Terrain Aided Navigation(TAN)technology has become increasingly important due to its effectiveness in environments where Global Positioning System(GPS)is unavailable.In recent years,TAN systems have been extensively r...Terrain Aided Navigation(TAN)technology has become increasingly important due to its effectiveness in environments where Global Positioning System(GPS)is unavailable.In recent years,TAN systems have been extensively researched for both aerial and underwater navigation applications.However,many TAN systems that rely on recursive Unmanned Aerial Vehicle(UAV)position estimation methods,such as Extended Kalman Filters(EKF),often face challenges with divergence and instability,particularly in highly non-linear systems.To address these issues,this paper proposes and investigates a hybrid two-stage TAN positioning system for UAVs that utilizes Particle Filter.To enhance the system’s robustness against uncertainties caused by noise and to estimate additional system states,a Fuzzy Particle Filter(FPF)is employed in the first stage.This approach introduces a novel terrain composite feature that enables a fuzzy expert system to analyze terrain non-linearities and dynamically adjust the number of particles in real-time.This design allows the UAV to be efficiently localized in GPS-denied environments while also reducing the computational complexity of the particle filter in real-time applications.In the second stage,an Error State Kalman Filter(ESKF)is implemented to estimate the UAV’s altitude.The ESKF is chosen over the conventional EKF method because it is more suitable for non-linear systems.Simulation results demonstrate that the proposed fuzzy-based terrain composite method achieves high positional accuracy while reducing computational time and memory usage.展开更多
In the heart of Addis Ababa,where tradition meets modern ambition,a gleaming structure of steel and glass is quietly reshaping Africa’s future.The new Africa Centres for Disease Control and Prevention(Africa CDC)Head...In the heart of Addis Ababa,where tradition meets modern ambition,a gleaming structure of steel and glass is quietly reshaping Africa’s future.The new Africa Centres for Disease Control and Prevention(Africa CDC)Headquarters is more than just a building-it’s a bold statement of partnership,progress,and a shared commitment to advancing public health across the continent.展开更多
BACKGROUND Early detection of esophageal squamous neoplasms(ESN)is essential for improving patient prognosis.Optical diagnosis of ESN remains challenging.Probebased confocal laser endomicroscopy(pCLE)enables accurate ...BACKGROUND Early detection of esophageal squamous neoplasms(ESN)is essential for improving patient prognosis.Optical diagnosis of ESN remains challenging.Probebased confocal laser endomicroscopy(pCLE)enables accurate in vivo histological observation and optical biopsy of ESN.However,interpretation of pCLE images requires histopathological expertise and extensive training.Artificial intelligence(AI)has been widely applied in digestive endoscopy;however,AI for pCLE diagnosis of ESN has not been reported.AIM To develop a pCLE computer-aided diagnostic system for ESN and assess its diagnostic performance and assistant efficiency for nonexpert endoscopists.METHODS The intelligent confocal laser endomicroscopy(iCLE)system consists of image recognition(based on inception-ResNet V2),video diagnosis,and quality judgment modules.This system was developed using pCLE images and videos and evaluated through image and prospective video recognition tests.Patients between June 2020 and January 2023 were prospectively enrolled.Expert and nonexpert endoscopists and the iCLE independently performed diagnoses for pCLE videos,with histopathology as the gold standard.Thereafter,the non-expert endoscopists performed a second assessment with iCLE assistance.RESULTS A total of 25056 images from 2803 patients were selected for iCLE training and validation.Another 2442 images from 226 patients were used for testing.iCLE achieved a high accuracy of 98.3%,sensitivity of 95.3%and specificity of 98.8%for diagnosing ESN images.A total of 2581 patients underwent upper gastrointestinal pCLE examination and were prospectively screened;54 patients with suspected ESN were enrolled.Overall,187 videos from 67 lesions were assessed by iCLE,three nonexpert and three expert endoscopists.iCLE achieved a high accuracy,sensitivity and specificity of 90.9%,92.0%,and 90.2%,respectively.Compared to experts,iCLE showed significantly higher sensitivity(92.0%vs 80.4%;P<0.001)and negative predictive value(94.4%vs 87.7%;P=0.003).With iCLE assistance,nonexpert endoscopists showed significant improvements in accuracy(from 83.6%to 88.6%)and sensitivity(from 76.0%to 89.8%).CONCLUSION iCLE system demonstrated high diagnostic performance for ESN.It can assist nonexpert endoscopists in improving the diagnostic efficiency of pCLE for ESN and has the potential for reducing unnecessary biopsies.展开更多
