The reflection and transmission characteristics of the guided modes in parallel-plate waveguides partially filled with one or multi chiral rods have been investigated by a method, which combines the multi- mode networ...The reflection and transmission characteristics of the guided modes in parallel-plate waveguides partially filled with one or multi chiral rods have been investigated by a method, which combines the multi- mode network theory with a rigorous mode matching procedure. The formulas of the reflection and transmis- sion coefficient matrix are derived. The numerical results for different cases are presented and have indicated that the chirality parameters and the geometrical dimensions of the chiral rods have significant influence on the reflection and transmission characteristics of the guided modes.展开更多
Metal organic framework(MOF) assembled with coordination bonds has the disadvantage of poor stability that limits its application in the field of stationary phase,while covalent organic framework(COF)assembled through...Metal organic framework(MOF) assembled with coordination bonds has the disadvantage of poor stability that limits its application in the field of stationary phase,while covalent organic framework(COF)assembled through covalent bonds exhibits excellent structural stability.It has been shown that the stationary phases prepared by combining MOF and COF can make up for the poor stability of MOF@SiO_(2),and the MOF/COF composites have superior chromatographic separation performance.However,the traditional methods for preparing COF/MOF based stationary phases are generally solvent thermal synthesis.In this study,a green and low-cost synthesis method was proposed for the preparation of MOF/COF@SiO_(2) stationary phase.Firstly,COF@SiO_(2) was prepared in a choline chloride/ethylene glycol based deep eutectic solvent(DES).Secondly,another acid-base tunable DES prepared by mixing p-toluenesulfonic acid(PTSA)and 2-methylimidazole in different proportions was introduced as the reaction solvent and reactant for rapid synthesis of MOF/COF@SiO_(2).Compared with the toxic transition metal-based MOFs selected in most previous studies,a lightweight and non-toxic S-zone metal(calcium) based MOF was employed in this study.PTSA and calcium will form the calcium/oxygen-containing organic acid framework in acidic DES,which assembles with terephthalic acid dissolved in basic DES to form MOF.The strong hydrogen bonding effect of DES can facilitate rapid assembly of Ca-MOF.The obtained Ca-MOF/COF@SiO_(2) can be used for multi-mode chromatography to efficiently separate multiple isomeric/hydrophilic/hydrophobic analytes.The synthesis method of Ca-MOF/COF@SiO_(2) is green and mild,especially the use of acid-base tunable DES promotes the rapid synthesis of non-toxic Ca-MOF/COF@silica composites,which offers an innovative approach of greenly synthesizing novel MOF/COF stationary phases and extends their applications in the field of chromatography.展开更多
The flow behavior of molten steel in the thin slab mold under high casting speed conditions was investigated,with a focus on the multi-mode continuous casting and rolling mold.A steel-slag two-phase flow model was est...The flow behavior of molten steel in the thin slab mold under high casting speed conditions was investigated,with a focus on the multi-mode continuous casting and rolling mold.A steel-slag two-phase flow model was established using large eddy simulation,the volume of fluid,and magnetohydrodynamics methods through numerical simulation.The maximum flow velocity and wave height at the steel-slag interface within the mold are critical evaluation criteria for analyzing asymmetric flow under varying casting speeds and electromagnetic braking.The results indicate that the asymmetric flows within the mold do not occur synchronously.The severity of the asymmetric flow correlates with the velocity difference across the steel-slag interface.A greater biased flow prolongs the time required to revert to a steady state.When the magnetic field intensity is set to 0.24 T and the magnetic pole position is at 390 mm from the steel-slag interface,this configuration can reduce the velocity of the steel-slag interface,thereby mitigating the asymmetric flow.Additionally,it can diminish the velocity,impact depth,and impact intensity on the narrow face of the jet,thus improving the distribution of velocity and turbulent kinetic energy within the mold.This configuration prolongs the time required for the steel-slag interface to transition from a stable state to its maximum velocity and shortens the time for the interface to return to stability from an unstable state.Moreover,it ensures the positional stability of the steel-slag interface,confining its position within−3 mm.展开更多
Low-carbon smart parks achieve selfbalanced carbon emission and absorption through the cooperative scheduling of direct current(DC)-based distributed photovoltaic,energy storage units,and loads.Direct current power li...Low-carbon smart parks achieve selfbalanced carbon emission and absorption through the cooperative scheduling of direct current(DC)-based distributed photovoltaic,energy storage units,and loads.Direct current power line communication(DC-PLC)enables real-time data transmission on DC power lines.With traffic adaptation,DC-PLC can be integrated with other complementary media such as 5G to reduce transmission delay and improve reliability.However,traffic adaptation for DC-PLC and 5G integration still faces the challenges such as coupling between traffic admission control and traffic partition,dimensionality curse,and the ignorance of extreme event occurrence.To address these challenges,we propose a deep reinforcement learning(DRL)-based delay sensitive and reliable traffic adaptation algorithm(DSRTA)to minimize the total queuing delay under the constraints of traffic admission control,queuing delay,and extreme events occurrence probability.DSRTA jointly optimizes traffic admission control and traffic partition,and enables learning-based intelligent traffic adaptation.The long-term constraints are incorporated into both state and bound of drift-pluspenalty to achieve delay awareness and enforce reliability guarantee.Simulation results show that DSRTA has lower queuing delay and more reliable quality of service(QoS)guarantee than other state-of-the-art algorithms.展开更多
Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstructio...Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstruction methods either compromise on accuracy with iterative algorithms or suffer from limited generalizability with task-specific deep learning approaches.Methods:We present LDM-PIR,a lightweight physics-conditioned diffusion multi-model for medical image reconstruction that addresses key challenges in magnetic resonance imaging(MRI),CT,and low-photon imaging.Unlike traditional iterative methods,which are computationally expensive,or task-specific deep learning approaches lacking generalizability,integrates three innovations.A physics-conditioned diffusion framework that embeds acquisition operators(Fourier/Radon transforms)and noise models directly into the reconstruction process.A multi-model architecture that unifies denoising,inpainting,and super-resolution via shared weight conditioning.A lightweight design(2.1M parameters)enabling rapid inference(0.8s/image on GPU).Through self-supervised fine-tuning with measurement consistency losses adapts to new imaging modalities using fewer annotated samples.Results:Achieves state-of-the-art performance on fastMRI(peak signal-to-noise ratio(PSNR):34.04 for single-coil/31.50 for multi-coil)and Lung Image Database Consortium and Image Database Resource Initiative(28.83 PSNR under Poisson noise).Clinical evaluations demonstrate superior preservation of anatomical structures,with SSIM improvements of 8.8%for single-coil and 4.36%for multi-coil MRI over uDPIR.Conclusion:It offers a flexible,efficient,and scalable solution for medical image reconstruction,addressing the challenges of noise,undersampling,and modality generalization.The model’s lightweight design allows for rapid inference,while its self-supervised fine-tuning capability minimizes reliance on large annotated datasets,making it suitable for real-world clinical applications.展开更多
In this study,we conducted an experiment to construct multi-model ensemble(MME)predictions for the El Niño-Southern Oscillation(ENSO)using a neural network,based on hindcast data released from five coupled oceana...In this study,we conducted an experiment to construct multi-model ensemble(MME)predictions for the El Niño-Southern Oscillation(ENSO)using a neural network,based on hindcast data released from five coupled oceanatmosphere models,which exhibit varying levels of complexity.This nonlinear approach demonstrated extraordinary superiority and effectiveness in constructing ENSO MME.Subsequently,we employed the leave-one-out crossvalidation and the moving base methods to further validate the robustness of the neural network model in the formulation of ENSO MME.In conclusion,the neural network algorithm outperforms the conventional approach of assigning a uniform weight to all models.This is evidenced by an enhancement in correlation coefficients and reduction in prediction errors,which have the potential to provide a more accurate ENSO forecast.展开更多
Traditional Chinese medicine(TCM)demonstrates distinctive advantages in disease prevention and treatment.However,analyzing its biological mechanisms through the modern medical research paradigm of“single drug,single ...Traditional Chinese medicine(TCM)demonstrates distinctive advantages in disease prevention and treatment.However,analyzing its biological mechanisms through the modern medical research paradigm of“single drug,single target”presents significant challenges due to its holistic approach.Network pharmacology and its core theory of network targets connect drugs and diseases from a holistic and systematic perspective based on biological networks,overcoming the limitations of reductionist research models and showing considerable value in TCM research.Recent integration of network target computational and experimental methods with artificial intelligence(AI)and multi-modal multi-omics technologies has substantially enhanced network pharmacology methodology.The advancement in computational and experimental techniques provides complementary support for network target theory in decoding TCM principles.This review,centered on network targets,examines the progress of network target methods combined with AI in predicting disease molecular mechanisms and drug-target relationships,alongside the application of multi-modal multi-omics technologies in analyzing TCM formulae,syndromes,and toxicity.Looking forward,network target theory is expected to incorporate emerging technologies while developing novel approaches aligned with its unique characteristics,potentially leading to significant breakthroughs in TCM research and advancing scientific understanding and innovation in TCM.展开更多
The multi-modal characteristics of mineral particles play a pivotal role in enhancing the classification accuracy,which is critical for obtaining a profound understanding of the Earth's composition and ensuring ef...The multi-modal characteristics of mineral particles play a pivotal role in enhancing the classification accuracy,which is critical for obtaining a profound understanding of the Earth's composition and ensuring effective exploitation utilization of its resources.However,the existing methods for classifying mineral particles do not fully utilize these multi-modal features,thereby limiting the classification accuracy.Furthermore,when conventional multi-modal image classification methods are applied to planepolarized and cross-polarized sequence images of mineral particles,they encounter issues such as information loss,misaligned features,and challenges in spatiotemporal feature extraction.To address these challenges,we propose a multi-modal mineral particle polarization image classification network(MMGC-Net)for precise mineral particle classification.Initially,MMGC-Net employs a two-dimensional(2D)backbone network with shared parameters to extract features from two types of polarized images to ensure feature alignment.Subsequently,a cross-polarized intra-modal feature fusion module is designed to refine the spatiotemporal features from the extracted features of the cross-polarized sequence images.Ultimately,the inter-modal feature fusion module integrates the two types of modal features to enhance the classification precision.Quantitative and qualitative experimental results indicate that when compared with the current state-of-the-art multi-modal image classification methods,MMGC-Net demonstrates marked superiority in terms of mineral particle multi-modal feature learning and four classification evaluation metrics.It also demonstrates better stability than the existing models.展开更多
In recent years,the analysis of encrypted network traffic has gained momentum due to the widespread use of Transport Layer Security and Quick UDP Internet Connections protocols,which complicate and prolong the analysi...In recent years,the analysis of encrypted network traffic has gained momentum due to the widespread use of Transport Layer Security and Quick UDP Internet Connections protocols,which complicate and prolong the analysis process.Classification models face challenges in understanding and classifying unknown traffic because of issues related to interpret ability and the representation of traffic data.To tackle these complexities,multi-modal representation learning can be employed to extract meaningful features and represent them in a lower-dimensional latent space.Recently,auto-encoder-based multi-modal representation techniques have shown superior performance in representing network traffic.By combining the advantages of multi-modal representation with efficient classifiers,we can develop robust network traffic classifiers.In this paper,we propose a novel multi-modal encoder-decoder model to create unified representations of network traffic,paired with a robust 1D-CNN(one-dimensional convolution neural network)classifier for effective traffic classification.The proposed model utilizes the ISCX Virtual Private Networknon Virtual Private Network 2016 datasets to extract general multi-modal representations and to train both shallow and deep learning models,such as Random Forest and the 1D-CNN model,for traffic classification.We compare these learning approaches based on the multi-modal representations generated from the autoencoder and the early feature fusion technique.For the classification task,both the Random Forest and 1D-CNN models,when trained on multimodal representations,achieve over 90%accuracy on a highly imbalanced dataset.展开更多
