期刊文献+
共找到1,029,471篇文章
< 1 2 250 >
每页显示 20 50 100
Non-Linear Analysis of Energy Absorption Systems under Impact Loads through FEM
1
作者 Elias Rigoberto Ledesma-Orozco Jose Angel Diosdado-De la Pena Gerardo Israel Pdrez-Soto Alonso Salazar-Garibay Juan Francisco Reveles-Arredondo Gilberto Villalobos-Llamas Pedro Duran-Resendiz 《Journal of Mechanics Engineering and Automation》 2012年第8期487-494,共8页
This paper presents a non-linear simulation of the impact on a structure with different energy absorption systems using finite element models. Literature review on bistable structure, aluminum foam and expandable poly... This paper presents a non-linear simulation of the impact on a structure with different energy absorption systems using finite element models. Literature review on bistable structure, aluminum foam and expandable polystyrene is presented and taken as basis to propose energy absorption systems. Using a base structure, these systems are implemented by means of finite element modeling. A comparison of the damage caused to the structure in case of impact without implementing energy absorption system, and implementing energy absorption systems based on bistable structures, polystyrene foam and aluminum foam are shown here in. The results demonstrate the advantages of using energy absorption systems on structures under impact loads. 展开更多
关键词 BISTABLE impact loads non-linear analysis energy absorption.
在线阅读 下载PDF
Assessing Brain Pathophysiology through Non-Linear Analysis of MEG in Ιdiopathic Generalized Epilepsy Cases
2
作者 Panagiotis E. Antoniou Adam Adamopoulos +2 位作者 Photios A. Anninos Haritomeni Piperidou Athanasia Kotini 《Journal of Behavioral and Brain Science》 2012年第4期445-453,共9页
Background: Non-linear signal analysis has proven to be a technique that is capable of revealing qualitative and quan- titative differentiations between different dynamical systems (biological or otherwise). In the pr... Background: Non-linear signal analysis has proven to be a technique that is capable of revealing qualitative and quan- titative differentiations between different dynamical systems (biological or otherwise). In the present work it has been demonstrated that this capability reveals quantitative differences in the Magnetoencephalograms (MEG) received from patients with Idiopathic Generalized Epilepsy (IGE) and from healthy volunteers. Method: We present MEG record- ings of 10 epileptic patients with IGE and the corresponding ones from 10 healthy volunteers. A 122-channel SQUID biomagnetometer in an electromagnetically shielded room was used to record the MEG signals and the Grassber- ger-Procaccia method for the estimation of the correlation dimension was applied in the phase space reconstruction of the recorded signal from each patient. Results: The aforementioned analysis demonstrates the existence of spatially diffused low dimensionality in the MEG signals of patients with IGE. Conclusion: The obtained results provide support for the hypothesis that low dimensionality in MEG signals is linked to functional brain pathogeny. 展开更多
关键词 non-linear analysis MEG IGE
暂未订购
Non-Linear Analysis of Masonry Structures Subjected to External Settlements
3
作者 Stefano Galassi Michele Paradiso Giacomo Tempesta 《Open Journal of Civil Engineering》 2013年第2期18-26,共9页
This article describes a methodology for the non-linear analysis of existing masonry structures subjected to external yielding constraints, with particular attention to the historical and cultural heritage constructio... This article describes a methodology for the non-linear analysis of existing masonry structures subjected to external yielding constraints, with particular attention to the historical and cultural heritage constructions. It is well known, indeed, that most of the arch and wall damages are often due to settlement of abutments, in the former case, and to settlement of foundations, in the latter one. The ability to observe and correctly analyze the cracking failure pattern, visible on such structures, is the main “diagnostic tool” for identifying its origin: the modification of load conditions over time, foundation settlements and earthquakes. The objective of this work is to identify a numeric modelling of masonry structures (such as