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Influence of multiple structural parameters on interior ballistics based on orthogonal test methods 被引量:11
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作者 Chao-bin Hu Xiao-bing Zhang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2019年第5期690-697,共8页
Influence of multiple structural parameters on the performance of a gun launch system driven by highpressure reactive gases is important for structural design and performance adjustment.A coupled lumped parameter mode... Influence of multiple structural parameters on the performance of a gun launch system driven by highpressure reactive gases is important for structural design and performance adjustment.A coupled lumped parameter model was utilized to predict the propellant combustion,and a dynamic finite element method was applied to approximate the mechanical interactions between the projectile and the barrel.The combustion and the mechanical interactions were coupled through a user subroutine interface in ABAQUS.The correctness and the capability of the finite element approximations in capturing small structural changes were validated by comparing predicted resistance with experiments.Based on the coupled model,the influence of structural parameters of a medium-caliber gun on the system performance was investigated.In order to reduce the research costs,orthogonal tests were designed to investigate the comprehensive effects of the parameters.According to statistical analysis,the important order of the structural parameters on the launching process was obtained.The results indicate that the influence of the width of the rotating band stands out among the studied parameters in the gun.The work provides a method to investigate the influence of multiple parameters on system performance and gives guidance for controlling the system performance. 展开更多
关键词 MULTIPLE PARAMETERS COUPLED model COMBUSTION Sensitivity analysis orthogonal test
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Warm Compaction Process of P/M Steels by Orthogonal Testing Method
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作者 叶途明 YI Jianhong +2 位作者 PENG Yuandong XIA Qinglin WANG Hongzhong 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2008年第1期105-108,共4页
In order to achieve higher density of P/M steels using the die wall lubrication compacting method or powder lubricant in warm compaction process, the influence of different process parameters on the green density of w... In order to achieve higher density of P/M steels using the die wall lubrication compacting method or powder lubricant in warm compaction process, the influence of different process parameters on the green density of warm compacted samples was studied. According to the orthogonal test method, the authors systematically study the influence of the different compaction pressure, condition of lubrication and compaction temperature on the green density of the sample in the warm compaction process, and put forward the optimal process parameter of warm compaction experiment. It is found that, a high compaction pressure (≥700 MPa), die wall lubrication combined with a small amount of internal lubricants, and fitting compaction temperature by different condition of lubrication, are the optimal parameters in warm compaction process. 展开更多
关键词 warm compaction orthogonal test method die wall lubrication particle rearrangement plastic deformation
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Estimating rock strength parameters across varied failure criteria:Application of spreadsheet and R-based orthogonal regression to triaxial test data
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作者 RobertoÚcar Luis Arlegui +1 位作者 Norly Belandria Francisco Torrijo 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期4685-4699,共15页
Triaxial tests,a staple in rock engineering,are labor-intensive,sample-demanding,and costly,making their optimization highly advantageous.These tests are essential for characterizing rock strength,and by adopting a fa... Triaxial tests,a staple in rock engineering,are labor-intensive,sample-demanding,and costly,making their optimization highly advantageous.These tests are essential for characterizing rock strength,and by adopting a failure criterion,they allow for the derivation of criterion parameters through regression,facilitating their integration into modeling programs.In this study,we introduce the application of an underutilized statistical technique—orthogonal regression—well-suited for analyzing triaxial test data.Additionally,we present an innovation in this technique by minimizing the Euclidean distance while incorporating orthogonality between vectors as a constraint,for the case of orthogonal linear regression.Also,we consider the Modified Least Squares method.We exemplify this approach by developing the necessary equations to apply the Mohr-Coulomb,Murrell,Hoek-Brown,andÚcar criteria,and implement these equations in both spreadsheet calculations and R scripts.Finally,we demonstrate the technique's application using five datasets of varied lithologies from specialized literature,showcasing its versatility and effectiveness. 展开更多
