This paper presents a compact ultra-low-power phase-locked loop (PLL) based binary phase-shift keying(BPSK)demodulator. The loop-filter-less(LPF-less) PLL is proposed to make phase of PLL output carrier signal track t...This paper presents a compact ultra-low-power phase-locked loop (PLL) based binary phase-shift keying(BPSK)demodulator. The loop-filter-less(LPF-less) PLL is proposed to make phase of PLL output carrier signal track the phase of BPSK signal in real time. Thus, the maximum date rate can be significantly extended to the half of the carrier frequency(f_(carrier)) with a very compact size compared to prior PLL-based BPSK demodulators. Furthermore, eliminating all the static power in our LPF-less PLL, the energy efficiency is obviously improved. Fabricated in a 40-nm CMOS process, our prototype occupies 0.0012-mm^(2)core active area, and achieves the maximum data rate of 6.78 Mb/s (f_(carrier)/2) at f_(carrier)of 13.56 MHz. The power consumption and energy efficiency is 4.47 μW and 0.66 pJ/bit at 6.78-Mb/s data rate, respectively.展开更多
A single-chip DVB-C quadrature amplitude modulation（QAM） demodulator is proposed,which integrates a 3.3V 10bit 40MSPS analog-to-digital converter and a forward error correction decoder. The demodulator chip can supp...A single-chip DVB-C quadrature amplitude modulation（QAM） demodulator is proposed,which integrates a 3.3V 10bit 40MSPS analog-to-digital converter and a forward error correction decoder. The demodulator chip can support 4-256 QAM with variable bit rate up to 80Mbps. It features a wide carrier offset acquisition range,optimal demodulation algorithm,and small circuit area. The chip is implemented in SMIC 0.25μm 1P5M mixed-signal CMOS technology with a die size of 3.5mm×3. 5mm. The maximum power consumption is 447mW.展开更多
Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,includi...Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018).展开更多
A new low-cost demodulator for ZigBee receivers satisfying requirements of IEEE802.15.4 standard is presented,which is designed for ISM 2.4 GHz band and based on Zero-IF receivers.This demodulator extracts symbols dir...A new low-cost demodulator for ZigBee receivers satisfying requirements of IEEE802.15.4 standard is presented,which is designed for ISM 2.4 GHz band and based on Zero-IF receivers.This demodulator extracts symbols directly from baseband signal rather than recovering PN code chips,so its structure is simple.Two main techniques are used to improve the performance of demodulator.One is Phase-Axis Crossing Detector(PACD) which detects the phase correlation of baseband signal.The other is symbol synchronization and sampling clock correction algorithm.The result shows that this demodulator performance,Symbol Error Rate(SER) and Packet Error Rate(PER) meet IEEE 802.15.4TM standard requirements and the demodulator can handle frequency offset in excess of 200 kHz,involving a Zero-IF receiver with a Noise Figure(NF) lower than 17 dB,which is easily imple-mented in standard CMOS technology.展开更多
A scheme of chaotic secure communication based on the parameter modulation and the inversion of a chaotic dynamical system is analyzed. According to this scheme, information signal is modulated by a bifurcation parame...A scheme of chaotic secure communication based on the parameter modulation and the inversion of a chaotic dynamical system is analyzed. According to this scheme, information signal is modulated by a bifurcation parameter of the transmitter, which is in chaotic state. In the receiver, a proportional integral feedback demodulator is used to demodulate the information signal, which only uses the available synchronizing error as well as stateness of receiver. The purpose of this demodulator is proposed to overcome the influence of differentiation operation, nonlinear part and singularities in chaotic system. Numerical simulation is proposed to show the effectiveness of this demodulator.展开更多
Based on the theory of Duffing oscillator weak signal detection and the technology of extended binary phase shift keying （EBPSK） modulation, the chaotic demodulator using the Duffing oscillator for EBPSK signals was...Based on the theory of Duffing oscillator weak signal detection and the technology of extended binary phase shift keying （EBPSK） modulation, the chaotic demodulator using the Duffing oscillator for EBPSK signals was proposed. The proposed demodulator could avoid the problem of demodulation filters design, and shows the excellent anti-noise capability of chaotic oscillator detection. Numerical and experimental tests were taken to investigate the impact of modulation parameters T and 0 on bit error performance of the proposed method, and the performance limits were gotten. The results show that the proposed chaotic demodulator works well under a very low signal-to-noise ratio （SNR） conditions, and gets SNR gains about 20 dB to 30 dB from the impulse filter.展开更多
