Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model a...Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model and conduct a multi-objective detailed evaluation of the driver’s manipulation during cyclic braking.Design/methodology/approach–The high-precision longitudinal train dynamics model was established and verified by the cyclic braking test data of the 20,000 t heavy-haul combination train on the long and steep downgrade.Then the genetic algorithm is employed for optimization subsequent to decoupling multiple cyclic braking procedures,with due consideration of driver operation rules.For evaluation,key manipulation assessments in the scenario are prioritized,supplemented by multi-objective evaluation requirements,and the computational model is employed for detailed evaluation analysis.Findings–Based on the model,experimental data reveal that the probability of longitudinal force error being less than 64.6 kN is approximately 68%,95%for less than 129.2 kN and 99.7%for less than 193.8 kN.Upon optimizing manipulations during the cyclic braking,the maximum reduction in coupler force spans from 21%∼23.9%.Andtheevaluation scoresimply that a proper elevationof the releasingspeed favorssafety.A high electric braking force,although beneficial to some extent for energy-saving,is detrimental to reducing coupler force.Originality/value–The results will provide a theoretical basis and practical guidance for further ensuring the safety and energy-efficient operation of heavy haul trains on long downhill sections and improving the operational quality of heavy-haul trains.展开更多
Precise droplet manipulation is critical in material synthesis,biochemical detection,and tissue engineering.However,the droplet velocity and volume manipulated by magnetic techniques are restricted owing to the low ma...Precise droplet manipulation is critical in material synthesis,biochemical detection,and tissue engineering.However,the droplet velocity and volume manipulated by magnetic techniques are restricted owing to the low magnetic force exerted on magnetic particles and beads.Furthermore,magnetic particles are prone to contaminate droplets owing to residues and corrosion.To address these issues,this paper proposes a hydrophilic hard-magnetic soft robot(HMSR)with strong magnetic controllability and chemical stability for precise droplet manipulation.A porous HMSR was synthesized by incorporating NdFeB particles and sacrificial sugar particles into an Ecoflex elastomer.Oxygen plasma treatment was applied to make the HMSR become hydrophilic and thus enhance the driving force exerted on droplets.Three forms of droplet manipulation were demonstrated:droplet transport,droplet splitting,and robot–magnet detachment.Theoretical analysis and experimental results revealed that the critical HMSR speed requisite for droplet transport and splitting was inversely proportional to the droplet volume.Notably,a 50μl droplet was transported in a 20 mT magnetic field at a maximum velocity of 200 mm/s.The maximum droplet volume that the HMSR could transport reached 900μl.Benefiting from its chemical stability,HMSR successfully manipulated chemical reactions of acidic and alkaline droplets.Additionally,the HMSR achieved targeted removal of microparticles through droplet adhesion to them.This HMSR with precise droplet manipulation capability holds broad prospects for applications in biochemical detection,material synthesis,and surgical robotics.展开更多
The state of polarization(SOP)on high-order Poincaréspheres(HOPSs),characterized by their distinctive phase profiles and polarization distributions,plays a crucial role in both classical and quantum optical appli...The state of polarization(SOP)on high-order Poincaréspheres(HOPSs),characterized by their distinctive phase profiles and polarization distributions,plays a crucial role in both classical and quantum optical applications.However,most existing metasurface-based implementations face inherent limitations:passive designs are restricted to represent a few predefined HOPS SOPs,while programmable versions typically constrain to 1-bit or 2-bit phase control resolution.In this paper,dynamic generation of HOPS beams with arbitrary SOP based on a transmissive space-time-coding metasurface is demonstrated.By combining 1-bit phase discretizations via PIN diodes with a time-coding strategy,the metasurface enables quasi-continuous complexamplitude modulation for harmonic waves in both x-and y-polarizations.Based on near-field diffraction theory,arbitrary SOPs on any HOPSm,n can be precisely generated using a linearly polarized basis,which is independently controlled by FPGA reconfiguration.We experimentally demonstrate that polarization holography on HOPS0,0 achieves high polarization purity>91.28%,and vector vortex beams on HOPS1,3 and HOPS−1,3 exhibit high orbital angular momentum mode purities>91.25%.This methodology holds great potential for structured wavefront shaping,vortex generation,and high-capacity planar photonics.展开更多
Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuron...Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.展开更多
OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patient...OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patients with KOA(Kellgren-Lawrence gradeⅡ-Ⅲ)were recruited from the Acupuncture-Moxibustion Rehabilitation Department,Anhui University of Chinese Medicine between October 2024 and May 2025.Participants were randomized into a TBHM group(n=30)or a transcutaneous electrical neuromuscular stimulation(TENS)group(n=30).Using two-way repeated measures ANOVA,biomechanical indicators,including rectus femoris tension,vastus medialis tension,vastus lateralis tension,patellar ligament tension,lateral patellar displacement(LPD),medial patellar displacement(MPD),normalized patellar mobility(LPD/patellar width[PW],MPD/PW),knee flexion range of motion,and functional indicators,including KOOS subscales,time up and go test(TUGT),were compared between groups at baseline and after 6 weeks of intervention.RESULTS After intervention,all biomechanical and knee joint function indicators in the TBHM group were significantly improved(P<0.05,P<0.01),while only the vastus medialis tension,TUGT and KOOS Pain,ADL and QoL scores in the control group were significantly improved(P<0.01).The improvement amplitudes of biomechanical indicators in the TBHM group,including rectus femoris tension,vastus lateralis tension,patellar ligament tension,MPD/PW,LPD/PW and knee flexion range of motion were better than those in the control group(P<0.05,P<0.01).In the functional evaluation,the interaction effects of the TBHM group in all dimensions of the KOOS score and TUGT were statistically significant(P<0.05,P<0.01).Post-hoc simple effect analysis confirmed that there were significant differences in the above indicators between the two groups after intervention(P<0.05),and all indicators showed a significant main effect of time(P<0.01),suggesting that the intervention measures had continuous and cumulative curative effects.CONCLUSION TBHM effectively improves joint function and quality of life in KOA patients by restoring dynamic equilibrium in soft tissue tension and patellar mobility,ultimately achieving the therapeutic goal of concurrent tissue-bone management.展开更多
OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently n...OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.展开更多
Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of curr...Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.展开更多
[Objectives]To investigate the effects of Visceral Manipulation combined with Enhanced Recovery after Surgery on postoperative recovery in patients undergoing gastrointestinal surgery,and to evaluate its impacts on in...[Objectives]To investigate the effects of Visceral Manipulation combined with Enhanced Recovery after Surgery on postoperative recovery in patients undergoing gastrointestinal surgery,and to evaluate its impacts on inflammatory stress response,gastrointestinal motility recovery,and blood oxygen levels.[Methods]A prospective randomized controlled design was adopted.Eighty patients undergoing gastrointestinal surgery from January 2022 to December 2023 were selected and randomly divided into an observation group(40 cases)and a control group(40 cases).The observation group received Visceral Manipulation therapy in addition to routine Enhanced Recovery after Surgery care,while the control group received only routine Enhanced Recovery after Surgery care.Clinical indicators,inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),gastrointestinal motility indicators(GAS,MTL,GIP),and blood oxygen levels were measured and compared between the two groups on postoperative days 1,5,and 10.[Results]The observation group showed significantly better outcomes in postoperative abdominal distension,time to first flatus and defecation,and hospital stay compared to the control group(P<0.05).Inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),and gastrointestinal motility indicators(GAS,MTL,GIP)were significantly improved in the observation group(P<0.05).Postoperative blood oxygen levels were also significantly higher in the observation group(P<0.05).[Conclusions]Visceral Manipulation combined with Enhanced Recovery after Surgery can significantly improve postoperative recovery in gastrointestinal surgery patients,alleviate inflammatory stress responses,promote gastrointestinal functional recovery,and enhance blood oxygen levels,demonstrating promising clinical application prospects.展开更多
Absorbing particles have attracted wide interest in multifarious fields due to their strong light absorption characteristics,which can be trapped by optical bottles(OBs),three-dimensional dark regions surrounded by li...Absorbing particles have attracted wide interest in multifarious fields due to their strong light absorption characteristics,which can be trapped by optical bottles(OBs),three-dimensional dark regions surrounded by light.Existing OB-based particle manipulation is typically limited to a single functionality,such as the stationary volume or the single manipulated object.This severely limits the versatility and selectivity of micro-manipulation,particularly in the multi-particle system.In this paper,we address these challenges by introducing a dynamic OBs generation method.By modulating optical vortices and multi-parabolic trajectory phases,a series of OBs with targeted positions,numbers,and states is encoded as a battery of holograms,which are imported into the spatial light modulator(SLM).Experimentally,by dynamically reconfiguring the corresponding holograms in the SLM,we validate selectively switching and moving OBs for dynamic particle manipulation.Consequently,a specific fraction of targeted particles can be selectively released,transported 7.2 mm away while the others remain trapped in place,or merged from two 3.5-mm-spaced OBs into a larger single entity.Our results deepen the applications of OB beams and may herald a new avenue for dynamic particle manipulation.展开更多
Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold...Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.展开更多
The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipul...The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipulation,to inten⁃tionally exploit people's cognitive and decision-making gaps to influence their decisions in practice,which is particu⁃larly detrimental to the sustainable development of the digital market.Limiting harmful algorithmic online manipula⁃tion in digital markets has become a challenging task.Globally,both the EU and China have responded to this issue,and the differences between them are so evident that their governance measures can serve as the typical case.The EU focuses on improving citizens'digital literacy and their ability to integrate into digital social life to independently ad⁃dress this issue,and expects to address harmful manipulation behavior through binding and applicable hard law,which is part of the digital strategy.By comparison,although there exist certain legal norms that have made relevant stipula⁃tions on manipulation issues,China continues to issue specific departmental regulations to regulate algorithmic recom⁃mender services,and pays more attention to addressing collective harm caused by algorithmic online manipulation through a multiple co-governance approach led by the government or industry associations to implement supervision.展开更多
Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapi...Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.展开更多
On-demand droplet manipulation plays a critical role in microfluidics,bio/chemical detection and microreactions.Acoustic droplet manipulation has emerged as a promising technique due to its non-contact nature,biocompa...On-demand droplet manipulation plays a critical role in microfluidics,bio/chemical detection and microreactions.Acoustic droplet manipulation has emerged as a promising technique due to its non-contact nature,biocompatibility and precision,circumventing the complexities associated with other methods requiring surface or droplet pretreatment.Despite their promise,existing methods for acoustic droplet manipulation often involve complex hardware setups and difficulty for controlling individual droplet amidst multiple ones.Here we fabricate simple yet effective acoustic tweezers for in-surface and out-of-surface droplet manipulation.It is found that droplets can be transported on the superhydrophobic surfaces when the acoustic radiation force surpasses the friction force.Using a two-axis acoustic tweezer,droplets can be maneuvered along arbitrarily programmed paths on the surfaces.By introducing multiple labyrinthine structures on the superhydrophobic surface,individual droplet manipulation is realized by constraining the unselected droplets in the labyrinthine structures.In addition,a three-axis acoustic tweezer is developed for manipulating droplets in three-dimensional space.Potential applications of the acoustic tweezers for micro-reaction,bio-assay and chemical analysis are also demonstrated.展开更多
Flexoelectricity,an electromechanical coupling between strain gradient and electrical polarization in dielectrics or semiconductors,has attracted significant scientific interest.It is reported that large flexoelectric...Flexoelectricity,an electromechanical coupling between strain gradient and electrical polarization in dielectrics or semiconductors,has attracted significant scientific interest.It is reported that large flexoelectric behaviors can be obtained at the nanoscale because of the size effect.However,the flexoelectric responses of centrosymmetric semiconductors(CSs)are extremely weak under a conventional beam-bending approach,owing to weak flexoelectric coefficients and small strain gradients.The flexoelectric-like effect is an enhanced electromechanical effect coupling the flexoelectricity and piezoelectricity.In this paper,a composite structure consisting of piezoelectric dielectric layers and a CS layer is proposed.The electromechanical response of the CS is significantly enhanced via antisymmetric piezoelectric polarization.Consequently,the cross-scale mechanically tuned carrier distribution in the semiconductor is realized.Meanwhile,the significant size dependence of the electromechanical fields in the semiconductor is demonstrated.The flexoelectronics suppression is found when the semiconductor thickness reaches a critical size(0.8μm).In addition,the first-order carrier density of the composite structure under local loads is illustrated.Our results can suggest the structural design for flexoelectric semiconductor devices.展开更多
Purpose:This study aimed to evaluate the relationship between peak tibial acceleration and peak ankle joint contact forces in response to stride length manipulation during level-ground running.Methods:Twenty-seven phy...Purpose:This study aimed to evaluate the relationship between peak tibial acceleration and peak ankle joint contact forces in response to stride length manipulation during level-ground running.Methods:Twenty-seven physically active participants ran 10 trials at preferred speed in each of 5 stride length conditions:preferred,±5%,and±10%of preferred stride length.Motion capture,force platform,and tibial acceleration data were directly measured,and ankle joint contact forces were estimated using an inverse-dynamics-based static optimization routine.Results:In general,peak axial tibial accelerations(p<0.001)as well as axial(p<0.001)and resultant(p<0.001)ankle joint contact forces increased with stride length.When averaged within the 10 strides of each stride condition,moderate positive correlations were observed between peak axial acceleration and joint contact force(r=0.49)as well as peak resultant acceleration and joint contact force(r=0.51).However,37%of participants illustrated either no relationship or negative correlations.Only weak correlations across participants existed between peak axial acceleration and joint contact force(r=0.12)as well as peak resultant acceleration and ankle joint contact force(r=0.18)when examined on a step-by-step basis.Conclusion:These results suggest that tibial acceleration should not be used as a surrogate for ankle joint contact force on a step-by-step basis in response to stride length manipulations during level-ground running.A 10-step averaged tibial acceleration metric may be useful for some runners,but an initial laboratory assessment would be required to identify these individuals.展开更多
