目的探讨慢性自发性荨麻疹(CSU)患者血清Mas相关G蛋白偶联受体成员X2(MRGPRX2)、白细胞介素-6(IL-6)及IL-24的水平在发病中的意义。方法收集2023年9月—2023年12月就诊于徐州医科大学附属医院的CSU患者75例,作为病例组,并根据病情严重...目的探讨慢性自发性荨麻疹(CSU)患者血清Mas相关G蛋白偶联受体成员X2(MRGPRX2)、白细胞介素-6(IL-6)及IL-24的水平在发病中的意义。方法收集2023年9月—2023年12月就诊于徐州医科大学附属医院的CSU患者75例,作为病例组,并根据病情严重程度分为轻度组、中度组、重度组,完成荨麻疹活动评分(urticaria activity score,UAS7)与慢性荨麻疹生活质量问卷评分(chronic urticaria quality of life questionnaire,CU-Q2oL);另选取60例健康者作为对照组。比较各组血清MRGPRX2、IL-6及IL-24水平,分析其与UAS7、CU-Q2oL得分的相关性。结果病例组血清MRGPRX2、IL-6及IL-24水平均高于对照组(P<0.05),CSU患者血清MRGPRX2、IL-6水平升高与其病情严重程度呈正相关(r=0.531,P<0.05;r=0.462,P<0.05),但IL-24水平升高与CSU患者病情严重程度无显著相关性(r=0.015,P>0.05)。经logistic回归分析显示,血清中MRGPRX2、IL-6、IL-24水平升高均是CSU发生的独立危险因素(P<0.05)。经受试者操作特征(ROC)曲线分析结果显示,血清中MRGPRX2、IL-6、IL-24水平3项指标联合预测的曲线下面积(AUC)高于单独指标(P<0.05)。结论血清MRGPRX2、IL-6及IL-24水平在CSU患者血清中呈高表达,且血清MRGPRX2、IL-6与其病情严重程度相关,三者联合检测CSU发生的效能优于各指标单独检测。展开更多
The Internet of Everything(IoE)coupled with Proactive Artificial Intelligence(AI)-Based Learning Agents(PLAs)through a cloud processing system is an idea that connects all computing resources to the Internet,making it...The Internet of Everything(IoE)coupled with Proactive Artificial Intelligence(AI)-Based Learning Agents(PLAs)through a cloud processing system is an idea that connects all computing resources to the Internet,making it possible for these devices to communicate with one another.Technologies featured in the IoE include embedding,networking,and sensing devices.To achieve the intended results of the IoE and ease life for everyone involved,sensing devices and monitoring systems are linked together.The IoE is used in several contexts,including intelligent cars’protection,navigation,security,and fuel efficiency.The Smart Things Monitoring System(STMS)framework,which has been proposed for early occurrence identification and theft prevention,is discussed in this article.The STMS uses technologies based on the IoE and PLAs to continuously and remotely observe,control,and monitor vehicles.The STMS is familiar with the platform used by the global positioning system;as a result,the STMS can maintain a real-time record of current vehicle positions.This information is utilized to locate the vehicle in an accident or theft.The findings of the STMS system are promising for precisely identifying crashes,evaluating incident severity,and locating vehicles after collisions have occurred.Moreover,we formulate an ad hoc STMS network communication scenario to evaluate the efficacy of data communication by utilizing various network parameters,such as round-trip time(RTT),data packet transmission,data packet reception,and loss.From our experimentation,we obtained an improved communication efficiency for STMS across multiple PLAs compared to the standard greedy routing and traditional AODV approaches.Our framework facilitates adaptable solutions with communication competence by deploying Proactive PLAs in a cloud-connected smart vehicular environment.展开更多
The hypersonic target detection and recognition system is studied,on the basis of overall planning and design,a multi-agent system(MAS)structure and intelligent+information processing mechanism based on target detecti...The hypersonic target detection and recognition system is studied,on the basis of overall planning and design,a multi-agent system(MAS)structure and intelligent+information processing mechanism based on target detection and recognition are proposed,and the multi-agent operation process is analyzed and designed in detail.In the specific agents construction,the information fusion technology is introduced to defining the embedded agents and their interrelations in the system structure,and the intelligent processing ability of complex and uncertain problems is emphatically analyzed from the aspects of autonomy and collaboration.The aim is to optimize the information processing strategy of the hypersonic target detection and recognition system and improve the robustness and rapidity of the system.展开更多