walls, arches, vaults, ruins) under any load condition and subjected to inelastic settlements impressed to some external constraints. The purpose of the numerical procedure is to interpret the behaviour of such structures in order to assess both the peak settlement value and their specific failure mode in correspondence to a geometry which is very often compromised. Therefore, this procedure allows one to estimate the degree of the structures’ vulnerability, in order to prevent any future damage, both local and global. The iterative algorithm proposed in this article, developed in a calculation software, processes the structure considering, not only the properties of constitutive material, non-homogeneous and anisotropic, but also the change of the structure’s shape during the settlements increase. In this way a non-linear analysis is performed both materically and geometrically. Through a direct comparison between numerical and experimental results, obtained by testing some simple structural models in a laboratory, it was ascertained, both from a qualitative and quantitative point of view, the correctness and the efficacy of the proposed procedure, which will be explained below. Therefore, this numerical procedure demonstrates to be a useful “diagnostic tool” by which, starting from the input of the masonry structure to be studied and simulating a presumable event, one can trace the source of the causes that have generated a certain failure, comparing the cracking pattern of real structure with that plotted by the software. 展开更多
关键词 MASONRY ARCHES Walls Ruins SETTLEMENTS Internal DISTORTIONS non-linear analysis
暂未订购
WEAKLY NON-LINEAR ANALYSIS ON IDENTIFICATION OF VORTEX,SOUND & HEAT AND THEIR INTERACTIONS IN SHEAR FLOW
4
作者 居鸿宾 钟芳源 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1996年第3期213-220,共8页
The identification of vortex,vortex,sound and heat motions and the interactions among them are discussed by means of velocity vector split and perturbation method in this paper.Especially the shear.flow is considered... The identification of vortex,vortex,sound and heat motions and the interactions among them are discussed by means of velocity vector split and perturbation method in this paper.Especially the shear.flow is considered.All the obtained weakly non-linear equarions have clear physics concept. Basing on the analysis.the interaction between first order sound and vortex.and the creation of the secnd order vortex are studied and some.experiment phenomena of airfoil.flow control by sound are explained. 展开更多
关键词 AERODYNAMICS aeroacoustics shear flow non-linear interaction unsteady flow
在线阅读 下载PDF
Seismic Assessment of Asymmetric Structures Behaviour by Using Static Non-linear Analysis
5
作者 Ivana Marino Luigi Petti 《Journal of Civil Engineering and Architecture》 2011年第5期402-411,共10页
The goal of this work is to investigate the seismic behaviour of plan-asymmetric structures by considering the least seismic-resistant directions and the spatial features of the seismic event. New tools for the analys... The goal of this work is to investigate the seismic behaviour of plan-asymmetric structures by considering the least seismic-resistant directions and the spatial features of the seismic event. New tools for the analysis of the seismic behaviour of plan-asymmetric structures are herein presented and the concepts of "Polar Spectrum" and limit domains are discussed. In particular, the capacity of the structure is described by using the limit domains based on the Non Linear Static Procedures, while the seismic demand is analysed by introducing a new representation of the spectral response. This representation is based on the construction of a spectral surface obtained by the spectral seismic response for different in-plan directions and the in-plan projection of this surface is herein defined "Polar Spectrum". The obtained results for two benchmark structures, verified by means of non-linear incremental dynamic analyses, have pointed out that non-linear static analyses, carried out for different in-plan directions of the incoming seismic action, have allowed us to accurately evaluate the least seismic resistant directions. 展开更多
关键词 Plan-asymmetric structures non-linear analyses polar spectrum.