In the fields of optoelectronics and semiconductors, reliable fixation and handling of brittle materials (glass, wafer, etc.) in high-temperature, vacuum, and vibration environments face particular technical challenge...In the fields of optoelectronics and semiconductors, reliable fixation and handling of brittle materials (glass, wafer, etc.) in high-temperature, vacuum, and vibration environments face particular technical challenges. These challenges include the inability of suction cups in a vacuum, the residue of chemical adhesives, and the easy damage of mechanical clamping. In this paper, fluorine-based bionic adhesive pads (FBAPs) obtained using molding technology to imitate gecko micropillar arrays are presented. FBAPs inhibit the substantial decay of adhesive properties at high temperatures and provide stable and reliable performance in vacuum and vibration environments. The results demonstrated that the decayed force values of the normal and tangential strength of the FBAP were only 9.01% and 5.82% of the planar samples when warmed up to 300℃ from 25℃, respectively. In a vacuum, all FBAPs exhibit less than 20% adhesion attenuation, and in a vibrational environment, they can withstand accelerations of at least 4.27 g. The design of the microstructure arrays enables the realization of efficient and non-destructive separation through mechanical rotation or blowing. It provides a bionic material basis for the fixation of brittle materials on smooth surfaces under complex environments and for transportation automation.展开更多
In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addi...In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addition,during feature fusion,the use of fixed sampling kernels makes it difficult to focus on local changes in features,leading to limited localization accuracy.This paper proposes an image manipulation localization method based on dual-branch hybrid convolution.First,a dual-branch hybrid convolution module is designed to expand the receptive field of the model to enhance the feature extraction ability of contextual semantic information,while also enabling the model to focus more on the high-frequency detail features of manipulation traces while localizing the manipulated area.Second,a multiscale content-aware feature fusion module is used to dynamically generate adaptive sampling kernels for each position in the feature map,enabling the model to focus more on the details of local features while locating the manipulated area.Experimental results on multiple datasets show that this method not only effectively improves the accuracy of image manipulation localization but also enhances the robustness of the model.展开更多
Electrotaxis,a method that utilizes an electric field to direct the motion of particles or droplets,typically involves a droplet on a flat surface being guided by an electrically charged tweezer above it.Traditional e...Electrotaxis,a method that utilizes an electric field to direct the motion of particles or droplets,typically involves a droplet on a flat surface being guided by an electrically charged tweezer above it.Traditional electrotaxis methods have relied on voltages over 1.5 kV for droplet control,but this has several disadvantages,such as high voltage demands,the danger of electric discharge to the droplet,possible adhesion of the droplet to the tweezer,and issues with droplet oscillation and overshoot,which impede its broader application.The present study proposes an innovative tweezer design that not only operates at reduced voltages but also reduces droplet oscillation relative to traditional tweezers.This tweezer features a coaxial tubular sheath encircling the electrode,which modifies the electric field’s influence on the droplet.Numerical simulations were employed to obtain the tweezer’s ideal dimensions and shape.The empirical evidence indicates that the new tweezer can adeptly steer droplets at a markedly lower voltage of 620 V,ensuring a more stable trajectory and significantly diminishing overshoot.The tweezer’s distinctive design also decreases the possibility of electric discharge to the droplet,thus improving the safety of the system for managing delicate droplets.In the experiment,the maximum droplet translation speed attained was 105 mm/s at an applied voltage of 1.2 kV.This represents a 29.6%increase in speed and a 70%decrease in the required voltage compared to the previously highest reported droplet speed.展开更多
[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese m...[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.展开更多
文摘Purpose–The study aims to build a high-precision longitudinal dynamics model for heavy-haul trains and validate it with line test data,present an optimization method for multi-stage cyclic brakes based on the model and conduct a multi-objective detailed evaluation of the driver’s manipulation during cyclic braking.Design/methodology/approach–The high-precision longitudinal train dynamics model was established and verified by the cyclic braking test data of the 20,000 t heavy-haul combination train on the long and steep downgrade.Then the genetic algorithm is employed for optimization subsequent to decoupling multiple cyclic braking procedures,with due consideration of driver operation rules.For evaluation,key manipulation assessments in the scenario are prioritized,supplemented by multi-objective evaluation requirements,and the computational model is employed for detailed evaluation analysis.Findings–Based on the model,experimental data reveal that the probability of longitudinal force error being less than 64.6 kN is approximately 68%,95%for less than 129.2 kN and 99.7%for less than 193.8 kN.Upon optimizing manipulations during the cyclic braking,the maximum reduction in coupler force spans from 21%∼23.9%.Andtheevaluation scoresimply that a proper elevationof the releasingspeed favorssafety.A high electric braking force,although beneficial to some extent for energy-saving,is detrimental to reducing coupler force.Originality/value–The results will provide a theoretical basis and practical guidance for further ensuring the safety and energy-efficient operation of heavy haul trains on long downhill sections and improving the operational quality of heavy-haul trains.
