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Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes 被引量:3
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作者 SUN Chang-Sheng WANG Yu-Qin +2 位作者 ZHANG Zhong-Liang LIOU Yuligh ZHOU Hong-Hao 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2021年第12期921-929,共9页
This work was aimed to establish a quality control method for evaluating the effects on glucose and lipids of the fruiting body of Isaria cicadae Miquel from strain Ic-17-7(Ic-17-7fb) using a rat model of type 2 diabe... This work was aimed to establish a quality control method for evaluating the effects on glucose and lipids of the fruiting body of Isaria cicadae Miquel from strain Ic-17-7(Ic-17-7fb) using a rat model of type 2 diabetes(T2DM). Random amplified polymorphic DNA, sequence-characterized amplified region, and high-performance liquid chromatography(HPLC) were used for the quality control of Ic-17-7fb. The pharmacological effects on streptozocin(STZ)-induced high fat diet(HFD)-fed Albino Wistar rats were evaluated. The rats underwent the following treatments: control, metformin, Ic-17-7fb(0.166 and 0.5 g·kg;) or without treatment. The fasting blood glucose(FBG), blood glucose, total cholesterol(TC), triglyceride(TG), high-density lipoprotein(HDL-c), and low-density lipoprotein(LDL-c) were measured. Ic-17-7fb amplified a single specific band by S11-2-F3 and S11-2-R3 primers. An HPLC-based quality and quantity method was established for industrial application. The contents of adenosine and N;-(2-hydroxyethyl) adenosine(HEA) of the cultivated Ic-17-7fb were analyzed. All of the validation lots of cultured Ic-17-7fb passed the quantity control of the training set(0.90 mg·g;of adenosine and 0.89 mg·g;of HEA). After two weeks of administration, the average FBG was 4.89 ± 0.42(control), 26.10 ± 5.77(model), 23.63 ± 6.15(metformin), 17.96 ± 9.36(Ic-17-7fb for 0.166 g·kg;), and 19.69 ±8.71 mmol·L;(Ic-17-7fb for 0.5 g·kg;). The FBG of Ic-17-7fb(0.166 g·kg;) treatment significantly reduced by 31.19%, compared with the model after two weeks of administration(P < 0.01). Metformin, Ic-17-7fb(0.166 g·kg;), and Ic-17-7fb(0.5 g·kg;) reduced TC, TG, HDL-c, and LDL-c compared with the T2DM model treatment at the 6 th week of treatment(P < 0.05). This study established the first quality standard for Ic-17-7fb, which can be effectively applied in the treatment of T2DM. The reliable quality control method and pharmacological effect will broaden its application space. 展开更多
关键词 Isaria cicadae Quality control ADENOSINE HEA Type 2 diabetes model Blood glucose and lipid
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Computational Design of Interval Type-2 Fuzzy Control for Formation and Containment of Multi-Agent Systems with Collision Avoidance Capability
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作者 Yann-Horng Lin Wen-Jer Chang +2 位作者 Yi-Chen Lee Muhammad Shamrooz Aslam Cheung-Chieh Ku 《Computer Modeling in Engineering & Sciences》 2025年第8期2231-2262,共32页
An Interval Type-2(IT-2)fuzzy controller design approach is proposed in this research to simultaneously achievemultiple control objectives inNonlinearMulti-Agent Systems(NMASs),including formation,containment,and coll... An Interval Type-2(IT-2)fuzzy controller design approach is proposed in this research to simultaneously achievemultiple control objectives inNonlinearMulti-Agent Systems(NMASs),including formation,containment,and collision avoidance.However,inherent nonlinearities and uncertainties present in practical control systems contribute to the challenge of achieving precise control performance.Based on the IT-2 Takagi-Sugeno Fuzzy Model(T-SFM),the fuzzy control approach can offer a more effective solution for NMASs facing uncertainties.Unlike existing control methods for NMASs,the Formation and Containment(F-and-C)control problem with collision avoidance capability under uncertainties based on the IT-2 T-SFM is discussed for the first time.Moreover,an IT-2 fuzzy tracking control approach is proposed to solve the formation task for leaders in NMASs without requiring communication.This