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Average Run Length in TEWMA Control Charts:Analytical Solutions for AR(p)Processes and Real Data Applications
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作者 Sirawit Makaew Yupaporn Areepong Saowanit Sukparungsee 《Computer Modeling in Engineering & Sciences》 2025年第5期1617-1634,共18页
This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is ... This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is an autoregressive model of order p,representing a time series with dependencies on its p previous values.Additionally,the study evaluates the accuracy of both explicit and numerical integral equation(NIE)solutions for AR(p)using the TEWMA control chart,focusing on the absolute percentage relative error.The results indicate that the explicit and approximate solutions are in close agreement.Furthermore,the study investigates the performance of exponentially weighted moving average(EWMA)and TEWMA control charts in detecting changes in the process,using the relative mean index(RMI)as a measure.The findings demonstrate that the TEWMA control chart outperforms the EWMA control chart in detecting process changes,especially when the value ofλis sufficiently large.In addition,an analysis using historical data from the SET index between January 2024 and May 2024 and historical data of global annual plastic production,the results of both data sets also emphasize the superior performance of the TEWMA control chart. 展开更多
关键词 EWMA control chart TEWMA control charts average run length shift detection explicit formula fredholm integral equation Banach’s fixed-point theorem AR(p)process
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LQR Discrete Time Control of a Buck Converter Using a Non-Minimal State Space Representation
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作者 Richard Tymerski 《Journal of Power and Energy Engineering》 2025年第1期32-46,共15页
This paper presents an advanced control strategy for DC-DC buck converters utilizing Non-Minimal State Space (NMSS) representation combined with Proportional-Integral-Plus (PIP) control, optimized through Linear Quadr... This paper presents an advanced control strategy for DC-DC buck converters utilizing Non-Minimal State Space (NMSS) representation combined with Proportional-Integral-Plus (PIP) control, optimized through Linear Quadratic Regulator (LQR) design. The proposed approach leverages NMSS to eliminate the need for state observers, enhancing robustness against model mismatch and improving overall system performance. The PIP controller extends traditional PI control by incorporating additional dynamic feedback. Experimental results demonstrate that the NMSS-PIP-LQR controlled buck converter achieves excellent dynamic performance. The design procedure is fully documented, and microcontroller implementation issues are discussed. 展开更多
关键词 DC-DC Buck Converter Non-Minimal State Space (NMSS) proportional-Integral-plus (pIp) control Linear Quadratic Regulator (LQR) f28069M Microcontroller
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一种应用于卫星通信的双频双圆极化Fabry-Perot谐振腔天线
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作者 罗伟 罗柳 +2 位作者 何鑫 王小雪 张红升 《电波科学学报》 北大核心 2025年第6期1043-1051,共9页