关键词 Rock failure criteria Nonlinear regression orthogonal regression Triaxial testing Dot product
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Optimization of Guide Vane Geometry in a Pump-as-Turbine through an Orthogonal Test Approach
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作者 Fengxia Shi Pengcheng Wang +1 位作者 Haonan Zhan Xiangyun Shi 《Fluid Dynamics & Materials Processing》 2025年第5期1221-1238,共18页
To investigate the impact of guide vane geometry—specifically,outlet angle,blade count,and radial height—on the performance of a Pump as Turbine(PAT),radial guide vanes were introduced upstream of the impeller in an... To investigate the impact of guide vane geometry—specifically,outlet angle,blade count,and radial height—on the performance of a Pump as Turbine(PAT),radial guide vanes were introduced upstream of the impeller in an IS80-50-315 low-specific-speed centrifugal PAT.Using an orthogonal test design,numerical simulations were conducted on 16 different PAT configurations,and the influence of vane geometry on performance was analyzed through a range analysis to determine the optimal parameter combinations.The results indicate that the number of guide vane blades significantly affects both the hydraulic efficiency and water head of the PAT under optimal operating conditions.Notably,the hydraulic efficiency of Configuration No.1(featuring five guide vane blades,a 6°outlet angle,and a 46 mm radial height)is 4.31%higher than that of Configuration No.13(with the same blade count but a 9°outlet angle and a 52 mm radial height).Additionally,Configuration No.1 exhibits lower turbulence kinetic energy dissipation and reduced blade loading.Furthermore,the study reveals that a smaller guide vane outlet angle and reduced radial height contribute to improved operational stability. 展开更多
关键词 Pump as turbine radial guide vanes orthogonal test transient analysis
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A review of test methods for uniaxial compressive strength of rocks:Theory,apparatus and data processing
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作者 Wei-Qiang Xie Xiao-Li Liu +2 位作者 Xiao-Ping Zhang Quan-Sheng Liu En-ZhiWang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1889-1905,共17页
The uniaxial compressive strength(UCS)of rocks is a vital geomechanical parameter widely used for rock mass classification,stability analysis,and engineering design in rock engineering.Various UCS testing methods and ... The uniaxial compressive strength(UCS)of rocks is a vital geomechanical parameter widely used for rock mass classification,stability analysis,and engineering design in rock engineering.Various UCS testing methods and apparatuses have been proposed over the past few decades.The objective of the present study is to summarize the status and development in theories,test apparatuses,data processing of the existing testing methods for UCS measurement.It starts with elaborating the theories of these test methods.Then the test apparatus and development trends for UCS measurement are summarized,followed by a discussion on rock specimens for test apparatus,and data processing methods.Next,the method selection for UCS measurement is recommended.It reveals that the rock failure mechanism in the UCS testing methods can be divided into compression-shear,compression-tension,composite failure mode,and no obvious failure mode.The trends of these apparatuses are towards automation,digitization,precision,and multi-modal test.Two size correction methods are commonly used.One is to develop empirical correlation between the measured indices and the specimen size.The other is to use a standard specimen to calculate the size correction factor.Three to five input parameters are commonly utilized in soft computation models to predict the UCS of rocks.The selection of the test methods for the UCS measurement can be carried out according to the testing scenario and the specimen size.The engineers can gain a comprehensive understanding of the UCS testing methods and its potential developments in various rock engineering endeavors. 展开更多
关键词 Uniaxial compressive strength(UCS) UCS testing methods test apparatus Data processing
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Fast Charge Test Method for Battery Pack Systems with Thermal Management
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作者 Zidan Gong Jun Yang +1 位作者 Zhaoming Li Yuebing Feng 《Journal of Electronic Research and Application》 2025年第4期214-223,共10页
This paper introduces a kind of substitute bench testing method for vehicle application development and testing method of the test requirements,including battery fast conversion cycle test equipment,enter type incubat... This paper introduces a kind of substitute bench testing method for vehicle application development and testing method of the test requirements,including battery fast conversion cycle test equipment,enter type incubator,liquid-cooled machine and ancillary equipment composed of a set of test system,through the walk-in constant temperature box to simulate the new energy vehicles under different environmental conditions of the test requirements,Liquid-cooled machine and auxiliary parts to complete the battery thermal management system need cooling fluid conditions,the battery conversion cycle test equipment to simulate the dc fast charging way of filling pile,complete battery thermal management system test,shorten the filling fast charging time and improve battery fast charge security,for troubleshooting and data collection and analysis,Improve work efficiency,save costs,and eliminate customer anxiety about battery life and charging time. 展开更多