control scheme makes the design process of the IT-2 fuzzy Formation Controller(FC)more straightforward and effective.According to the communication interaction protocol,the IT-2 Containment Controller(CC)design approach is proposed for followers to ensure convergence into the region defined by the leaders.Leveraging the IT-2 T-SFM representation,the analysis methods developed for linear Multi-Agent Systems(MASs)are successfully extended to perform containment analysis without requiring the additional assumptions imposed in existing research.Notably,the IT-2 fuzzy tracking controller can also be applied in collision avoidance situations to track the desired trajectories calculated by the avoidance algorithm under the Artificial Potential Field(APF).Benefiting from the combination of vortex and source APFs,the leaders can properly adjust the system dynamics to prevent potential collision risk.Integrating the fuzzy theory and APFs avoidance algorithm,an IT-2 fuzzy controller design approach is proposed to achieve the F-and-C purposewhile ensuring collision avoidance capability.Finally,amulti-ship simulation is conducted to validate the feasibility and effectiveness of the designed IT-2 fuzzy controller. 展开更多
关键词 Interval type-2 Takagi-Sugeno fuzzy model multi-agent systems formation and containment control fuzzy collision avoidance artificial potential field
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A Nash Game Approach to Mixed H_2/H_∞ Model Predictive Control: Part 3–Output Feedback Case
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作者 Pakkiriswamy Aadaleesan Prabirkumar Saha 《International Journal of Automation and computing》 EI CSCD 2018年第5期616-624,共9页
In this paper, the state-feedback Nash game based mixed H2/H∞ design^([1, 2])has been extended for output feedback case. The algorithm is applied to control bioreactor system with a Laguerre-Wavelet Network(LWN)^... In this paper, the state-feedback Nash game based mixed H2/H∞ design^([1, 2])has been extended for output feedback case. The algorithm is applied to control bioreactor system with a Laguerre-Wavelet Network(LWN)^([3, 4])model of the bioreactor.This is achieved by using the LWN model as a deviation model and by successively linearising the deviation model along the state trajectory. For reducing the approximation error and to improve the controller performance, symbolic derivation algorithm, viz.,automatic differentiation is employed. A cautionary note is also given on the fragility of the output feedback mixed H2/H∞ model predictive controller^([4, 5])due to its sensitivity to its own parametric changes. 展开更多
关键词 Robust model predictive control mixed H2/H∞ control Nash game output feedback model predictive control (MPC) automatic differentiation fragility of controller.
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GH_2 Control for Uncertain Discrete-time-delay Fuzzy Systems Based on a Switching Fuzzy Model and Piecewise Lyapunov Function
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作者 Zhi-Le Xia Jun-Min Li 《International Journal of Automation and computing》 EI 2009年第3期261-266,共6页
Generalized H2 (GH2) stability analysis and controller design of the uncertain discrete-time Takagi-Sugeno (T-S) fuzzy systems with state delay are studied based on a switching fuzzy model and piecewise Lyapunov f... Generalized H2 (GH2) stability analysis and controller design of the uncertain discrete-time Takagi-Sugeno (T-S) fuzzy systems with state delay are studied based on a switching fuzzy model and piecewise Lyapunov function. GH2 stability sufficient conditions are derived in terms of linear matrix inequalities (LMIs). The interactions among the fuzzy subsystems are considered. Therefore, the proposed conditions are less conservative than the previous results. Since only a set of LMIs is involved, the controller design is quite simple and numerically tractable. To illustrate the validity of the proposed method, a design example is provided. 展开更多
关键词 Generalized H2 (GH2 control fuzzy systems linear matrix inequalities (LMIs) piecewise Lyapunov function switchingfuzzy model.