为探索更高性能的卫星通信天线,提出了一种基于法布里-珀罗(Fabry-Perot,F-P)谐振腔的双频双圆极化天线。该天线通过加载两种双层部分反射表面(partial reflective surface,PRS)构建双谐振腔,使得来自馈源的电磁波在双腔体内多次反射并... 为探索更高性能的卫星通信天线,提出了一种基于法布里-珀罗(Fabry-Perot,F-P)谐振腔的双频双圆极化天线。该天线通过加载两种双层部分反射表面(partial reflective surface,PRS)构建双谐振腔,使得来自馈源的电磁波在双腔体内多次反射并同相叠加,从而实现高增益圆极化辐射。所设计的PRS基于电磁超表面技术分别具有高通和低通功能,使得天线获得了双频特性。采用2×2的切角微带贴片天线阵列作为馈源,并基于顺序旋转馈电技术改善了馈源轴比特性。天线样机的测试结果表明,C波段和Ku波段的工作带宽分别为8.03%和4.14%,峰值增益为14.78 dBi和14.52 dBi。该天线性能满足频分双工卫星通信系统要求,适用于未来高速卫星互联网的地面设备。 展开更多
关键词 卫星通信 法布里-珀罗(f-p)谐振腔天线 电磁超表面 双频双圆极化 顺序旋转馈电技术
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miR-204-5p通过靶向结合转录因子E2F1下调RRM2的表达以抑制乳腺癌细胞增殖并影响细胞周期分布
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作者 褚旭 李翔 +1 位作者 赵浩 邹燕 《四川医学》 2025年第7期773-780,共8页
目的探讨miR-204-5p调控乳腺癌细胞恶性表型的具体机制,为乳腺癌靶向药物的开发以及新治疗靶标的挖掘提供新思路。方法qRT-PCR检测乳腺癌细胞中miR-204-5p、E2F1和RRM2的表达水平。CCK-8和克隆形成实验检测乳腺癌细胞增殖能力,流式细胞... 目的探讨miR-204-5p调控乳腺癌细胞恶性表型的具体机制,为乳腺癌靶向药物的开发以及新治疗靶标的挖掘提供新思路。方法qRT-PCR检测乳腺癌细胞中miR-204-5p、E2F1和RRM2的表达水平。CCK-8和克隆形成实验检测乳腺癌细胞增殖能力,流式细胞术检测细胞周期变化,生信预测和双荧光素酶活性检测miR-204-5p和E2F1,E2F1和RRM2的结合关系。结果双荧光素酶活性检测结果表明miR-204-5p靶向结合E2F1抑制E2F1的表达,转录因子E2F1能够通过靶向结合关系促进RRM2的表达。回复实验结果表明miR-204-5p可以通过结合转录因子E2F1抑制乳腺癌细胞的增殖并诱导细胞G1期阻滞,E2F1可以通过结合RRM2促进乳腺癌细胞增殖抑制细胞G1期阻滞。结论miR-204-5p可以通过结合转录因子E2F1抑制RRM2的表达,从而诱导乳腺癌细胞停滞于G1期,抑制乳腺癌细胞的增殖,这为乳腺癌靶向药物的开发以及新治疗靶标的挖掘提供了新的思路。 展开更多
关键词 miR-204-5p 乳腺癌 E2f1 RRM2 增殖 G1期阻滞
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Control Efficacy of Validamycin A·(0.2 Billion Spores/ml) Paenibacillus polymyxa DN-1 3% AS for Rice Sheath Blight
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作者 胡飞 苏卫华 +4 位作者 李昌春 周子燕 胡本进 徐丽娜 郑进国 《Agricultural Science & Technology》 CAS 2016年第11期2615-2618,共4页
With validamycin A.(0.2 billion spores/ml) Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for' rich sheath blight were in... With validamycin A.(0.2 billion spores/ml) Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for' rich sheath blight were investigated. The results of two- year test showed that when the application amount was in the range of 45-90 g.a.i/ hm^2, the field efficacy of validamycin A-(0.2 billion spores/ml) P. polymyxa DN-1 3% AS in the initial infection stage of rich sheath blight (Le., the diseased plant rate was below 5%) reached 80.38%-89.06%, and that in the peak infection stage (i.e., the diseased plant rate was higher than 10%) reached only 41.12%-53.26%. The field efficacy of validamycin A.(0.2 billion spores/ml) P. polymyxa DN-1 3% AS at the early onset of rich sheath blight was significantly better than that at the onset, so that the application time of validamycin A .(0.2 billion spores/ml) P. polymyxa DN-1 3% AS should be appropriately brought forward in the prevention and control of rice sheath blight. 展开更多
关键词 Validamycin A-(0.2 billion spores/roll p. polymyxa DN-1 3% AS Rice sheath blight Initial infection stage peak infection stage control efficacy
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SiC_(p)/Cu基复合材料性能提升与界面调控优化的研究进展
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作者 张云龙 王俊青 +5 位作者 张唯一 王伟娥 任晓雪 李成海 翟梓棫 刘德宝 《聊城大学学报(自然科学版)》 2026年第1期75-83,共9页
