Nerve growth factor （NGF） was first discovered more than 5 decades ago as a molecule that promotes the survival and maturation of developing neurons in the peripheral nervous system . NGF released from target ceils ...Nerve growth factor （NGF） was first discovered more than 5 decades ago as a molecule that promotes the survival and maturation of developing neurons in the peripheral nervous system . NGF released from target ceils activates tropomyosin-related kinase A （TrkA） on axon terminals and triggers activation ofPI3K/Akt, MEK/ ERK, and PLCT signaling pathways. The signal then travels retrogradely along axon to cell body to promote neuronal survival . However, the nature of the retrograde signal remains mysterious.展开更多
文摘Nerve growth factor （NGF） was first discovered more than 5 decades ago as a molecule that promotes the survival and maturation of developing neurons in the peripheral nervous system . NGF released from target ceils activates tropomyosin-related kinase A （TrkA） on axon terminals and triggers activation ofPI3K/Akt, MEK/ ERK, and PLCT signaling pathways. The signal then travels retrogradely along axon to cell body to promote neuronal survival . However, the nature of the retrograde signal remains mysterious.