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Non-Fragile Controller Design for 2-D Discrete Uncertain Systems Described by the Roesser Model
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作者 Amit Dhawan 《Journal of Signal and Information Processing》 2012年第2期248-251,共4页
This paper is concerned with the design problem of non-fragile controller for a class of two-dimensional (2-D) discrete uncertain systems described by the Roesser model. The parametric uncertainties are assumed to be ... This paper is concerned with the design problem of non-fragile controller for a class of two-dimensional (2-D) discrete uncertain systems described by the Roesser model. The parametric uncertainties are assumed to be norm-bounded. The aim of this paper is to design a memoryless non-fragile state feedback control law such that the closed-loop system is asymptotically stable for all admissible parameter uncertainties and controller gain variations. A new linear matrix inequality (LMI) based sufficient condition for the existence of such controllers is established. Finally, a numerical example is provided to illustrate the applicability of the proposed method. 展开更多
关键词 2-D DISCRETE Systems NON-FRAGILE control Roesser model Linear MATRIX INEQUALITY LYAPUNOV Methods
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Delay-Dependent Robust H Control for Uncertain 2-D Discrete State Delay Systems Described by the General Model
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作者 Arun Kumar Singh Akshata Tandon Amit Dhawan 《Circuits and Systems》 2016年第11期3645-3669,共25页
This paper considers the problem of delay-dependent robust optimal H<sub>∞</sub> control for a class of uncertain two-dimensional (2-D) discrete state delay systems described by the general model (GM). Th... This paper considers the problem of delay-dependent robust optimal H<sub>∞</sub> control for a class of uncertain two-dimensional (2-D) discrete state delay systems described by the general model (GM). The parameter uncertainties are assumed to be norm-bounded. A linear matrix inequality (LMI)-based sufficient condition for the existence of delay-dependent g-suboptimal state feedback robust H<sub>∞</sub> controllers which guarantees not only the asymptotic stability of the closed-loop system, but also the H<sub>∞</sub> noise attenuation g over all admissible parameter uncertainties is established. Furthermore, a convex optimization problem is formulated to design a delay-dependent state feedback robust optimal H<sub>∞</sub> controller which minimizes the H<sub>∞</sub> noise attenuation g of the closed-loop system. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed method. 展开更多
关键词 2-D Discrete System General model H control Linear Matrix Inequality State Delays Uncertain System
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Robust Optimal H Control for Uncertain 2-D Discrete State-Delayed Systems Described by the General Model
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作者 Arun Kumar Singh Amit Dhawan 《Journal of Signal and Information Processing》 2016年第2期78-114,共17页
This paper investigates the problem of robust optimal H<sub>∞</sub> control for uncertain two-dimensional (2-D) discrete state-delayed systems described by the general model (GM) with norm-bounded uncerta... This paper investigates the problem of robust optimal H<sub>∞</sub> control for uncertain two-dimensional (2-D) discrete state-delayed systems described by the general model (GM) with norm-bounded uncertainties. A sufficient condition for the existence of g-suboptimal robust H<sub><sub></sub></sub><sub>∞</sub> state feedback controllers is established, based on linear matrix inequality (LMI) approach. Moreover, a convex optimization problem is developed to design a robust optimal state feedback controller which minimizes the H<sub><sub><sub></sub></sub></sub><sub>∞</sub> noise attenuation level of the resulting closed-loop system. Finally, two illustrative examples are given to demonstrate the effectiveness of the proposed method. 展开更多