Carbon dots(CDs)-based composites have shown impressive performance in fields of information encryption and sensing,however,a great challenge is to simultaneously implement multi-mode luminescence and room-temperature...Carbon dots(CDs)-based composites have shown impressive performance in fields of information encryption and sensing,however,a great challenge is to simultaneously implement multi-mode luminescence and room-temperature phosphorescence(RTP)detection in single system due to the formidable synthesis.Herein,a multifunctional composite of Eu&CDs@p RHO has been designed by co-assembly strategy and prepared via a facile calcination and impregnation treatment.Eu&CDs@p RHO exhibits intense fluorescence(FL)and RTP coming from two individual luminous centers,Eu3+in the free pores and CDs in the interrupted structure of RHO zeolite.Unique four-mode color outputs including pink(Eu^(3+),ex.254 nm),light violet(CDs,ex.365 nm),blue(CDs,254 nm off),and green(CDs,365 nm off)could be realized,on the basis of it,a preliminary application of advanced information encoding has been demonstrated.Given the free pores of matrix and stable RTP in water of confined CDs,a visual RTP detection of Fe^(3+)ions is achieved with the detection limit as low as 9.8μmol/L.This work has opened up a new perspective for the strategic amalgamation of luminous vips with porous zeolite to construct the advanced functional materials.展开更多
Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials prov...Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.展开更多
Hepatology encompasses various aspects,such as metabolic-associated fatty liver disease,viral hepatitis,alcoholic liver disease,liver cirrhosis,liver failure,liver tumors,and liver transplantation.The global epidemiol...Hepatology encompasses various aspects,such as metabolic-associated fatty liver disease,viral hepatitis,alcoholic liver disease,liver cirrhosis,liver failure,liver tumors,and liver transplantation.The global epidemiological situation of liver diseases is grave,posing a substantial threat to human health and quality of life.Characterized by high incidence and mortality rates,liver diseases have emerged as a prominent global public health concern.In recent years,the rapid advan-cement of artificial intelligence(AI),deep learning,and radiomics has transfor-med medical research and clinical practice,demonstrating considerable potential in hepatology.AI is capable of automatically detecting abnormal cells in liver tissue sections,enhancing the accu-racy and efficiency of pathological diagnosis.Deep learning models are able to extract features from computed tomography and magnetic resonance imaging images to facilitate liver disease classification.Machine learning models are capable of integrating clinical data to forecast disease progression and treatment responses,thus supporting clinical decision-making for personalized medicine.Through the analysis of imaging data,laboratory results,and genomic information,AI can assist in diagnosis,forecast disease progression,and optimize treatment plans,thereby improving clinical outcomes for liver disease patients.This minireview intends to comprehensively summarize the state-of-the-art theories and applications of AI in hepatology,explore the opportunities and challenges it presents in clinical practice,basic research,and translational medicine,and propose future research directions to guide the advancement of hepatology and ultimately improve patient outcomes.展开更多
How to energy-efficiently maintain the topology of wireless sensor networks(WSNs) is still a difficult problem because of their numerous nodes,highly dynamic nature,varied application scenarios and limited resources.A...How to energy-efficiently maintain the topology of wireless sensor networks(WSNs) is still a difficult problem because of their numerous nodes,highly dynamic nature,varied application scenarios and limited resources.An energy-efficient multi-mode clusters maintenance(M2CM) method is proposed based on localized and event-driven mechanism in this work,which is different from the conventional clusters maintenance model with always periodically re-clustered among the whole network style based on time-trigger for hierarchical WSNs.M2 CM can meet such demands of clusters maintenance as adaptive local maintenance for the damaged clusters according to its changes in time and space field.,the triggers of M2 CM include such events as nodes' residual energy being under the threshold,the load imbalance of cluster head,joining in or exiting from any cluster for new node or disable one,etc.Based on neighboring relationship of the damaged clusters,one can start a single cluster(inner-cluster) maintenance or clusters(inter-cluster) maintenance program to meet diverse demands in the topology management of hierarchical WSNs.The experiment results based on NS2 simulation show that the proposed method can significantly save energy used in maintaining a damaged network,effectively narrow down the influenced area of clusters maintenance,and increase transmitted data and prolong lifetime of network compared to the traditional schemes.展开更多
The bootstrap resampling method is applied to an ensemble artificial neural network (ANN) approach (which combines machine learning with physical data obtained from a numerical weather prediction model) to provide a m...The bootstrap resampling method is applied to an ensemble artificial neural network (ANN) approach (which combines machine learning with physical data obtained from a numerical weather prediction model) to provide a multi-ANN model super-ensemble for application to multi-step-ahead forecasting of wind speed and of the associated power generated from a wind turbine. A statistical combination of the individual forecasts from the various ANNs of the super-ensemble is used to construct the best deterministic forecast, as well as the prediction uncertainty interval associated with this forecast. The bootstrapped neural-network methodology is validated using measured wind speed and power data acquired from a wind turbine in an operational wind farm located in northern China.展开更多
