AIM:To assess the effect of human leukocyte antigen(HLA) mismatching on liver graft outcome and acute rejection from a meta-analysis of available cohort studies.METHODS:Articles in PubMed/MEDLINE,EMBASE and the Cochra...AIM:To assess the effect of human leukocyte antigen(HLA) mismatching on liver graft outcome and acute rejection from a meta-analysis of available cohort studies.METHODS:Articles in PubMed/MEDLINE,EMBASE and the Cochrane database from January 1970 to June 2009,including non-English literature identified in these databases,were searched.Only studies comparing HLA or sub-phenotype matching with mismatching were extracted.The percentage of graft survival was extracted by "Engauge Digitizer" from survival curves if the raw data were not displayed.A meta-analysis was performed when at least 3 studies provided data.RESULTS:Sixteen studies met the inclusion criteria.A lower number of HLA mismatches(0-2 vs 3-6) did reduce the incidence of acute rejection(relative risk:0.77,P = 0.03).The degree of HLA mismatching(0-2 vs 3-6) had no significant effect on 1-year [hazard ratio(HR):1.04,P = 0.68] and 5-year(HR:1.09,P = 0.38) graft survival.In sub-phenotype analysis,the degree of HLA-A,B and DR mismatching(0 vs 1-2) had no significant effect on 1-year and 5-year graft survival,either.The HRs and P-values were 0.95,0.71(HLA-A,1-year);1.06,0.60(HLA-A,5-year);0.77,0.16(HLA-B,1-year);1.07,0.56(HLA-DR,1-year);1.18,0.23(HLADR,5-year),respectively.CONCLUSION:The results of this systematic review imply that good HLA compatibility can reduce the incidence of acute rejection in spite of having no influence on graft outcomes.To obtain a short recovery time and minimize rejection post transplantation,HLA matching studies should be considered before the operation.展开更多
A linear matrix inequality （LMI）-based sliding surface design method for integral sliding mode control of uncertain time- delay systems with mismatching uncertainties is proposed. The uncertain time-delay system und...A linear matrix inequality （LMI）-based sliding surface design method for integral sliding mode control of uncertain time- delay systems with mismatching uncertainties is proposed. The uncertain time-delay system under consideration may have mis- matching norm bounded uncertainties in the state matrix as well as the input matrix, A sufficient condition for the existence of a sliding surface is given to guarantee asymptotic stability of the full order slJdJng mode dynamics. An LMI characterization of the slid- ing surface is given, together with an integral sliding mode control law guaranteeing the existence of a sliding mode from the initial time. Finally, a simulation is given to show the effectiveness of the proposed method.展开更多
After a brief recall of the Sidelobe Canceler (SLC) working principle, including the derivation of a general formula for the Cancellation Ratio (CR), the effects of channel mismatching are investigated. In particular,...After a brief recall of the Sidelobe Canceler (SLC) working principle, including the derivation of a general formula for the Cancellation Ratio (CR), the effects of channel mismatching are investigated. In particular, curves providing CRvalues as a function of amplitude and phase channel mismatching, radar bandwidth, and jammer direction of arrival (JDOA) are provided for the cases of one and two auxiliary antennas. Subsequently, a time -space processor for performance restoration is analyzed in detail. In addition to the above mentioned quantities, the attainable CR value is expressed as a function of the space-time processor parameters. The contribution of the paper is related to the derivation of a number of mathematical equations of CR for several cases of practical interest for the radar engineer. In addition, several curves are presented to assist design of SLC systems.展开更多
This paper attempts at an in-depth exploration of lexical mismatching, a pattern of vocabulary errors. In this paper, errors per se were collected from 107 writing samples of Chinese college students, and then investi...This paper attempts at an in-depth exploration of lexical mismatching, a pattern of vocabulary errors. In this paper, errors per se were collected from 107 writing samples of Chinese college students, and then investigated from a variety of linguistic perspectives. Traditional theoretical approaches, i.e. CA and EA, are incorporated in the source analysis for a more comprehensive interpretation. Hopefully, the findings of the study will shed lights on lexical instruction and acquisition in the field of SLA.展开更多
The grid-connected or standalone PV central inverter architecture is comprised of several PV modules which are connected in different ways to form the PV array.The power generation capability of the PV array is primar...The grid-connected or standalone PV central inverter architecture is comprised of several PV modules which are connected in different ways to form the PV array.The power generation capability of the PV array is primarily affected by partial shading conditions(PSC).Due to PSCs,the power output of the PV array is dramatically reduced,and mismatching losses are induced in the PV modules.Based on the extent of these problems,multiple peaks also appear in the power-voltage(P-V)curve,which makes it very difficult to track the global maximum power point(GMPP).The main objective of this research paper is to model and simulate the series(S),series-parallel(SP),bridge-link(BL),honey-comb(HC),total-cross-tied(TCT)and proposed triple-tied(TT)solar PV array configurations under various partial shading scenarios.The performance of all PV configurations is evaluated under a uniform approach,considering eight different shading scenarios.The performance of the considered PV configurations is analyzed in terms of their mismatching power losses,fill factors,efficiency,global maximum power points(GMPPs),local maximum power points(LMPPs),voltages and currents at GMPPs,open circuit voltage and short circuit currents.The above-mentioned PV configurations are modeled and simulated in a Matlab/Simulink environment by considering the KC-200GT module parameters.展开更多
Several results on optical-axis perturbation and elimination of the mismatching error C of a monolithic triaxial ring resonator （MTRR） are reported. Based on the augmented 5×5 ray matrix method, by simultaneous...Several results on optical-axis perturbation and elimination of the mismatching error C of a monolithic triaxial ring resonator （MTRR） are reported. Based on the augmented 5×5 ray matrix method, by simultaneously considering axial displacement of a mirror and the misalignments in three planar square ring resonators of a MTRR, the rules of optical-axis perturbation are obtained. The mismatching error C of the MTRR is eliminated. The results obtained are important for cavity design, as well as in the improvement and alignment of MTRR.展开更多
