互联网已经走进了小学生的日常生活，必须开发利用互联网带给他们的有益作用，改善或矫正负面影响。本研究针对北京城区高年级小学生互联网使用行为的特点以及“病理性互联网使用（Pathological Internet Use，简称PIU）”状况进行了抽...互联网已经走进了小学生的日常生活，必须开发利用互联网带给他们的有益作用，改善或矫正负面影响。本研究针对北京城区高年级小学生互联网使用行为的特点以及“病理性互联网使用（Pathological Internet Use，简称PIU）”状况进行了抽样调查和分析。调查结果显示：北京城区小学生普遍都有上网行为，使用者向低龄化发展趋势明显，每周上网时间较长、极少数有网吧上网经历、上网目的主要是娱乐。其中PIU学生的检出率为1．25％。小学生安全健康上网，还需要家长、学校、社会等多方积极引导。展开更多
The accession of Antoninus Pius saw a distinct change in imperial frontier policy in Britain. Upon taking power, Antoninus’ representative in Britain, Q. Lollius Urbicus,1 undertook the systematic re-occupation of lo...The accession of Antoninus Pius saw a distinct change in imperial frontier policy in Britain. Upon taking power, Antoninus’ representative in Britain, Q. Lollius Urbicus,1 undertook the systematic re-occupation of lowland Scotland and a new展开更多
目的观察iRoot Bp pIus在年轻恒牙创伤意外露髓后的疗效。方法选取2017年1月至2020年12月该院收治的年轻恒牙创伤意外露髓患者128例作为研究对象,采用随机数表法分为观察组和对照组,每组64例。对照组给予矿物三氧化聚合体直接盖髓填充...目的观察iRoot Bp pIus在年轻恒牙创伤意外露髓后的疗效。方法选取2017年1月至2020年12月该院收治的年轻恒牙创伤意外露髓患者128例作为研究对象,采用随机数表法分为观察组和对照组,每组64例。对照组给予矿物三氧化聚合体直接盖髓填充术治疗,观察组采用iRoot Bp pIus直接盖髓填充术治疗。比较两组患者临床疗效。结果两组患者术后3、6、12个月成功治愈率比较,差异均无统计学意义(P>0.05);观察组患者手术治疗、牙齿填充效果明显优于对照组,差异均有统计学意义(P<0.05)。结论在年轻恒牙创伤意外露髓后应用iRoot Bp pIus可改善患者症状,提高牙齿美观度,促进其早日康复。展开更多
Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
目的:运用网络药理学方法探讨左归丸治疗骨质疏松的潜在药效机制。方法:从《中华人民共和国药典》收集左归丸中各中药的归经信息,TCMSP、BATMAN-TCM数据库中查找中药活性成分和靶标,Drugbank、DisGeNET数据库中查找骨质疏松的潜在靶点,...目的:运用网络药理学方法探讨左归丸治疗骨质疏松的潜在药效机制。方法:从《中华人民共和国药典》收集左归丸中各中药的归经信息,TCMSP、BATMAN-TCM数据库中查找中药活性成分和靶标,Drugbank、DisGeNET数据库中查找骨质疏松的潜在靶点,利用Cytoscape软件构建和分析中药-归经网络、靶标-疾病网络,利用DAVID对靶标-疾病网络中最大连通片子模块节点基因进行功能富集分析。结果:左归丸所含中药主要归肾、肝经,其潜在活性化合物73个、51个靶标与骨质疏松相关,靶标-疾病网络中3个关键子模块主要生物学功能涉及转化生长因子β(transforming growth factor-β,TGF-beta)、雌激素(Estrogen)、甲状腺激素(Thyroid hormone)、磷脂酰肌醇3激酶-蛋白激酶B(phosphatidylinositol 3-kinase and protein kinase B,PI3K-Akt)等16个信号通路,影响骨代谢平衡。结论:左归丸“补肾壮骨”法治疗骨质疏松,可能通过调控骨代谢平衡中成骨、破骨分化多个生物学过程发挥治疗作用。展开更多
文摘互联网已经走进了小学生的日常生活，必须开发利用互联网带给他们的有益作用，改善或矫正负面影响。本研究针对北京城区高年级小学生互联网使用行为的特点以及“病理性互联网使用（Pathological Internet Use，简称PIU）”状况进行了抽样调查和分析。调查结果显示：北京城区小学生普遍都有上网行为，使用者向低龄化发展趋势明显，每周上网时间较长、极少数有网吧上网经历、上网目的主要是娱乐。其中PIU学生的检出率为1．25％。小学生安全健康上网，还需要家长、学校、社会等多方积极引导。
文摘The accession of Antoninus Pius saw a distinct change in imperial frontier policy in Britain. Upon taking power, Antoninus’ representative in Britain, Q. Lollius Urbicus,1 undertook the systematic re-occupation of lowland Scotland and a new
文摘目的观察iRoot Bp pIus在年轻恒牙创伤意外露髓后的疗效。方法选取2017年1月至2020年12月该院收治的年轻恒牙创伤意外露髓患者128例作为研究对象,采用随机数表法分为观察组和对照组,每组64例。对照组给予矿物三氧化聚合体直接盖髓填充术治疗,观察组采用iRoot Bp pIus直接盖髓填充术治疗。比较两组患者临床疗效。结果两组患者术后3、6、12个月成功治愈率比较,差异均无统计学意义(P>0.05);观察组患者手术治疗、牙齿填充效果明显优于对照组,差异均有统计学意义(P<0.05)。结论在年轻恒牙创伤意外露髓后应用iRoot Bp pIus可改善患者症状,提高牙齿美观度,促进其早日康复。
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
文摘目的:运用网络药理学方法探讨左归丸治疗骨质疏松的潜在药效机制。方法:从《中华人民共和国药典》收集左归丸中各中药的归经信息,TCMSP、BATMAN-TCM数据库中查找中药活性成分和靶标,Drugbank、DisGeNET数据库中查找骨质疏松的潜在靶点,利用Cytoscape软件构建和分析中药-归经网络、靶标-疾病网络,利用DAVID对靶标-疾病网络中最大连通片子模块节点基因进行功能富集分析。结果:左归丸所含中药主要归肾、肝经,其潜在活性化合物73个、51个靶标与骨质疏松相关,靶标-疾病网络中3个关键子模块主要生物学功能涉及转化生长因子β(transforming growth factor-β,TGF-beta)、雌激素(Estrogen)、甲状腺激素(Thyroid hormone)、磷脂酰肌醇3激酶-蛋白激酶B(phosphatidylinositol 3-kinase and protein kinase B,PI3K-Akt)等16个信号通路,影响骨代谢平衡。结论:左归丸“补肾壮骨”法治疗骨质疏松,可能通过调控骨代谢平衡中成骨、破骨分化多个生物学过程发挥治疗作用。
