Ca (II) speciation and effect of Gd (III) speciation on Ca (II) speciation in human blood plasma were studied by computer simulation. [CaHCO3](-) is a predominant compound species of Ca (II). Gd (III) can compete with...Ca (II) speciation and effect of Gd (III) speciation on Ca (II) speciation in human blood plasma were studied by computer simulation. [CaHCO3](-) is a predominant compound species of Ca (II). Gd (III) can compete with Ca (II) for biological molecules. The presence of Gd (III) results in a increase of concentration of free Ca (II) and a decrease of concentration of Ca (II) compounds.展开更多
Forward osmosis(FO), as an emerging technology, is influenced by different factors such as operating conditions,module characteristics, and membrane properties. The general aim of this study was to develop a suitable(...Forward osmosis(FO), as an emerging technology, is influenced by different factors such as operating conditions,module characteristics, and membrane properties. The general aim of this study was to develop a suitable(flexible,comprehensive, and convenient to use) computational tool which is able to simulate osmosis through an asymmetric membrane oriented in pressure retarded osmosis(PRO) mode in a wide variety of scenarios. For this purpose, an agent-based model was created in NetLogo platform, which is an easy-to-use application environment with graphical visualization abilities and well suited for modeling a complex system evolving over time. The simulation results were validated with empirical data obtained from literature and a great agreement was observed. The effect of various parameters on process performance was investigated in terms of temperature,cross-flow velocity, length of the module, pure water permeability coefficient, and structural parameter of the membrane. Results demonstrated that the increase in all parameters, except structural parameter of the membrane and the length of module led to the increase of average water flux. Moreover, nine different draw solutes were selected in order to assess the influence of net bulk osmotic pressure difference between the draw solution(DS) and feed solution(FS)(known as the driving force of FO process) on water flux. Based on the findings of this paper, the performance of FO process(PRO mode) can be efficiently evaluated using the NetL ogo platform.展开更多
In this paper further mathematical analysis on 'correlation transfer technique' by Polge el al. is carried out, the tenable conditions and the extent of suitability for the said method are proved as well. In c...In this paper further mathematical analysis on 'correlation transfer technique' by Polge el al. is carried out, the tenable conditions and the extent of suitability for the said method are proved as well. In consideration of the influence of skewness of the sea surface elevation on spectral shape, a 'quasi-correlation transfer techique' is developed by the modification of the simulated target spectrum. Meanwhile, the numerical simulation of the non-Gaussian process of wind waves is carried out in view of the two conditions of the surface elevation probability distribution and the spectrum. By using its simulated results, the influence of skewness of the sea surface elevation on two parameters in the distribution of wave heights (which had been fitted by using the Weibull distribution) is analysed. The 'quasi- correlation tranfer technique' is verified and compared with the selection wave data observed in the Jiaozhou Bay in the period of 1980 to 1981. Results make clear (hat, as far as the statistical distribution of the wave heights and the distribution of the maximum (minimum) values of the sea surface elevation are concerned, the said method is obviously superior to the conventional mothed of the linear wave superposition, and that the simulated results are closer to the observation data.展开更多
A one -dimensional time-dependent photochemical model is used to simulate the influence of ion-produced NOx and HOx radicals on the Antarctic ozone depletion in polar night and polar spring at a latitude of 73 degrees...A one -dimensional time-dependent photochemical model is used to simulate the influence of ion-produced NOx and HOx radicals on the Antarctic ozone depletion in polar night and polar spring at a latitude of 73 degrees south.Vertical transport and nitrogen-oxygen (NOx). hydrogen-oxygen (HOx) production by ionic reactions have been introduced into the model.NOx and HOx produced by precipitating ions are transported into the lower stratosphere by vertical motion and have some effects in the development of the Antarctic ozone depletion.From winter through spring the calculated ozone column decreases to 269.4 DU. However, this value is significantly higher than the total ozone observed at several Antarctic ozone stations.展开更多
The application of parametric modeling method of Pro/E in the modular dougong is researched,and the disassembly and assembly operation of the dougong is implemented through the collision detection by the coordinate me...The application of parametric modeling method of Pro/E in the modular dougong is researched,and the disassembly and assembly operation of the dougong is implemented through the collision detection by the coordinate method in VRML. Direct interaction of VRML scene at the Web is implemented by using Java Script to manipulate VRML Object DOM.展开更多