High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relati...High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relatively good prognosis,advanced cases often respond poorly to standard chemotherapy.Immune checkpoint inhibitors,such as pembrolizumab,have shown strong and lasting effects in MSI-H CRC.Pembrolizumab is now approved as a first-line treatment for metastatic MSI-H CRC due to its superior outcomes compared to traditional chemotherapy.CASE SUMMARY A 44-year-old male with MSI-H transverse colon cancer presented with hematochezia,abdominal pain,and significant weight loss.Imaging revealed a bulky tumor with invasion of adjacent structures and multiple liver lesions.A diverting ileostomy was performed followed by 36 cycles of pembrolizumab.The patient achieved a clinical and radiologic complete response.One month after completing the treatment,the patient underwent laparoscopic right hemicolectomy.A spontaneous transection of the colon at the original tumor site was unexpectedly identified.Final pathology confirmed pathological complete response(ypT0N0)with fibrosis.The patient recovered well after surgery,and follow-up showed no evidence of recurrence.CONCLUSION Immune checkpoint inhibitors may cause delayed structural damage to bowel tissue even after apparent complete tumor regression.展开更多
BACKGROUND Immunotherapy is an approved treatment for metastatic rectal cancer in patients with defective mismatch repair(MMR).AIM To examine the clinical efficacy of neoadjuvant immunotherapy combined with radiothera...BACKGROUND Immunotherapy is an approved treatment for metastatic rectal cancer in patients with defective mismatch repair(MMR).AIM To examine the clinical efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for the treatment of locally advanced rectal cancer(LARC),with a focus on patients with proficient MMR(pMMR)and mic-rosatellite stability.METHODS Two researchers searched multiple databases for publications up to September 2024.All included publications examined neoadjuvant immunotherapy for LARC,and reported major pathological response(MPR),pathological complete response(pCR),clinical complete response(CCR),and rates of R0 resection and anus-pre-serving surgery.Meta-analysis,subgroup analysis,sensitivity analysis,and ana-lysis of publication bias were performed.RESULTS We included 15 publications(796 patients).The MPR,pCR,and CCR were sig-nificantly better in the group that received immunotherapy(all P<0.05),espe-cially for patients with pMMR.In addition,the rate of R0 resection and anus-preserving surgery were also significantly greater in the group that received neoadjuvant immunotherapy(both P<0.05).Hematological toxicity and abnormal liver function were the most common clinical adverse events above grade 3.Most patients successfully completed the immunotherapy treatment.The incidence of immune-related adverse reactions was 0%-13.5%,and the severities of these events were generally considered acceptable.CONCLUSION The addition of neoadjuvant immunotherapy improved the clinical remission rate of patients who had LARC with pMMR,and the treatment-related adverse reactions were generally acceptable.Neoadjuvant immunotherapy combined with radiotherapy and chemotherapy should be considered for patients with LARC.展开更多
BACKGROUND Endoscopy allows for the direct observation of primary tumor characteristics and responses after neoadjuvant treatment.However,reports on endoscopic evaluation following neoadjuvant immunotherapy remain lim...BACKGROUND Endoscopy allows for the direct observation of primary tumor characteristics and responses after neoadjuvant treatment.However,reports on endoscopic evaluation following neoadjuvant immunotherapy remain limited.AIM To examine the predictive value of endoscopic findings of primary tumors for responses to neoadjuvant immunotherapy.METHODS This retrospective study,conducted at a tertiary center in China,evaluated 74 patients with colorectal cancer,including 17 with deficient mismatch repair(dMMR)and 15 with proficient mismatch repair(pMMR)tumors.Patients underwent neoadjuvant immunotherapy followed by surgery.Endoscopic findings before and after neoadjuvant immunotherapy were reviewed and compared with the pathology of the resected specimens.RESULTS In the pMMR group(n=57 evaluable patients),endoscopy identified 11/17 patients who achieved a complete response(CR),while misidentifying 1/40 patients with residual disease as CR(64.7%vs 2.5%,P<0.01).Conversely,22/40 patients with residual disease were accurately identified as achieving a partial response(PR),with 1/17 patients who achieved CR misclassified as PR(55.0%vs 5.9%,P<0.01).The sensitivity,specificity,and accuracy of endoscopic diagnosis for pathological CR were 64.7%,97.5%,and 87.7%,respectively.In the dMMR cohort,endoscopy classified 9/17 patients as CR and 2 of the remaining patients with residual tumors as PR(64.3%vs 66.7%,P=0.73).The method demonstrated 100%sensitivity and 82.4%accuracy in diagnosing pathological CR.CONCLUSION Endoscopic evidence of CR or PR was well correlated with postoperative pathological outcomes in the pMMR cohort.Despite endoscopic indications of tumor residue,a complete pathological response post-surgery was possible in the dMMR cohort.展开更多
BACKGROUND Hereditary factors are more prevalent in early-onset colorectal cancers(EOCRC)etiology.Lynch syndrome(LS)is the most common hereditary colorectal cancer(CRC)syndrome that results from mutations in DNA misma...BACKGROUND Hereditary factors are more prevalent in early-onset colorectal cancers(EOCRC)etiology.Lynch syndrome(LS)is the most common hereditary colorectal cancer(CRC)syndrome that results from mutations in DNA mismatch repair(MMR)genes.This phenomenon is defined as microsatellite instability(MSI).Immunohistochemistry(IHC)is a widely used,practical,and cost-effective method for the screening of MSI.However,using IHC alone may be insufficient to identify patients with MSI and LS.AIM To determine the clinicopathological features in EOCRC,IHC performance,and the frequency of genetic testing for EOCRC patients.METHODS A retrospective review was conducted on patients with CRC aged≤50 years who underwent surgery at our center between January 2014 and July 2021.MMR proteins were screened using IHC.Of the 131 patients included,IHC was performed on 130.Patients were classified as MSI or microsatellite-stable(MSS),and their features were compared.Additionally,data from patients who received genetic counseling were analyzed.RESULTS Thirty patients with MSI were designated as group 1,whereas 100 with MSS were defined as group 2.The mean age in group 1 was the lowest(median age:42 vs 46,P<0.05).Group 1 exhibited a higher frequency of tumors in the right colon and a lower frequency in the rectum.Lymph node involvement and distant metastases were less common in group 1,and in group 2,tumors were generally diagnosed at a more advanced stage.Genetic testing was performed in 53 patients(40%),with a definitive LS diagnosis established in 13/17 patients(76.4%)in group 1 and 1/36(2.7%)patients in group 2,resulting in a total of 14 patients(26.4%)with confirmed LS.CONCLUSION MSI tumors show a better prognosis.IHC is very effective for screening MSI,but may not be sufficient alone.Low genetic counseling rates highlight the need for hospital-based surveillance programs.展开更多
Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with h...Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with higher rates of Kirsten rat sarcoma viral oncogene homolog and v-raf murine sarcoma viral oncogene homolog B1 mutations and deficient mismatch repair,leading to microsatellite instability-high status.Left-sided CC typically presents in younger individuals,demonstrates a more favorable prognosis,and is often Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 wild-type,making it more responsive to antiepidermal growth factor receptor therapy.RCC typically responds poorly to antiepidermal growth factor receptor agents;however,it may benefit from triplet chemotherapy(5-fluorouracil+leucovorin+oxaliplatin+irinotecan)with or without anti-angiogenic agents.Comprehensive molecular profiling remains challenging in low-resource settings due to limited access to advanced diagnostic tools.This review explores key epidemiological and molecular differences between RCC and left-sided CC.In the absence of complete genomic data,tumor sidedness can be a helpful guide for making treatment decisions.Here,we propose a practical algorithm that integrates basic immunohistochemistry to assess a tumor’s mismatch repair status and laterality,potentially facilitating therapy selection in resource-constrained environments.Recognizing laterality-specific trends in prognosis and treatment response can improve personalized care and outcomes for patients with CC in these environments,highlighting the essential role of cost-effective biomarker strategies.展开更多
Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications.These two measurements are always done simultaneously in wearable sweat se...Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications.These two measurements are always done simultaneously in wearable sweat sensing platforms.However,concentration measurements of biomarkers are always delayed on the timeline compared with their production,whereas there is no such delay for sweating rate.Thus,a timeline mismatch exists between these two measurements.This means that the concentration vs rate correlation constructed on the basis of such measurements will deviate from the actual correlation.This study demonstrates the existence of this mismatch and explains its cause using sweat Na^(+)measurements.It also proposes an effective approach that applies a point-by-point compensation for the delay between Na+measurements and the real-time sweating rates,such that the data on the repositioned concentration vs time curve correspond to exactly the same point on the timeline as their production.A vison sensor is developed to measure the sweating rate with high accuracy at a frequency of more than 0.1 Hz.Off-body and on-body measurements of sweating rate and Na^(+)concentration are carried out,and concentration–rate correlations are constructed using both measured and repositioned concentration curves.The least squares and random forest methods are employed to fit the constructed correlations and evaluate the reliability of the proposed approach.The use of the repositioned concentration curve gives a constructed correlation that is much closer to the actual one.This study indicates the necessity to rearrange sensor-measured biomarker concentration vs time curves when correlations of concentration with sweating rate need to be constructed and proposes a practical point-by-point data repositioning strategy for doing so.The results presented here will benefit the study of sweat biomarkers with unclear correlations with sweating rate,as well as providing a basis for the development of more reliable sweat-based diagnostic methods.展开更多
Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining s...Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining samples do not correspond one-to-one correctly.Mismatched datasets caused by missing samples make the industrial data unavailable for further machine learning.In order to align the mismatched samples,this article presents a cooperative iteration matching method(CIMM)based on the modified dynamic time warping(DTW).The proposed method regards the sequentially accumulated industrial data as the time series.Mismatched samples are aligned by the DTW.In addition,dynamic constraints are applied to the warping distance of the DTW process to make the alignment more efficient.Then a series of models are trained with the cumulated samples iteratively.Several groups of numerical experiments on different missing patterns and missing locations are designed and analyzed to prove the effectiveness and the applicability of the proposed method.展开更多
BACKGROUND Mismatch repair deficient/microsatellite instability-high(MMR-D/MSI-H)colorectal cancers(CRCs)possess a distinctive genomic profile that results in a spectrum of phenotypic attributes setting them apart fro...BACKGROUND Mismatch repair deficient/microsatellite instability-high(MMR-D/MSI-H)colorectal cancers(CRCs)possess a distinctive genomic profile that results in a spectrum of phenotypic attributes setting them apart from their mismatch repair proficient(MMR-P)or microsatellite stable(MSS)counterparts.CRCs have several prognostic factors,including stage,tumor differentiation,location,lymphovascular and perineural invasion,tumor budding,tumor infiltrating lymphocytes,lymph node yield(LNY),and lymph node ratio(LNR).AIM To determine the unique phenotypic characteristics of MMR-D/MSI-H CRCs and leverage the conventional wisdom of LNY and LNR with the distinctive characteristics of MMR-D/MSI-H CRCs.METHODS This retrospective analysis involved 223 stage I-III CRC patients who underwent surgical resection without neoadjuvant treatment.Clinical and histological features were obtained from patient records and by re-examining the hematoxylin and eosin-stained slides.MMR/MSI status was evaluated for all patients using either MMR immunohistochemistry or MSI testing.RESULTS Of the 223 patients in our study,87(39.01%)were MMR-D/MSI-H CRCs while 136(60.99%)were MMR-P/MSS CRCs.The MMR-D/MSI-H CRCs exhibited significant statistical differences compared to the MMR-P/MSS CRCs in several factors,including location,stage,tumor budding,lymphovascular and perineural invasion,lymphocytic response,LNY,LNR,and size of uninvolved lymph nodes.LNY and LNR were significantly higher in MMR-D/MSI-H group compared with the MMR-P/MSS group(P=0.003 and P<0.001,respectively).Also,the interquartile range of the largest uninvolved lymph node was 1 cm(0.8 cm-1.2 cm)in MMR-D/MSI-H CRCs compared to 0.7 cm(0.6 cm-0.97 cm)in MMRP/MSS CRCs.The overall survival for the MMR-P/MSS CRC group was 71%at five years,and the MMR-D/MSIH CRC group was 92%at five years(P<0.001).CONCLUSION MMR-D/MSI-H CRCs possess a unique genomic profile that leads to distinct phenotypic characteristics,including an enhanced immune response.This distinctive profile underscores the substantial prognostic and predictive value of MMR-D/MSI-H status in CRC.展开更多