基金supported by the Science and Technology Program from the State Grid Corporation of China(Grant No.5700-202155453A-0-0-00):“Development of flexible liquid metal based micro-sensor with anti-electromagnetic interference ability for power engineering applications.”。
文摘Precise droplet manipulation is critical in material synthesis,biochemical detection,and tissue engineering.However,the droplet velocity and volume manipulated by magnetic techniques are restricted owing to the low magnetic force exerted on magnetic particles and beads.Furthermore,magnetic particles are prone to contaminate droplets owing to residues and corrosion.To address these issues,this paper proposes a hydrophilic hard-magnetic soft robot(HMSR)with strong magnetic controllability and chemical stability for precise droplet manipulation.A porous HMSR was synthesized by incorporating NdFeB particles and sacrificial sugar particles into an Ecoflex elastomer.Oxygen plasma treatment was applied to make the HMSR become hydrophilic and thus enhance the driving force exerted on droplets.Three forms of droplet manipulation were demonstrated:droplet transport,droplet splitting,and robot–magnet detachment.Theoretical analysis and experimental results revealed that the critical HMSR speed requisite for droplet transport and splitting was inversely proportional to the droplet volume.Notably,a 50μl droplet was transported in a 20 mT magnetic field at a maximum velocity of 200 mm/s.The maximum droplet volume that the HMSR could transport reached 900μl.Benefiting from its chemical stability,HMSR successfully manipulated chemical reactions of acidic and alkaline droplets.Additionally,the HMSR achieved targeted removal of microparticles through droplet adhesion to them.This HMSR with precise droplet manipulation capability holds broad prospects for applications in biochemical detection,material synthesis,and surgical robotics.
基金National Natural Science Foundation of China(62271056,62171186,62201037)Technology Innovation Center of Infrared Remote Sensing Metrology Technology of State Administration for Market Regulation(AKYKF2423)+5 种基金National Key Research and Development Program of China(2022YFF0604801)Beijing Natural Science Foundation Haidian Original Innovation Joint Fund(L222042)Open Research Fund of State Key Laboratory of Millimeter Waves(K202326)Open Research Fund of State Key Laboratory of Space-Ground Integrated Information Technology(6142221200201)Basic Research Foundation of Beijing Institute of Technology,China(BITBLR2020014)111 Project of China(B14010).
文摘The state of polarization(SOP)on high-order Poincaréspheres(HOPSs),characterized by their distinctive phase profiles and polarization distributions,plays a crucial role in both classical and quantum optical applications.However,most existing metasurface-based implementations face inherent limitations:passive designs are restricted to represent a few predefined HOPS SOPs,while programmable versions typically constrain to 1-bit or 2-bit phase control resolution.In this paper,dynamic generation of HOPS beams with arbitrary SOP based on a transmissive space-time-coding metasurface is demonstrated.By combining 1-bit phase discretizations via PIN diodes with a time-coding strategy,the metasurface enables quasi-continuous complexamplitude modulation for harmonic waves in both x-and y-polarizations.Based on near-field diffraction theory,arbitrary SOPs on any HOPSm,n can be precisely generated using a linearly polarized basis,which is independently controlled by FPGA reconfiguration.We experimentally demonstrate that polarization holography on HOPS0,0 achieves high polarization purity>91.28%,and vector vortex beams on HOPS1,3 and HOPS−1,3 exhibit high orbital angular momentum mode purities>91.25%.This methodology holds great potential for structured wavefront shaping,vortex generation,and high-capacity planar photonics.
文摘Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.