Internet Intermation Server(IIS)是允许在公共Intranet或Internet上发布信息的Web服务器，已经成为当今流行的Web服务器之一。它通过使用超文本传输协议（HTTP）传输信息，还能通过配置它来提供文件传输协议（FTP）和gopher服务。正...Internet Intermation Server(IIS)是允许在公共Intranet或Internet上发布信息的Web服务器，已经成为当今流行的Web服务器之一。它通过使用超文本传输协议（HTTP）传输信息，还能通过配置它来提供文件传输协议（FTP）和gopher服务。正因为如此，保护IIS的安全已经成为网络管理工作的重要组成部分。我们该如何加强IIS的安全机制，并建立高度安全、可靠的Web服务器?确保IIS服务器的安全，首先应该为此搭建一个安全的系统，然后再结合IIS自身的特性和安全隐患进行必要的安全防护设置，这样才可以更大程度地保证其服务正常运行。展开更多
This paper provides background information on fatigue and describes the methodology used in Creo Simulation （Pro/Mechanica） fatigue analysis. It covers history and physics of fatigue, the E-N approach-Strain Cycles ...This paper provides background information on fatigue and describes the methodology used in Creo Simulation （Pro/Mechanica） fatigue analysis. It covers history and physics of fatigue, the E-N approach-Strain Cycles Includes the effect of mean residual stresses, hysteresis loop capture and rainflow cycle counting. Factors that affect fatigue life include component size, loading type, surface finish, surface treatment and effect of surface treatments on endurance limit. This paper describes practical problem solution and fatigue strength analysis of the wing-hinge to fuselage connection in Creo Simulation （Pro/Mechanica） environment. It also includes a procedure for calculating the buckling load factor and failure index.展开更多
Virtual screening can be a helpful approach to propose treatments for COVID-19 by developing inhibitors for blocking the attachment of the virus to human cells. This study uses molecular docking, recovery time and dyn...Virtual screening can be a helpful approach to propose treatments for COVID-19 by developing inhibitors for blocking the attachment of the virus to human cells. This study uses molecular docking, recovery time and dynamics to analyze if potential inhibitors of main protease (M<sup>pro</sup>) of SARS-CoV-2 can interfere in the attachment of nanobodies, specifically Nb20, in the receptor binding domain (RBD) of SARS-CoV-2. The potential inhibitors are four compounds previously identified in a fluorescence resonance energy transfer (FRET)-based enzymatic assay for the SARS-CoV-2 M<sup>pro</sup>: Boceprevir, Calpain Inhibitor II, Calpain Inhibitor XII, and GC376. The findings reveal that Boceprevir has the higher affinity with the RBD/Nb20 complex, followed by Calpain Inhibitor XII, GC376 and Calpain Inhibitor II. The recovery time indicates that the RBD/Nb20 complex needs a relatively short time to return to what it was before the presence of the ligands. For the RMSD the Boceprevir and Calpain Inhibitor II have the shortest interaction times, while Calpain Inhibitor XII shows slightly more interaction, but with significant pose fluctuations. On the other hand, GC376 remains stably bound for a longer duration compared to the other compounds, suggesting that they can potentially interfere with the neutralization process of Nb20.展开更多
基金the NSFC for financial support of this work (Project Nos.29890280, 29971029).
文摘Ca (II) speciation and effect of Gd (III) speciation on Ca (II) speciation in human blood plasma were studied by computer simulation. [CaHCO3](-) is a predominant compound species of Ca (II). Gd (III) can compete with Ca (II) for biological molecules. The presence of Gd (III) results in a increase of concentration of free Ca (II) and a decrease of concentration of Ca (II) compounds.
文摘Forward osmosis(FO), as an emerging technology, is influenced by different factors such as operating conditions,module characteristics, and membrane properties. The general aim of this study was to develop a suitable(flexible,comprehensive, and convenient to use) computational tool which is able to simulate osmosis through an asymmetric membrane oriented in pressure retarded osmosis(PRO) mode in a wide variety of scenarios. For this purpose, an agent-based model was created in NetLogo platform, which is an easy-to-use application environment with graphical visualization abilities and well suited for modeling a complex system evolving over time. The simulation results were validated with empirical data obtained from literature and a great agreement was observed. The effect of various parameters on process performance was investigated in terms of temperature,cross-flow velocity, length of the module, pure water permeability coefficient, and structural parameter of the membrane. Results demonstrated that the increase in all parameters, except structural parameter of the membrane and the length of module led to the increase of average water flux. Moreover, nine different draw solutes were selected in order to assess the influence of net bulk osmotic pressure difference between the draw solution(DS) and feed solution(FS)(known as the driving force of FO process) on water flux. Based on the findings of this paper, the performance of FO process(PRO mode) can be efficiently evaluated using the NetL ogo platform.