A partly clumped-particles combined with joint planes model was developed to simulate the microstructure of quartz mica schist.It considers grain-scale heterogeneity including microgeometry heterogeneity and grain-sca...A partly clumped-particles combined with joint planes model was developed to simulate the microstructure of quartz mica schist.It considers grain-scale heterogeneity including microgeometry heterogeneity and grain-scale elastic heterogeneity.Clumped-particles with larger volume and larger stiffness were used to represent stiff minerals such as quartz,the rest of unclumped particles with smaller stiffness were used to represent soft minerals such as mica.The joint planes,which have smaller stiffness and strength than mica,were used to describe schist.The extensive sensitivity studies have shown that the clump’s radius,clump’s content and joint plane’s strength affect the microscopic and macroscopic behaviors of sample.For DanBa quartz mica schist,the model calibrated uniaxial tests and well matched with the stress-strain curves,crack initiation stress and crack damage stress of laboratory test.展开更多
Gastric cancer(GC)remains a major global health challenge,because of its poor prognosis and limited treatment options in advanced stages1,2.Recent advancements in immunotherapy,highlighted by the findings of the CHECK...Gastric cancer(GC)remains a major global health challenge,because of its poor prognosis and limited treatment options in advanced stages1,2.Recent advancements in immunotherapy,highlighted by the findings of the CHECKMATE-649,ORIENT-16,and KEYNOTE-859 trials,have markedly transformed the treatment paradigm for advanced gastric cancer(AGC)3-5.展开更多
BACKGROUND Colorectal cancer is one of the malignant tumors with a high incidence and mortality rate globally,and the occurrence of liver metastasis significantly affects patient survival prognosis.In recent years,the...BACKGROUND Colorectal cancer is one of the malignant tumors with a high incidence and mortality rate globally,and the occurrence of liver metastasis significantly affects patient survival prognosis.In recent years,the application of immune checkpoint inhibitors(ICIs)in cancer treatment has made important progress,especially showing good therapeutic effects in patients with high microsatellite instability or mismatch repair deficiency.However,for the majority of patients with microsatellite stable(MSS)or proficient mismatch repair(pMMR)colorectal cancer,the efficacy of ICIs is limited,prompting researchers to explore combination therapy strategies to improve efficacy.Targeted drugs such as tyrosine kinase inhibitors(TKIs)and radiotherapy are believed to work synergistically with ICIs by modifying the tumor microenvironment and enhancing antigen presentation.AIM To investigate the efficacy and safety of the combination therapy of radiotherapy,ICIs,and TKIs in patients with MSS or pMMR colorectal cancer liver metastasis(CCLM),in order to provide new clinical treatment references.METHODS A retrospective analysis was conducted on the clinical data of 43 MSS or pMMR CCLM patients treated at our hospital from September 2021 to July 2024.Based on the treatment interventions received,the patients were divided into a control group(n=21,receiving ICIs and TKIs combination therapy)and an observation group(n=22,receiving radiotherapy,ICIs,and TKIs triple therapy).The therapeutic effects,serum tumor markers(carcinoembryonic antigen and RESULTS The disease control rate in the observation group(63.64%)was significantly higher than that of the control group(23.81%)(P<0.05)).Both groups showed a decrease in carcinoembryonic antigen and carbohydrate antigen 199 levels post-treatment,with the observation group demonstrating a more significant change(P<0.05).The median progression-free survival and median overall survival in the control group were 5.1 months and 7.6 months,respectively,while the observation group had a median progression-free survival and overall survival of 4.3 months and 6.9 months,respectively.The control group had longer survival times than the observation group,but the differences were not statistically significant(P>0.05).The incidence of adverse reactions,including nausea and vomiting,gastrointestinal reactions,skin reactions,bone marrow suppression,liver and kidney function impairment,neurotoxicity,leukopenia,neutropenia,and thrombocytopenia,showed no significant differences between the two groups(P>0.05).CONCLUSION Compared to the ICIs and TKIs combination therapy,the radiotherapy,ICIs,and TKIs triple therapy can further improve the disease control rate and serum tumor marker levels in MSS or pMMR CCLM patients without increasing the risk of related adverse reactions,making it a treatment regimen worthy of further validation.展开更多
Spatiotemporal optical vortices(STOVs)have attracted significant attention for their unique properties.Recently,the second harmonic generation(SHG)of STOV pulses has been experimentally demonstrated,but the phase sing...Spatiotemporal optical vortices(STOVs)have attracted significant attention for their unique properties.Recently,the second harmonic generation(SHG)of STOV pulses has been experimentally demonstrated,but the phase singularity dynamics during this process remain elusive.Here,we theoretically investigate the separation and tilting of the phase singularities in STOVs during the SHG.Using the nonlinear Maxwell equation,we show that singularity separation is governed by group velocity mismatch,with accurate predictions provided by a Simpson-type integral under weak spatiotemporal walk-off conditions.In addition,paraxial wave equation analysis reveals that propagation induces singularity tilting,driven by spatial phase shifts.Our results not only offer deeper insights into the spatiotemporal coupling induced by complex nonlinear interactions but also reveal the underlying physical mechanisms in frequency up-conversion of space–time light pulses.展开更多
The surface wrinkled structures of materials endow them with various properties,such as hydrophilicity/hydrophobicity,adhesion,large specific surface area,etc.,which have been applied in self-cleaning surfaces,strong ...The surface wrinkled structures of materials endow them with various properties,such as hydrophilicity/hydrophobicity,adhesion,large specific surface area,etc.,which have been applied in self-cleaning surfaces,strong adhesives,ultra-sensitive sensors,etc.However,traditional wrinkled surfaces with single wrinkled structures cannot meet the demand for intelligent regulation,making the widespread application rather challenging.Recently,stimuli-responsive wrinkled surfaces,which are capable of reversibly regulating wrinkled structures(amplitude,period,etc.),have been developed to broaden their applications.Here,an overview of stimuli-responsive wrinkled surfaces is provided.First,the mechanism and design principle of surface wrinkled structures based on film/substrate bilayer systems are comprehensively analyzed.Subsequently,the latest advancements in the preparation and application of stimuli-responsive wrinkled surfaces are presented from the perspective of types of external stimuli(light,temperature,pH,humidity,solvent,and strain).Finally,the current challenges and future prospects of the stimuli-responsive wrinkled surfaces are illustrated.This review provides some insights and valuable references for the rational design of stimuli-responsive wrinkled surfaces.展开更多