关键词 Thermal management battery pack system Fast-charging bench system test method
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A new test method for friction in incremental sheet forming
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作者 Guang-can YANG Da-wei ZHANG +1 位作者 Chong TIAN Sheng-dun ZHAO 《Transactions of Nonferrous Metals Society of China》 2025年第12期3985-4006,共22页
An analytical model for contact area and contact stress considering the loading history in incremental sheet forming(ISF)was established.Then,by integrating with the directional characteristics of friction force and h... An analytical model for contact area and contact stress considering the loading history in incremental sheet forming(ISF)was established.Then,by integrating with the directional characteristics of friction force and horizontal force in the process,a friction test method reflecting the forming characteristics of ISF was proposed.Friction coefficients during the forming processes of parts with different wall angles were measured under various plane curves,process paths,and lubrication conditions.Furthermore,the accuracy of the analytical model,as well as the measured friction coefficients and their variation trends,was verified through comparative analysis with experimental results,simulation data,and outcomes from other existing models.The results indicate that the influence of the plane curve characteristics and process paths of parts on the friction condition is not significant.Under the lubrication conditions of L-HM46 oil,MoS_(2)grease,graphite powder,and dry friction,the friction coefficient shows a gradually increasing trend.Notably,when the wall angle is≤40°,the friction coefficient remains relatively constant;however,when the wall angle exceeds 40°,the friction coefficient increases progressively. 展开更多
关键词 incremental sheet forming friction test method contact area friction coefficient forming force
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Synergistic reinforcement using pressure releasing and energy absorbing method under hard roof:Physical model test
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作者 Qi Wang Jiting Liu +3 位作者 Bei Jiang Zhenhua Jiang Yusong Deng Chuanjie Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第9期5845-5860,共16页
During fully mechanized caving mining of thick coal seams,a large amount of strain energy accumulates in the roof,especially when the roof is thick and hard,making it difficultfor the roof to collapse naturally.When t... During fully mechanized caving mining of thick coal seams,a large amount of strain energy accumulates in the roof,especially when the roof is thick and hard,making it difficultfor the roof to collapse naturally.When the roof eventually collapses,the accumulated energy is released instantaneously,exerting a strong impact on the roadway.To address this issue,we proposed the synergistic control method of directional comprehensive pressure relief and energy-absorbing support(PREA)for roadways with hard roofs.In this study,we developed a three-dimensional physical model test apparatus for roof cutting and pressure relief.The 122108 ventilation roadway at the Caojiatan Coal Mine,which has a thick and hard roof,was taken as the engineering example.We analyzed the evolution patterns of stress and displacement in both the stope and the roadway surrounding rocks under different schemes.The PREA reinforcement mechanism for the roadway was investigated through comparative model tests between the new and original methods.The results showed that,compared to the original method,the new method reduced surrounding rock stress by up to 60.4%,and the roadway convergence decreased by up to 52.1%.Based on these results,we proposed corresponding engineering recommendations,which can guide fieldreinforcement design and application.The results demonstrate that the PREA method effectively reduces stress and ensures the safety and stability of the roadway. 展开更多
关键词 Directional comprehensive pressure relief High-strength support Three-dimensional model test Reinforcing method Synergistic control
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Price composition analysis of blood glucose meters and blood glucose test strips in Hubei Province based on the World Health Organization/Health Action International standard survey method
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作者 Jianing Zheng Yushu Liu +2 位作者 Xi Wang Hongye Li Chenxi Liu 《Journal of Chinese Pharmaceutical Sciences》 2025年第10期954-966,共13页