The design and measured results of a broad-band direct quadrature phase shift keying(QPSK) modulator and demodulator are described in this paper.The circuits are fabricated using 1-m GaAs HBT technology.To suppress th...The design and measured results of a broad-band direct quadrature phase shift keying(QPSK) modulator and demodulator are described in this paper.The circuits are fabricated using 1-m GaAs HBT technology.To suppress the local oscillator(LO) leakage,the double-balanced mixer is selected as the core unit in the modulator/demodulator.An embedded four-way quadrature divider which includes a Lange coupler and two Baluns is utilized in the system to generate quadrature-phase LO signals.As results of a back-to-back test,the system can operate at data rates in excess of 2 Gb/s(1 Gb/s per I and Q channels) at 30 GHz.The supplies of the modulator and demodulator are 5.0 V and 4.5 V with size of 1.35 mm×3.5 mm and 1.36 mm×3.4 mm,respectively.展开更多
This paper presents a wideband frequency-shift keying （FSK） demodulator suitable for a digital data transmission chain of wireless neural stimulation microsystems such as cochlear implants and retinal prostheses. Th...This paper presents a wideband frequency-shift keying （FSK） demodulator suitable for a digital data transmission chain of wireless neural stimulation microsystems such as cochlear implants and retinal prostheses. The demodulator circuit derives a constant frequency clock directly from an FSK carrier, and uses this clock to sample the data bits. The circuit occupies 0.03 mm^2 using a 0.6 μm, 2M/2P, standard CMOS process, and consumes 0.25 mW at 5 V. This circuit was experimentally tested at transmission speed of up to 2.5 Mbps while receiving a 5-10 MHz FSK carrier signal in a cochlear implant system.展开更多
Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of ...Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of enhancing BMP-dependent regeneration while preventing HO.This study focuses on the ability of the collagen receptor,discoidin domain receptor 2(DDR2),to regulate BMP activity.As will be shown,induction of bone formation by subcutaneous BMP2 implants is severely compromised in Ddr2-deficient mice.In addition,Ddr2 deficiency attenuates HO in mice expressing the ACVR1 mutation associated with human fibrodysplasia ossificans progressiva.In cells migrating into BMP2 implants,DDR2 is co-expressed with GLI1,a skeletal stem cell marker,and DDR2/GLI1-positive cells participate in BMP2-induced bone formation where they contribute to chondrogenic and osteogenic lineages.Consistent with this distribution,conditional knockout of Ddr2 in Gli1-expressing cells inhibited bone formation to the same extent seen in globally Ddr2-deficient animals.This response was explained by selective inhibition of Gli1+cell proliferation without changes in apoptosis.The basis for this DDR2 requirement was explored further using bone marrow stromal cells.Although Ddr2 deficiency inhibited BMP2-dependent chondrocyte and osteoblast differentiation and in vivo,bone formation,early BMP responses including SMAD phosphorylation remained largely intact.Instead,Ddr2 deficiency reduced the nuclear/cytoplasmic ratio of the Hippo pathway intermediates,YAP and TAZ.This suggests that DDR2 regulates Hippo pathway-mediated responses to the collagen matrix,which subsequently affect BMP responsiveness.In summary,DDR2 is an important modulator of BMP signaling and a potential therapeutic target both for enhancing regeneration and treating HO.展开更多
Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodu...Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and noradrenaline.The neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal system.Cholecystokinin(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target regions.For instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety regulation.Conversely,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.展开更多
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental...Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.展开更多
The principle of optical time-domain reflection localization limits the sensing spatial resolution of Raman distributed optical fiber sensing.We provide a solution for a Raman distributed optical fiber sensing system ...The principle of optical time-domain reflection localization limits the sensing spatial resolution of Raman distributed optical fiber sensing.We provide a solution for a Raman distributed optical fiber sensing system with kilometer-level sensing distance and submeter spatial resolution.Based on this,we propose a Raman distributed optical fiber sensing scheme based on chaotic pulse cluster demodulation.Chaotic pulse clusters are used as the probe signal,in preference to conventional pulsed or chaotic single-pulse lasers.Furthermore,the accurate positioning of the temperature variety region along the sensing fiber can be realized using chaotic pulse clusters.The proposed demodulation scheme can enhance the signal-to-noise ratio by improving the correlation between the chaotic reference and the chaotic Raman anti-Stokes scattering signals.The experiment achieved a sensing spatial resolution of 30 cm at a distributed temperature-sensing distance of∼6.0 km.Furthermore,we explored the influence of chaotic pulse width and detector bandwidth on the sensing spatial resolution.In addition,the theoretical experiments proved that the sensing spatial resolution in the proposed scheme was independent of the pulse width and sensing distance.展开更多