Transient stability assessment(TSA)based on artificial intelligence typically has two distinct model management approaches:a unified management approach for all faulted lines and a separate management approach for eac...Transient stability assessment(TSA)based on artificial intelligence typically has two distinct model management approaches:a unified management approach for all faulted lines and a separate management approach for each faulted line.To address the shortcomings of the aforementioned approaches,namely accuracy,training time,and model management complexity,a multi-model management approach for power system TSA based on multi-moment feature clustering has been proposed.First,the steady-state and transient features present under fault conditions were obtained through a transient simulation of line faults.The input sample set was then constructed using the aforementioned multi-moment electrical features and the embedded faulty line numbers.Subsequently,K-means clustering was conducted on each line based on the similarity of their electrical features,employing t-SNE dimensionality reduction.The PSO-CNN model was trained separately for each cluster to generate several independent TSA models.Finally,a model effectiveness evaluation system consisting of five metrics was established,and the effect of the sample imbalance ratio on the model effectiveness was investigated.The model effectiveness was evaluated using the IEEE 39-bus system algorithm.The results showed that the multi-model management strategy based on multi-moment feature clustering can effectively combine the two advantages of superior evaluation performance and streamlined model management by fully extracting system features.Moreover,this approach allows for more flexible adjustments to line topology changes.展开更多
Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combinin...Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.展开更多
To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review a...To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review and SwissADME platform.Genes related to the inflammation were collected using Genecards and OMIM databases,and the intersection genes were submitted on STRING and DAVID websites.Then,the protein interaction network(PPI),gene ontology(GO)and pathway(KEGG)were analyzed.Cytoscape 3.7.2 software was used to construct the“Hibiscus mutabilis L.-active ingredient-target-inflammation”network diagram,and AutoDockTools-1.5.6 software was used for the molecular docking verification.The antiinflammatory effect of Hibiscus mutabilis L.active ingredient was verified by the RAW264.7 inflammatory cell model.The results showed that 11 active components and 94 potential targets,1029 inflammatory targets and 24 intersection targets were obtained from Hibiscus mutabilis L..The key anti-inflammatory active ingredients of Hibiscus mutabilis L.are quercetin,apigenin and luteolin.Its action pathway is mainly related to NF-κB,cancer pathway and TNF signaling pathway.Cell experiments showed that total flavonoids of Hibiscus mutabilis L.could effectively inhibit the expression of tumor necrosis factor(TNF-α),interleukin 8(IL-8)and epidermal growth factor receptor(EGFR)in LPS-induced RAW 264.7 inflammatory cells.It also downregulates the phosphorylation of human nuclear factor ĸB inhibitory protein α(IĸBα)and NF-κB p65 subunit protein(p65).Overall,the anti-inflammatory effect of Hibiscus mutabilis L.is related to many active components,many signal pathways and targets,which provides a theoretical basis for its further development and application.展开更多
Gait recognition is a key biometric for long-distance identification,yet its performance is severely degraded by real-world challenges such as varying clothing,carrying conditions,and changing viewpoints.While combini...Gait recognition is a key biometric for long-distance identification,yet its performance is severely degraded by real-world challenges such as varying clothing,carrying conditions,and changing viewpoints.While combining silhouette and skeleton data is a promising direction,effectively fusing these heterogeneous modalities and adaptively weighting their contributions in response to diverse conditions remains a central problem.This paper introduces GaitMAFF,a novelMulti-modal Adaptive Feature Fusion Network,to address this challenge.Our approach first transforms discrete skeleton joints into a dense SkeletonMap representation to align with silhouettes,then employs an attention-based module to dynamically learn the fusion weights between the two modalities.These fused features are processed by a powerful spatio-temporal backbone withWeighted Global-Local Feature FusionModules(WFFM)to learn a discriminative representation.Extensive experiments on the challenging CCPG and Gait3D datasets show that GaitMAFF achieves state-of-the-art performance,with an average Rank-1 accuracy of 84.6%on CCPG and 58.7%on Gait3D.These results demonstrate that our adaptive fusion strategy effectively integrates complementary multimodal information,significantly enhancing gait recognition robustness and accuracy in complex scenes and providing a practical solution for real-world applications.展开更多
The existence of absorption and reflection of light underwater leads to problems such as color distortion and blue-green bias in underwater images.In this study,a depthwise separable convolution-based generative adver...The existence of absorption and reflection of light underwater leads to problems such as color distortion and blue-green bias in underwater images.In this study,a depthwise separable convolution-based generative adversarial network(GAN)algorithm was proposed.Taking GAN as the basic framework,it combined a depthwise separable convolution module,attention mechanism,and reconstructed convolution module to realize the enhancement of underwater degraded images.Multi-scale features were captured by the depthwise separable convolution module,and the attention mechanism was utilized to enhance attention to important features.The reconstructed convolution module further extracts and fuses local and global features.Experimental results showed that the algorithm performs well in improving the color bias and blurring of underwater images,with PSNR reaching 27.835,SSIM reaching 0.883,UIQM reaching 3.205,and UCIQE reaching 0.713.The enhanced image outperforms the comparison algorithm in both subjective and objective metrics.展开更多
Autism spectrum disorder(AsD)is a highly heterogeneous neurodevelopmental disorder.Early diagnosis and intervention are crucial for improving outcomes.Traditional single-modality diagnostic methods are subjective,limi...Autism spectrum disorder(AsD)is a highly heterogeneous neurodevelopmental disorder.Early diagnosis and intervention are crucial for improving outcomes.Traditional single-modality diagnostic methods are subjective,limited,and struggle to reveal the underlying pathological mechanisms.In contrast,multimodal data analysis integrates behavioral,physiological,and neuroimaging information with advanced machine-learning and deeplearning algorithms to overcome these limitations.In this review,we surveyed the recent pediatric AsD literature,highlighting artificial intelligence-driven diagnostic techniques,multimodal data fusion strategies,and emerging trends in ASD assessment.We surveyed studies that integrated two or more modalities and summarized the fusion levels,learning paradigms,tasks,datasets,and metrics.Multimodal approaches outperform singlemodality baselines in classification,severity estimation,and subtyping by leveraging complementary information and reducing modality-specific biases.Multimodal approaches significantly enhance diagnostic accuracy and comprehensiveness,enabling early screening of AsD,symptom subtyping,severity assessment,and personalized interventions.Advances in multimodal fusion techniques have promoted progress in precision medicine for the treatment of ASD.展开更多
基金Supported by the National Natural Science Foundation of China (No.60307003, No.60371010) and the Natural Science Foundation of Zhejiang Province (No.602153).