关键词 2-D Discrete Systems General model H control Linear Matrix Inequality State Feedback Uncertain System
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基于J2EE/MVC Model 2的公共图书管理系统的研究 被引量:14
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作者 屈霞 刘自强 张小鸣 《计算机工程与设计》 CSCD 北大核心 2009年第20期4651-4653,4657,共4页
针对当前基于Web的各图书管理系统普遍存在的缺乏业务服务能力的问题,根据多馆共建的思想,提出了一种全新的基于J2EE/MVC Model2的公共图书馆管理系统。分析了J2EE架构,阐述了系统的MVCModel2模式软件架构。给出了4层组件的开发思路,在... 针对当前基于Web的各图书管理系统普遍存在的缺乏业务服务能力的问题,根据多馆共建的思想,提出了一种全新的基于J2EE/MVC Model2的公共图书馆管理系统。分析了J2EE架构,阐述了系统的MVCModel2模式软件架构。给出了4层组件的开发思路,在业务层强调了会话外观和利用BMP精确控制数据库的设计思想,并通过实例介绍BMP的开发过程。系统性能已达到实际使用要求,系统对于树立集成管理、大图书馆管理、创新管理理念,采取科学合理的运行机制有重要意义。 展开更多
关键词 图书管理系统 J2EE MVC model 2 会话外观 Bean管理持久性
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探究互联网自我管理模式对2型糖尿病患者血糖控制效果及自我管理能力的影响 被引量:1
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作者 温雪 《糖尿病新世界》 2025年第8期157-161,共5页
目的评估互联网自我管理模式对2型糖尿病患者血糖控制效果及自我管理能力的影响。方法选取2023年7-12月钦州市第二人民医院收治的245例2型糖尿病患者,根据护理方法差异分为对照组(常规护理,125例)与观察组(互联网自我管理模式,120例),... 目的评估互联网自我管理模式对2型糖尿病患者血糖控制效果及自我管理能力的影响。方法选取2023年7-12月钦州市第二人民医院收治的245例2型糖尿病患者,根据护理方法差异分为对照组(常规护理,125例)与观察组(互联网自我管理模式,120例),对比两组血糖控制效果及自我管理水平。结果护理后,两组患者的自我管理水平各维度评分均高于护理前,且观察组评分均高于对照组,差异均有统计学意义(P均<0.05)。护理后,观察组血糖水平(糖化血红蛋白、空腹血糖、餐后2 h血糖)均低于对照组,差异均有统计学意义(P均<0.05)。结论互联网自我管理模式可提升2型糖尿病患者自我管理能力,有效控制患者血糖水平。 展开更多
关键词 2型糖尿病 互联网自我管理模式 血糖控制 糖尿病自我管理行为量表
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面向超临界CO_(2)射流开采的三维地质模型动态更新与可视化管控平台开发
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作者 林允 《中国矿业》 北大核心 2025年第S2期147-150,共4页
针对超临界二氧化碳(SC-CO_(2))射流开采过程中地质条件复杂性和动态变化挑战,本文研究了三维地质模型的动态更新方法与可视化管控平台开发。通过整合多源地质数据与实时监测信息,构建了基于数值流形法的多场耦合模型,实现了地质结构、... 针对超临界二氧化碳(SC-CO_(2))射流开采过程中地质条件复杂性和动态变化挑战,本文研究了三维地质模型的动态更新方法与可视化管控平台开发。通过整合多源地质数据与实时监测信息,构建了基于数值流形法的多场耦合模型,实现了地质结构、应力场、渗流场的热-力-化学(TMC)全过程动态模拟。平台采用HOOPS Visualize引擎和WebGL技术,开发了具有四维时空特征的可视化管控系统,支持SC-CO_(2)射流作业的实时监测、分析与优化。 展开更多
关键词 超临界CO_(2) 射流 三维地质模型 动态更新 数值流形法 多场耦合 可视化管控
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司美格鲁肽对比卡格列净治疗二甲双胍控制不佳的2型糖尿病患者的成本-效用分析 被引量:3
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作者 徐跃洳 王钰博 +3 位作者 潘慧敏 单慧亭 陈迹 杨建华 《中国药房》 北大核心 2025年第9期1087-1092,共6页
目的对二甲双胍控制不佳的2型糖尿病(T2DM)患者使用卡格列净或司美格鲁肽治疗的长期经济性进行评价。方法从我国卫生体系角度出发,构建Markov模型,基于SUSTAIN 8研究数据模拟我国T2DM患者在二甲双胍基础上联用卡格列净或司美格鲁肽治疗3... 目的对二甲双胍控制不佳的2型糖尿病(T2DM)患者使用卡格列净或司美格鲁肽治疗的长期经济性进行评价。方法从我国卫生体系角度出发,构建Markov模型,基于SUSTAIN 8研究数据模拟我国T2DM患者在二甲双胍基础上联用卡格列净或司美格鲁肽治疗30年的长期成本和效用,并以2024年我国人均国内生产总值(GDP)的1倍作为意愿支付(WTP)阈值计算增量成本-效果比(ICER)和增量净货币收益(INMB)。通过单因素敏感性分析、概率敏感性分析以及情境分析确认基础分析结论的稳定性。结果与卡格列净+二甲双胍方案相比,司美格鲁肽+二甲双胍方案的ICER为260485.67元/质量调整生命年(QALY),大于本研究设定的WTP阈值(95749元/QALY),INMB为-61576.24元,卡格列净+二甲双胍方案更具经济性优势。司美格鲁肽+二甲双胍方案组糖尿病无并发症治疗成本对INMB的影响最大,但参数在选定范围内的变动不会驱动结果发生逆转。随着WTP阈值的增加,司美格鲁肽+二甲双胍方案在经济性上的可接受概率呈上升趋势。在当前WTP阈值下,司美格鲁肽的年成本需下降42.95%,司美格鲁肽+二甲双胍方案才能成为更具经济性优势的方案。结论从中国卫生体系角度出发,对于单用二甲双胍血糖控制不佳的T2DM患者,卡格列净+二甲双胍方案相较于司美格鲁肽+二甲双胍方案更具经济性优势。 展开更多
关键词 司美格鲁肽 卡格列净 二甲双胍 2型糖尿病 血糖控制不佳 MARKOV模型 药物经济学 队列模拟
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Controllable rectification on the thermal conductivity of porous YBa_(2)Cu_(3)O_(7−x) superconductors from 3D-printing 被引量:1
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作者 Yanbin Ma Baoqiang Zhang +1 位作者 Xingyi Zhang You-He Zhou 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第1期182-191,共10页