随着高端制造、电子封装与热管理等领域对材料综合性能的持续提升要求,传统铜及其合金材料在强度、耐磨性与导电导热性能方面逐渐显现出瓶颈。碳化硅颗粒增强铜基复合材料(SiC_(p)/Cu)因其优异的力学、电学与热物理性能,受到广泛关注。... 随着高端制造、电子封装与热管理等领域对材料综合性能的持续提升要求,传统铜及其合金材料在强度、耐磨性与导电导热性能方面逐渐显现出瓶颈。碳化硅颗粒增强铜基复合材料(SiC_(p)/Cu)因其优异的力学、电学与热物理性能,受到广泛关注。围绕SiC颗粒粒径、含量及分布等组成设计参数的优化,系统综述了SiC_(p)/Cu基复合材料在耐磨、导电、导热和耐蚀等方面的性能提升机制,探讨了Cu基体微合金化与SiC颗粒表面修饰的界面调控策略以及多相协同增强的设计理念,将为高性能SiC_(p)/Cu基复合材料的设计开发提供参考依据。 展开更多
关键词 SiC_(p)/Cu基复合材料 界面调控 性能提升机制 材料设计优化
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数字化F-P前端的仿真验证
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作者 史会贤 马琳 许骏 《电子技术应用》 2025年第1期94-102,共9页
提出一种基于差分电容原理的新型数字化F-P滤波器电路控制系统,并基于FPGA对该系统进行了理论分析以及硬件验证,验证结果表明该系统避免了现有F-P滤光器模拟电路控制系统的系统时间稳定性差的问题,具有极高的抗干扰能力,为高稳定无漂移... 提出一种基于差分电容原理的新型数字化F-P滤波器电路控制系统,并基于FPGA对该系统进行了理论分析以及硬件验证,验证结果表明该系统避免了现有F-P滤光器模拟电路控制系统的系统时间稳定性差的问题,具有极高的抗干扰能力,为高稳定无漂移的F-P控制系统提供了新思路。 展开更多
关键词 数字化 f-p 伺服控制 电容测距
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I/F起动结合改进滑模观测器的PMSM全速域控制 被引量:1
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作者 张旭梅 谢佳莉 黄安贻 《安徽大学学报(自然科学版)》 北大核心 2025年第3期60-71,共12页
为提高永磁同步电机全速域无传感器控制性能,该文研究了永磁同步电机无传感器全速域控制策略和算法,提出了一种I/F起动结合改进滑模观测器的控制策略,即在零低速域采用I/F起动控制,在中高速域采用改进滑模观测器,通过电流切换法来实现... 为提高永磁同步电机全速域无传感器控制性能,该文研究了永磁同步电机无传感器全速域控制策略和算法,提出了一种I/F起动结合改进滑模观测器的控制策略,即在零低速域采用I/F起动控制,在中高速域采用改进滑模观测器,通过电流切换法来实现两种不同速域控制方式的切换.针对所提控制策略的有效性,该文还开展了仿真分析和实验研究,结果表明,该文所提电流切换法能有效实现不同速域转速的平稳切换,并且中高速域的转速控制精度亦得到显著提高. 展开更多
关键词 永磁同步电机 无传感器控制 I/f起动 改进滑模观测器
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面阵对称翻转变换用于F-P微小角度测量系统 被引量:1
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作者 吴晨光 沈小燕 周世南 《中国测试》 北大核心 2025年第1期111-118,共8页
法布里珀罗(F-P)标准具应用于位移和角度测量时,其干涉成像同心圆环圆心坐标的准确计算对测量结果具有关键影响。针对面阵CCD传感器上干涉成像同心圆环在移动时存在的误差,利用干涉成像同心圆环有效信息,提出一种面阵像元正反细分的对... 法布里珀罗(F-P)标准具应用于位移和角度测量时,其干涉成像同心圆环圆心坐标的准确计算对测量结果具有关键影响。针对面阵CCD传感器上干涉成像同心圆环在移动时存在的误差,利用干涉成像同心圆环有效信息,提出一种面阵像元正反细分的对称翻转算法,在理论分析的基础上进行算法和实验验证。将该算法应用于F-P微小角度测量系统并进行比对实验研究。实验结果表明该算法可将圆心坐标标准差减小至0.0028个像素单位;在±150″测量范围内,F-P微小角度测量系统的测量值与ELCOMAT HR自准直仪两者的示值误差不大于0.38″,经拟合修正后两者示值误差不大于0.06″,测量准确度得到有效提高。 展开更多
关键词 f-p标准具 对称翻转变换 像元平滑细分 圆心坐标计算 微小角度测量
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Moving fast, thinking fast:The relations of physical activity levels and bouts to neuroelectric indices of inhibitory control in preadolescents 被引量:3
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作者 Dominika M.Pindus Eric S.Drollette +9 位作者 Lauren B.Raine Shih-Chun Kao Naiman Khan Daniel R.Westfall Morgan Hamill Rebecca Shorin Emily Calobrisi Dinesh John Arthur F.Kramer Charles H.Hillman 《Journal of Sport and Health Science》 SCIE 2019年第4期301-314,共14页
Background:Structured vigorous physical activity(VPA)can improve cognitive control in children,but studies relating daily physical activity(PA)to cognitive control have yielded conflicting findings.While objectively m... Background:Structured vigorous physical activity(VPA)can improve cognitive control in children,but studies relating daily physical activity(PA)to cognitive control have yielded conflicting findings.While objectively measured daily PA summarizes all occurrences of PA within a registered period,a minimum duration of continuous PA is required for registration of a PA bout.Because brief bouts of high-intensity PA can account for a large proportion of children’s daily activity-related energy expenditure,this study assessed whether daily and bouted VPA were selectively