文摘In this paper further mathematical analysis on 'correlation transfer technique' by Polge el al. is carried out, the tenable conditions and the extent of suitability for the said method are proved as well. In consideration of the influence of skewness of the sea surface elevation on spectral shape, a 'quasi-correlation transfer techique' is developed by the modification of the simulated target spectrum. Meanwhile, the numerical simulation of the non-Gaussian process of wind waves is carried out in view of the two conditions of the surface elevation probability distribution and the spectrum. By using its simulated results, the influence of skewness of the sea surface elevation on two parameters in the distribution of wave heights (which had been fitted by using the Weibull distribution) is analysed. The 'quasi- correlation tranfer technique' is verified and compared with the selection wave data observed in the Jiaozhou Bay in the period of 1980 to 1981. Results make clear (hat, as far as the statistical distribution of the wave heights and the distribution of the maximum (minimum) values of the sea surface elevation are concerned, the said method is obviously superior to the conventional mothed of the linear wave superposition, and that the simulated results are closer to the observation data.
文摘A one -dimensional time-dependent photochemical model is used to simulate the influence of ion-produced NOx and HOx radicals on the Antarctic ozone depletion in polar night and polar spring at a latitude of 73 degrees south.Vertical transport and nitrogen-oxygen (NOx). hydrogen-oxygen (HOx) production by ionic reactions have been introduced into the model.NOx and HOx produced by precipitating ions are transported into the lower stratosphere by vertical motion and have some effects in the development of the Antarctic ozone depletion.From winter through spring the calculated ozone column decreases to 269.4 DU. However, this value is significantly higher than the total ozone observed at several Antarctic ozone stations.
文摘The application of parametric modeling method of Pro/E in the modular dougong is researched,and the disassembly and assembly operation of the dougong is implemented through the collision detection by the coordinate method in VRML. Direct interaction of VRML scene at the Web is implemented by using Java Script to manipulate VRML Object DOM.
文摘This paper provides background information on fatigue and describes the methodology used in Creo Simulation （Pro/Mechanica） fatigue analysis. It covers history and physics of fatigue, the E-N approach-Strain Cycles Includes the effect of mean residual stresses, hysteresis loop capture and rainflow cycle counting. Factors that affect fatigue life include component size, loading type, surface finish, surface treatment and effect of surface treatments on endurance limit. This paper describes practical problem solution and fatigue strength analysis of the wing-hinge to fuselage connection in Creo Simulation （Pro/Mechanica） environment. It also includes a procedure for calculating the buckling load factor and failure index.
文摘Virtual screening can be a helpful approach to propose treatments for COVID-19 by developing inhibitors for blocking the attachment of the virus to human cells. This study uses molecular docking, recovery time and dynamics to analyze if potential inhibitors of main protease (M<sup>pro</sup>) of SARS-CoV-2 can interfere in the attachment of nanobodies, specifically Nb20, in the receptor binding domain (RBD) of SARS-CoV-2. The potential inhibitors are four compounds previously identified in a fluorescence resonance energy transfer (FRET)-based enzymatic assay for the SARS-CoV-2 M<sup>pro</sup>: Boceprevir, Calpain Inhibitor II, Calpain Inhibitor XII, and GC376. The findings reveal that Boceprevir has the higher affinity with the RBD/Nb20 complex, followed by Calpain Inhibitor XII, GC376 and Calpain Inhibitor II. The recovery time indicates that the RBD/Nb20 complex needs a relatively short time to return to what it was before the presence of the ligands. For the RMSD the Boceprevir and Calpain Inhibitor II have the shortest interaction times, while Calpain Inhibitor XII shows slightly more interaction, but with significant pose fluctuations. On the other hand, GC376 remains stably bound for a longer duration compared to the other compounds, suggesting that they can potentially interfere with the neutralization process of Nb20.