Superconducting YBa_(2)Cu_(3)O_(7−x)(YBCO)bulks have promising applications in quasi-permanent magnets,levitation,etc.Recently,a new way of fabricating porous YBCO bulks,named direct-ink-writing(DIW)3D-printing method... Superconducting YBa_(2)Cu_(3)O_(7−x)(YBCO)bulks have promising applications in quasi-permanent magnets,levitation,etc.Recently,a new way of fabricating porous YBCO bulks,named direct-ink-writing(DIW)3D-printing method,has been reported.In this method,the customized precursor paste and programmable shape are two main advantages.Here,we have put forward a new way to customize the YBCO 3D-printing precursor paste which is doped with Al_(2)O_(3)nanoparticles to obtain YBCO with higher thermal conductivity.The great rheological properties of precursor paste after being doped with Al_(2)O_(3)nanoparticles can help the macroscopic YBCO samples with high thermal conductivity fabricated stably with high crystalline and lightweight properties.Test results show that the peak thermal conductivity of Al_(2)O_(3)-doped YBCO can reach twice as much as pure YBCO,which makes a great effort to reduce the quench propagation speed.Based on the microstructure analysis,one can find that the thermal conductivity of Al_(2)O_(3)-doped YBCO has been determined by its components and microstructures.In addition,a macroscopic theoretical model has been proposed to assess the thermal conductivity of different microstructures,whose calculated results take good agreement with the experimental results.Meanwhile,a microstructure with high thermal conductivity has been found.Finally,a macroscopic YBCO bulk with the presented high thermal conductivity microstructure has been fabricated by the Al_(2)O_(3)-doped method.Compared with YBCO fabricated by the traditional 3D-printed,the Al_(2)O_(3)-doped structural YBCO bulks present excellent heat transfer performances.Our customized design of 3D-printing precursor pastes and novel concept of structural design for enhancing the thermal conductivity of YBCO superconducting material can be widely used in other DIW 3D-printing materials. 展开更多
关键词 Al_(2)O_(3)-doped YBCO thermal conductivity theoretical model controllable design DIW 3D-printing
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Kalman Filter for Generalized 2-D Roesser Models 被引量:2
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作者 盛梅 邹云 《Defence Technology(防务技术)》 SCIE EI CAS 2007年第1期43-48,共6页
The design problem of the state filter for the generalized stochastic 2-D Roesser models, which appears when both the state and measurement are simultaneously subjected to the interference from white noise, is discuss... The design problem of the state filter for the generalized stochastic 2-D Roesser models, which appears when both the state and measurement are simultaneously subjected to the interference from white noise, is discussed. The well-known Kalman filter design is extended to the generalized 2-D Roesser models. Based on the method of “scanning line by line”,the filtering problem of generalized 2-D Roesser models with mode-energy reconstruction is solved. The formula of the optimal filtering, which minimizes the variance of the estimation error of the state vectors, is derived. The validity of the designed filter is verified by the calculation steps and the examples are introduced. 展开更多
关键词 广义系统 二维Roesser模型 卡尔曼滤波器 控制论
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Study of modeling and simulation of full digital controlled PMIG/MAG welding system based on Matlab/Simulink
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作者 王伟明 刘嘉 +2 位作者 苏建中 殷树言 马德 《China Welding》 EI CAS 2004年第1期31-35,共5页
This paper presents an integrated simulation model for full digital controlled PMIG/MAG welding system with Matlab/Simulink, and it consists of power inverter, digital control system and dynamic arc-load model. An int... This paper presents an integrated simulation model for full digital controlled PMIG/MAG welding system with Matlab/Simulink, and it consists of power inverter, digital control system and dynamic arc-load model. An integrated simulation study was done for full digital PMIG/MAG welding, and a method of connecting dynamic arc-load model to the system with controlled current source was presented, in addition, the simulation results were utilized to study the issues of digital control PMIG/MAG welding in this paper. The experimental results validated the developed simulation model, and this simulation study can be applied in implementation of the full digital PMIG/MAG welding and analysis of system dynamic process. 展开更多