As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are in...As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are increasingly recognized as core requirements for next-generation intelligent computing center designs^([1, 2]). For short-range optical interconnections of intra-chip and inter-chip—typically covering tens of meters or less—microring resonant modulators (MRM) are emerging as an ideal solution.展开更多
Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of...Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of sensory stimuli,and it is this valence that serves as the foundational motivation for our subsequent actions.Simply put,all motivational actions fall into two categories:pleasure-seeking behavior guided by positive emotional valence,and pain-avoiding behavior driven by negative emotional valence[1].The ability to shift from one emotional valence to another is an important characteristic of affective states,while the instability of emotional states underlies many psychiatric disorders,highlighting the clinical importance of managing and understanding these fluctuations.This ability to adapt emotional responses can be attained by modulating the gain across distinct neural pathways,thus enabling the nuanced and smooth assignment of valence through the strengthening or weakening of circuit activity[1,2].展开更多
With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most i...With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most important component of high-precision ADC,is widely used in high-quality audio,high-precision instrument measurement,and other fields due to its advantages of high precision,strong noise resistance,and low hardware cost.This article designs a discrete structure third-order four-bit high-precision Sigma-Delta modulator through modeling,with an oversampling rate set to 512.Under ideal conditions,the simulation results show that the SDNR reaches 152.7db and the ENOB is 25.24bits.After introducing non-ideal noise,the system performance has decreased.The simulation results show that the SDNR is as high as 124.5db and the ENOB is 20.39bits.This indicates that the design can achieve high-precision conversion and provide assistance for further research in the future.展开更多
Recently, the rapid progress of quantum sensing research reveals that Rydberg atoms have great potential in becoming high-precision centimeter-scale antennas for low-frequency fields. In order to facilitate efficient ...Recently, the rapid progress of quantum sensing research reveals that Rydberg atoms have great potential in becoming high-precision centimeter-scale antennas for low-frequency fields. In order to facilitate efficient and reliable detection of low-frequency fields via Rydberg atoms, we designed and implemented a heterodyne method based on the linear response to external signals under the condition of Rydberg electromagnetically induced transparency(EIT). Instead of relying on observing changes in the absorption of light by Rydberg atoms, our method focuses on the phase modulation effect on the probe laser induced by low-frequency fields via the Rydberg EIT mechanism and utilizes a special demodulation process to accurately retrieve signals including both amplitude and phase. The general principles of our method apply to both electric and magnetic fields, and it is even possible to realize a combination of both functionalities in the same apparatus. In particular, we experimentally demonstrate the full cycle of operations with respect to both cases. In measuring low-frequency electric fields,we discover that the Rydberg dipole–dipole interaction among atoms induces a linear superposition of Rydberg states with different angular momentum, generating a first-order response corresponding to the signature of the linear Stark effect. As Rydberg atoms have excellent coupling strengths with electric fields, our results indicate that our method can hopefully achieve high-precision performance for practical tasks in the future.展开更多
