Acid doped Polyaniline(PANI)due to their increased electrical conductivity,are considered to be the most promising conducting filler materials.Hence,the present study,reports the synthesis of the PANI followed by acid...Acid doped Polyaniline(PANI)due to their increased electrical conductivity,are considered to be the most promising conducting filler materials.Hence,the present study,reports the synthesis of the PANI followed by acid doping,electrical conductivity and dielectric properties measurements of H2SO4;HCl and(Conc.HCl+NaNO2mixture)doped PANI.In order to know the effect of acetone washing on the electrical properties of acid doped PANI samples,the electrical properties of the non-acetone washed acid doped PANI samples are compared with that of their acetone washed counterparts.The PANI salt was prepared by conventional route using aniline hydrochloride and ammonium persulphate as an oxidant.PANI salt was subjected to 0.5M NaOH to form PANI base,which was further doped separately with H2SO4;HCl and(Conc.HCl+NaNO2mixture)respectively followed by acetone washing.A comparative electrical conductivity study between the acetone washed and unwashed PANI salt and H2SO4,HCl and Conc.HCl+NaNO2 mixture doped PANI were characterized by dielectric and impedance study.展开更多
Polycystic ovarian syndrome(PCOS)is a frequently encountered disease with hormonal and metabolic dysfunction in women of reproductive age.Nano-sized titanium dioxide(nTiO_(2))has been widely used in skin care products...Polycystic ovarian syndrome(PCOS)is a frequently encountered disease with hormonal and metabolic dysfunction in women of reproductive age.Nano-sized titanium dioxide(nTiO_(2))has been widely used in skin care products,paints,food,and cosmetics.In this study,we found a substantial elevation of Ti in the follicular fluid of females diagnosed with nonhyperandrogenic PCOS(non-HA PCOS).Therefore,we orally subjected female rats to nTiO_(2) at 10 and 100 mg/kg body weight for 10 weeks.We found that nTiO_(2) triggered non-HA PCOS-like symptoms,including the increase of cystic follicles,estrous cycle disorder,and abnormal ovulation,but without high testosterone.By transcriptome sequencing,we identified that nTiO_(2) exposure inhibited the steroid hormone synthesis and activated the proapoptotic pathways.Upon validating these altered pathways,we discovered that aromatase(Cyp19a1)overexpression contributed to the decline in testosterone/estradiol ratio.Mean-while,the apoptosis of granulosa cells was increased by nTiO_(2) exposure,which might result in the disorder of follicular development.This study presents the evidences revealing a pronounced correlation between nTiO_(2) exposure and the emergence of non-HA PCOS,urging people to promote the safe utilization of nTiO_(2).展开更多
文摘Acid doped Polyaniline(PANI)due to their increased electrical conductivity,are considered to be the most promising conducting filler materials.Hence,the present study,reports the synthesis of the PANI followed by acid doping,electrical conductivity and dielectric properties measurements of H2SO4;HCl and(Conc.HCl+NaNO2mixture)doped PANI.In order to know the effect of acetone washing on the electrical properties of acid doped PANI samples,the electrical properties of the non-acetone washed acid doped PANI samples are compared with that of their acetone washed counterparts.The PANI salt was prepared by conventional route using aniline hydrochloride and ammonium persulphate as an oxidant.PANI salt was subjected to 0.5M NaOH to form PANI base,which was further doped separately with H2SO4;HCl and(Conc.HCl+NaNO2mixture)respectively followed by acetone washing.A comparative electrical conductivity study between the acetone washed and unwashed PANI salt and H2SO4,HCl and Conc.HCl+NaNO2 mixture doped PANI were characterized by dielectric and impedance study.
基金supported by the National Natural Science Foundation of China(Nos.81871161 and 32301082)Fujian Provincial Health Technology Project for their attribution from(No.2023GGB01)the Natural Science Foundation of Fujian Province(No.2021J01343).
文摘Polycystic ovarian syndrome(PCOS)is a frequently encountered disease with hormonal and metabolic dysfunction in women of reproductive age.Nano-sized titanium dioxide(nTiO_(2))has been widely used in skin care products,paints,food,and cosmetics.In this study,we found a substantial elevation of Ti in the follicular fluid of females diagnosed with nonhyperandrogenic PCOS(non-HA PCOS).Therefore,we orally subjected female rats to nTiO_(2) at 10 and 100 mg/kg body weight for 10 weeks.We found that nTiO_(2) triggered non-HA PCOS-like symptoms,including the increase of cystic follicles,estrous cycle disorder,and abnormal ovulation,but without high testosterone.By transcriptome sequencing,we identified that nTiO_(2) exposure inhibited the steroid hormone synthesis and activated the proapoptotic pathways.Upon validating these altered pathways,we discovered that aromatase(Cyp19a1)overexpression contributed to the decline in testosterone/estradiol ratio.Mean-while,the apoptosis of granulosa cells was increased by nTiO_(2) exposure,which might result in the disorder of follicular development.This study presents the evidences revealing a pronounced correlation between nTiO_(2) exposure and the emergence of non-HA PCOS,urging people to promote the safe utilization of nTiO_(2).