related to cognitive control in preadolescents relative to other PA intensities.Methods:A total of 75 children between the ages of 8 and 10 years(49%girls)wore an ActiGraph wGT 3 X+on the hip for 7 days.The acceleration signal from the vertical axis was summarized over 1 s,5 s,and 15 s epochs.Daily and boutecd modercate PA,moderate-to-vigorous PA,and VPA were measured.PA bouts were expressed as the frequency and time spent in 2 different continuous PA bouts,one lasting≥10 s and the other lasting≥30 s at a given intensity.Inhibitory control was assessed using behavioral responses to a modified flanker task(mean reaction time(RTmean)and accuracy).Attentional resource allocation and co gnitive processing speed were measured using the amplitude and latency of the P3 component of event-related brain potentials,respectively.Associations between PA,behavioral indices of inhibitory control,P3 amplitude,and latency were assessed using hierarchical regression models.Results:Daily VPA was not related to RTmean or accuracy on either congruent or incongruent trials.In contrast,more time spent in VPA bouts lasting≥30 s predicted shorter P3 latency across epochs and flanker congruencies(allβ≤-0.24,all p≤0.04).The associations between shorter P3 latency and the time spent in moderate-to-vigorous PA bouts lasting≥30 s were less consistent and largely limited to congruent trials(congruent:β(-0.3 1,-0.34)).No significant associations were observed upon correction for false discovery rate.Conclusion:The pattern of uncorrected associations aligns with the dose-response literature and suggests that brief VPA bouts may yield the greatest benefits to cognitive processing speed in preadolescents.Future studies using measures of brain structure and function are needed to understand the mechanisms linking bouted VPA to neurocognitive function during childhood. 展开更多
关键词 ACCELEROMETRY Bouts Children ERpS INHIBITORY control p3 physical activity
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Time-delay Compensation Method for Networked Control System Based on Time-delay Prediction and Implicit PIGPC 被引量:1
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作者 Zhong-Da Tian Xian-Wen Gao +1 位作者 Bi-Lian Gong Tong Shi 《International Journal of Automation and computing》 EI CSCD 2015年第6期648-656,共9页
A network time-delay compensation method based on time-delay prediction and implicit proportional-integral-based generalized predictive controller(PIGPC) is proposed. The least squares support vector machine(LSSVM) is... A network time-delay compensation method based on time-delay prediction and implicit proportional-integral-based generalized predictive controller(PIGPC) is proposed. The least squares support vector machine(LSSVM) is used to predict the current time-delay, the parameters of the least squares support vector machine are optimized by particle swarm optimization(PSO) algorithm,and the predicted time-delay is used instead of the actual time-delay as the parameters of the network time-delay compensation controller. In order to improve the compensation effect of implicit generalized predictive controller(GPC), this paper puts forward an implicit generalized predictive control algorithm with proportional-integral-based(PI) structure and designs the controller based on implicit PIGPC. Through the simulation results, the effectiveness of this design in the paper is verified. 展开更多