Unmanned Aerial Vehicle(UAV)-aided communication,prized for its network reconfigurability,operational flexibility,and cost-effectiveness,is a key enabler of the low-altitude economy.However,the high possibilities of l...Unmanned Aerial Vehicle(UAV)-aided communication,prized for its network reconfigurability,operational flexibility,and cost-effectiveness,is a key enabler of the low-altitude economy.However,the high possibilities of line-of-sight links and the broadcast nature of air-ground UAV communications make it vulnerable and prone to eavesdropping by malicious nodes.展开更多
Unmanned Aerial Vehicle(UAV)-aided communication holds great potential to enhance the transmission performance.However,the information security remains a fundamental requirement due to the high possibilities of line-o...Unmanned Aerial Vehicle(UAV)-aided communication holds great potential to enhance the transmission performance.However,the information security remains a fundamental requirement due to the high possibilities of line-of-sight links and the broadcast nature.展开更多
Porcine Contagious Pleuropneumonia(PCP)is a respiratory infectious disease of pigs caused by Actinobacillus pleuropneumoniae.The disease has been prevalent in pig farms since it was first identified in 1957(Pattison e...Porcine Contagious Pleuropneumonia(PCP)is a respiratory infectious disease of pigs caused by Actinobacillus pleuropneumoniae.The disease has been prevalent in pig farms since it was first identified in 1957(Pattison et al.1957).展开更多
Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide req...Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide requisite information for follow up designing segments such as structural analysis, design of technological process and manufacturing etc, and thereby lead to the reduction of product design period and the quality and reliability improvement of ICE components. So the developing situations of ICE components' 2 D drafting, 3 D modeling of ICE, overall CAD of ICE as well as component design expert system etc. are surveyed, which are the typical applications of computer aided modeling techniques in ICE component design process, and some existent problems and tasks are pointed out so as to make some references for the further research work.展开更多
The importance and complexity of prioritizing construction projects (PCP) in urban road network planning lead to the necessity to develop an aided decision making program (ADMP). Cost benefit ratio model and stage rol...The importance and complexity of prioritizing construction projects (PCP) in urban road network planning lead to the necessity to develop an aided decision making program (ADMP). Cost benefit ratio model and stage rolled method are chosen as the theoretical foundations of the program, and then benefit model is improved to accord with the actuality of urban traffic in China. Consequently, program flows, module functions and data structures are designed, and particularly an original data structure of road ...展开更多
目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细...目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细胞亚群CD11b、CD86、CD206的表达及巨噬细胞自噬探针CD11b+DALGreen、CD86+DALGreen、CD206+DALGreen的表达。ELISA法检测治疗前后血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-10、转化生长因子(TGF)-β1等炎性因子的表达。采用荧光定量PCR法检测治疗前后患者外周血中组蛋白去乙酰化酶(HDAC)2 m RNA、Unc-51样激酶1(ULK1)m RNA的表达。结果 治疗后,患者CD11b、CD206、CD11b+DALGreen、CD206+DALGreen、ULK1 m RNA表达明显升高(P<0.05);CD86、TNF-α、IL-1β、HDAC2 m RNA的表达明显下降(P<0.05);CD4^(+)T淋巴细胞计数、IL-10、TGF-β1表达呈上升趋势(P>0.05)。结论 参芩龙清肺培元颗粒可能通过调节HDAC2/ULK1信号轴,促进巨噬细胞自噬,调节M1/M2的平衡,抑制炎症反应,从而发挥治疗HIV/AIDS患者合并肺部感染的作用。展开更多
针对LAR路由协议的区域策略,提出一种改进的路由协议TTI-LAR。通过引进拦截时间(Time to Intercept)权值选择参与路由的中间节点,有效地降低了网络开销,提高了路由的可靠性。仿真结果表明,TTI_LAR路由协议与LAR路由协议相比,性能得到进...针对LAR路由协议的区域策略,提出一种改进的路由协议TTI-LAR。通过引进拦截时间(Time to Intercept)权值选择参与路由的中间节点,有效地降低了网络开销,提高了路由的可靠性。仿真结果表明,TTI_LAR路由协议与LAR路由协议相比,性能得到进一步改善。展开更多
Today the development of information technology changes people's daily life in many aspects, including the translationmarket. The application of computer aided translation(CAT) greatly improves the efficiency and ...Today the development of information technology changes people's daily life in many aspects, including the translationmarket. The application of computer aided translation(CAT) greatly improves the efficiency and quality of translation work. Thispaper tries to introduce the development of CAT technology and the application of CAT on the Internet and gives some suggestionson CAT teaching.展开更多
With the development of computer technology, Computer-Aided Translation(CAT) is widely used in the translation process, thus increasing the efficiency of the entire translation work. The purpose of this article is to ...With the development of computer technology, Computer-Aided Translation(CAT) is widely used in the translation process, thus increasing the efficiency of the entire translation work. The purpose of this article is to analyze the importance of introducing CAT technology into translation teaching and explore some ways of integrating CAT technology with translation teaching, so as to improve the quality of the translators and the translation work.展开更多