文摘AIM:To assess the effect of human leukocyte antigen(HLA) mismatching on liver graft outcome and acute rejection from a meta-analysis of available cohort studies.METHODS:Articles in PubMed/MEDLINE,EMBASE and the Cochrane database from January 1970 to June 2009,including non-English literature identified in these databases,were searched.Only studies comparing HLA or sub-phenotype matching with mismatching were extracted.The percentage of graft survival was extracted by "Engauge Digitizer" from survival curves if the raw data were not displayed.A meta-analysis was performed when at least 3 studies provided data.RESULTS:Sixteen studies met the inclusion criteria.A lower number of HLA mismatches(0-2 vs 3-6) did reduce the incidence of acute rejection(relative risk:0.77,P = 0.03).The degree of HLA mismatching(0-2 vs 3-6) had no significant effect on 1-year [hazard ratio(HR):1.04,P = 0.68] and 5-year(HR:1.09,P = 0.38) graft survival.In sub-phenotype analysis,the degree of HLA-A,B and DR mismatching(0 vs 1-2) had no significant effect on 1-year and 5-year graft survival,either.The HRs and P-values were 0.95,0.71(HLA-A,1-year);1.06,0.60(HLA-A,5-year);0.77,0.16(HLA-B,1-year);1.07,0.56(HLA-DR,1-year);1.18,0.23(HLADR,5-year),respectively.CONCLUSION:The results of this systematic review imply that good HLA compatibility can reduce the incidence of acute rejection in spite of having no influence on graft outcomes.To obtain a short recovery time and minimize rejection post transplantation,HLA matching studies should be considered before the operation.
基金supported in part by the National Basic Research Program of China(973 Program)(61334)
文摘A linear matrix inequality （LMI）-based sliding surface design method for integral sliding mode control of uncertain time- delay systems with mismatching uncertainties is proposed. The uncertain time-delay system under consideration may have mis- matching norm bounded uncertainties in the state matrix as well as the input matrix, A sufficient condition for the existence of a sliding surface is given to guarantee asymptotic stability of the full order slJdJng mode dynamics. An LMI characterization of the slid- ing surface is given, together with an integral sliding mode control law guaranteeing the existence of a sliding mode from the initial time. Finally, a simulation is given to show the effectiveness of the proposed method.
文摘After a brief recall of the Sidelobe Canceler (SLC) working principle, including the derivation of a general formula for the Cancellation Ratio (CR), the effects of channel mismatching are investigated. In particular, curves providing CRvalues as a function of amplitude and phase channel mismatching, radar bandwidth, and jammer direction of arrival (JDOA) are provided for the cases of one and two auxiliary antennas. Subsequently, a time -space processor for performance restoration is analyzed in detail. In addition to the above mentioned quantities, the attainable CR value is expressed as a function of the space-time processor parameters. The contribution of the paper is related to the derivation of a number of mathematical equations of CR for several cases of practical interest for the radar engineer. In addition, several curves are presented to assist design of SLC systems.
文摘This paper attempts at an in-depth exploration of lexical mismatching, a pattern of vocabulary errors. In this paper, errors per se were collected from 107 writing samples of Chinese college students, and then investigated from a variety of linguistic perspectives. Traditional theoretical approaches, i.e. CA and EA, are incorporated in the source analysis for a more comprehensive interpretation. Hopefully, the findings of the study will shed lights on lexical instruction and acquisition in the field of SLA.
基金This work was supported by the Science and Engineering Research Board(SERB),Department of Science and Technology,Government of India under the Grant No:ECR/2017/000316。
文摘The grid-connected or standalone PV central inverter architecture is comprised of several PV modules which are connected in different ways to form the PV array.The power generation capability of the PV array is primarily affected by partial shading conditions(PSC).Due to PSCs,the power output of the PV array is dramatically reduced,and mismatching losses are induced in the PV modules.Based on the extent of these problems,multiple peaks also appear in the power-voltage(P-V)curve,which makes it very difficult to track the global maximum power point(GMPP).The main objective of this research paper is to model and simulate the series(S),series-parallel(SP),bridge-link(BL),honey-comb(HC),total-cross-tied(TCT)and proposed triple-tied(TT)solar PV array configurations under various partial shading scenarios.The performance of all PV configurations is evaluated under a uniform approach,considering eight different shading scenarios.The performance of the considered PV configurations is analyzed in terms of their mismatching power losses,fill factors,efficiency,global maximum power points(GMPPs),local maximum power points(LMPPs),voltages and currents at GMPPs,open circuit voltage and short circuit currents.The above-mentioned PV configurations are modeled and simulated in a Matlab/Simulink environment by considering the KC-200GT module parameters.
基金supported by the National Natural Science Foundation of China under Grant Nos.60608002and 60608002
文摘Several results on optical-axis perturbation and elimination of the mismatching error C of a monolithic triaxial ring resonator （MTRR） are reported. Based on the augmented 5×5 ray matrix method, by simultaneously considering axial displacement of a mirror and the misalignments in three planar square ring resonators of a MTRR, the rules of optical-axis perturbation are obtained. The mismatching error C of the MTRR is eliminated. The results obtained are important for cavity design, as well as in the improvement and alignment of MTRR.
文摘High microsatellite instability(MSI-H)colorectal cancer(CRC),caused by deficient mismatch repair,accounts for about 15%of all CRC cases and is more common in right-sided tumors.While early-stage MSI-H CRC has a relatively good prognosis,advanced cases often respond poorly to standard chemotherapy.Immune checkpoint inhibitors,such as pembrolizumab,have shown strong and lasting effects in MSI-H CRC.Pembrolizumab is now approved as a first-line treatment for metastatic MSI-H CRC due to its superior outcomes compared to traditional chemotherapy.CASE SUMMARY A 44-year-old male with MSI-H transverse colon cancer presented with hematochezia,abdominal pain,and significant weight loss.Imaging revealed a bulky tumor with invasion of adjacent structures and multiple liver lesions.A diverting ileostomy was performed followed by 36 cycles of pembrolizumab.The patient achieved a clinical and radiologic complete response.One month after completing the treatment,the patient underwent laparoscopic right hemicolectomy.A spontaneous transection of the colon at the original tumor site was unexpectedly identified.Final pathology confirmed pathological complete response(ypT0N0)with fibrosis.The patient recovered well after surgery,and follow-up showed no evidence of recurrence.CONCLUSION Immune checkpoint inhibitors may cause delayed structural damage to bowel tissue even after apparent complete tumor regression.