关键词 PMIG/MAG welding full digital control system(DSP) SIMULINK dynamic arc-load model 2-PI regulator
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Model Helicopter Control Using Body-Mounted Vibro-Tactile Transducers
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作者 Rui Zhou Merhran Mehrandezh Raman Paranjape 《World Journal of Engineering and Technology》 2014年第4期322-330,共9页
The sense of touch as a man-machine communication channel can be as acute as the sense of sight and sound. In some scenarios such as those seen in aerobatics, stunt flying, and combat flights, tactile sensors can even... The sense of touch as a man-machine communication channel can be as acute as the sense of sight and sound. In some scenarios such as those seen in aerobatics, stunt flying, and combat flights, tactile sensors can even outperform the conventional non-contact sensors in terms of situation awareness. Fusion of tactile sensory information with those obtained via sight and sound can avoid diverting the user’s attention away from the operational task at hand as well. In this study, the performance of an operator, to servo control the motion of a 2-dof model helicopter with pitch/yaw maneuverability, subjected to an intuitive body-referenced arrangement of a cluster of vibro-tactile sensors is investigated. A blindfolded operator will then control the helicopter to a safe attraction zone via a joystick based on this tactile sensory information. A fine-tuned local controller would take over for the end-of-motion precise homing. This study can pave the way towards a systematic integration and characterization of tactile sensors in high performance weapon platforms with improved situation awareness in visually awkward maneuvers such as those seen in aerial combat scenarios. 展开更多
关键词 Haptics Flight control Linear Quadratic REGULATORS (LQR) TACTILE IMMERSIVE control 2-Dof model Helicopter MECHATRONICS Real-Time control
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A decomposition model to analyze effect of SO_2 emission density of China
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作者 张平淡 杜雯翠 +1 位作者 焦胜 何理 《Journal of Central South University》 SCIE EI CAS 2014年第2期701-708,共8页
A decomposition model was applied to study the resource-saving and environment-friendly effects of air pollutant emissions(taking industrial SO2 emission as an example) in China.From the results,it is found that 38.93... A decomposition model was applied to study the resource-saving and environment-friendly effects of air pollutant emissions(taking industrial SO2 emission as an example) in China.From the results,it is found that 38.93% and 61.07% are contributed to environment-friendly and resource-saving effects,respectively,by the dramatic decrease in industrial SO2 emission density(nearly 70% from 2001 to 2010).This indicates that China has achieved important progress during the 11th FYP(five-year plan) compared with the 10th FYP.A simultaneous equations model was also employed to analyze the influencing factors by using data from 30 provinces in China.The results imply that the influence of environmental regulation on environment-friendly effect is not obvious during the 10th FYP but obvious during the 11th FYP.Thus,the government should continue promoting the environment-friendly effect by further enhancing environmental regulation and strengthening the role of environmental management. 展开更多
关键词 two-oriented society air pollution control decomposition model environmental regulation SO2 emission
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Establishment of blood glucose control model in diabetic mice
