条边。关键信号通路,如“Some pathways of EMT in cancer cells”、“Development_Regulation of epithelial-to-mesenchymal transition(EMT)”和核心节点,如TNF-α和STAT3,可能受lncRNA PVT1直接调控并参与上皮性卵巢癌EMT过程。结论:通过生物信息学方法发现LncRNA PVT1与上皮性卵巢癌EMT过程存在调控关系。展开更多
文摘PV （photovoltaic） solar panels generally produce electricity in the 6% to 12% efficiency range, the rest is being dissipated in thermal losses. To recover this amount, hybrid photovoltaic thermal systems （PV/T） have been devised. These are devices that simultaneously convert solar energy into electricity and heat. It is thus interesting to study the PV/T system as part of a closed loop single phase water CDU （coolant distribution unit） in laminar forced convection. In particular, the analysis was conducted on the optimal cooling performance of the thermal part, testing polynomial channel profiles of varying order （from zero to fourth） for channels of a real industrial module heat sink, under the following conditions： ideal flux of 1,000 W/m2 on one side, insulation on the opposite side, periodic conditions on the remaining sides, fully developed thermal and velocity profile in laminar flow of water. Through the use of a genetic algorithm, we have optimized the shape of the channel＇s sidewalls in terms of heat transfer maximization. In terms of Nusselt number, results show that fourth order profiles are the most efficient. When limits to allowable pressure loss and module weight are introduced, these bring generally to a lower efficiency of the system than the unconstrained case.
文摘目的:探索上皮性卵巢癌(EOC)中lncRNA PVT1调控上皮-间皮质转化(EMT)的关键通路和枢纽基因。方法:收集EOC相关基因,通过疾病富集分析验证其可靠性。然后,通过通路富集分析,发现EOC显著富集的通路,筛选出与EMT过程相关的通路。通过整合MetaCore数据库中四种算法构建的子网络,得到lncRNA PVT1的调控网络。最后,通过构建EOC相关EMT通路-基因网络,综合分析EMT通路和lncRNA PVT1调控网络,确定上皮性卵巢癌EMT过程中lncRNA PVT1调控的关键信号通路和核心节点。结果:共收集到EOC相关基因1138个。获得了77条与EOC相关的显著富集通路,其中6条通路与EMT过程相关。lncRNA PVT1的调控网络包含377个节点和1182条边。关键信号通路,如“Some pathways of EMT in cancer cells”、“Development_Regulation of epithelial-to-mesenchymal transition(EMT)”和核心节点,如TNF-α和STAT3,可能受lncRNA PVT1直接调控并参与上皮性卵巢癌EMT过程。结论:通过生物信息学方法发现LncRNA PVT1与上皮性卵巢癌EMT过程存在调控关系。