文摘The reflection and transmission characteristics of the guided modes in parallel-plate waveguides partially filled with one or multi chiral rods have been investigated by a method, which combines the multi- mode network theory with a rigorous mode matching procedure. The formulas of the reflection and transmis- sion coefficient matrix are derived. The numerical results for different cases are presented and have indicated that the chirality parameters and the geometrical dimensions of the chiral rods have significant influence on the reflection and transmission characteristics of the guided modes.
基金supported by National Natural Science Foundation of China (Nos.21906124,32302202)Natural Science Foundation of Hubei Province (No.2017CFB220)Natural Science Foundation of Shandong Province (No.ZR2023MH278)。
文摘Metal organic framework(MOF) assembled with coordination bonds has the disadvantage of poor stability that limits its application in the field of stationary phase,while covalent organic framework(COF)assembled through covalent bonds exhibits excellent structural stability.It has been shown that the stationary phases prepared by combining MOF and COF can make up for the poor stability of MOF@SiO_(2),and the MOF/COF composites have superior chromatographic separation performance.However,the traditional methods for preparing COF/MOF based stationary phases are generally solvent thermal synthesis.In this study,a green and low-cost synthesis method was proposed for the preparation of MOF/COF@SiO_(2) stationary phase.Firstly,COF@SiO_(2) was prepared in a choline chloride/ethylene glycol based deep eutectic solvent(DES).Secondly,another acid-base tunable DES prepared by mixing p-toluenesulfonic acid(PTSA)and 2-methylimidazole in different proportions was introduced as the reaction solvent and reactant for rapid synthesis of MOF/COF@SiO_(2).Compared with the toxic transition metal-based MOFs selected in most previous studies,a lightweight and non-toxic S-zone metal(calcium) based MOF was employed in this study.PTSA and calcium will form the calcium/oxygen-containing organic acid framework in acidic DES,which assembles with terephthalic acid dissolved in basic DES to form MOF.The strong hydrogen bonding effect of DES can facilitate rapid assembly of Ca-MOF.The obtained Ca-MOF/COF@SiO_(2) can be used for multi-mode chromatography to efficiently separate multiple isomeric/hydrophilic/hydrophobic analytes.The synthesis method of Ca-MOF/COF@SiO_(2) is green and mild,especially the use of acid-base tunable DES promotes the rapid synthesis of non-toxic Ca-MOF/COF@silica composites,which offers an innovative approach of greenly synthesizing novel MOF/COF stationary phases and extends their applications in the field of chromatography.
基金support from the National Natural Science Foundation of China(Grant Nos.52174313 and 52304350)thank all members of the Hebei High Quality Steel Continuous Casting Engineering Technology Research Center at North China University of Science and Technology,Tangshan,China.
文摘The flow behavior of molten steel in the thin slab mold under high casting speed conditions was investigated,with a focus on the multi-mode continuous casting and rolling mold.A steel-slag two-phase flow model was established using large eddy simulation,the volume of fluid,and magnetohydrodynamics methods through numerical simulation.The maximum flow velocity and wave height at the steel-slag interface within the mold are critical evaluation criteria for analyzing asymmetric flow under varying casting speeds and electromagnetic braking.The results indicate that the asymmetric flows within the mold do not occur synchronously.The severity of the asymmetric flow correlates with the velocity difference across the steel-slag interface.A greater biased flow prolongs the time required to revert to a steady state.When the magnetic field intensity is set to 0.24 T and the magnetic pole position is at 390 mm from the steel-slag interface,this configuration can reduce the velocity of the steel-slag interface,thereby mitigating the asymmetric flow.Additionally,it can diminish the velocity,impact depth,and impact intensity on the narrow face of the jet,thus improving the distribution of velocity and turbulent kinetic energy within the mold.This configuration prolongs the time required for the steel-slag interface to transition from a stable state to its maximum velocity and shortens the time for the interface to return to stability from an unstable state.Moreover,it ensures the positional stability of the steel-slag interface,confining its position within−3 mm.
基金supported by the Science and Technology Project of State Grid Corporation of China under grant 52094021N010(5400-202199534A-0-5-ZN)。
文摘Low-carbon smart parks achieve selfbalanced carbon emission and absorption through the cooperative scheduling of direct current(DC)-based distributed photovoltaic,energy storage units,and loads.Direct current power line communication(DC-PLC)enables real-time data transmission on DC power lines.With traffic adaptation,DC-PLC can be integrated with other complementary media such as 5G to reduce transmission delay and improve reliability.However,traffic adaptation for DC-PLC and 5G integration still faces the challenges such as coupling between traffic admission control and traffic partition,dimensionality curse,and the ignorance of extreme event occurrence.To address these challenges,we propose a deep reinforcement learning(DRL)-based delay sensitive and reliable traffic adaptation algorithm(DSRTA)to minimize the total queuing delay under the constraints of traffic admission control,queuing delay,and extreme events occurrence probability.DSRTA jointly optimizes traffic admission control and traffic partition,and enables learning-based intelligent traffic adaptation.The long-term constraints are incorporated into both state and bound of drift-pluspenalty to achieve delay awareness and enforce reliability guarantee.Simulation results show that DSRTA has lower queuing delay and more reliable quality of service(QoS)guarantee than other state-of-the-art algorithms.