Femtosecond laser processing is an important machining method for micro-optical components such as Fresnel zone plate(FZP).However,the low processing efficiency of the femtosecond laser restricts its application.Here,...Femtosecond laser processing is an important machining method for micro-optical components such as Fresnel zone plate(FZP).However,the low processing efficiency of the femtosecond laser restricts its application.Here,a femtosecond laser Bessel beam is proposed to process micro-FZP,which is modulated from a Gaussian beam to a Bessel annular beam.The processing time for FZP with an outer diameter of 60μm is reduced from 30 min to 1.5 min on an important semiconductor material gallium arsenide(GaAs),which significantly improves the processing efficiency.In the modulation process,a central ablation hole that has an adverse effect on the diffraction performance is produced,and the adverse effect is eliminated by superimposing the blazed grating hologram.Meanwhile,the FZP machined by spatial light modulator(SLM)has good morphology and higher diffraction efficiency,which provides a strong guarantee for the application of micro-FZP in computed tomography and solar photovoltaic cells.展开更多
Objectives:The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery,particularly in cancer therapy.This study aimed to evaluate the cytotoxicity,apoptosis ind...Objectives:The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery,particularly in cancer therapy.This study aimed to evaluate the cytotoxicity,apoptosis induction,and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus,Phragmites communis,and Pinus densiflora,as well as their combined extract(GMAS 01/COM),on human lung cancer cells(A549)and normal cell lines,including murine macrophages(RAW 264.7)and human keratinocytes(HaCaT).Methods:Plant extracts were prepared using aqueous extraction,sonication,and rotary evaporation.The total phenolic and flavonoid contents were quantified using the Folin-Ciocalteu and AlCl3 colorimetric methods,respectively.Antioxidant potential was evaluated via 2,2-Diphenyl-1-picrylhydrazyl(DPPH)scavenging and reducing power assays.Cytotoxicity was assessed using an MTT assay,while reactive oxygen species(ROS)generation was quantified using a 2′,7′-Dichlorodihydrofluorescein diacetate(DCFH-DA)assay.Anticancer properties,including colony formation inhibition and migration suppression,were examined using colony formation and wound healing assays.The expression of apoptotic and inflammatory mediators was analysed through qPCR.Results:GMAS 01 selectively induced apoptosis in A549 cells without cytotoxic effects on RAW264.7 and HaCaT cells.Mechanistically,it elevated intracellular ROS and activated the intrinsic mitochondrial apoptotic pathway,evidenced by p53 upregulation,increased Bax,and decreased Bcl-2 expression.GMAS 01 also significantly inhibited colony formation and migration in A549 cells.In RAW264.7 cells,it reduced nitric oxide(NO)production and downregulated iNOS,COX-2,IL-6,and IL-8,indicating strong immunomodulatory activity.Conclusion:GMAS 01 exhibits potent antioxidant,anti-inflammatory,and anticancer effects,likely mediated through ROS-induced mitochondrial apoptosis.However,mechanistic interpretations are limited by the absence of protein-level validation and pathway inhibition studies.Upcoming studies should aim to verify the underlying mechanisms and evaluate their potential for real-world application.展开更多
In this paper,we present a novel first-order digitalΣΔconverter tailored for digital-to-analog applications,focusing on achieving both high yield and reduced silicon estate.Our approach incorporates a substantial le...In this paper,we present a novel first-order digitalΣΔconverter tailored for digital-to-analog applications,focusing on achieving both high yield and reduced silicon estate.Our approach incorporates a substantial level of dithering noise into the input signal,strategically aimed at mitigating the spurious frequencies commonly encountered in such converters.Validation of our design is performed through simulations using a high-level simulator specialized in mixed-signal circuit analysis.The results underscore the enhanced performance of our circuit,especially in reducing spurious frequencies,highlighting its efficiency and effectiveness.The final circuit exhibits an effective number of bits of 13.展开更多
Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturat...Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition.展开更多
基金supported by the National Natural Science Foundation of China under grant 62222409 and 62174153by Key Research Program of Frontier Sciences, CAS, under grant ZDBS-LY-JSC008。
文摘This paper presents a compact ultra-low-power phase-locked loop (PLL) based binary phase-shift keying(BPSK)demodulator. The loop-filter-less(LPF-less) PLL is proposed to make phase of PLL output carrier signal track the phase of BPSK signal in real time. Thus, the maximum date rate can be significantly extended to the half of the carrier frequency(f_(carrier)) with a very compact size compared to prior PLL-based BPSK demodulators. Furthermore, eliminating all the static power in our LPF-less PLL, the energy efficiency is obviously improved. Fabricated in a 40-nm CMOS process, our prototype occupies 0.0012-mm^(2)core active area, and achieves the maximum data rate of 6.78 Mb/s (f_(carrier)/2) at f_(carrier)of 13.56 MHz. The power consumption and energy efficiency is 4.47 μW and 0.66 pJ/bit at 6.78-Mb/s data rate, respectively.