文摘OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patients with KOA(Kellgren-Lawrence gradeⅡ-Ⅲ)were recruited from the Acupuncture-Moxibustion Rehabilitation Department,Anhui University of Chinese Medicine between October 2024 and May 2025.Participants were randomized into a TBHM group(n=30)or a transcutaneous electrical neuromuscular stimulation(TENS)group(n=30).Using two-way repeated measures ANOVA,biomechanical indicators,including rectus femoris tension,vastus medialis tension,vastus lateralis tension,patellar ligament tension,lateral patellar displacement(LPD),medial patellar displacement(MPD),normalized patellar mobility(LPD/patellar width[PW],MPD/PW),knee flexion range of motion,and functional indicators,including KOOS subscales,time up and go test(TUGT),were compared between groups at baseline and after 6 weeks of intervention.RESULTS After intervention,all biomechanical and knee joint function indicators in the TBHM group were significantly improved(P<0.05,P<0.01),while only the vastus medialis tension,TUGT and KOOS Pain,ADL and QoL scores in the control group were significantly improved(P<0.01).The improvement amplitudes of biomechanical indicators in the TBHM group,including rectus femoris tension,vastus lateralis tension,patellar ligament tension,MPD/PW,LPD/PW and knee flexion range of motion were better than those in the control group(P<0.05,P<0.01).In the functional evaluation,the interaction effects of the TBHM group in all dimensions of the KOOS score and TUGT were statistically significant(P<0.05,P<0.01).Post-hoc simple effect analysis confirmed that there were significant differences in the above indicators between the two groups after intervention(P<0.05),and all indicators showed a significant main effect of time(P<0.01),suggesting that the intervention measures had continuous and cumulative curative effects.CONCLUSION TBHM effectively improves joint function and quality of life in KOA patients by restoring dynamic equilibrium in soft tissue tension and patellar mobility,ultimately achieving the therapeutic goal of concurrent tissue-bone management.
文摘OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.
文摘Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.
基金Supported by Guiding Project of Shiyan City,Hubei Province in 2022(22Y30).
文摘[Objectives]To investigate the effects of Visceral Manipulation combined with Enhanced Recovery after Surgery on postoperative recovery in patients undergoing gastrointestinal surgery,and to evaluate its impacts on inflammatory stress response,gastrointestinal motility recovery,and blood oxygen levels.[Methods]A prospective randomized controlled design was adopted.Eighty patients undergoing gastrointestinal surgery from January 2022 to December 2023 were selected and randomly divided into an observation group(40 cases)and a control group(40 cases).The observation group received Visceral Manipulation therapy in addition to routine Enhanced Recovery after Surgery care,while the control group received only routine Enhanced Recovery after Surgery care.Clinical indicators,inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),gastrointestinal motility indicators(GAS,MTL,GIP),and blood oxygen levels were measured and compared between the two groups on postoperative days 1,5,and 10.[Results]The observation group showed significantly better outcomes in postoperative abdominal distension,time to first flatus and defecation,and hospital stay compared to the control group(P<0.05).Inflammatory factors(TNF-α,IL-6,hs-CRP),traumatic stress hormones(cortisol,epinephrine,norepinephrine),and gastrointestinal motility indicators(GAS,MTL,GIP)were significantly improved in the observation group(P<0.05).Postoperative blood oxygen levels were also significantly higher in the observation group(P<0.05).[Conclusions]Visceral Manipulation combined with Enhanced Recovery after Surgery can significantly improve postoperative recovery in gastrointestinal surgery patients,alleviate inflammatory stress responses,promote gastrointestinal functional recovery,and enhance blood oxygen levels,demonstrating promising clinical application prospects.
基金National Natural Science Foundation of China(12174122)Natural Science Foundation of Guangdong Province(2022A1515011482,2024A1515010556)+2 种基金National College Students Innovation and Entrepreneurship Training Program(20241057432014)Special Funds for the Cultivation of Guangdong College Students’Scientific and Technological Innovation(“Climbing Program”Special Funds)(pdjh2024b124)Extracurricular Scientific Program of School of Optoelectronic Science and Engineering,South China Normal University(24GDKB03).
文摘Absorbing particles have attracted wide interest in multifarious fields due to their strong light absorption characteristics,which can be trapped by optical bottles(OBs),three-dimensional dark regions surrounded by light.Existing OB-based particle manipulation is typically limited to a single functionality,such as the stationary volume or the single manipulated object.This severely limits the versatility and selectivity of micro-manipulation,particularly in the multi-particle system.In this paper,we address these challenges by introducing a dynamic OBs generation method.By modulating optical vortices and multi-parabolic trajectory phases,a series of OBs with targeted positions,numbers,and states is encoded as a battery of holograms,which are imported into the spatial light modulator(SLM).Experimentally,by dynamically reconfiguring the corresponding holograms in the SLM,we validate selectively switching and moving OBs for dynamic particle manipulation.Consequently,a specific fraction of targeted particles can be selectively released,transported 7.2 mm away while the others remain trapped in place,or merged from two 3.5-mm-spaced OBs into a larger single entity.Our results deepen the applications of OB beams and may herald a new avenue for dynamic particle manipulation.
基金supported by the National Natural Science Foundation of China(Nos.21904095,22004089)Peiyang Talents Project of Tianjin University+1 种基金Young Thousand Talented ProgramProgram of Tianjin Science and Technology Major Project and Engineering(No.19ZXYXSY00090)。
文摘Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.
