Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metasta- sis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that ...Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metasta- sis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV- PyMT, a highly malignant spontaneous breast tumor model, IL-25 （also called IL-17E） was expressed by tumor- infiltrating CD4＋ T cells and macrophages. An IL-25 neu- tralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macro- phages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subse- quent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.展开更多
文摘Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metasta- sis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV- PyMT, a highly malignant spontaneous breast tumor model, IL-25 （also called IL-17E） was expressed by tumor- infiltrating CD4＋ T cells and macrophages. An IL-25 neu- tralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macro- phages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subse- quent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.