This article begins with a brief analysis of the significance of translation technology in different spheres of modern life,followed by a distinction between machine translation(MT)and computer-aided translation(CAT)....This article begins with a brief analysis of the significance of translation technology in different spheres of modern life,followed by a distinction between machine translation(MT)and computer-aided translation(CAT).It then describes some translation resources and tools and examines the negative and positive aspects of computer-aided translations.Finally it comes to a conclusion that it would be greatly efficient and productive for the translators to acquire the new skills in the translation workplace.展开更多
文摘Terrain Aided Navigation(TAN)technology has become increasingly important due to its effectiveness in environments where Global Positioning System(GPS)is unavailable.In recent years,TAN systems have been extensively researched for both aerial and underwater navigation applications.However,many TAN systems that rely on recursive Unmanned Aerial Vehicle(UAV)position estimation methods,such as Extended Kalman Filters(EKF),often face challenges with divergence and instability,particularly in highly non-linear systems.To address these issues,this paper proposes and investigates a hybrid two-stage TAN positioning system for UAVs that utilizes Particle Filter.To enhance the system’s robustness against uncertainties caused by noise and to estimate additional system states,a Fuzzy Particle Filter(FPF)is employed in the first stage.This approach introduces a novel terrain composite feature that enables a fuzzy expert system to analyze terrain non-linearities and dynamically adjust the number of particles in real-time.This design allows the UAV to be efficiently localized in GPS-denied environments while also reducing the computational complexity of the particle filter in real-time applications.In the second stage,an Error State Kalman Filter(ESKF)is implemented to estimate the UAV’s altitude.The ESKF is chosen over the conventional EKF method because it is more suitable for non-linear systems.Simulation results demonstrate that the proposed fuzzy-based terrain composite method achieves high positional accuracy while reducing computational time and memory usage.
文摘In the heart of Addis Ababa,where tradition meets modern ambition,a gleaming structure of steel and glass is quietly reshaping Africa’s future.The new Africa Centres for Disease Control and Prevention(Africa CDC)Headquarters is more than just a building-it’s a bold statement of partnership,progress,and a shared commitment to advancing public health across the continent.
基金Supported by the National Key Research and Development Program of China,No.2023YFC2413800the Taishan Scholars Program of Shandong Province,No.tsqn202306344the National Natural Science Foundation of China,No.82270580 and No.82070552.
文摘BACKGROUND Early detection of esophageal squamous neoplasms(ESN)is essential for improving patient prognosis.Optical diagnosis of ESN remains challenging.Probebased confocal laser endomicroscopy(pCLE)enables accurate in vivo histological observation and optical biopsy of ESN.However,interpretation of pCLE images requires histopathological expertise and extensive training.Artificial intelligence(AI)has been widely applied in digestive endoscopy;however,AI for pCLE diagnosis of ESN has not been reported.AIM To develop a pCLE computer-aided diagnostic system for ESN and assess its diagnostic performance and assistant efficiency for nonexpert endoscopists.METHODS The intelligent confocal laser endomicroscopy(iCLE)system consists of image recognition(based on inception-ResNet V2),video diagnosis,and quality judgment modules.This system was developed using pCLE images and videos and evaluated through image and prospective video recognition tests.Patients between June 2020 and January 2023 were prospectively enrolled.Expert and nonexpert endoscopists and the iCLE independently performed diagnoses for pCLE videos,with histopathology as the gold standard.Thereafter,the non-expert endoscopists performed a second assessment with iCLE assistance.RESULTS A total of 25056 images from 2803 patients were selected for iCLE training and validation.Another 2442 images from 226 patients were used for testing.iCLE achieved a high accuracy of 98.3%,sensitivity of 95.3%and specificity of 98.8%for diagnosing ESN images.A total of 2581 patients underwent upper gastrointestinal pCLE examination and were prospectively screened;54 patients with suspected ESN were enrolled.Overall,187 videos from 67 lesions were assessed by iCLE,three nonexpert and three expert endoscopists.iCLE achieved a high accuracy,sensitivity and specificity of 90.9%,92.0%,and 90.2%,respectively.Compared to experts,iCLE showed significantly higher sensitivity(92.0%vs 80.4%;P<0.001)and negative predictive value(94.4%vs 87.7%;P=0.003).With iCLE assistance,nonexpert endoscopists showed significant improvements in accuracy(from 83.6%to 88.6%)and sensitivity(from 76.0%to 89.8%).CONCLUSION iCLE system demonstrated high diagnostic performance for ESN.It can assist nonexpert endoscopists in improving the diagnostic efficiency of pCLE for ESN and has the potential for reducing unnecessary biopsies.