文摘The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipulation,to inten⁃tionally exploit people's cognitive and decision-making gaps to influence their decisions in practice,which is particu⁃larly detrimental to the sustainable development of the digital market.Limiting harmful algorithmic online manipula⁃tion in digital markets has become a challenging task.Globally,both the EU and China have responded to this issue,and the differences between them are so evident that their governance measures can serve as the typical case.The EU focuses on improving citizens'digital literacy and their ability to integrate into digital social life to independently ad⁃dress this issue,and expects to address harmful manipulation behavior through binding and applicable hard law,which is part of the digital strategy.By comparison,although there exist certain legal norms that have made relevant stipula⁃tions on manipulation issues,China continues to issue specific departmental regulations to regulate algorithmic recom⁃mender services,and pays more attention to addressing collective harm caused by algorithmic online manipulation through a multiple co-governance approach led by the government or industry associations to implement supervision.
基金supported by the National Natural Science Foundation of China(Nos.52025132,U24A20205,52303373,21621091,22021001,and 22121001)the China Postdoctoral Science Foundation(No.2024M763174)+2 种基金the 111 Project(Nos.B17027,B16029)the Natural Science Foundation of Fujian Province of China(No.2022J02059)the New Cornerstone Science Foundation through the Xplorer Prize。
文摘Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.
基金supported by National Natural Science Foundation of China(Nos.12072381,22072185,21805315)Guangdong Basic and Applied Basic Research Foundation(No.2024A1515011812)Science and Technology Innovation Project of Guangzhou(No.202102020263).
文摘On-demand droplet manipulation plays a critical role in microfluidics,bio/chemical detection and microreactions.Acoustic droplet manipulation has emerged as a promising technique due to its non-contact nature,biocompatibility and precision,circumventing the complexities associated with other methods requiring surface or droplet pretreatment.Despite their promise,existing methods for acoustic droplet manipulation often involve complex hardware setups and difficulty for controlling individual droplet amidst multiple ones.Here we fabricate simple yet effective acoustic tweezers for in-surface and out-of-surface droplet manipulation.It is found that droplets can be transported on the superhydrophobic surfaces when the acoustic radiation force surpasses the friction force.Using a two-axis acoustic tweezer,droplets can be maneuvered along arbitrarily programmed paths on the surfaces.By introducing multiple labyrinthine structures on the superhydrophobic surface,individual droplet manipulation is realized by constraining the unselected droplets in the labyrinthine structures.In addition,a three-axis acoustic tweezer is developed for manipulating droplets in three-dimensional space.Potential applications of the acoustic tweezers for micro-reaction,bio-assay and chemical analysis are also demonstrated.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFB2011400)the National Natural Science Foundation of China(Grant No.52375081).
文摘Flexoelectricity,an electromechanical coupling between strain gradient and electrical polarization in dielectrics or semiconductors,has attracted significant scientific interest.It is reported that large flexoelectric behaviors can be obtained at the nanoscale because of the size effect.However,the flexoelectric responses of centrosymmetric semiconductors(CSs)are extremely weak under a conventional beam-bending approach,owing to weak flexoelectric coefficients and small strain gradients.The flexoelectric-like effect is an enhanced electromechanical effect coupling the flexoelectricity and piezoelectricity.In this paper,a composite structure consisting of piezoelectric dielectric layers and a CS layer is proposed.The electromechanical response of the CS is significantly enhanced via antisymmetric piezoelectric polarization.Consequently,the cross-scale mechanically tuned carrier distribution in the semiconductor is realized.Meanwhile,the significant size dependence of the electromechanical fields in the semiconductor is demonstrated.The flexoelectronics suppression is found when the semiconductor thickness reaches a critical size(0.8μm).In addition,the first-order carrier density of the composite structure under local loads is illustrated.Our results can suggest the structural design for flexoelectric semiconductor devices.
基金funded in part by the Natural Sciences and Engineering Research Council of Canada(RGPIN 024042021 and CGS D-534891-2019)the NSERC CREATE Wearable Technology Research and Collaboration training program(graduate fellowship and undergraduate summer research fellowship).
