Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and in...Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the blood-brain barrier, and alteration in the extracellular matrix （ECM）. One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth （Figure 1A）.展开更多
To the Editor:Stroke is among the leading public health problems in China,with high rates of recurrent stroke,cardiovascular events and mortality,resulting in a considerable medical and economic burden.[1]The identifi...To the Editor:Stroke is among the leading public health problems in China,with high rates of recurrent stroke,cardiovascular events and mortality,resulting in a considerable medical and economic burden.[1]The identification of new molecular markers and therapeutic targets is necessary to better refine the risk prediction of cardiovascular events and develop new treatment strategies for ischemic stroke.Succinate is a tricarboxylic acid(TCA)cycle intermediate and has received considerable attention for its involvement in various signaling pathways associated with cardiovascular diseases.[2–4]Recent studies have reported that succinate is a novel mediator that promotes atherosclerotic lesion progression,fibroblast activation,and apoptosis resistance.展开更多
文摘Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the blood-brain barrier, and alteration in the extracellular matrix （ECM）. One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth （Figure 1A）.
基金This study was supported by the National Natural Science Foundation of China(Nos.82273706 and 82220108001)the Suzhou Science and Technology Project(No.SYW2024067)+1 种基金Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University(No.YXY2302013)the Project of MOE Key Laboratory of Geriatric Diseases and Immunology(No.JYN202406).
文摘To the Editor:Stroke is among the leading public health problems in China,with high rates of recurrent stroke,cardiovascular events and mortality,resulting in a considerable medical and economic burden.[1]The identification of new molecular markers and therapeutic targets is necessary to better refine the risk prediction of cardiovascular events and develop new treatment strategies for ischemic stroke.Succinate is a tricarboxylic acid(TCA)cycle intermediate and has received considerable attention for its involvement in various signaling pathways associated with cardiovascular diseases.[2–4]Recent studies have reported that succinate is a novel mediator that promotes atherosclerotic lesion progression,fibroblast activation,and apoptosis resistance.