文摘Unmanned Aerial Vehicle(UAV)-aided communication,prized for its network reconfigurability,operational flexibility,and cost-effectiveness,is a key enabler of the low-altitude economy.However,the high possibilities of line-of-sight links and the broadcast nature of air-ground UAV communications make it vulnerable and prone to eavesdropping by malicious nodes.
文摘Unmanned Aerial Vehicle(UAV)-aided communication holds great potential to enhance the transmission performance.However,the information security remains a fundamental requirement due to the high possibilities of line-of-sight links and the broadcast nature.
基金supported by the University-Industry Col aborative Education Program,China(220904860093831)。
文摘Porcine Contagious Pleuropneumonia(PCP)is a respiratory infectious disease of pigs caused by Actinobacillus pleuropneumoniae.The disease has been prevalent in pig farms since it was first identified in 1957(Pattison et al.1957).
文摘Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide requisite information for follow up designing segments such as structural analysis, design of technological process and manufacturing etc, and thereby lead to the reduction of product design period and the quality and reliability improvement of ICE components. So the developing situations of ICE components' 2 D drafting, 3 D modeling of ICE, overall CAD of ICE as well as component design expert system etc. are surveyed, which are the typical applications of computer aided modeling techniques in ICE component design process, and some existent problems and tasks are pointed out so as to make some references for the further research work.
文摘The importance and complexity of prioritizing construction projects (PCP) in urban road network planning lead to the necessity to develop an aided decision making program (ADMP). Cost benefit ratio model and stage rolled method are chosen as the theoretical foundations of the program, and then benefit model is improved to accord with the actuality of urban traffic in China. Consequently, program flows, module functions and data structures are designed, and particularly an original data structure of road ...
文摘目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细胞亚群CD11b、CD86、CD206的表达及巨噬细胞自噬探针CD11b+DALGreen、CD86+DALGreen、CD206+DALGreen的表达。ELISA法检测治疗前后血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-10、转化生长因子(TGF)-β1等炎性因子的表达。采用荧光定量PCR法检测治疗前后患者外周血中组蛋白去乙酰化酶(HDAC)2 m RNA、Unc-51样激酶1(ULK1)m RNA的表达。结果 治疗后,患者CD11b、CD206、CD11b+DALGreen、CD206+DALGreen、ULK1 m RNA表达明显升高(P<0.05);CD86、TNF-α、IL-1β、HDAC2 m RNA的表达明显下降(P<0.05);CD4^(+)T淋巴细胞计数、IL-10、TGF-β1表达呈上升趋势(P>0.05)。结论 参芩龙清肺培元颗粒可能通过调节HDAC2/ULK1信号轴,促进巨噬细胞自噬,调节M1/M2的平衡,抑制炎症反应,从而发挥治疗HIV/AIDS患者合并肺部感染的作用。
文摘Today the development of information technology changes people's daily life in many aspects, including the translationmarket. The application of computer aided translation(CAT) greatly improves the efficiency and quality of translation work. Thispaper tries to introduce the development of CAT technology and the application of CAT on the Internet and gives some suggestionson CAT teaching.
文摘With the development of computer technology, Computer-Aided Translation(CAT) is widely used in the translation process, thus increasing the efficiency of the entire translation work. The purpose of this article is to analyze the importance of introducing CAT technology into translation teaching and explore some ways of integrating CAT technology with translation teaching, so as to improve the quality of the translators and the translation work.
文摘This article begins with a brief analysis of the significance of translation technology in different spheres of modern life,followed by a distinction between machine translation(MT)and computer-aided translation(CAT).It then describes some translation resources and tools and examines the negative and positive aspects of computer-aided translations.Finally it comes to a conclusion that it would be greatly efficient and productive for the translators to acquire the new skills in the translation workplace.