文摘Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstruction methods either compromise on accuracy with iterative algorithms or suffer from limited generalizability with task-specific deep learning approaches.Methods:We present LDM-PIR,a lightweight physics-conditioned diffusion multi-model for medical image reconstruction that addresses key challenges in magnetic resonance imaging(MRI),CT,and low-photon imaging.Unlike traditional iterative methods,which are computationally expensive,or task-specific deep learning approaches lacking generalizability,integrates three innovations.A physics-conditioned diffusion framework that embeds acquisition operators(Fourier/Radon transforms)and noise models directly into the reconstruction process.A multi-model architecture that unifies denoising,inpainting,and super-resolution via shared weight conditioning.A lightweight design(2.1M parameters)enabling rapid inference(0.8s/image on GPU).Through self-supervised fine-tuning with measurement consistency losses adapts to new imaging modalities using fewer annotated samples.Results:Achieves state-of-the-art performance on fastMRI(peak signal-to-noise ratio(PSNR):34.04 for single-coil/31.50 for multi-coil)and Lung Image Database Consortium and Image Database Resource Initiative(28.83 PSNR under Poisson noise).Clinical evaluations demonstrate superior preservation of anatomical structures,with SSIM improvements of 8.8%for single-coil and 4.36%for multi-coil MRI over uDPIR.Conclusion:It offers a flexible,efficient,and scalable solution for medical image reconstruction,addressing the challenges of noise,undersampling,and modality generalization.The model’s lightweight design allows for rapid inference,while its self-supervised fine-tuning capability minimizes reliance on large annotated datasets,making it suitable for real-world clinical applications.
基金The fund from Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract No.SML2021SP310the National Natural Science Foundation of China under contract Nos 42227901 and 42475061the Key R&D Program of Zhejiang Province under contract No.2024C03257.
文摘In this study,we conducted an experiment to construct multi-model ensemble(MME)predictions for the El Niño-Southern Oscillation(ENSO)using a neural network,based on hindcast data released from five coupled oceanatmosphere models,which exhibit varying levels of complexity.This nonlinear approach demonstrated extraordinary superiority and effectiveness in constructing ENSO MME.Subsequently,we employed the leave-one-out crossvalidation and the moving base methods to further validate the robustness of the neural network model in the formulation of ENSO MME.In conclusion,the neural network algorithm outperforms the conventional approach of assigning a uniform weight to all models.This is evidenced by an enhancement in correlation coefficients and reduction in prediction errors,which have the potential to provide a more accurate ENSO forecast.
文摘Traditional Chinese medicine(TCM)demonstrates distinctive advantages in disease prevention and treatment.However,analyzing its biological mechanisms through the modern medical research paradigm of“single drug,single target”presents significant challenges due to its holistic approach.Network pharmacology and its core theory of network targets connect drugs and diseases from a holistic and systematic perspective based on biological networks,overcoming the limitations of reductionist research models and showing considerable value in TCM research.Recent integration of network target computational and experimental methods with artificial intelligence(AI)and multi-modal multi-omics technologies has substantially enhanced network pharmacology methodology.The advancement in computational and experimental techniques provides complementary support for network target theory in decoding TCM principles.This review,centered on network targets,examines the progress of network target methods combined with AI in predicting disease molecular mechanisms and drug-target relationships,alongside the application of multi-modal multi-omics technologies in analyzing TCM formulae,syndromes,and toxicity.Looking forward,network target theory is expected to incorporate emerging technologies while developing novel approaches aligned with its unique characteristics,potentially leading to significant breakthroughs in TCM research and advancing scientific understanding and innovation in TCM.
基金supported by the National Natural Science Foundation of China(Grant Nos.62071315 and 62271336).
文摘The multi-modal characteristics of mineral particles play a pivotal role in enhancing the classification accuracy,which is critical for obtaining a profound understanding of the Earth's composition and ensuring effective exploitation utilization of its resources.However,the existing methods for classifying mineral particles do not fully utilize these multi-modal features,thereby limiting the classification accuracy.Furthermore,when conventional multi-modal image classification methods are applied to planepolarized and cross-polarized sequence images of mineral particles,they encounter issues such as information loss,misaligned features,and challenges in spatiotemporal feature extraction.To address these challenges,we propose a multi-modal mineral particle polarization image classification network(MMGC-Net)for precise mineral particle classification.Initially,MMGC-Net employs a two-dimensional(2D)backbone network with shared parameters to extract features from two types of polarized images to ensure feature alignment.Subsequently,a cross-polarized intra-modal feature fusion module is designed to refine the spatiotemporal features from the extracted features of the cross-polarized sequence images.Ultimately,the inter-modal feature fusion module integrates the two types of modal features to enhance the classification precision.Quantitative and qualitative experimental results indicate that when compared with the current state-of-the-art multi-modal image classification methods,MMGC-Net demonstrates marked superiority in terms of mineral particle multi-modal feature learning and four classification evaluation metrics.It also demonstrates better stability than the existing models.
文摘In recent years,the analysis of encrypted network traffic has gained momentum due to the widespread use of Transport Layer Security and Quick UDP Internet Connections protocols,which complicate and prolong the analysis process.Classification models face challenges in understanding and classifying unknown traffic because of issues related to interpret ability and the representation of traffic data.To tackle these complexities,multi-modal representation learning can be employed to extract meaningful features and represent them in a lower-dimensional latent space.Recently,auto-encoder-based multi-modal representation techniques have shown superior performance in representing network traffic.By combining the advantages of multi-modal representation with efficient classifiers,we can develop robust network traffic classifiers.In this paper,we propose a novel multi-modal encoder-decoder model to create unified representations of network traffic,paired with a robust 1D-CNN(one-dimensional convolution neural network)classifier for effective traffic classification.The proposed model utilizes the ISCX Virtual Private Networknon Virtual Private Network 2016 datasets to extract general multi-modal representations and to train both shallow and deep learning models,such as Random Forest and the 1D-CNN model,for traffic classification.We compare these learning approaches based on the multi-modal representations generated from the autoencoder and the early feature fusion technique.For the classification task,both the Random Forest and 1D-CNN models,when trained on multimodal representations,achieve over 90%accuracy on a highly imbalanced dataset.
