In this article, some of the main contributions to BI （Bio-Impedance） parameter-based systems for medical, biological and industrial fields, oriented to develop micro laboratory systems are summarized. These small s...In this article, some of the main contributions to BI （Bio-Impedance） parameter-based systems for medical, biological and industrial fields, oriented to develop micro laboratory systems are summarized. These small systems are enabled by the development of new measurement techniques and systems （labs）, based on the impedance as biomarker. The electrical properties of the life mater allow the straightforward, low cost and usually non-invasive measurement methods to define its status or value, with the possibility to know its time evolution. This work proposes a review of bio-impedance based methods being employed to develop new LoC （Lab-on-a-Chips） systems, and some open problems identified as main research challenges, such as, the accuracy limits of measurements techniques, the role of the microelectrode-biological impedance modeling in measurements and system portability specifications demanded for many applications.展开更多
The aim of this study was to compare scintigraphy,the standard method,and the 13C-octanoic acid breath test(OBT)for measuring gastric emptying.Patients with functional dyspepsia(N = 21,8 men and 13 women;ages,40-75)un...The aim of this study was to compare scintigraphy,the standard method,and the 13C-octanoic acid breath test(OBT)for measuring gastric emptying.Patients with functional dyspepsia(N = 21,8 men and 13 women;ages,40-75)underwent standardized dynamic scintigraphy and OBT.Scintigraphic images were obtained for 90 min and breath samples for 4 hr.The gastric half-emptying time for solids(T1/2)was calculated by two previously described mathematical models for the OBT samples:the nonlinear least-squares method and the geometrical method.T1/2 was significantly longer measured by OBT than by scintigraphy(167±50 min for the nonlinear least-squares method(P < 0.05)and 185±52 min for the geometrical method(P < 0.005)vs.109 ±74 min for scintigraphy).No correlation appeared between T1/2 measured by scintigraphy and T1/2 measured by OBT(r = 0.26)for nonlinear least-squares method and(r =-0.13)for geometrical method).Furthermore,the correlation between the two mathematical models appeared to be low(r = 0.15).Although OBT is simple and safe,its correlation with scintigraphy appears to be weak.The usefulness of this test for measuring gastric emptying thus requires further validation.展开更多
Background and aim:Real-world data on the effectiveness and safety of treatment with the direct-acting antiviral agent-based regimen are limited on the Chinese mainland.The aim of this study was to conduct a multicent...Background and aim:Real-world data on the effectiveness and safety of treatment with the direct-acting antiviral agent-based regimen are limited on the Chinese mainland.The aim of this study was to conduct a multicenter,prospective,real-world study of ombitasvir/paritaprevir/ritonavir(OBT/PTV/r)combined with dasabuvir(DSV)in hepatitis C virus(HCV)genotype 1b-infected non-cirrhotic or compensated cirrhotic Chinese adult patients.Materials and methods:Genotype 1b-infected patients were enrolled at eight sites in China.Patients received 25/150/100 mg of OBT/PTV/r once daily combined with 250 mg of DSV twice daily for 8 weeks or 12 weeks.Sustained virological response at 12 weeks post-treatment(SVR12)and the incidence of adverse events were assessed.We have also evaluated the effect of intensive questioning of patients who were overdue for SVR12 testing.Intention-to-treat(ITT)and modified ITT(mITT)populations were used in the analysis.Results:One hundred forty patients were included,among whom 90.0%(126/140)were newly diagnosed,9.3%(13/140)had compensated cirrhosis,92.9%(130/140)received 12 weeks of treatment,and 7.1%(10/140)received 8 weeks of treatment.In the mITT population,the virological response rate at week 4 was 96.4%(108/112),and at the end of treatment was 100%(102/102).Among these patients,139 patients completed 12 weeks of treatment,and 73 patients were followed-up.All followed-up patients achieved SVR12.There was no adverse event-related discontinuation.Serious adverse events during treatment were reported in two(1.4%)patients,and none were considered to be drug-related.Sixty-six(47.1%)patients did not return to receive the HCV RNA test at 12 weeks post-treatment.Conclusions:The rate of SVR12 was consistent with Phase III clinical studies.OBT/PTV/r combined with DSV showed effectiveness in Chinese adult patients,and both tolerability and safety profile were favorable.However,patient compliance should be further improved in the real world.展开更多
文摘In this article, some of the main contributions to BI （Bio-Impedance） parameter-based systems for medical, biological and industrial fields, oriented to develop micro laboratory systems are summarized. These small systems are enabled by the development of new measurement techniques and systems （labs）, based on the impedance as biomarker. The electrical properties of the life mater allow the straightforward, low cost and usually non-invasive measurement methods to define its status or value, with the possibility to know its time evolution. This work proposes a review of bio-impedance based methods being employed to develop new LoC （Lab-on-a-Chips） systems, and some open problems identified as main research challenges, such as, the accuracy limits of measurements techniques, the role of the microelectrode-biological impedance modeling in measurements and system portability specifications demanded for many applications.
