A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C7-tertiary alcohol with ZnI2/Et3SiH, a novel mild and stereospecific tertiar...A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C7-tertiary alcohol with ZnI2/Et3SiH, a novel mild and stereospecific tertiary alcohol reduction system, and the tandem oxidation/cyclopropanation reactions.展开更多
基金Acknowledgement This research was financially supported in part by the China Postdoctoral Science Foundation and the Na- tional Basic Research Program of China （Nos. 2010CB833200, 2010CB833300）, the National Natural Science Foundation of China （Nos. 20832007, 21102167）, the Science and Technology Commission of Shanghai Municipality （No. 12DZ1930902） and the Knowledge Innovation Program of Chinese Academy of Sciences. We thank Zhejiangshenzhou Pharmaceutical Co., Ltd for providing starting materials.
文摘A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C7-tertiary alcohol with ZnI2/Et3SiH, a novel mild and stereospecific tertiary alcohol reduction system, and the tandem oxidation/cyclopropanation reactions.