文摘A single-chip DVB-C quadrature amplitude modulation（QAM） demodulator is proposed,which integrates a 3.3V 10bit 40MSPS analog-to-digital converter and a forward error correction decoder. The demodulator chip can support 4-256 QAM with variable bit rate up to 80Mbps. It features a wide carrier offset acquisition range,optimal demodulation algorithm,and small circuit area. The chip is implemented in SMIC 0.25μm 1P5M mixed-signal CMOS technology with a die size of 3.5mm×3. 5mm. The maximum power consumption is 447mW.
基金supported by the Hellenic Foundation for Research and Innovation,HFRI,“2nd Call for HFRI Research Projects to support Faculty Members&Researchers”Project 02667 to GL.
文摘Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018).
基金Supported by Zhejiang Province Important Sci-Tech Foundation Item (No.2006C11107)
文摘A new low-cost demodulator for ZigBee receivers satisfying requirements of IEEE802.15.4 standard is presented,which is designed for ISM 2.4 GHz band and based on Zero-IF receivers.This demodulator extracts symbols directly from baseband signal rather than recovering PN code chips,so its structure is simple.Two main techniques are used to improve the performance of demodulator.One is Phase-Axis Crossing Detector(PACD) which detects the phase correlation of baseband signal.The other is symbol synchronization and sampling clock correction algorithm.The result shows that this demodulator performance,Symbol Error Rate(SER) and Packet Error Rate(PER) meet IEEE 802.15.4TM standard requirements and the demodulator can handle frequency offset in excess of 200 kHz,involving a Zero-IF receiver with a Noise Figure(NF) lower than 17 dB,which is easily imple-mented in standard CMOS technology.
文摘A scheme of chaotic secure communication based on the parameter modulation and the inversion of a chaotic dynamical system is analyzed. According to this scheme, information signal is modulated by a bifurcation parameter of the transmitter, which is in chaotic state. In the receiver, a proportional integral feedback demodulator is used to demodulate the information signal, which only uses the available synchronizing error as well as stateness of receiver. The purpose of this demodulator is proposed to overcome the influence of differentiation operation, nonlinear part and singularities in chaotic system. Numerical simulation is proposed to show the effectiveness of this demodulator.
基金supported by the National Natural Science Foundation of China under Grant No.41476089
文摘Based on the theory of Duffing oscillator weak signal detection and the technology of extended binary phase shift keying （EBPSK） modulation, the chaotic demodulator using the Duffing oscillator for EBPSK signals was proposed. The proposed demodulator could avoid the problem of demodulation filters design, and shows the excellent anti-noise capability of chaotic oscillator detection. Numerical and experimental tests were taken to investigate the impact of modulation parameters T and 0 on bit error performance of the proposed method, and the performance limits were gotten. The results show that the proposed chaotic demodulator works well under a very low signal-to-noise ratio （SNR） conditions, and gets SNR gains about 20 dB to 30 dB from the impulse filter.