文摘The aim of this study was to compare scintigraphy,the standard method,and the 13C-octanoic acid breath test(OBT)for measuring gastric emptying.Patients with functional dyspepsia(N = 21,8 men and 13 women;ages,40-75)underwent standardized dynamic scintigraphy and OBT.Scintigraphic images were obtained for 90 min and breath samples for 4 hr.The gastric half-emptying time for solids(T1/2)was calculated by two previously described mathematical models for the OBT samples:the nonlinear least-squares method and the geometrical method.T1/2 was significantly longer measured by OBT than by scintigraphy(167±50 min for the nonlinear least-squares method(P < 0.05)and 185±52 min for the geometrical method(P < 0.005)vs.109 ±74 min for scintigraphy).No correlation appeared between T1/2 measured by scintigraphy and T1/2 measured by OBT(r = 0.26)for nonlinear least-squares method and(r =-0.13)for geometrical method).Furthermore,the correlation between the two mathematical models appeared to be low(r = 0.15).Although OBT is simple and safe,its correlation with scintigraphy appears to be weak.The usefulness of this test for measuring gastric emptying thus requires further validation.
基金This work was supported by a grant for clinical investigation from Key Projects of Guangdong Science and Technology Plan of China(2014B020212025).
文摘Background and aim:Real-world data on the effectiveness and safety of treatment with the direct-acting antiviral agent-based regimen are limited on the Chinese mainland.The aim of this study was to conduct a multicenter,prospective,real-world study of ombitasvir/paritaprevir/ritonavir(OBT/PTV/r)combined with dasabuvir(DSV)in hepatitis C virus(HCV)genotype 1b-infected non-cirrhotic or compensated cirrhotic Chinese adult patients.Materials and methods:Genotype 1b-infected patients were enrolled at eight sites in China.Patients received 25/150/100 mg of OBT/PTV/r once daily combined with 250 mg of DSV twice daily for 8 weeks or 12 weeks.Sustained virological response at 12 weeks post-treatment(SVR12)and the incidence of adverse events were assessed.We have also evaluated the effect of intensive questioning of patients who were overdue for SVR12 testing.Intention-to-treat(ITT)and modified ITT(mITT)populations were used in the analysis.Results:One hundred forty patients were included,among whom 90.0%(126/140)were newly diagnosed,9.3%(13/140)had compensated cirrhosis,92.9%(130/140)received 12 weeks of treatment,and 7.1%(10/140)received 8 weeks of treatment.In the mITT population,the virological response rate at week 4 was 96.4%(108/112),and at the end of treatment was 100%(102/102).Among these patients,139 patients completed 12 weeks of treatment,and 73 patients were followed-up.All followed-up patients achieved SVR12.There was no adverse event-related discontinuation.Serious adverse events during treatment were reported in two(1.4%)patients,and none were considered to be drug-related.Sixty-six(47.1%)patients did not return to receive the HCV RNA test at 12 weeks post-treatment.Conclusions:The rate of SVR12 was consistent with Phase III clinical studies.OBT/PTV/r combined with DSV showed effectiveness in Chinese adult patients,and both tolerability and safety profile were favorable.However,patient compliance should be further improved in the real world.