The purpose of this study is to evaluate the price and composition of blood glucose meters and blood glucose test papers in Hubei Province,so as to improve the affordability of blood glucose monitoring for diabetes pa... The purpose of this study is to evaluate the price and composition of blood glucose meters and blood glucose test papers in Hubei Province,so as to improve the affordability of blood glucose monitoring for diabetes patients.Using the standard survey method jointly developed by the World Health Organization(WHO)and Health Action International(HAI)for drug price composition analysis,central level data was collected through literature review,policy review,and interviews with key informants.Field research was conducted in Wuhan and Yichang to trace price data at various levels of the supply chain.At the central level,data shows that China has implemented multiple policies related to the management and pricing of blood glucose meters and test strips,but has not yet introduced price restrictions for blood glucose meters and test strips;At the supply chain level,data shows that the price composition of blood glucose meters and test strips in Hubei Province is mainly composed of manufacturer prices and retail markups,followed by supply chain taxes and wholesale markups.It can be seen from this that China has established a comprehensive medical device registration,sales,quality control and management standard system through a series of policies.At present,China has not issued price policies for blood glucose meters and blood glucose test papers.Therefore,we can reduce product prices by including medical insurance,government subsidies,competitive bidding,and reducing supply chain taxes,thus improving the affordability of blood glucose monitoring for diabetes patients. 展开更多
关键词 WHO/HAI standard survey method Hubei province Blood glucose meters Blood glucose test strips Price composition
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Fuzzy Analysis Method for Orthogonal Test on Seed Propagation of Eurya chinensis
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作者 叶耀雄 黄倩琳 +2 位作者 翟欣 周永东 叶永昌 《Agricultural Science & Technology》 CAS 2015年第8期1639-1642,共4页
Fuzzy analysis method for orthogonal test was used to study the effect of different sowing depth, seed soaking time, illumination intensity and culture soil on the seed germination rate of Eurya chinensis. The results... Fuzzy analysis method for orthogonal test was used to study the effect of different sowing depth, seed soaking time, illumination intensity and culture soil on the seed germination rate of Eurya chinensis. The results showed that the effect of seed soaking time on the sowing and seedling of Eurya chinensis was the biggest, and the ethers were illumination intensity, sowing depth and culture soil. The germi- nation rate was the highest when composite soil was used as culture soil and seeds were soaked for 48 h and sowed in topsoil, and a layer of sunshade net was used. 展开更多
关键词 Eurya chinensis Seed propagation orthogonal test Fuzzy analysis
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Optimization of the Ethanol Extraction Method of Monoester Alkaloids from Radix Aconiti Preparata Based on HPLC-MS and Orthogonal Test
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作者 Changkai ZHOU Rui ZHANG +13 位作者 Xiuling SHANG Lihua ZHOU Zukang ZHANG Jing GAO Hongxia YU Hongyan JI Xiaomin XING Qie GUO Donghua LIU Fangang MENG Jingchun YAO Na ZHANG Yongjun LIU Fanbo JING 《Agricultural Biotechnology》 CAS 2020年第3期73-77,共5页
[Objectives] This study was conducted to optimize the ethanol extraction technology of monoester alkaloids from Radix Aconiti Preparata. [Methods]On the basis of defined extraction times,ethanol concentration,ethanol ... [Objectives] This study was conducted to optimize the ethanol extraction technology of monoester alkaloids from Radix Aconiti Preparata. [Methods]On the basis of defined extraction times,ethanol concentration,ethanol times and extraction time were investigated by HPLC-MS combined with orthogonal test to optimize extraction process using the content of monoester alkaloids( the sum of benzoyl neoaconitine,benzoyl hypoaconitine and benzoyl aconitine) as an index.[Results]The optimum ethanol extraction technology was as follows: 75% ethanol,ethanol amount 25 times of the medicinal material,and each extraction for 1. 5 h.[Conclusions] The optimal extraction technology is simple,feasible,stable and reliable. It can provide reference for the industrial production and quality control of monoester alkaloids from Radix Aconiti Preparata. 展开更多
关键词 Radix aconiti preparata monoester alkaloid HPLC-MS orthogonal test
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Precision and trueness of a method for determing antimony content in groundwater using hydride generation-atomic fluorescence spectrometry
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作者 Bing-bing Liu Lin Zhang Ke Li 《Journal of Groundwater Science and Engineering》 2026年第1期49-58,共10页
At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systema... At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater. 展开更多
关键词 Mandel's h and k statistics Grubbs test Cochran test Repeatability limit Reproducibility limit method bias value
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Optimization and Testing for PCR System of Rice by Orthogonal Design 被引量:8
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作者 程芳艳 李春光 +5 位作者 刘永巍 孟巧霞 张景龙 宋冬明 刘华招 孟昭河 《Agricultural Science & Technology》 CAS 2010年第2期61-64,共4页
