In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,...In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,motile count,progressive motile count,and morphology,are unclear for women with polycystic ovary syndrome(PCOS).A secondary analysis was conducted based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatory disorder between 2011 and 2016 in China.A total of 1000 women received ovulation induction(acupuncture and clomiphene).We randomized the women with PCOS in 27 hospitals in China who received one of four interventions(acupuncture plus clomiphene,sham acupuncture plus clomiphene,acupuncture plus placebo,or sham acupuncture plus placebo).Semen analysis was performed for every male partner according to the World Health Organization(WHO)criteria.The outcomes included conception,clinical pregnancy,and live birth.Logistic regression was used to evaluate the predictive value of semen analysis among ovulatory women for conception,clinical pregnancy,and live birth.Among the 1000 couples,the number of couples who attained ovulation,conception,clinical pregnancy,and live birth were 780,320,235,and 205,respectively.Semen volume and motility were applied and used as prediction parameters for conception(area under the curve(AUC)of 0.62(95%confidence interval(CI),0.55–0.69)),clinical pregnancy(AUC of 0.67(95%CI:0.61–0.73)),and live birth(AUC of 0.57(95%CI:0.50–0.64)).No poor calibration was shown for these models in Hosmer–Lemeshow tests.The predictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatory dysfunction is limited.展开更多
Ovulatory dysfunction(OD)is one of the main causes of infertility in women of childbearing age,which not only affects their reproductive ability,but also physical and mental health.Traditional treatment strategies hav...Ovulatory dysfunction(OD)is one of the main causes of infertility in women of childbearing age,which not only affects their reproductive ability,but also physical and mental health.Traditional treatment strategies have limited efficacies,and the emergence of biomedicines provides a promising alternative solution via the strategies of combining engineered design with modern advanced technology.This review explores the pathophysiological characteristics and related induction mechanisms of OD,and evaluates the current cutting-edge advances in its treatments.It emphasizes the potentials of biomedicines strategies such as hydrogels,nanoparticles and extracellular vesicles in improving therapeutic precision and efficacy.By mimicking natural physiological processes,and achieving controlled drug release,these advanced drug carriers are expected to address the challenges in ovarian microenvironment reprogramming,tissue repair,and metabolic and immune regulation.Despite the promising progress,there are still challenges in terms of biomedical complexity,differences between animal models and human physiology,and the demand for intelligent drug carriers in the therapy of OD.Future researches are mainly dedicated to developing precise personalized biomedicines in OD therapy through interdisciplinary collaboration,promoting the development of reproductive regenerative medicine.展开更多
基金This study was supported by the National Public Welfare Projects for Chinese Medicine(201107005)the National Key Research and Development Program of China(2019YFC1709500)+2 种基金the Project of Heilongjiang University of Chinese Medicine(2018RCQ12 and 2019BS09)the Projects of Heilongjiang Provincial Administration of Traditional Chinese medicine(ZHY2020-102)Xuzhou Clinical Medical Team Talent Introduction Project--Academician Yixun Liu Integrated Chinese and Western medicine,Maternity and Reproductive Technology Innovation Team,and Academician Yixun Liu Workstation Project.
文摘In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,motile count,progressive motile count,and morphology,are unclear for women with polycystic ovary syndrome(PCOS).A secondary analysis was conducted based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatory disorder between 2011 and 2016 in China.A total of 1000 women received ovulation induction(acupuncture and clomiphene).We randomized the women with PCOS in 27 hospitals in China who received one of four interventions(acupuncture plus clomiphene,sham acupuncture plus clomiphene,acupuncture plus placebo,or sham acupuncture plus placebo).Semen analysis was performed for every male partner according to the World Health Organization(WHO)criteria.The outcomes included conception,clinical pregnancy,and live birth.Logistic regression was used to evaluate the predictive value of semen analysis among ovulatory women for conception,clinical pregnancy,and live birth.Among the 1000 couples,the number of couples who attained ovulation,conception,clinical pregnancy,and live birth were 780,320,235,and 205,respectively.Semen volume and motility were applied and used as prediction parameters for conception(area under the curve(AUC)of 0.62(95%confidence interval(CI),0.55–0.69)),clinical pregnancy(AUC of 0.67(95%CI:0.61–0.73)),and live birth(AUC of 0.57(95%CI:0.50–0.64)).No poor calibration was shown for these models in Hosmer–Lemeshow tests.The predictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatory dysfunction is limited.
基金supported by the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(Grant Nos.2025GXNSFDA069002,China and 2024GXNSFAA010089,China)the Guangxi Key Research and Development Program(Grant No.Guike AB22080045,China)the Major Talent Project of Guangxi Autonomous Region.
文摘Ovulatory dysfunction(OD)is one of the main causes of infertility in women of childbearing age,which not only affects their reproductive ability,but also physical and mental health.Traditional treatment strategies have limited efficacies,and the emergence of biomedicines provides a promising alternative solution via the strategies of combining engineered design with modern advanced technology.This review explores the pathophysiological characteristics and related induction mechanisms of OD,and evaluates the current cutting-edge advances in its treatments.It emphasizes the potentials of biomedicines strategies such as hydrogels,nanoparticles and extracellular vesicles in improving therapeutic precision and efficacy.By mimicking natural physiological processes,and achieving controlled drug release,these advanced drug carriers are expected to address the challenges in ovarian microenvironment reprogramming,tissue repair,and metabolic and immune regulation.Despite the promising progress,there are still challenges in terms of biomedical complexity,differences between animal models and human physiology,and the demand for intelligent drug carriers in the therapy of OD.Future researches are mainly dedicated to developing precise personalized biomedicines in OD therapy through interdisciplinary collaboration,promoting the development of reproductive regenerative medicine.