在线阅读 下载PDF
Non-linear Analysis of Bridge“Guglie”in Venice:Sensitivity to Designed and Realized Shape
6
作者 Daniele Baraldi Anna Manzato Antonella Cecchi 《Journal of Civil Engineering and Architecture》 2019年第2期77-87,共11页
In this paper,numerical non-linear analyses of the “Guglie” bridge,located in the historical city of Venice(Italy),are proposed.The focus is twofold:on the sensitivity of the realized shape of the bridge by referenc... In this paper,numerical non-linear analyses of the “Guglie” bridge,located in the historical city of Venice(Italy),are proposed.The focus is twofold:on the sensitivity of the realized shape of the bridge by reference to originally designed shape;and on sensitivity to mechanical parameters of constituent materials.The history of this bridge is very interesting,and the bridge actually built is different from the Marchesini’s project(1580).In fact,in the original design drawing,the shape of the arch is a perfect circle arch,while the shape of the actually built arch is not perfectly circular.Hence,in the aim to evaluate sensitivity of bridge behaviour to designed and realized shape,non-linear analyses are carried on by means of FEMs(Finite Element Models)under in-plane state hypothesis.Furthermore,parametric tests are also performed for evaluating the influence of masonry mechanical parameters on non-linear bridge behaviour. 展开更多
关键词 FEM MASONRY bridge PUSHOVER analysis PARAMETRIC tests MOHR-COULOMB yield CRITERION
在线阅读 下载PDF
Crystal structure,thermal analysis,and luminescence properties of six heterocyclic lanthanide complexes
7
作者 SONG Zihe ZHAO Jinjin +1 位作者 REN Ning ZHANG Jianjun 《无机化学学报》 北大核心 2026年第1期181-192,共12页
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'... Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6. 展开更多
关键词 lanthanide complexes fluorescence property crystal structure thermal analysis
在线阅读 下载PDF
Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 被引量:1
8
作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
暂未订购
Comprehensive pan-cancer analysis of the receptor-interacting protein kinase family expression,genomic alterations,and functional implications
9
作者 Wan-Rong Li Xin Li Jian Wang 《Life Research》 2026年第1期35-44,共10页
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations... Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications. 展开更多
关键词 RIPK family pan-cancer analysis tumor mutation burden microsatellite instability gene set enrichment analysis
暂未订购
Advanced isoconversional kinetic analysis of lepidolite sulfation product decomposition reactions for selectively extracting lithium
10
作者 Yubo Liu Baozhong Ma +4 位作者 Jiahui Cheng Xiang Li Hui Yang Chengyan Wang Yongqiang Chen 《International Journal of Minerals,Metallurgy and Materials》 2026年第1期217-227,共11页
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A... The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium. 展开更多
关键词 LITHIUM LEPIDOLITE decomposition reactions KINETICS isoconversional analysis
在线阅读 下载PDF
Global research status in the treatment of glaucoma:a systematic bibliometric analysis
11
作者 Wen-Hui Liu Chang Shu +1 位作者 Bei-Di Jia Xiao-Rong Li 《International Journal of Ophthalmology(English edition)》 2026年第2期379-392,共14页
AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current resea... AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation. 展开更多
关键词 glaucoma treatment bibliometric analysis SURGERY minimally invasive glaucoma surgery NANOPARTICLE
原文传递
Combined Fault Tree Analysis and Bayesian Network for Reliability Assessment of Marine Internal Combustion Engine
12
作者 Ivana Jovanović Çağlar Karatuğ +1 位作者 Maja Perčić Nikola Vladimir 《哈尔滨工程大学学报(英文版)》 2026年第1期239-258,共20页
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ... This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels. 展开更多
关键词 Fault tree analysis Bayesian network RELIABILITY REDUNDANCY Internal combustion engine
在线阅读 下载PDF
Sensitivity analysis of rod rearrangement in criticality safety for PWR fuel assemblies under transportation accidents
13
作者 Xin‑Ling Dai De‑Chang Cai +1 位作者 Yan‑Min Zhang Jin Cai 《Nuclear Science and Techniques》 2026年第1期263-282,共20页
To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains i... To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers. 展开更多
关键词 Criticality safety analysis Fuel transports Rods mispositioning accident Non-uniform arrangement
在线阅读 下载PDF
Heavy metal risks and policy analysis on using industrial waste salts for making value-added snow-melting agents
14
作者 Yubiao Ma Jiaxin Yin +2 位作者 Yunfei Wang Lei Wang Jianxin Zhu 《Journal of Environmental Sciences》 2026年第1期756-766,共11页
Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may po... Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management. 展开更多
关键词 Snow-melting agent Heavy metals Industrial waste salts recycled Comparative analysis
原文传递
Evaluation of the protective effects of Crocus sativus L.against cypermethrin induced reproductive toxicity in male rats through the Nrf2 pathway and in silico ADMET analysis
15
作者 Fareena Tariq Farah Ijaz +9 位作者 Yasameen Hameed Jasim Farah Naz Channa Sohail Ahmed Ahmed Shandookh Hameed Sobia Alyas Ahmed Raheem Rayshan Tahira Bibi Nazima Yousaf Khan Sadia Bibi Jameel Ahmed Buzdar 《Traditional Medicine Research》 2026年第3期12-25,共14页
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i... Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice. 展开更多
关键词 Crocus sativus L. CYPERMETHRIN male reproductive toxicity Nrf2 pathway in silico ADMET analysis
暂未订购
Non-linear buffeting response analysis of long-span suspension bridges with central buckle 被引量:12
16
作者 Wang Hao1,2,Li Aiqun1,Zhao Gengwen1 and Li Jian2 1.College of Civil Engineering,Southeast University,Nanjing 210096,China 2.Civil and Environmental Engineering,University of Illinois at Urbana-Champaign,Urbana,IL 61801,USA 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2010年第2期259-270,共12页
The rigid central buckle employed in the Runyang Suspension Bridge (RSB) was the first time it was used in a suspension bridge in China. By using a spectral representation method and FFT technique combined with measur... The rigid central buckle employed in the Runyang Suspension Bridge (RSB) was the first time it was used in a suspension bridge in China. By using a spectral representation method and FFT technique combined with measured data,a 3D fluctuating wind field considering the tower wind effect is simulated. A novel FE model for buffeting analysis is then presented,in which a specific user-defined Matrix27 element in ANSYS is employed to simulate the aeroelastic forces and its stiffness or damping matrices are parameterized by wind velocity and vibration frequency. A nonlinear time history analysis is carried out to study the influence of the rigid central buckle on the wind-induced buffeting response of a long-span suspension bridge. The results can be used as a reference for wind resistance design of long-span suspension bridges with a rigid central buckle in the future. 展开更多
关键词 suspension bridge buffeting response central buckle nonlinear time history analysis ANSYS
在线阅读 下载PDF
DDM regression analysis of the in-situ stress field in a non-linear fault zone 被引量:10
17
作者 Ke Li Ying-yi Wang Xing-chun Huang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2012年第7期567-573,共7页
A multivariable regression analysis of the in-situ stress field, which considers the non-linear deformation behavior of faults in practical projects, is presented based on a newly developed three-dimensional displacem... A multivariable regression analysis of the in-situ stress field, which considers the non-linear deformation behavior of faults in practical projects, is presented based on a newly developed three-dimensional displacement discontinuity method (DDM) program. The Bar- ton-Bandis model and the Kulhaway model are adopted as the normal and the tangential deformation model of faults, respectively, where the Mohr-Coulomb failure criterion is satisfied. In practical projects, the values of the mechanical parameters of rock and faults are restricted in a bounded range for in-situ test, and the optimal mechanical parameters are obtained from this range by a loop. Comparing with the traditional finite element method (FEM), the DDM regression results are more accurate. 展开更多
关键词 displacement discontinuity method (DDM) in-situ stress regression analysis FAULTS ROCK
在线阅读 下载PDF
Genome-wide analysis of the S-phase kinase-association protein1(ClSKP1) family and the role of S-RNase targeting by an SCF(Cullin1-SKP1-F-box) complex in the self-incompatibility of‘Xiangshui' lemon 被引量:1
18
作者 Yuze Li Wei Lin +9 位作者 Jiawei Zhu Moying Lan Cong Luo Yili Zhang Rongzhen Liang Liming Xia Wangli Hu Xiao Mo Guixiang Huang Xinhua He 《Horticultural Plant Journal》 2025年第2期593-607,共15页