[Objective] This study was to screen the economic or stable PCR system of rice and detect the generality of the selected system in different molecular markers based on PCR.[Method] With DNA extracted from rice leaves ... [Objective] This study was to screen the economic or stable PCR system of rice and detect the generality of the selected system in different molecular markers based on PCR.[Method] With DNA extracted from rice leaves by CTAB method as the template,PCR system was optimized by L16(45)orthogonal design.[Result] Clear bands were amplified from 16 different combinations,but the amplification effects and yields had difference.The most economic and applicable system was as follows:20 ng DNA template,150 μmol/L dNT... 展开更多
关键词 RICE PCR system optimization orthogonal design Dominant molecular markers testing
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Virtual rutting test of asphalt mixture using discrete element method 被引量:7
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作者 张德育 黄晓明 高英 《Journal of Southeast University(English Edition)》 EI CAS 2012年第2期215-220,共6页
In order to investigate the permanent deformation behavior of asphalt mixtures from discontinuity, the virtual rutting test of asphalt mixtures is developed by the discrete element method (DEM). A digital specimen g... In order to investigate the permanent deformation behavior of asphalt mixtures from discontinuity, the virtual rutting test of asphalt mixtures is developed by the discrete element method (DEM). A digital specimen generation procedure considering aggregate gradation and irregular shape is developed based on the probability theory and the Monte Carlo method. The virtual rutting test is then conducted based on the generated digital specimen. In addition, on the basis of the time-temperature superposition (TTS) principle, a calculation method is used to reduce the computation time of the virtual rutting test. The simulation results are compared with the laboratory measurements. The results show that the calculation method based on the TFS principle in the discrete element (DE) viscoelastic model can significantly reduce the computation time. The deformation law of asphalt mixtures in the virtual rutting test is similar to the laboratory measurements, and the deformation and the dynamic stability of the virtual rutting test are slightly greater than the laboratory measurements. The two-dimensional virtual rutting test can predict the permanent deformation performance of asphalt mixtures. 展开更多
关键词 asphalt mixture permanent deformation discrete element method virtual rutting test
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Research on the Testing Methods of Instrumental System in the Marine Magnetic Survey 被引量:1
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作者 边刚 刘雁春 +2 位作者 于波 肖付民 卞光浪 《Marine Science Bulletin》 CAS 2007年第2期1-11,共11页
Testing methods of instrumental system in the marine magnetic survey have been studied in this paper, and the feasibility of each method has been testified by the observed data. The conclusion shows that the method br... Testing methods of instrumental system in the marine magnetic survey have been studied in this paper, and the feasibility of each method has been testified by the observed data. The conclusion shows that the method brought out can effectively eliminate the systematic error caused by the instrumental system, and greatly improve the surveying precision and the reliability of the survey results. 展开更多
关键词 Marine magnetic survey instrumental system testing method
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New Fatigue Test and Statistical Method for Metallic Materials Used in Vehicle Transmissions 被引量:1
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作者 陈欣 项昌乐 《Journal of Beijing Institute of Technology》 EI CAS 1999年第2期39-42,共4页
Aim To improve the efficiency of fatigue material tests and relevant statistical treatment of test data. Methods\ Least square approach and other special treatments were used. Results and Conclusion\ The concepts... Aim To improve the efficiency of fatigue material tests and relevant statistical treatment of test data. Methods\ Least square approach and other special treatments were used. Results and Conclusion\ The concepts of each phase in fatigue tests and statistical treatment are clarified. The method proposed leads to three important properties. Reduced number of specimens brings to the advantage of lowering test expenditures. The whole test procedure has more flexibility for there is no need to conduct many tests at the same stress level as in traditional cases. 展开更多
关键词 fatigue test statistical method test specimens
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Method of Growth in Finding the Test Cube of Industrial Robots
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作者 陆际联 赵占芳 张强 《Journal of Beijing Institute of Technology》 EI CAS 2001年第2期197-203,共7页