关键词 Networked control system time-delay compensation p
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Application of pH control to a tubular flow reactor 被引量:1
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作者 .Halil Vural Ayla Altinten +2 位作者 Hale Hapoglu Sebahat Erdogan Mustafa Alpbaz 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第1期154-161,共8页
Tubular flow reactors are mainly used in chemical industry and waste water discharged units. Control of output variables is very difficult because of the existence of high dead-time in these types of reactors. In the ... Tubular flow reactors are mainly used in chemical industry and waste water discharged units. Control of output variables is very difficult because of the existence of high dead-time in these types of reactors. In the present work, sodium hydroxide and acetic acid solutions were sent to the tubular flow reactor. The aim was to control p H at 7 in the nonlinear region. The p H control of a tubular flow reactor with high time delay and a highly nonlinear behavior in p H neutralization reaction was investigated experimentally in the face of the various load and set point changes. Firstly, efficiency of conventional Proportional-Integral-Derivative(PID) algorithm in the experiments was tested. Then self-tuning PID(STPID) control system was applied by using the ARMAX model. The model parameters were calculated from input–output data by using PRBS signal as disturbance and Bierman algorithm. Lastly, the experimental fuzzy control of p H based on fuzzy model was achieved to compare the success of fuzzy approach with the performance of other control cases studied. 展开更多
关键词 Tubular flow reactor p H control Self tuning pID control pID control fuzzy control
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Interval Type-2 Fuzzy Hierarchical Adaptive Cruise Following-Control for Intelligent Vehicles 被引量:5
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作者 Hong Mo Yinghui Meng +1 位作者 Fei-Yue Wang Dongrui Wu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2022年第9期1658-1672,共15页
Intelligent vehicles can effectively improve traffic congestion and road traffic safety.Adaptive cruise followingcontrol(ACFC)is a vital part of intelligent vehicles.In this paper,a new hierarchical vehicle-following ... Intelligent vehicles can effectively improve traffic congestion and road traffic safety.Adaptive cruise followingcontrol(ACFC)is a vital part of intelligent vehicles.In this paper,a new hierarchical vehicle-following control strategy is presented by synthesizing the variable time headway model,type-2 fuzzy control,feedforward+fuzzy proportion integration(PI)feedback(F+FPIF)control,and inverse longitudinal dynamics model of vehicles.Firstly,a traditional variable time headway model is improved considering the acceleration of the lead car.Secondly,an interval type-2 fuzzy logic controller(IT2 FLC)is designed for the upper structure of the ACFC system to simulate the driver's operating habits.To reduce the nonlinear influence and improve