基金Supported by Start-up Fund for Doctor's Scientific Research in Shanxi Cancer Hospital,No.Dr202314and Natural Exploration Category of Shanxi Basic Research Plan,No.202203021221284.
文摘BACKGROUND Immunotherapy is an approved treatment for metastatic rectal cancer in patients with defective mismatch repair(MMR).AIM To examine the clinical efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for the treatment of locally advanced rectal cancer(LARC),with a focus on patients with proficient MMR(pMMR)and mic-rosatellite stability.METHODS Two researchers searched multiple databases for publications up to September 2024.All included publications examined neoadjuvant immunotherapy for LARC,and reported major pathological response(MPR),pathological complete response(pCR),clinical complete response(CCR),and rates of R0 resection and anus-pre-serving surgery.Meta-analysis,subgroup analysis,sensitivity analysis,and ana-lysis of publication bias were performed.RESULTS We included 15 publications(796 patients).The MPR,pCR,and CCR were sig-nificantly better in the group that received immunotherapy(all P<0.05),espe-cially for patients with pMMR.In addition,the rate of R0 resection and anus-preserving surgery were also significantly greater in the group that received neoadjuvant immunotherapy(both P<0.05).Hematological toxicity and abnormal liver function were the most common clinical adverse events above grade 3.Most patients successfully completed the immunotherapy treatment.The incidence of immune-related adverse reactions was 0%-13.5%,and the severities of these events were generally considered acceptable.CONCLUSION The addition of neoadjuvant immunotherapy improved the clinical remission rate of patients who had LARC with pMMR,and the treatment-related adverse reactions were generally acceptable.Neoadjuvant immunotherapy combined with radiotherapy and chemotherapy should be considered for patients with LARC.
基金Supported by the National Natural Science Foundation of China,No.82072732.
文摘BACKGROUND Endoscopy allows for the direct observation of primary tumor characteristics and responses after neoadjuvant treatment.However,reports on endoscopic evaluation following neoadjuvant immunotherapy remain limited.AIM To examine the predictive value of endoscopic findings of primary tumors for responses to neoadjuvant immunotherapy.METHODS This retrospective study,conducted at a tertiary center in China,evaluated 74 patients with colorectal cancer,including 17 with deficient mismatch repair(dMMR)and 15 with proficient mismatch repair(pMMR)tumors.Patients underwent neoadjuvant immunotherapy followed by surgery.Endoscopic findings before and after neoadjuvant immunotherapy were reviewed and compared with the pathology of the resected specimens.RESULTS In the pMMR group(n=57 evaluable patients),endoscopy identified 11/17 patients who achieved a complete response(CR),while misidentifying 1/40 patients with residual disease as CR(64.7%vs 2.5%,P<0.01).Conversely,22/40 patients with residual disease were accurately identified as achieving a partial response(PR),with 1/17 patients who achieved CR misclassified as PR(55.0%vs 5.9%,P<0.01).The sensitivity,specificity,and accuracy of endoscopic diagnosis for pathological CR were 64.7%,97.5%,and 87.7%,respectively.In the dMMR cohort,endoscopy classified 9/17 patients as CR and 2 of the remaining patients with residual tumors as PR(64.3%vs 66.7%,P=0.73).The method demonstrated 100%sensitivity and 82.4%accuracy in diagnosing pathological CR.CONCLUSION Endoscopic evidence of CR or PR was well correlated with postoperative pathological outcomes in the pMMR cohort.Despite endoscopic indications of tumor residue,a complete pathological response post-surgery was possible in the dMMR cohort.
文摘BACKGROUND Hereditary factors are more prevalent in early-onset colorectal cancers(EOCRC)etiology.Lynch syndrome(LS)is the most common hereditary colorectal cancer(CRC)syndrome that results from mutations in DNA mismatch repair(MMR)genes.This phenomenon is defined as microsatellite instability(MSI).Immunohistochemistry(IHC)is a widely used,practical,and cost-effective method for the screening of MSI.However,using IHC alone may be insufficient to identify patients with MSI and LS.AIM To determine the clinicopathological features in EOCRC,IHC performance,and the frequency of genetic testing for EOCRC patients.METHODS A retrospective review was conducted on patients with CRC aged≤50 years who underwent surgery at our center between January 2014 and July 2021.MMR proteins were screened using IHC.Of the 131 patients included,IHC was performed on 130.Patients were classified as MSI or microsatellite-stable(MSS),and their features were compared.Additionally,data from patients who received genetic counseling were analyzed.RESULTS Thirty patients with MSI were designated as group 1,whereas 100 with MSS were defined as group 2.The mean age in group 1 was the lowest(median age:42 vs 46,P<0.05).Group 1 exhibited a higher frequency of tumors in the right colon and a lower frequency in the rectum.Lymph node involvement and distant metastases were less common in group 1,and in group 2,tumors were generally diagnosed at a more advanced stage.Genetic testing was performed in 53 patients(40%),with a definitive LS diagnosis established in 13/17 patients(76.4%)in group 1 and 1/36(2.7%)patients in group 2,resulting in a total of 14 patients(26.4%)with confirmed LS.CONCLUSION MSI tumors show a better prognosis.IHC is very effective for screening MSI,but may not be sufficient alone.Low genetic counseling rates highlight the need for hospital-based surveillance programs.