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作者 Cai-Hua Rao Lun Liu +2 位作者 Jian Gao Zi-Hao Du Chen Gao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2022年第12期1908-1914,共7页
AIM:To explore the established method of the diabetic mouse blood glucose control model and preliminar y observation of its influence on the retinas of diabetic mice.METHODS:The db/db BKS-DB(Lepr^(ko/ko))mice were ran... AIM:To explore the established method of the diabetic mouse blood glucose control model and preliminar y observation of its influence on the retinas of diabetic mice.METHODS:The db/db BKS-DB(Lepr^(ko/ko))mice were randomly divided into two groups:the poor blood glucose control group(PG group,n=18)and the stable blood glucose control group(SG group,n=12),with BKS-DB(Lepr^(wt/wt))as the normal blood glucose control group(NG group,n=18).According to the blood glucose values for 5 intervals which were monitored during the period of adaption,the PG group was injected with insulin aspart twice daily,fasted for 2h and then returned to normal.The SG group was injected with insulin aspart twice and insulin glargine once daily and fed with a quantitative ration.Fundus images were collected after eight weeks.The glycosylated hemoglobin(Hb A1c),mean blood glucose level(MBG),standard deviation of blood glucose(SDBG),coefficient of variation of blood glucose(CVBG),and mean amplitude of glycemic excursion(MAGE)in each group were examined and calculated.RESULTS:The Hb A1c,MBG,SDBG,CVBG,and MAGE levels in the PG group were significantly higher than those in the NG and SG groups(all P<0.05).MBG,SDBG,CVBG,and MAGE levels in the SG group were higher than those in the NG group(all P<0.05).There was no significant difference in Hb A1c levels between the NG and SG groups(P>0.05).Preliminary observation of fundus images in the PG group and SG groups showed scattered retinal bleeding spots,while bleeding was more obvious in the PG group.CONCLUSION:The blood glucose control model of type 2 diabetes mellitus mice can be successfully established by subcutaneous injection of insulin aspart insulin glargine and rationed food,which is valuable for studying the mechanism of blood glucose fluctuations in diabetic complications in vivo. 展开更多
关键词 type 2 diabetes blood glucose control animal models
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Direct model reference adaptive control using K_p=LDU factorization for multivariable discrete-time plants
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作者 Junling LI Xuejun XIE Wei CHEN 《控制理论与应用(英文版)》 EI 2008年第4期392-398,共7页
For a large class of discrete-time multivariable plants with arbitrary relative degrees,the design and analysis of the direct model reference adaptive control scheme are investigated under less restrictive assumptions... For a large class of discrete-time multivariable plants with arbitrary relative degrees,the design and analysis of the direct model reference adaptive control scheme are investigated under less restrictive assumptions.The algorithm is based on a new parametrization derived from the high frequency gain matrix factorization Kp=LDU under the condition that the signs of the leading principal minors of/fp are known.By reproving the discrete-time Lp and L2σnorm relationship between inputs and outputs,establishing the properties of discrete-time adaptive law,defining the normalizing signal,and relating the signal with all signals in the closed-loop system,the stability and convergence of the discrete-time multivariable model reference adaptive control scheme are analyzed rigorously in a systematic fashion as in the continuous-time case. 展开更多
关键词 Discrete-time systems Swapping lemma L2σ-nonn Normalizing signal model reference adaptive control
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Output Feedback Robust H_(∞) Control for Discrete 2D Switched Systems