基金supported by the National Basic Research Program of China (2010CB327505)
文摘The design and measured results of a broad-band direct quadrature phase shift keying(QPSK) modulator and demodulator are described in this paper.The circuits are fabricated using 1-m GaAs HBT technology.To suppress the local oscillator(LO) leakage,the double-balanced mixer is selected as the core unit in the modulator/demodulator.An embedded four-way quadrature divider which includes a Lange coupler and two Baluns is utilized in the system to generate quadrature-phase LO signals.As results of a back-to-back test,the system can operate at data rates in excess of 2 Gb/s(1 Gb/s per I and Q channels) at 30 GHz.The supplies of the modulator and demodulator are 5.0 V and 4.5 V with size of 1.35 mm×3.5 mm and 1.36 mm×3.4 mm,respectively.
基金Project supported by the National Basic Research Program (973) of China (No. G2000036508) and the National Natural Science Foun-dation of China (No. 60475018)
文摘This paper presents a wideband frequency-shift keying （FSK） demodulator suitable for a digital data transmission chain of wireless neural stimulation microsystems such as cochlear implants and retinal prostheses. The demodulator circuit derives a constant frequency clock directly from an FSK carrier, and uses this clock to sample the data bits. The circuit occupies 0.03 mm^2 using a 0.6 μm, 2M/2P, standard CMOS process, and consumes 0.25 mW at 5 V. This circuit was experimentally tested at transmission speed of up to 2.5 Mbps while receiving a 5-10 MHz FSK carrier signal in a cochlear implant system.
基金Scientific Research Training Program for Young Talents of Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(F.W.),NIH/NIDCR grants DE029012 and DE029465Department of Defense Grant PR190899(R.T.F.)Michigan Musculoskeletal Health Core Center(NIH/NIAMS P30 AR069620)。
文摘Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of enhancing BMP-dependent regeneration while preventing HO.This study focuses on the ability of the collagen receptor,discoidin domain receptor 2(DDR2),to regulate BMP activity.As will be shown,induction of bone formation by subcutaneous BMP2 implants is severely compromised in Ddr2-deficient mice.In addition,Ddr2 deficiency attenuates HO in mice expressing the ACVR1 mutation associated with human fibrodysplasia ossificans progressiva.In cells migrating into BMP2 implants,DDR2 is co-expressed with GLI1,a skeletal stem cell marker,and DDR2/GLI1-positive cells participate in BMP2-induced bone formation where they contribute to chondrogenic and osteogenic lineages.Consistent with this distribution,conditional knockout of Ddr2 in Gli1-expressing cells inhibited bone formation to the same extent seen in globally Ddr2-deficient animals.This response was explained by selective inhibition of Gli1+cell proliferation without changes in apoptosis.The basis for this DDR2 requirement was explored further using bone marrow stromal cells.Although Ddr2 deficiency inhibited BMP2-dependent chondrocyte and osteoblast differentiation and in vivo,bone formation,early BMP responses including SMAD phosphorylation remained largely intact.Instead,Ddr2 deficiency reduced the nuclear/cytoplasmic ratio of the Hippo pathway intermediates,YAP and TAZ.This suggests that DDR2 regulates Hippo pathway-mediated responses to the collagen matrix,which subsequently affect BMP responsiveness.In summary,DDR2 is an important modulator of BMP signaling and a potential therapeutic target both for enhancing regeneration and treating HO.
文摘Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and noradrenaline.The neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal system.Cholecystokinin(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target regions.For instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety regulation.Conversely,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.
基金supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL)5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL)the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。
文摘Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.
基金supported by the National Natural Science Foundation of China(Grant Nos.U23A20375 and 62075151)the National Key Research and Development Program of China(Grant No.202103021223042).