This paper explores the value creation of business process management （BPM） and managerial accounting system （MAS） using a case study. The findings show that BPM shortens the management chain and increases the con...This paper explores the value creation of business process management （BPM） and managerial accounting system （MAS） using a case study. The findings show that BPM shortens the management chain and increases the connections among functions in the organization by right reassignment. Accounting indicators in MAS provide necessary information about business processes, which assists performance evaluation in BPM, and meanwhile, incentive schemes give enough motives, which guide employees to take actions in accordance with the organizational strategies and processes＇ goals. The information effect and motive effect of MAS increase employees＇ work satisfaction and their cooperation with each other. In the end, the integration of BPM and MAS improves the organizational economic performance, thus creating value for the organization. The results explain the reason why so much BPM fails in practice, because right assignment, performance evaluation system, and incentive schemes constitute organizational architecture, which is critical to organizational value. Additionally, the value creation of BPM and MAS depends on their coordination with the external environment, the internal situation, and the organizational strategy. From the view of managerial accounting perspective, MAS not only changes with the organization development but also facilitates the organization development.展开更多
Dear Editor, As a promising multi-agent systems(MASs) operation, autonomous interception has attracted more and more attentions in these years, where defenders prevent intruders from reaching destinations.So far, most...Dear Editor, As a promising multi-agent systems(MASs) operation, autonomous interception has attracted more and more attentions in these years, where defenders prevent intruders from reaching destinations.So far, most of the relevant methods are applied in ideal environments without agent damages. As a remedy, this letter proposes a more realistic interception method for MASs suffered by damages.展开更多
Nitrogen-14(^(14)N)overtone(OT)spectroscopy under fast magic angle spinning(MAS)conditions(>60 kHz)has emerged as a powerful technique for observing correlations and distances between ^(14)N and ^(1)H,owing to the ...Nitrogen-14(^(14)N)overtone(OT)spectroscopy under fast magic angle spinning(MAS)conditions(>60 kHz)has emerged as a powerful technique for observing correlations and distances between ^(14)N and ^(1)H,owing to the absence of the first-order quadrupolar broadenings.In addition,^(14)N^(OT) allows selective manipulation of ^(14)N nuclei for each site.Despite extensive theoretical and experimental studies,the spin dynamics of ^(14)N^(OT) remains under debate.In this study,we conducted experimental investigations to assess the spin dynamics of ^(14)N^(OT) using the rotational-echo saturation-pulse double-resonance(RESPDOR)sequence,which monitors population transfer induced by a^(14)N^(OT) pulse.The ^(14)N^(OT) spin dynamics is well represented by a model of a two-energy-level system.Unlike spin-1/2,the maximum excitation efficiency of ^(14)N^(OT) coherences of powdered solids,denoted by p,depends on the radiofrequency field(rf-field)strength due to orientation dependence of effective nutation fields even when pulse lengths are optimized.It is also found that the p factor,contributing to the ^(14)N^(OT) spin dynamics,is nearly independent of the B0 field.Consequently,the filtering efficiency of RESPDOR experiments exhibits negligible dependence on B0 when the ^(14)N^(OT) pulse length is optimized.The study also identifies the optimal experimental conditions for ^(14)N^(OT)/^(1)H RESPDOR correlation experiments.展开更多
文摘目的探讨慢性自发性荨麻疹(CSU)患者血清Mas相关G蛋白偶联受体成员X2(MRGPRX2)、白细胞介素-6(IL-6)及IL-24的水平在发病中的意义。方法收集2023年9月—2023年12月就诊于徐州医科大学附属医院的CSU患者75例,作为病例组,并根据病情严重程度分为轻度组、中度组、重度组,完成荨麻疹活动评分(urticaria activity score,UAS7)与慢性荨麻疹生活质量问卷评分(chronic urticaria quality of life questionnaire,CU-Q2oL);另选取60例健康者作为对照组。比较各组血清MRGPRX2、IL-6及IL-24水平,分析其与UAS7、CU-Q2oL得分的相关性。结果病例组血清MRGPRX2、IL-6及IL-24水平均高于对照组(P<0.05),CSU患者血清MRGPRX2、IL-6水平升高与其病情严重程度呈正相关(r=0.531,P<0.05;r=0.462,P<0.05),但IL-24水平升高与CSU患者病情严重程度无显著相关性(r=0.015,P>0.05)。经logistic回归分析显示,血清中MRGPRX2、IL-6、IL-24水平升高均是CSU发生的独立危险因素(P<0.05)。经受试者操作特征(ROC)曲线分析结果显示,血清中MRGPRX2、IL-6、IL-24水平3项指标联合预测的曲线下面积(AUC)高于单独指标(P<0.05)。结论血清MRGPRX2、IL-6及IL-24水平在CSU患者血清中呈高表达,且血清MRGPRX2、IL-6与其病情严重程度相关,三者联合检测CSU发生的效能优于各指标单独检测。
基金funded by the Ministry of Science and Technology,Taiwan,grant number(MOST 111-2221-E167-025-MY2).