The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the ... The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the SCF complex and degraded by the 26S protease accounts for the bulk of the available self-incompatibility studies.In this study,15 ClSKP1s from the‘Xiangshui'lemon genome and ubiquitome exist in the same SKP1 conserved domain(CD)as SKP1s in other species.The q PCR results showed that SKP1-6 and SKP1-14 have tissue expression patterns specific for expression in pollen.In addition,SKP1-6 and SKP1-14 in the stigma,style and ovary were significantly upregulated after self-pollination compared to those after cross-pollination.A subcellular location showed that SKP1-6 and SKP1-14 were located in the nucleus.In addition,yeast two-hybrid(Y2H)assays,bimolecular fluorescence complementation(BiFC)and luciferase complementation imaging(LCI)assays showed that SKP1-6 interacted with F-box1,F-box33,F-box34,F-box17,F-box19,Cullin1-2 and 26S proteasome subunit 4 homolog A(26S PS4HA).SKP1-14 interacted with F-box17,F-box19,F-box35,Cullin1-2 and 26S PS4HA.The interaction of Cullin1-2 and the F-box with SKP1 as a bridge was verified by a yeast three-hybrid experiment.The ability of S3-RNase to inhibit pollen and pollen tube growth and development was assessed using in vitro pollen co-culture experiments with recombinant S3-RNase proteins.Overall,this study provides important experimental evidence and theoretical basis for understanding the mechanism of self-incompatibility in plants by revealing the key role of the SCF complex in‘Xiangshui'lemon,which is bridged by ClSKP1-6,in self-incompatibility.The results of this study are of great significance for the future indepth exploration of the molecular mechanism of the SCF complex and its wide application in the self-incompatibility of plants. 展开更多
关键词 LEMON SKP1 SCF SELF-INCOMPATIBILITY Expression analysis Functional analysis
在线阅读 下载PDF
Enhancing Solar Photovoltaic Efficiency:A Computational Fluid Dynamics Analysis 被引量:1
19
作者 Rahool Rai Fareed Hussain Mangi +1 位作者 Kashif Ahmed Sudhakar Kumaramsay 《Energy Engineering》 EI 2025年第1期153-166,共14页
The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar ener... The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar energy,among the various renewable sources,is particularly appealing due to its abundant availability.However,the efficiency of commercial solar photovoltaic(PV)modules is hindered by several factors,notably their conversion efficiency,which averages around 19%.This efficiency can further decline to 10%–16%due to temperature increases during peak sunlight hours.This study investigates the cooling of PV modules by applying water to their front surface through Computational fluid dynamics(CFD).The study aimed to determine the optimal conditions for cooling the PV module by analyzing the interplay between water film thickness,Reynolds number,and their effects on temperature reduction and heat transfer.The CFD analysis revealed that the most effective cooling condition occurred with a 5 mm thick water film and a Reynolds number of 10.These specific parameters were found to maximize the heat transfer and temperature reduction efficiency.This finding is crucial for the development of practical and efficient cooling systems for PV modules,potentially leading to improved performance and longevity of solar panels.Alternative cooling fluids or advanced cooling techniques that might offer even better efficiency or practical benefits. 展开更多
关键词 PV module efficiency water film thickness reynolds number CFD analysis PV/T renewable energy
在线阅读 下载PDF
A hybrid-stress solid-shell element for non-linear analysis of piezoelectric structures 被引量:1
20
作者 SZE K Y 《Science China(Technological Sciences)》 SCIE EI CAS 2009年第3期575-583,共9页
This paper presents eight-node solid-shell elements for geometric non-linear analyze of piezoelectric structures. To subdue shear, trapezoidal and thickness locking, the assumed natural strain method and an ad hoc mod... This paper presents eight-node solid-shell elements for geometric non-linear analyze of piezoelectric structures. To subdue shear, trapezoidal and thickness locking, the assumed natural strain method and an ad hoc modified generalized laminate stiffness matrix are employed. With the generalized stresses arising from the modified generalized laminate stiffness matrix assumed to be independent from the ones obtained from the displacement, an extended Hellinger-Reissner functional can be derived. By choosing the assumed generalized stresses similar to the assumed stresses of a previous solid ele- ment, a hybrid-stress solid-shell element is formulated. The presented finite shell element is able to model arbitrary curved shell structures. Non-linear numerical examples demonstrate the ability of the proposed model to analyze nonlinear piezoelectric devices. 展开更多
关键词 PIEZOELECTRIC structures solid-shell element hybrid-stress GEOMETRIC non-linear
原文传递
上一页 1 2 250 下一页 到第
使用帮助 返回顶部