文摘Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with higher rates of Kirsten rat sarcoma viral oncogene homolog and v-raf murine sarcoma viral oncogene homolog B1 mutations and deficient mismatch repair,leading to microsatellite instability-high status.Left-sided CC typically presents in younger individuals,demonstrates a more favorable prognosis,and is often Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 wild-type,making it more responsive to antiepidermal growth factor receptor therapy.RCC typically responds poorly to antiepidermal growth factor receptor agents;however,it may benefit from triplet chemotherapy(5-fluorouracil+leucovorin+oxaliplatin+irinotecan)with or without anti-angiogenic agents.Comprehensive molecular profiling remains challenging in low-resource settings due to limited access to advanced diagnostic tools.This review explores key epidemiological and molecular differences between RCC and left-sided CC.In the absence of complete genomic data,tumor sidedness can be a helpful guide for making treatment decisions.Here,we propose a practical algorithm that integrates basic immunohistochemistry to assess a tumor’s mismatch repair status and laterality,potentially facilitating therapy selection in resource-constrained environments.Recognizing laterality-specific trends in prognosis and treatment response can improve personalized care and outcomes for patients with CC in these environments,highlighting the essential role of cost-effective biomarker strategies.
基金support from the National Natural Science Foundation of China(Grant No.61901295)the Nanchang Microsystem Institute of Tianjin University.
文摘Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications.These two measurements are always done simultaneously in wearable sweat sensing platforms.However,concentration measurements of biomarkers are always delayed on the timeline compared with their production,whereas there is no such delay for sweating rate.Thus,a timeline mismatch exists between these two measurements.This means that the concentration vs rate correlation constructed on the basis of such measurements will deviate from the actual correlation.This study demonstrates the existence of this mismatch and explains its cause using sweat Na^(+)measurements.It also proposes an effective approach that applies a point-by-point compensation for the delay between Na+measurements and the real-time sweating rates,such that the data on the repositioned concentration vs time curve correspond to exactly the same point on the timeline as their production.A vison sensor is developed to measure the sweating rate with high accuracy at a frequency of more than 0.1 Hz.Off-body and on-body measurements of sweating rate and Na^(+)concentration are carried out,and concentration–rate correlations are constructed using both measured and repositioned concentration curves.The least squares and random forest methods are employed to fit the constructed correlations and evaluate the reliability of the proposed approach.The use of the repositioned concentration curve gives a constructed correlation that is much closer to the actual one.This study indicates the necessity to rearrange sensor-measured biomarker concentration vs time curves when correlations of concentration with sweating rate need to be constructed and proposes a practical point-by-point data repositioning strategy for doing so.The results presented here will benefit the study of sweat biomarkers with unclear correlations with sweating rate,as well as providing a basis for the development of more reliable sweat-based diagnostic methods.
基金the Key National Natural Science Foundation of China(No.U1864211)the National Natural Science Foundation of China(No.11772191)the Natural Science Foundation of Shanghai(No.21ZR1431500)。
文摘Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining samples do not correspond one-to-one correctly.Mismatched datasets caused by missing samples make the industrial data unavailable for further machine learning.In order to align the mismatched samples,this article presents a cooperative iteration matching method(CIMM)based on the modified dynamic time warping(DTW).The proposed method regards the sequentially accumulated industrial data as the time series.Mismatched samples are aligned by the DTW.In addition,dynamic constraints are applied to the warping distance of the DTW process to make the alignment more efficient.Then a series of models are trained with the cumulated samples iteratively.Several groups of numerical experiments on different missing patterns and missing locations are designed and analyzed to prove the effectiveness and the applicability of the proposed method.
文摘BACKGROUND Mismatch repair deficient/microsatellite instability-high(MMR-D/MSI-H)colorectal cancers(CRCs)possess a distinctive genomic profile that results in a spectrum of phenotypic attributes setting them apart from their mismatch repair proficient(MMR-P)or microsatellite stable(MSS)counterparts.CRCs have several prognostic factors,including stage,tumor differentiation,location,lymphovascular and perineural invasion,tumor budding,tumor infiltrating lymphocytes,lymph node yield(LNY),and lymph node ratio(LNR).AIM To determine the unique phenotypic characteristics of MMR-D/MSI-H CRCs and leverage the conventional wisdom of LNY and LNR with the distinctive characteristics of MMR-D/MSI-H CRCs.METHODS This retrospective analysis involved 223 stage I-III CRC patients who underwent surgical resection without neoadjuvant treatment.Clinical and histological features were obtained from patient records and by re-examining the hematoxylin and eosin-stained slides.MMR/MSI status was evaluated for all patients using either MMR immunohistochemistry or MSI testing.RESULTS Of the 223 patients in our study,87(39.01%)were MMR-D/MSI-H CRCs while 136(60.99%)were MMR-P/MSS CRCs.The MMR-D/MSI-H CRCs exhibited significant statistical differences compared to the MMR-P/MSS CRCs in several factors,including location,stage,tumor budding,lymphovascular and perineural invasion,lymphocytic response,LNY,LNR,and size of uninvolved lymph nodes.LNY and LNR were significantly higher in MMR-D/MSI-H group compared with the MMR-P/MSS group(P=0.003 and P<0.001,respectively).Also,the interquartile range of the largest uninvolved lymph node was 1 cm(0.8 cm-1.2 cm)in MMR-D/MSI-H CRCs compared to 0.7 cm(0.6 cm-0.97 cm)in MMRP/MSS CRCs.The overall survival for the MMR-P/MSS CRC group was 71%at five years,and the MMR-D/MSIH CRC group was 92%at five years(P<0.001).CONCLUSION MMR-D/MSI-H CRCs possess a unique genomic profile that leads to distinct phenotypic characteristics,including an enhanced immune response.This distinctive profile underscores the substantial prognostic and predictive value of MMR-D/MSI-H status in CRC.
基金supported by the Natural Science Foundation of Hubei Province(2021CFA081)the Fundamental Research Funds for the Central Universities(2042023kf0210)the National Natural Science Foundation of China(42277160).
文摘A partly clumped-particles combined with joint planes model was developed to simulate the microstructure of quartz mica schist.It considers grain-scale heterogeneity including microgeometry heterogeneity and grain-scale elastic heterogeneity.Clumped-particles with larger volume and larger stiffness were used to represent stiff minerals such as quartz,the rest of unclumped particles with smaller stiffness were used to represent soft minerals such as mica.The joint planes,which have smaller stiffness and strength than mica,were used to describe schist.The extensive sensitivity studies have shown that the clump’s radius,clump’s content and joint plane’s strength affect the microscopic and macroscopic behaviors of sample.For DanBa quartz mica schist,the model calibrated uniaxial tests and well matched with the stress-strain curves,crack initiation stress and crack damage stress of laboratory test.