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作者 Wenjun Gao Yang Yang +3 位作者 Hongtao Duan Mingsheng Li Jinrong Ma Songwei Jin 《Computer Systems Science & Engineering》 SCIE EI 2021年第10期69-85,共17页
The two-dimensional(2-D)system has a wide range of applications in different fields,including satellite meteorological maps,process control,and digital filtering.Therefore,the research on the stability of 2-D systems ... The two-dimensional(2-D)system has a wide range of applications in different fields,including satellite meteorological maps,process control,and digital filtering.Therefore,the research on the stability of 2-D systems is of great significance.Considering that multiple systems exist in switching and alternating work in the actual production process,but the system itself often has external perturbation and interference.To solve the above problems,this paper investigates the output feedback robust H_(∞)stabilization for a class of discrete-time 2-D switched systems,which the Roesser model with uncertainties represents.First,sufficient conditions for exponential stability are derived via the average dwell time method,when the system’s interference and external input are zero.Furthermore,in the case of introducing the external interference,the weighted robust H_(∞)disturbance attenuation performance of the underlying system is further analyzed.An output feedback controller is then proposed to guarantee that the resulting closed-loop system is exponentially stable and has a prescribed disturbance attenuation levelγ.All theorems mentioned in the article will also be given in the form of linear matrix inequalities(LMI).Finally,a numerical example is given,which takes two uncertain values respectively and solves the output feedback controller’s parameters by the theorem proposed in the paper.According to the required controller parameter values,the validity of the theorem proposed in the article is compared and verified by simulation. 展开更多
关键词 2-D systems robust H_(∞)control LMI output feedback switched systems Roesser model
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Robust Resource Management Control for CO2 Emission and Reduction of Greenhouse Effect: Stochastic Game Approach
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作者 Bor-Sen Chen Ying-Po Lin 《Journal of Environmental Protection》 2011年第9期1172-1191,共20页
With the increasingly severe global warming, investments in clean technology, reforestation and political action have been studied to reduce CO2 emission. In this study, a nonlinear stochastic model is proposed to des... With the increasingly severe global warming, investments in clean technology, reforestation and political action have been studied to reduce CO2 emission. In this study, a nonlinear stochastic model is proposed to describe the dynamics of CO2 emission with control inputs: clean technology, reforestation and carbon tax, under stochastic uncertainties. For the efficient resources management, a robust tracking control is designed to force resources tracking a desired reference output. The worst-case effect of stochastic parametric fluctuations, external disturbances and uncertain initial conditions on the tracking performance is considered and minimized from the dynamic game theory perspective. This stochastic game problem, in which one player (stochastic uncertainty) maximizes the tracking error and another player (control input) minimizes the tracking error, could be equivalent to a robust minimax tracking problem. To avoid solving the HJI, a fuzzy model is proposed to approximate the nonlinear CO2 emission model. Then the nonlinear stochastic game problem could be easily solved by fuzzy stochastic game approach via LMI technique. 展开更多
关键词 CO2 Emission System Dynamic GAME Theory GREENHOUSE Effect LMI RESOURCE Management control ROBUST Tracking control T-S Fuzzy model
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