the tracking accuracy for the desired acceleration,the control strategy of F+FPIF is given for the lower control structure.Thirdly,the lower control method proposed in this paper is compared with the fuzzy PI control and the traditional method(no lower controller for tracking desired acceleration)separately.Meanwhile,the proportion integration differentiation(PID),linear quadratic regulator(LQR),subsection function control(SFC)and type-1 fuzzy logic control(T1 FLC)are respectively compared with the IT2 FLC in control performance under different scenes.Finally,the simulation results show the effectiveness of IT2 FLC for the upper structure and F+FPIF control for the lower structure. 展开更多
关键词 Adaptive cruise following-control(ACfC) feedforward%pLUS%fuzzy proportion integration(pI)feedback(f%pLUS%fpIf) type-2 fuzzy control variable time headway
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光纤F-P腔高品质因子检波器理论模型研究
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作者 赵和平 刘波 +2 位作者 杨迪 闫诚 邢美华 《光学与光电技术》 2025年第5期108-117,共10页
针对波长解调型光纤加速度检波器灵敏度低的问题,建立了光纤法布里-珀罗(FabryPérot,F-P)波长解调型加速度检波器的理论模型。以光纤F-P加速度检波器的物理模型为切入点,结合F-P干涉仪的基本原理,理论研究其检波原理,并剖析弹性结... 针对波长解调型光纤加速度检波器灵敏度低的问题,建立了光纤法布里-珀罗(FabryPérot,F-P)波长解调型加速度检波器的理论模型。以光纤F-P加速度检波器的物理模型为切入点,结合F-P干涉仪的基本原理,理论研究其检波原理,并剖析弹性结构体的刚度、质量、腔长、阻尼和折射率对灵敏度的影响。通过实验搭建基于F-P干涉的光纤加速度检波器,验证了模型中主要参数对灵敏度和性能的影响。引入品质因子(Figure of Merit)作为指标,结合实验数据对传感器的综合性能进行量化评价,进一步验证了理论模型的正确性和适用性。对比分析FBG和F-P加速度传感器的综合性能,检波器的谐振频率约为740 Hz,在10~310 Hz频率范围较为平坦,相应的灵敏度为6.59~15.21 nm/G,动态范围达81.3 dB,动态分辨率6.25μG/√Hz,传感器灵敏度比基于FBG的传感器灵敏度理论上高出约2个数量级,为光纤类波长解调型高品质因子F-P加速度检波器的设计提供了新思路。 展开更多
关键词 品质因子 法布里-珀罗腔(f-p) 光纤检波器 加速度 波长调制
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远红外波段F-P可调滤波器的设计
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作者 赵倩倩 杜玉军 +3 位作者 魏威 鲁骞 杨锦航 郭彦双 《光学与光电技术》 2025年第2期31-38,共8页
为了实现气体成分判定和浓度定量检测,设计了9~12.6μm远红外波段的F-P可调滤波器,对于影响其光学性能的MEMS微结构特定光学元件进行了重点设计。为解决Si基底在9μm以上的光谱透过问题,设计了ZnS和BaF2双层材料构成的增透膜,使其透过率... 为了实现气体成分判定和浓度定量检测,设计了9~12.6μm远红外波段的F-P可调滤波器,对于影响其光学性能的MEMS微结构特定光学元件进行了重点设计。为解决Si基底在9μm以上的光谱透过问题,设计了ZnS和BaF2双层材料构成的增透膜,使其透过率在9~12.6μm范围内达到97%以上。移动反射镜和固定反射镜均采用由PbTe和BaF2组成的HLHLH高反膜,在所设计的光谱波段实现了高达98%的反射率。通过TFCalc和MATLAB软件仿真对设计进行验证,证明了设计的合理性。仿真结果可为远波段的可调滤波器设计提供借鉴,此类设计可广泛应用于气体传感器、环境监测、医学诊断设备等,特别是在小型化、集成化的传感器系统中。 展开更多
关键词 远红外波段 f-p可调滤波器 MEMS微结构 增透膜 反射镜
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The Main Diseases and Control Measures of Panax notoginseng(Burk) F. H. Chen in Wuzhou City 被引量:1
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作者 Chen Yinghui Liu Zhuowu +2 位作者 Qiu Weihua Tan Xinxing Li Jinfeng 《Plant Diseases and Pests》 CAS 2014年第2期35-37,共3页
The main symptoms of root rot,anthracnose,blight and damping-off of Panax notoginseng( Burk) F. H. Chen are introduced in the paper,and the corresponding control measures are elaborated from the aspects of agricultura... The main symptoms of root rot,anthracnose,blight and damping-off of Panax notoginseng( Burk) F. H. Chen are introduced in the paper,and the corresponding control measures are elaborated from the aspects of agricultural management measures,seed disinfection,seedbed treatment and chemical control. 展开更多
关键词 panax notoginseng(Burk) f.H.Chen DISEASES control Wuzhou