基金supported by The National Key Research and Development Program of China(Grant no.2021YFA0910100)Healthy Zhejiang One Million People Cohort(Grant no.K-20230085)+5 种基金Post-doctoral Innovative Talent Support Program(Grant no.BX2023375)Lingyan Project of Zhejiang Provincial Department of Science and Technology(Grant no.2025C02059)the National Natural Science Foundation of China(Grant nos.82304946,82473489,and 82403546)Natural Science Foundation of Zhejiang Province(Grant nos.LR21H280001,LGF22H160056,ZCLQN25H1602,and LMS25H160006)Medicine and Health Science Fund of Zhejiang Province Health Commission(Grant nos.2025KY047 and 2022KY658)Traditional Chinese Medicine Science and Technology Project of Zhejiang Provincial Health Commission(Grant no.2022ZA023).
文摘Gastric cancer(GC)remains a major global health challenge,because of its poor prognosis and limited treatment options in advanced stages1,2.Recent advancements in immunotherapy,highlighted by the findings of the CHECKMATE-649,ORIENT-16,and KEYNOTE-859 trials,have markedly transformed the treatment paradigm for advanced gastric cancer(AGC)3-5.
文摘BACKGROUND Colorectal cancer is one of the malignant tumors with a high incidence and mortality rate globally,and the occurrence of liver metastasis significantly affects patient survival prognosis.In recent years,the application of immune checkpoint inhibitors(ICIs)in cancer treatment has made important progress,especially showing good therapeutic effects in patients with high microsatellite instability or mismatch repair deficiency.However,for the majority of patients with microsatellite stable(MSS)or proficient mismatch repair(pMMR)colorectal cancer,the efficacy of ICIs is limited,prompting researchers to explore combination therapy strategies to improve efficacy.Targeted drugs such as tyrosine kinase inhibitors(TKIs)and radiotherapy are believed to work synergistically with ICIs by modifying the tumor microenvironment and enhancing antigen presentation.AIM To investigate the efficacy and safety of the combination therapy of radiotherapy,ICIs,and TKIs in patients with MSS or pMMR colorectal cancer liver metastasis(CCLM),in order to provide new clinical treatment references.METHODS A retrospective analysis was conducted on the clinical data of 43 MSS or pMMR CCLM patients treated at our hospital from September 2021 to July 2024.Based on the treatment interventions received,the patients were divided into a control group(n=21,receiving ICIs and TKIs combination therapy)and an observation group(n=22,receiving radiotherapy,ICIs,and TKIs triple therapy).The therapeutic effects,serum tumor markers(carcinoembryonic antigen and RESULTS The disease control rate in the observation group(63.64%)was significantly higher than that of the control group(23.81%)(P<0.05)).Both groups showed a decrease in carcinoembryonic antigen and carbohydrate antigen 199 levels post-treatment,with the observation group demonstrating a more significant change(P<0.05).The median progression-free survival and median overall survival in the control group were 5.1 months and 7.6 months,respectively,while the observation group had a median progression-free survival and overall survival of 4.3 months and 6.9 months,respectively.The control group had longer survival times than the observation group,but the differences were not statistically significant(P>0.05).The incidence of adverse reactions,including nausea and vomiting,gastrointestinal reactions,skin reactions,bone marrow suppression,liver and kidney function impairment,neurotoxicity,leukopenia,neutropenia,and thrombocytopenia,showed no significant differences between the two groups(P>0.05).CONCLUSION Compared to the ICIs and TKIs combination therapy,the radiotherapy,ICIs,and TKIs triple therapy can further improve the disease control rate and serum tumor marker levels in MSS or pMMR CCLM patients without increasing the risk of related adverse reactions,making it a treatment regimen worthy of further validation.
基金supported by the National Key Research and Development Program of China(Grant Nos.2023YFB3611000 and 2022YFA1405000)the National Natural Science Foundation of China(Grant Nos.62227821 and 62305157).
文摘Spatiotemporal optical vortices(STOVs)have attracted significant attention for their unique properties.Recently,the second harmonic generation(SHG)of STOV pulses has been experimentally demonstrated,but the phase singularity dynamics during this process remain elusive.Here,we theoretically investigate the separation and tilting of the phase singularities in STOVs during the SHG.Using the nonlinear Maxwell equation,we show that singularity separation is governed by group velocity mismatch,with accurate predictions provided by a Simpson-type integral under weak spatiotemporal walk-off conditions.In addition,paraxial wave equation analysis reveals that propagation induces singularity tilting,driven by spatial phase shifts.Our results not only offer deeper insights into the spatiotemporal coupling induced by complex nonlinear interactions but also reveal the underlying physical mechanisms in frequency up-conversion of space–time light pulses.
基金support from the National Natural Science Foundation of China(No.52103299)the science foundation of national key laboratory of science and technology on advanced composites in special environments(No.6142905241301).
文摘The surface wrinkled structures of materials endow them with various properties,such as hydrophilicity/hydrophobicity,adhesion,large specific surface area,etc.,which have been applied in self-cleaning surfaces,strong adhesives,ultra-sensitive sensors,etc.However,traditional wrinkled surfaces with single wrinkled structures cannot meet the demand for intelligent regulation,making the widespread application rather challenging.Recently,stimuli-responsive wrinkled surfaces,which are capable of reversibly regulating wrinkled structures(amplitude,period,etc.),have been developed to broaden their applications.Here,an overview of stimuli-responsive wrinkled surfaces is provided.First,the mechanism and design principle of surface wrinkled structures based on film/substrate bilayer systems are comprehensively analyzed.Subsequently,the latest advancements in the preparation and application of stimuli-responsive wrinkled surfaces are presented from the perspective of types of external stimuli(light,temperature,pH,humidity,solvent,and strain).Finally,the current challenges and future prospects of the stimuli-responsive wrinkled surfaces are illustrated.This review provides some insights and valuable references for the rational design of stimuli-responsive wrinkled surfaces.