In order to find the test cube for industrial robots as specified by ISO 9283, a seed cube is grown up in an irregular working space of the robot, provided that the corners of the cube do not exceed the boundary of t... In order to find the test cube for industrial robots as specified by ISO 9283, a seed cube is grown up in an irregular working space of the robot, provided that the corners of the cube do not exceed the boundary of the working space. All possible cubes are searched, and the cube with the maximum volume is selected. The calculation examples show that the method of growth can be used for a variety of industrial robots. The method of growth can determine the test cube and test points of irregular working space according to ISO 9283, and can avoid blindness and randomness in the selection of test points. 展开更多
关键词 robot performance test test cube method of growth
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Methodology Validation of Microbial Limit Test of Bupi Qiangli Ointment
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作者 李江萍 杨亮 蒋玲 《Agricultural Science & Technology》 CAS 2017年第2期365-367,共3页
[Objective] This study was conducted to establish a microbial limit test method for Bupi Qiangli Ointment. [Method] The conventional method and medium dilution method were used for bacterial, mold and yeast counting i... [Objective] This study was conducted to establish a microbial limit test method for Bupi Qiangli Ointment. [Method] The conventional method and medium dilution method were used for bacterial, mold and yeast counting in sample recovery test. [Result] The medium dilution method (1:10 test solution, 0.5 ml/plate) could effectively eliminate the inhibition effect of the Bupi Qiangli Ointment, and the recovery of Staphylococcus aureus was greater than 70% in the 3 batches of samples; and the conventional method exhibited the recoveries of E. coil, Bacillus subtilis, Candida albicans and Aspergillus greater than 70% in the 3 batches of samples. [Conclusion] Due to Bupi Qiangli Ointment has strongly antibacterial effect on Staphylococcus au- reus, the medium dilution method was used for bacterial counting, and the conventional method was used for mold and yeast counting; and the conventional method was used for controlled bacterium examination of E. coll. 展开更多
关键词 Bupi Qiangli Ointment Microbial limit tests method validation Medium dilution method
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Investigation on the test method of rupture forces of thermal bonding seams in nonwovens shopping bags
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作者 王来力 吴雄英 丁雪梅 《产业用纺织品》 北大核心 2009年第11期41-44,共4页
超声波热黏合的非织造布接缝不同于普通机织物和针织物等的车缝接缝。运用正交试验设计方法,对纺粘法PP非织造布购物袋热黏合接缝断裂强力测试中的试样宽度、拉伸速率和隔距三个因素进行优化。试验结果表明,试样宽度对纺粘法PP非织造... 超声波热黏合的非织造布接缝不同于普通机织物和针织物等的车缝接缝。运用正交试验设计方法,对纺粘法PP非织造布购物袋热黏合接缝断裂强力测试中的试样宽度、拉伸速率和隔距三个因素进行优化。试验结果表明,试样宽度对纺粘法PP非织造布热黏合接缝断裂强力的测试结果影响最大,并且接缝的断裂强力随着试样宽度的增加而增加。选用试样宽度为200mm、拉伸速率为50mm/min、隔距为100mm的组合所得出的测试结果能比较真实地反映实际的接缝断裂强力。 展开更多
关键词 非织造布 热黏合接缝 测试方法 正交试验
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Application of fuzzy analytical method in the optimization of liposome preparation by orthogonal experiments 被引量:2
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作者 甄鹏 范晓婧 +3 位作者 马良 管峥 卢炜 胡新 《Journal of Chinese Pharmaceutical Sciences》 CAS 2009年第1期37-42,共6页
A new statistical method, the fuzzy analytical method, was introduced in the optimization processes of liposome preparation. It took the full advantage of the information from orthogonal experiments to obtain the opti... A new statistical method, the fuzzy analytical method, was introduced in the optimization processes of liposome preparation. It took the full advantage of the information from orthogonal experiments to obtain the optimal liposome preparation conditions by considering all the evaluation indexes. Liposomes were made by the modified reverse-phase evaporation method and the properties of liposomes including size, encapsulation efficiency and physical stability were selected as the evaluation indexes to indicate the quality of liposomes. The experimental data of these properties were analyzed by three different methods including direct observation, variance analysis and fuzzy analytical method. The optimal preparation conditions obtained from these methods were validated with further experiments. The results of all possible combinations of levels for all factors in orthogonal experiments were acquired by the fuzzy analytical method. All evaluation indexes were taken into account and the optimal preparation condition was obtained. The optimal preparation conditions from direct observation and fuzzy analytical method were different and further validation studies indicated that the optimal conditions obtained from the fuzzy analytical method were in agreement with that from traditional statistical analysis. Fuzzy analytical method avoided the problem resulted from the traditional method, in which different levels of the same factor were obtained when considering different evaluation indexes. More information could be obtained from the fuzzy analytical method and the blind area within the experimental range was eliminated. As a result, fuzzy analytical method can be applied in the optimization processes of liposome preparation. 展开更多
关键词 orthogonal experiment Liposome preparation Fuzzy analytical method
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