基金supported by the National Natural Science Foundation of China(No.22288101)the 111 Project(No.B17020)。
文摘Carbon dots(CDs)-based composites have shown impressive performance in fields of information encryption and sensing,however,a great challenge is to simultaneously implement multi-mode luminescence and room-temperature phosphorescence(RTP)detection in single system due to the formidable synthesis.Herein,a multifunctional composite of Eu&CDs@p RHO has been designed by co-assembly strategy and prepared via a facile calcination and impregnation treatment.Eu&CDs@p RHO exhibits intense fluorescence(FL)and RTP coming from two individual luminous centers,Eu3+in the free pores and CDs in the interrupted structure of RHO zeolite.Unique four-mode color outputs including pink(Eu^(3+),ex.254 nm),light violet(CDs,ex.365 nm),blue(CDs,254 nm off),and green(CDs,365 nm off)could be realized,on the basis of it,a preliminary application of advanced information encoding has been demonstrated.Given the free pores of matrix and stable RTP in water of confined CDs,a visual RTP detection of Fe^(3+)ions is achieved with the detection limit as low as 9.8μmol/L.This work has opened up a new perspective for the strategic amalgamation of luminous vips with porous zeolite to construct the advanced functional materials.
基金supported by Natural Science Foundation of Jilin Province(No.SKL202302002)Key Research and Development project of Jilin Provincial Science and Technology Department(No.20210204142YY)+2 种基金The Science and Technology Development Program of Jilin Province(No.2020122256JC)Beijing Kechuang Medical Development Foundation Fund of China(No.KC2023-JX-0186BQ079)Talent Reserve Program(TRP),the First Hospital of Jilin University(No.JDYY-TRP-2024007)。
文摘Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.
文摘Hepatology encompasses various aspects,such as metabolic-associated fatty liver disease,viral hepatitis,alcoholic liver disease,liver cirrhosis,liver failure,liver tumors,and liver transplantation.The global epidemiological situation of liver diseases is grave,posing a substantial threat to human health and quality of life.Characterized by high incidence and mortality rates,liver diseases have emerged as a prominent global public health concern.In recent years,the rapid advan-cement of artificial intelligence(AI),deep learning,and radiomics has transfor-med medical research and clinical practice,demonstrating considerable potential in hepatology.AI is capable of automatically detecting abnormal cells in liver tissue sections,enhancing the accu-racy and efficiency of pathological diagnosis.Deep learning models are able to extract features from computed tomography and magnetic resonance imaging images to facilitate liver disease classification.Machine learning models are capable of integrating clinical data to forecast disease progression and treatment responses,thus supporting clinical decision-making for personalized medicine.Through the analysis of imaging data,laboratory results,and genomic information,AI can assist in diagnosis,forecast disease progression,and optimize treatment plans,thereby improving clinical outcomes for liver disease patients.This minireview intends to comprehensively summarize the state-of-the-art theories and applications of AI in hepatology,explore the opportunities and challenges it presents in clinical practice,basic research,and translational medicine,and propose future research directions to guide the advancement of hepatology and ultimately improve patient outcomes.
基金supported by the National Natural Science Foundation of China(Grant No.61170219)the Joint Research Foundation of the Ministry of Education of the People’s Republic of China and China Mobile(Grant No.MCM20150202)the Science and Technology Project Affiliated to Chongqing Education Commission(KJ1602201)
文摘How to energy-efficiently maintain the topology of wireless sensor networks(WSNs) is still a difficult problem because of their numerous nodes,highly dynamic nature,varied application scenarios and limited resources.An energy-efficient multi-mode clusters maintenance(M2CM) method is proposed based on localized and event-driven mechanism in this work,which is different from the conventional clusters maintenance model with always periodically re-clustered among the whole network style based on time-trigger for hierarchical WSNs.M2 CM can meet such demands of clusters maintenance as adaptive local maintenance for the damaged clusters according to its changes in time and space field.,the triggers of M2 CM include such events as nodes' residual energy being under the threshold,the load imbalance of cluster head,joining in or exiting from any cluster for new node or disable one,etc.Based on neighboring relationship of the damaged clusters,one can start a single cluster(inner-cluster) maintenance or clusters(inter-cluster) maintenance program to meet diverse demands in the topology management of hierarchical WSNs.The experiment results based on NS2 simulation show that the proposed method can significantly save energy used in maintaining a damaged network,effectively narrow down the influenced area of clusters maintenance,and increase transmitted data and prolong lifetime of network compared to the traditional schemes.
文摘The bootstrap resampling method is applied to an ensemble artificial neural network (ANN) approach (which combines machine learning with physical data obtained from a numerical weather prediction model) to provide a multi-ANN model super-ensemble for application to multi-step-ahead forecasting of wind speed and of the associated power generated from a wind turbine. A statistical combination of the individual forecasts from the various ANNs of the super-ensemble is used to construct the best deterministic forecast, as well as the prediction uncertainty interval associated with this forecast. The bootstrapped neural-network methodology is validated using measured wind speed and power data acquired from a wind turbine in an operational wind farm located in northern China.
基金supported by the Science and Technology Project of SGCC(5100-202199558A-0-5-ZN).
