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“DNA谷歌”开辟生物学研究新领域
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作者 吴玉(编译) 《自然杂志》 2025年第6期426-426,476,共2页
互联网有谷歌,如今生物学领域有了MetaGraph。这款搜索引擎能够快速筛选公共数据库中储存的海量生物数据。相关研究成果2025年10月8日发表于《自然》。“这是一项了不起的成就。”法国巴斯德研究所的Rayan Chikhi表示,“他们为分析原始... 互联网有谷歌,如今生物学领域有了MetaGraph。这款搜索引擎能够快速筛选公共数据库中储存的海量生物数据。相关研究成果2025年10月8日发表于《自然》。“这是一项了不起的成就。”法国巴斯德研究所的Rayan Chikhi表示,“他们为分析原始生物数据设定了一个新标准。”这些数据包括DNA、RNA和蛋白质序列,来源于可能包含千万亿级DNA碱基的数据库,相当于拍字节级(1拍字节=1 000万亿字节)的信息,其数量甚至超过谷歌庞大索引中的所有网页。 展开更多
关键词 DNA谷歌 生物学研究 MetaGraph 自然 公共数据库
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研究人员把67万亿碱基压缩进硬盘,一键搜索全球基因库
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《生物医学工程与临床》 2025年第6期740-740,共1页
据Karasilov M 2025年108日(Nature,2025 Oct 8.doi:10.1038/s41586-025-09603-w.)报道,瑞士苏黎世联邦理工学院等机构的研究人员开发出了一种名为MetaGraph的方法,让任何人都能像使用谷歌搜索一样,快速、准确、低成本地在全球基因数据... 据Karasilov M 2025年108日(Nature,2025 Oct 8.doi:10.1038/s41586-025-09603-w.)报道,瑞士苏黎世联邦理工学院等机构的研究人员开发出了一种名为MetaGraph的方法,让任何人都能像使用谷歌搜索一样,快速、准确、低成本地在全球基因数据库中搜寻特定的DNA、RNA或蛋白质序列;这意味着一线医生或许能瞬间比对肿瘤患者的基因突变,环保科学家能快速监测水体中的抗生素耐药基因,研究人员能发现物种间未知的基因交流,这不仅是技术上的突破,更是推动精准医疗、公共卫生和基础科研民主化的关键一步。 展开更多
关键词 全球基因数据库 基因突变 MetaGraph
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Paper evolution graph: multi-view structural retrieval for academic literature 被引量:1
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作者 Dan-ping LIAO Yun-tao QIAN 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2019年第2期187-205,共19页
Academic literature retrieval concerns about the selection of papers that are most likely to match a user's information needs. Most of the retrieval systems are limited to list-output models, in which the retrieva... Academic literature retrieval concerns about the selection of papers that are most likely to match a user's information needs. Most of the retrieval systems are limited to list-output models, in which the retrieval results are isolated from each other. In this paper, we aim to uncover the relationships between the retrieval results and propose a method to build structural retrieval results for academic literature, which we call a paper evolution graph(PEG).The PEG describes the evolution of diverse aspects of input queries through several evolution chains of papers. By using the author, citation, and content information, PEGs can uncover various underlying relationships among the papers and present the evolution of articles from multiple viewpoints. Our system supports three types of input queries: keyword query, single-paper query, and two-paper query. The construction of a PEG consists mainly of three steps. First, the papers are soft-clustered into communities via metagraph factorization, during which the topic distribution of each paper is obtained. Second, topically cohesive evolution chains are extracted from the communities that are relevant to the query. Each chain focuses on one aspect of the query. Finally, the extracted chains are combined to generate a PEG, which fully covers all the topics of the query. Experimental results on a real-world dataset demonstrate that the proposed method can construct meaningful PEGs. 展开更多
关键词 PAPER EVOLUTION GRAPH Academic literature RETRIEVAL Metagraph FACTORIZATION Topic coherence
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