文摘Purpose:This study aimed to evaluate the relationship between peak tibial acceleration and peak ankle joint contact forces in response to stride length manipulation during level-ground running.Methods:Twenty-seven physically active participants ran 10 trials at preferred speed in each of 5 stride length conditions:preferred,±5%,and±10%of preferred stride length.Motion capture,force platform,and tibial acceleration data were directly measured,and ankle joint contact forces were estimated using an inverse-dynamics-based static optimization routine.Results:In general,peak axial tibial accelerations(p<0.001)as well as axial(p<0.001)and resultant(p<0.001)ankle joint contact forces increased with stride length.When averaged within the 10 strides of each stride condition,moderate positive correlations were observed between peak axial acceleration and joint contact force(r=0.49)as well as peak resultant acceleration and joint contact force(r=0.51).However,37%of participants illustrated either no relationship or negative correlations.Only weak correlations across participants existed between peak axial acceleration and joint contact force(r=0.12)as well as peak resultant acceleration and ankle joint contact force(r=0.18)when examined on a step-by-step basis.Conclusion:These results suggest that tibial acceleration should not be used as a surrogate for ankle joint contact force on a step-by-step basis in response to stride length manipulations during level-ground running.A 10-step averaged tibial acceleration metric may be useful for some runners,but an initial laboratory assessment would be required to identify these individuals.
基金supported by the National Natural Science Foundation of China(No.52075249)the Tianyuan Laboratory Fund(No.24-JSKY-ZZKT-14).
文摘In the fields of optoelectronics and semiconductors, reliable fixation and handling of brittle materials (glass, wafer, etc.) in high-temperature, vacuum, and vibration environments face particular technical challenges. These challenges include the inability of suction cups in a vacuum, the residue of chemical adhesives, and the easy damage of mechanical clamping. In this paper, fluorine-based bionic adhesive pads (FBAPs) obtained using molding technology to imitate gecko micropillar arrays are presented. FBAPs inhibit the substantial decay of adhesive properties at high temperatures and provide stable and reliable performance in vacuum and vibration environments. The results demonstrated that the decayed force values of the normal and tangential strength of the FBAP were only 9.01% and 5.82% of the planar samples when warmed up to 300℃ from 25℃, respectively. In a vacuum, all FBAPs exhibit less than 20% adhesion attenuation, and in a vibrational environment, they can withstand accelerations of at least 4.27 g. The design of the microstructure arrays enables the realization of efficient and non-destructive separation through mechanical rotation or blowing. It provides a bionic material basis for the fixation of brittle materials on smooth surfaces under complex environments and for transportation automation.
基金National Natural Science Foundation of China(61703363)Shanxi Provincial Basic Research Program(202403021221206)+2 种基金Key Project of Shanxi Provincial Strategic Research on Science and Technology(202304031401011)Funding Project for Scientific Research Innovation Team on Data Mining and Industrial Intelligence Applications(YCXYTD-202402)Yuncheng University Research Project(YQ-2020021)。
文摘In existing image manipulation localization methods,the receptive field of standard convolution is limited,and during feature transfer,it is easy to lose high-frequency information about traces of manipulation.In addition,during feature fusion,the use of fixed sampling kernels makes it difficult to focus on local changes in features,leading to limited localization accuracy.This paper proposes an image manipulation localization method based on dual-branch hybrid convolution.First,a dual-branch hybrid convolution module is designed to expand the receptive field of the model to enhance the feature extraction ability of contextual semantic information,while also enabling the model to focus more on the high-frequency detail features of manipulation traces while localizing the manipulated area.Second,a multiscale content-aware feature fusion module is used to dynamically generate adaptive sampling kernels for each position in the feature map,enabling the model to focus more on the details of local features while locating the manipulated area.Experimental results on multiple datasets show that this method not only effectively improves the accuracy of image manipulation localization but also enhances the robustness of the model.
文摘Electrotaxis,a method that utilizes an electric field to direct the motion of particles or droplets,typically involves a droplet on a flat surface being guided by an electrically charged tweezer above it.Traditional electrotaxis methods have relied on voltages over 1.5 kV for droplet control,but this has several disadvantages,such as high voltage demands,the danger of electric discharge to the droplet,possible adhesion of the droplet to the tweezer,and issues with droplet oscillation and overshoot,which impede its broader application.The present study proposes an innovative tweezer design that not only operates at reduced voltages but also reduces droplet oscillation relative to traditional tweezers.This tweezer features a coaxial tubular sheath encircling the electrode,which modifies the electric field’s influence on the droplet.Numerical simulations were employed to obtain the tweezer’s ideal dimensions and shape.The empirical evidence indicates that the new tweezer can adeptly steer droplets at a markedly lower voltage of 620 V,ensuring a more stable trajectory and significantly diminishing overshoot.The tweezer’s distinctive design also decreases the possibility of electric discharge to the droplet,thus improving the safety of the system for managing delicate droplets.In the experiment,the maximum droplet translation speed attained was 105 mm/s at an applied voltage of 1.2 kV.This represents a 29.6%increase in speed and a 70%decrease in the required voltage compared to the previously highest reported droplet speed.
基金Supported by Hospital-level Project of Shiyan Taihe Hospital(2018JJXM093).
文摘[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.