文摘The principle of optical time-domain reflection localization limits the sensing spatial resolution of Raman distributed optical fiber sensing.We provide a solution for a Raman distributed optical fiber sensing system with kilometer-level sensing distance and submeter spatial resolution.Based on this,we propose a Raman distributed optical fiber sensing scheme based on chaotic pulse cluster demodulation.Chaotic pulse clusters are used as the probe signal,in preference to conventional pulsed or chaotic single-pulse lasers.Furthermore,the accurate positioning of the temperature variety region along the sensing fiber can be realized using chaotic pulse clusters.The proposed demodulation scheme can enhance the signal-to-noise ratio by improving the correlation between the chaotic reference and the chaotic Raman anti-Stokes scattering signals.The experiment achieved a sensing spatial resolution of 30 cm at a distributed temperature-sensing distance of∼6.0 km.Furthermore,we explored the influence of chaotic pulse width and detector bandwidth on the sensing spatial resolution.In addition,the theoretical experiments proved that the sensing spatial resolution in the proposed scheme was independent of the pulse width and sensing distance.
基金supported by the National Natural Science Foundation of China (Grant Nos. 61925505 and 62405070)"Pioneer" and "Leading Goose" R&D Program of Zhejiang Province (Grant No. 2024C01112)National Key Research and Development Program of China (Grant No. 2023YFB2807100)。
文摘As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are increasingly recognized as core requirements for next-generation intelligent computing center designs^([1, 2]). For short-range optical interconnections of intra-chip and inter-chip—typically covering tens of meters or less—microring resonant modulators (MRM) are emerging as an ideal solution.
基金supported by grants from the Key-Area Research and Development Program of Guangdong province(2019B030335001)the National Natural Science Foundation of China(32200815)the China Postdoctoral Science Foundation(2022M721218).
文摘Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of sensory stimuli,and it is this valence that serves as the foundational motivation for our subsequent actions.Simply put,all motivational actions fall into two categories:pleasure-seeking behavior guided by positive emotional valence,and pain-avoiding behavior driven by negative emotional valence[1].The ability to shift from one emotional valence to another is an important characteristic of affective states,while the instability of emotional states underlies many psychiatric disorders,highlighting the clinical importance of managing and understanding these fluctuations.This ability to adapt emotional responses can be attained by modulating the gain across distinct neural pathways,thus enabling the nuanced and smooth assignment of valence through the strengthening or weakening of circuit activity[1,2].
文摘With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most important component of high-precision ADC,is widely used in high-quality audio,high-precision instrument measurement,and other fields due to its advantages of high precision,strong noise resistance,and low hardware cost.This article designs a discrete structure third-order four-bit high-precision Sigma-Delta modulator through modeling,with an oversampling rate set to 512.Under ideal conditions,the simulation results show that the SDNR reaches 152.7db and the ENOB is 25.24bits.After introducing non-ideal noise,the system performance has decreased.The simulation results show that the SDNR is as high as 124.5db and the ENOB is 20.39bits.This indicates that the design can achieve high-precision conversion and provide assistance for further research in the future.
基金supported by the Science and Technology Commission of Shanghai Municipality (Grant No.24DP2600202)the National Key R&D Program of China (Grant No.2024YFB4504002)+2 种基金Industrial Technology Development Research Program of Shanghai Institute of Optics and Fine Mechanicsthe National Natural Science Foundation of China (Grant No.92165107)the China Postdoctoral Science Foundation (Grant Nos.2024M753359 for S.J.and2022M723270 for X.W.)。
文摘Recently, the rapid progress of quantum sensing research reveals that Rydberg atoms have great potential in becoming high-precision centimeter-scale antennas for low-frequency fields. In order to facilitate efficient and reliable detection of low-frequency fields via Rydberg atoms, we designed and implemented a heterodyne method based on the linear response to external signals under the condition of Rydberg electromagnetically induced transparency(EIT). Instead of relying on observing changes in the absorption of light by Rydberg atoms, our method focuses on the phase modulation effect on the probe laser induced by low-frequency fields via the Rydberg EIT mechanism and utilizes a special demodulation process to accurately retrieve signals including both amplitude and phase. The general principles of our method apply to both electric and magnetic fields, and it is even possible to realize a combination of both functionalities in the same apparatus. In particular, we experimentally demonstrate the full cycle of operations with respect to both cases. In measuring low-frequency electric fields,we discover that the Rydberg dipole–dipole interaction among atoms induces a linear superposition of Rydberg states with different angular momentum, generating a first-order response corresponding to the signature of the linear Stark effect. As Rydberg atoms have excellent coupling strengths with electric fields, our results indicate that our method can hopefully achieve high-precision performance for practical tasks in the future.