文摘Transient stability assessment(TSA)based on artificial intelligence typically has two distinct model management approaches:a unified management approach for all faulted lines and a separate management approach for each faulted line.To address the shortcomings of the aforementioned approaches,namely accuracy,training time,and model management complexity,a multi-model management approach for power system TSA based on multi-moment feature clustering has been proposed.First,the steady-state and transient features present under fault conditions were obtained through a transient simulation of line faults.The input sample set was then constructed using the aforementioned multi-moment electrical features and the embedded faulty line numbers.Subsequently,K-means clustering was conducted on each line based on the similarity of their electrical features,employing t-SNE dimensionality reduction.The PSO-CNN model was trained separately for each cluster to generate several independent TSA models.Finally,a model effectiveness evaluation system consisting of five metrics was established,and the effect of the sample imbalance ratio on the model effectiveness was investigated.The model effectiveness was evaluated using the IEEE 39-bus system algorithm.The results showed that the multi-model management strategy based on multi-moment feature clustering can effectively combine the two advantages of superior evaluation performance and streamlined model management by fully extracting system features.Moreover,this approach allows for more flexible adjustments to line topology changes.
文摘Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.
文摘To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review and SwissADME platform.Genes related to the inflammation were collected using Genecards and OMIM databases,and the intersection genes were submitted on STRING and DAVID websites.Then,the protein interaction network(PPI),gene ontology(GO)and pathway(KEGG)were analyzed.Cytoscape 3.7.2 software was used to construct the“Hibiscus mutabilis L.-active ingredient-target-inflammation”network diagram,and AutoDockTools-1.5.6 software was used for the molecular docking verification.The antiinflammatory effect of Hibiscus mutabilis L.active ingredient was verified by the RAW264.7 inflammatory cell model.The results showed that 11 active components and 94 potential targets,1029 inflammatory targets and 24 intersection targets were obtained from Hibiscus mutabilis L..The key anti-inflammatory active ingredients of Hibiscus mutabilis L.are quercetin,apigenin and luteolin.Its action pathway is mainly related to NF-κB,cancer pathway and TNF signaling pathway.Cell experiments showed that total flavonoids of Hibiscus mutabilis L.could effectively inhibit the expression of tumor necrosis factor(TNF-α),interleukin 8(IL-8)and epidermal growth factor receptor(EGFR)in LPS-induced RAW 264.7 inflammatory cells.It also downregulates the phosphorylation of human nuclear factor ĸB inhibitory protein α(IĸBα)and NF-κB p65 subunit protein(p65).Overall,the anti-inflammatory effect of Hibiscus mutabilis L.is related to many active components,many signal pathways and targets,which provides a theoretical basis for its further development and application.
基金funded by the Natural Science Foundation of Chongqing Municipality,grant number CSTB2022NSCQ-MSX0503.
文摘Gait recognition is a key biometric for long-distance identification,yet its performance is severely degraded by real-world challenges such as varying clothing,carrying conditions,and changing viewpoints.While combining silhouette and skeleton data is a promising direction,effectively fusing these heterogeneous modalities and adaptively weighting their contributions in response to diverse conditions remains a central problem.This paper introduces GaitMAFF,a novelMulti-modal Adaptive Feature Fusion Network,to address this challenge.Our approach first transforms discrete skeleton joints into a dense SkeletonMap representation to align with silhouettes,then employs an attention-based module to dynamically learn the fusion weights between the two modalities.These fused features are processed by a powerful spatio-temporal backbone withWeighted Global-Local Feature FusionModules(WFFM)to learn a discriminative representation.Extensive experiments on the challenging CCPG and Gait3D datasets show that GaitMAFF achieves state-of-the-art performance,with an average Rank-1 accuracy of 84.6%on CCPG and 58.7%on Gait3D.These results demonstrate that our adaptive fusion strategy effectively integrates complementary multimodal information,significantly enhancing gait recognition robustness and accuracy in complex scenes and providing a practical solution for real-world applications.
文摘The existence of absorption and reflection of light underwater leads to problems such as color distortion and blue-green bias in underwater images.In this study,a depthwise separable convolution-based generative adversarial network(GAN)algorithm was proposed.Taking GAN as the basic framework,it combined a depthwise separable convolution module,attention mechanism,and reconstructed convolution module to realize the enhancement of underwater degraded images.Multi-scale features were captured by the depthwise separable convolution module,and the attention mechanism was utilized to enhance attention to important features.The reconstructed convolution module further extracts and fuses local and global features.Experimental results showed that the algorithm performs well in improving the color bias and blurring of underwater images,with PSNR reaching 27.835,SSIM reaching 0.883,UIQM reaching 3.205,and UCIQE reaching 0.713.The enhanced image outperforms the comparison algorithm in both subjective and objective metrics.
基金supported by the National Key Research and Development Program of China(Research Grant Number:2023YFC3603600).
文摘Autism spectrum disorder(AsD)is a highly heterogeneous neurodevelopmental disorder.Early diagnosis and intervention are crucial for improving outcomes.Traditional single-modality diagnostic methods are subjective,limited,and struggle to reveal the underlying pathological mechanisms.In contrast,multimodal data analysis integrates behavioral,physiological,and neuroimaging information with advanced machine-learning and deeplearning algorithms to overcome these limitations.In this review,we surveyed the recent pediatric AsD literature,highlighting artificial intelligence-driven diagnostic techniques,multimodal data fusion strategies,and emerging trends in ASD assessment.We surveyed studies that integrated two or more modalities and summarized the fusion levels,learning paradigms,tasks,datasets,and metrics.Multimodal approaches outperform singlemodality baselines in classification,severity estimation,and subtyping by leveraging complementary information and reducing modality-specific biases.Multimodal approaches significantly enhance diagnostic accuracy and comprehensiveness,enabling early screening of AsD,symptom subtyping,severity assessment,and personalized interventions.Advances in multimodal fusion techniques have promoted progress in precision medicine for the treatment of ASD.