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f波振幅和P波离散度对心房颤动患者血栓栓塞事件的预测价值
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作者 吴晓燕 《医疗装备》 2025年第24期18-21,共4页
目的探讨f波振幅和P波离散度对心房颤动患者血栓栓塞事件的预测价值。方法回顾性分析2022年1月至2024年12月于东台市人民医院就诊的91例心房颤动患者的临床资料,根据随访期间血栓栓塞事件发生情况分为发生组(21例)与未发生组(70例)。比... 目的探讨f波振幅和P波离散度对心房颤动患者血栓栓塞事件的预测价值。方法回顾性分析2022年1月至2024年12月于东台市人民医院就诊的91例心房颤动患者的临床资料,根据随访期间血栓栓塞事件发生情况分为发生组(21例)与未发生组(70例)。比较两组的f波振幅和P波离散度,绘制受试者工作特征(ROC)曲线,分析f波振幅和P波离散度单独及联合预测心房颤动患者发生血栓栓塞事件的效能。结果发生组f波振幅低于未发生组,P波离散度高于未发生组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,f波振幅联合P波离散度预测心房颤动患者发生血栓栓塞事件的曲线下面积(AUC)为0.971,高于两者单独预测的AUC(0.922、0.894)。结论心电图f波振幅降低、P波离散度升高可预测心房颤动患者的血栓栓塞事件,两者联合预测的价值高于单独预测。 展开更多
关键词 f波振幅 p波离散度 心房颤动 血栓栓塞 心电图
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LncRNA CASC9/miR-195-5p/E2F7信号通路在二氢杨梅素抑制食管鳞状细胞癌增殖和转移中的作用研究
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作者 郑璇 黄兰香 +4 位作者 崔逸爽 吴亚男 洪紫谦 张梦诗 孙国贵 《中华中医药学刊》 北大核心 2025年第8期65-70,I0013-I0018,共12页
目的探讨二氢杨梅素(dihydromyricetin,DMY)对食管鳞癌(Esophageal squamous cell carcinoma,ESCC)增殖和转移的影响及是否由LncRNA CASC9/miR-195-5p/E2F7轴介导。方法采用梯度浓度(0、25、50、100μmol/L)的DMY处理ESCC细胞,以探究DMY... 目的探讨二氢杨梅素(dihydromyricetin,DMY)对食管鳞癌(Esophageal squamous cell carcinoma,ESCC)增殖和转移的影响及是否由LncRNA CASC9/miR-195-5p/E2F7轴介导。方法采用梯度浓度(0、25、50、100μmol/L)的DMY处理ESCC细胞,以探究DMY对ESCC细胞增殖、迁移和侵袭的影响。利用生物信息学手段预测了ESCC中LncRNA CASC9/miR-195-5p/E2F7轴之间是否存在相互作用。实时荧光定量聚合酶链反应(Real-time quantitative polymerase chain reaction,RT-qPCR)实验检测细胞中LncRNA CASC9、miR-195-5p和E2F7的表达,RT-qPCR、蛋白免疫印迹(Western blot)和双荧光素酶报告基因实验进一步验证其调控关系。通过细胞计数试剂盒-8(Cell counting kit-8,CCK-8)、集落形成、划痕以及Transwell侵袭实验分别检测细胞活性、增殖、迁移以及侵袭能力。应用Western blot实验检测上皮间充质转化(Epithelial-mesenchymal transition,EMT)标志物如E-钙黏蛋白(E-cadherin)、N-钙黏蛋白(N-Cadherin)、波形蛋白(Vimentin)的表达。结果DMY可以显著抑制ESCC细胞增殖、迁移和侵袭。生物信息学分析及细胞水平验证发现LncRNA CASC9在ESCC中高表达,DMY处理后可通过下调ESCC细胞中LncRNA CASC9的表达水平,从而抑制ESCC细胞增殖、迁移和侵袭。此外,miR-195-5p在ESCC中表达下调,而E2F7表达上调。RT-qPCR、Western blot和双荧光素酶报告基因实验进一步证实LncRNA CASC9通过吸附miR-195-5p进而调控E2F7的表达。敲低E2F7可以逆转敲低miR-195-5p对ESCC细胞增殖、转移以及EMT进程的促进作用,而过表达E2F7可逆转过表达miR-195-5p产生的抑制作用。结论DMY可通过LncRNA CASC9/miR-195-5p/E2F7轴抑制ESCC的增殖和转移。 展开更多
关键词 二氢杨梅素 LncRNA CASC9 miR-195-5p E2f7 食管鳞癌 转移
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Screening of Bacillus subtilis HAAS01 and Its Biocontrol Effect on Fusarium wilt in Sweet Potato 被引量:1
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作者 Chengyang Li Lianjun Wang +9 位作者 Shasha Chai Yinghua Xu Chong Wang Yi Liu Jian Lei Xiaojie Jin Xianliang Cheng Yuanyuan Yang Xinsun Yang Wenying Zhang 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第8期1779-1793,共15页
Fusarium wilt,a disease caused by Fusarium oxysporum f.sp batatas(Fob)is an important disease in sweet potato production.Using endophytic bacteria for biological control of sweet potato diseases is one of the importan... Fusarium wilt,a disease caused by Fusarium oxysporum f.sp batatas(Fob)is an important disease in sweet potato production.Using endophytic bacteria for biological control of sweet potato diseases is one of the important ways.A Bacillus subtilis with antagonistic effect on Fusarium wilt of sweet potato was isolated from soil by confrontation culture.According to the biological characteristics,16S rDNA sequence analysis,and physiological and