基金Projects(51875584,51875585,51975590)supported by the National Natural Science Foundation of China。
文摘Femtosecond laser processing is an important machining method for micro-optical components such as Fresnel zone plate(FZP).However,the low processing efficiency of the femtosecond laser restricts its application.Here,a femtosecond laser Bessel beam is proposed to process micro-FZP,which is modulated from a Gaussian beam to a Bessel annular beam.The processing time for FZP with an outer diameter of 60μm is reduced from 30 min to 1.5 min on an important semiconductor material gallium arsenide(GaAs),which significantly improves the processing efficiency.In the modulation process,a central ablation hole that has an adverse effect on the diffraction performance is produced,and the adverse effect is eliminated by superimposing the blazed grating hologram.Meanwhile,the FZP machined by spatial light modulator(SLM)has good morphology and higher diffraction efficiency,which provides a strong guarantee for the application of micro-FZP in computed tomography and solar photovoltaic cells.
文摘Objectives:The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery,particularly in cancer therapy.This study aimed to evaluate the cytotoxicity,apoptosis induction,and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus,Phragmites communis,and Pinus densiflora,as well as their combined extract(GMAS 01/COM),on human lung cancer cells(A549)and normal cell lines,including murine macrophages(RAW 264.7)and human keratinocytes(HaCaT).Methods:Plant extracts were prepared using aqueous extraction,sonication,and rotary evaporation.The total phenolic and flavonoid contents were quantified using the Folin-Ciocalteu and AlCl3 colorimetric methods,respectively.Antioxidant potential was evaluated via 2,2-Diphenyl-1-picrylhydrazyl(DPPH)scavenging and reducing power assays.Cytotoxicity was assessed using an MTT assay,while reactive oxygen species(ROS)generation was quantified using a 2′,7′-Dichlorodihydrofluorescein diacetate(DCFH-DA)assay.Anticancer properties,including colony formation inhibition and migration suppression,were examined using colony formation and wound healing assays.The expression of apoptotic and inflammatory mediators was analysed through qPCR.Results:GMAS 01 selectively induced apoptosis in A549 cells without cytotoxic effects on RAW264.7 and HaCaT cells.Mechanistically,it elevated intracellular ROS and activated the intrinsic mitochondrial apoptotic pathway,evidenced by p53 upregulation,increased Bax,and decreased Bcl-2 expression.GMAS 01 also significantly inhibited colony formation and migration in A549 cells.In RAW264.7 cells,it reduced nitric oxide(NO)production and downregulated iNOS,COX-2,IL-6,and IL-8,indicating strong immunomodulatory activity.Conclusion:GMAS 01 exhibits potent antioxidant,anti-inflammatory,and anticancer effects,likely mediated through ROS-induced mitochondrial apoptosis.However,mechanistic interpretations are limited by the absence of protein-level validation and pathway inhibition studies.Upcoming studies should aim to verify the underlying mechanisms and evaluate their potential for real-world application.
文摘In this paper,we present a novel first-order digitalΣΔconverter tailored for digital-to-analog applications,focusing on achieving both high yield and reduced silicon estate.Our approach incorporates a substantial level of dithering noise into the input signal,strategically aimed at mitigating the spurious frequencies commonly encountered in such converters.Validation of our design is performed through simulations using a high-level simulator specialized in mixed-signal circuit analysis.The results underscore the enhanced performance of our circuit,especially in reducing spurious frequencies,highlighting its efficiency and effectiveness.The final circuit exhibits an effective number of bits of 13.
文摘Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition.
