Normal appendix is 4 to 5 mm in diameter and approximately 8 cm in length;although it may be up to 30 cm long. Appendicitis is the inflammation of the appendix and is the most common cause of acute abdominal pain. Rig...Normal appendix is 4 to 5 mm in diameter and approximately 8 cm in length;although it may be up to 30 cm long. Appendicitis is the inflammation of the appendix and is the most common cause of acute abdominal pain. Right lower quadrant pain, nausea, vomiting and fever are common signs of appendicitis but 20% to 33% of patients with suspected appendicitis present with atypical features. Case presentation: we presented a 14-year-old boy with abdominal pain predominantly in hypogastric area and LLQ (Left Lower Quadrant) that after ultrasound and CT study a large appendix 22 mm in diameter and 17 cm in length was detected. Conclusion: appendix position and size is very variable and appendicitis could be presented by different clinical features. In this case, the patient was presented with LLQ pain rather than RLQ (Right Lower Quadrant) pain due to its large size and elongation to the left side.展开更多
Medical hemostatic gauze is one of the most common agents for bleeding management used in pre-hospital care and clinical treatment.An ideal hemostat requires the features including fast coagulation ability,high biocom...Medical hemostatic gauze is one of the most common agents for bleeding management used in pre-hospital care and clinical treatment.An ideal hemostat requires the features including fast coagulation ability,high biocompatibility and low cost,which is difficult to be achieved simultaneously.Herein,we reported a chemical immobilization method to uniformly anchor the zeolitic imidazolate framework(ZIF-8)nanoparticles on polyvinyl alcohol(PVA)membrane,which dramatically accelerated the in vivo conversion process of prothrombin to thrombin,achieving a short hemostasis time around 60 s with a low amount of blood loss of 23 mg.Later,the hemostatic mechanism was unveiled by two pathways involving the activation of platelets and the conversion of prothrombin,indicating that this ZIF-8-based membrane works in a similar way to natural platelet-based physiological processes.More importantly,the convenient manufacturing and excellent biocompatibility of ZIF-8-based membrane provide a practical candidate hemostat for clinical bleeding management.展开更多
文摘Normal appendix is 4 to 5 mm in diameter and approximately 8 cm in length;although it may be up to 30 cm long. Appendicitis is the inflammation of the appendix and is the most common cause of acute abdominal pain. Right lower quadrant pain, nausea, vomiting and fever are common signs of appendicitis but 20% to 33% of patients with suspected appendicitis present with atypical features. Case presentation: we presented a 14-year-old boy with abdominal pain predominantly in hypogastric area and LLQ (Left Lower Quadrant) that after ultrasound and CT study a large appendix 22 mm in diameter and 17 cm in length was detected. Conclusion: appendix position and size is very variable and appendicitis could be presented by different clinical features. In this case, the patient was presented with LLQ pain rather than RLQ (Right Lower Quadrant) pain due to its large size and elongation to the left side.
基金supported by the National Natural Science Foundation of China(U23A2070 and 22201223)Chutian Scholar Foundation of Hubei Province and Natural Science Foundation of Hubei Province,China(2022CFA023).
文摘Medical hemostatic gauze is one of the most common agents for bleeding management used in pre-hospital care and clinical treatment.An ideal hemostat requires the features including fast coagulation ability,high biocompatibility and low cost,which is difficult to be achieved simultaneously.Herein,we reported a chemical immobilization method to uniformly anchor the zeolitic imidazolate framework(ZIF-8)nanoparticles on polyvinyl alcohol(PVA)membrane,which dramatically accelerated the in vivo conversion process of prothrombin to thrombin,achieving a short hemostasis time around 60 s with a low amount of blood loss of 23 mg.Later,the hemostatic mechanism was unveiled by two pathways involving the activation of platelets and the conversion of prothrombin,indicating that this ZIF-8-based membrane works in a similar way to natural platelet-based physiological processes.More importantly,the convenient manufacturing and excellent biocompatibility of ZIF-8-based membrane provide a practical candidate hemostat for clinical bleeding management.