biochemical analysis,the Bacillus subtilis HAAS01 was named.A pot experiment was conducted for the biological control experiment of strain HAAS01,and the endogenous hormone content,antioxidant enzyme activity,soluble protein content,and related gene expressions of sweet potato plants were detected.The results showed that the HAAS01 strain could promote the production of endogenous hormones and resist the infection of plant diseases together with defensive enzymes and upregulation of related gene expressions.In summary,Bacillus subtilis HAAS01 was effective in controlling Fusarium wilt of sweet potato and has potential for application and development. 展开更多
关键词 Bacillus subtilis HAAS01 Ipomoea batatas(L.)Lam. fusarium wilt fusarium oxysporum f.sp batatas biological control
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5-Aminolevulinic acid against strawberry Fusarium wilt:Bidirectional regulation of biocontrol agents and pathogens 被引量:1
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作者 Hao Yang Jianting Zhang +3 位作者 Haiwen Zhang Rongxiang Cao Donglan Tang Liangju Wang 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第6期1349-1361,共13页
Strawberry Fusarium wilt (SFW) is a systematic soil-borne disease caused by Fusarium oxysporum f.sp.fragaria (Fof),which infects the vascular bundles,blocking water and nutrient transport from roots to the aboveground... Strawberry Fusarium wilt (SFW) is a systematic soil-borne disease caused by Fusarium oxysporum f.sp.fragaria (Fof),which infects the vascular bundles,blocking water and nutrient transport from roots to the aboveground.It is a severe pathogen which spreads rapidly and destroys strawberry production.Finding a way to control this disease is of great scientific value and practical importance.In this study,three fungi were isolated from the vascular tissues of sick strawberries in the field.After DNA sequencing,they were identified as Fof,Aspergillus fumigatus and Trichoderma harzianum,respectively,among which the first two are pathogens and the third is a probiotic.All fungi were controlled by thiophanate-methyl (TM),a commercial fungicide.On PDA medium,20 mg·L^(-1)5-aminolevulinic acid (ALA),a natural non-protein amino acid,promoted T.harzianum proliferation,but inhibited Fof and A.fumigatus.In confrontation test,the growth of Fof or A.fumigatus was inhibited by T.harzianum and exogenous ALA promoted T.harzianum growth but significantly inhibited the pathogen growth.When three species of fungi were separately or combinedly inoculated on healthy strawberry plants,T.harzianum promoted plant growth and development while Fof or A.fumigatus caused growth retardation,where Fof directly caused leaf yellowing and plant wilting.When the plants inoculated with different fungus were treated with ALA,the results turned out that ALA alleviated SFW symptoms by bidirectionally promoting T.harzianum proliferation and inhibiting Fof and A.fumigatus.Thus,ALA might be used in comprehensively controlling SFW in strawberry industry. 展开更多
关键词 5-Aminolevulinic acid Antagonistic effect Disease control fusarium oxysporum f.sp.fragaria(fof) Strawberry fusarium wilt(SfW) Trichoderma harzianum
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