文摘The Internet of Everything(IoE)coupled with Proactive Artificial Intelligence(AI)-Based Learning Agents(PLAs)through a cloud processing system is an idea that connects all computing resources to the Internet,making it possible for these devices to communicate with one another.Technologies featured in the IoE include embedding,networking,and sensing devices.To achieve the intended results of the IoE and ease life for everyone involved,sensing devices and monitoring systems are linked together.The IoE is used in several contexts,including intelligent cars’protection,navigation,security,and fuel efficiency.The Smart Things Monitoring System(STMS)framework,which has been proposed for early occurrence identification and theft prevention,is discussed in this article.The STMS uses technologies based on the IoE and PLAs to continuously and remotely observe,control,and monitor vehicles.The STMS is familiar with the platform used by the global positioning system;as a result,the STMS can maintain a real-time record of current vehicle positions.This information is utilized to locate the vehicle in an accident or theft.The findings of the STMS system are promising for precisely identifying crashes,evaluating incident severity,and locating vehicles after collisions have occurred.Moreover,we formulate an ad hoc STMS network communication scenario to evaluate the efficacy of data communication by utilizing various network parameters,such as round-trip time(RTT),data packet transmission,data packet reception,and loss.From our experimentation,we obtained an improved communication efficiency for STMS across multiple PLAs compared to the standard greedy routing and traditional AODV approaches.Our framework facilitates adaptable solutions with communication competence by deploying Proactive PLAs in a cloud-connected smart vehicular environment.
基金This work was supported by the National Natural Science Foundation of China(61471391).
文摘The hypersonic target detection and recognition system is studied,on the basis of overall planning and design,a multi-agent system(MAS)structure and intelligent+information processing mechanism based on target detection and recognition are proposed,and the multi-agent operation process is analyzed and designed in detail.In the specific agents construction,the information fusion technology is introduced to defining the embedded agents and their interrelations in the system structure,and the intelligent processing ability of complex and uncertain problems is emphatically analyzed from the aspects of autonomy and collaboration.The aim is to optimize the information processing strategy of the hypersonic target detection and recognition system and improve the robustness and rapidity of the system.
文摘This paper explores the value creation of business process management （BPM） and managerial accounting system （MAS） using a case study. The findings show that BPM shortens the management chain and increases the connections among functions in the organization by right reassignment. Accounting indicators in MAS provide necessary information about business processes, which assists performance evaluation in BPM, and meanwhile, incentive schemes give enough motives, which guide employees to take actions in accordance with the organizational strategies and processes＇ goals. The information effect and motive effect of MAS increase employees＇ work satisfaction and their cooperation with each other. In the end, the integration of BPM and MAS improves the organizational economic performance, thus creating value for the organization. The results explain the reason why so much BPM fails in practice, because right assignment, performance evaluation system, and incentive schemes constitute organizational architecture, which is critical to organizational value. Additionally, the value creation of BPM and MAS depends on their coordination with the external environment, the internal situation, and the organizational strategy. From the view of managerial accounting perspective, MAS not only changes with the organization development but also facilitates the organization development.
基金supported by the Science and Technology Project of State Grid Corporation of China, China (5100202199557A-0-5-ZN)。
文摘Dear Editor, As a promising multi-agent systems(MASs) operation, autonomous interception has attracted more and more attentions in these years, where defenders prevent intruders from reaching destinations.So far, most of the relevant methods are applied in ideal environments without agent damages. As a remedy, this letter proposes a more realistic interception method for MASs suffered by damages.
文摘Nitrogen-14(^(14)N)overtone(OT)spectroscopy under fast magic angle spinning(MAS)conditions(>60 kHz)has emerged as a powerful technique for observing correlations and distances between ^(14)N and ^(1)H,owing to the absence of the first-order quadrupolar broadenings.In addition,^(14)N^(OT) allows selective manipulation of ^(14)N nuclei for each site.Despite extensive theoretical and experimental studies,the spin dynamics of ^(14)N^(OT) remains under debate.In this study,we conducted experimental investigations to assess the spin dynamics of ^(14)N^(OT) using the rotational-echo saturation-pulse double-resonance(RESPDOR)sequence,which monitors population transfer induced by a^(14)N^(OT) pulse.The ^(14)N^(OT) spin dynamics is well represented by a model of a two-energy-level system.Unlike spin-1/2,the maximum excitation efficiency of ^(14)N^(OT) coherences of powdered solids,denoted by p,depends on the radiofrequency field(rf-field)strength due to orientation dependence of effective nutation fields even when pulse lengths are optimized.It is also found that the p factor,contributing to the ^(14)N^(OT) spin dynamics,is nearly independent of the B0 field.Consequently,the filtering efficiency of RESPDOR experiments exhibits negligible dependence on B0 when the ^(14)N^(OT) pulse length is optimized.The study also identifies the optimal experimental conditions for ^(14)N^(OT)/^(1)H RESPDOR correlation experiments.
文摘目的探讨血清Mas相关G蛋白偶联受体X2(Mas-related G protein-coupled receptor X2,MRGPRX2)以及细胞因子白介素(interleukin,IL)-4、IL-5、IL-6、IL-13、IL-23、IL-33水平与慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)的相关性。方法收集2021年2月至2023年9月在复旦大学附属华山医院皮肤科就诊的55例CSU患者及同期21例健康体检者的基本临床信息和实验室数据,并评估CSU患者的疾病活动度和严重程度。采集所有受试者的外周血,通过酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测MRGPRX2,用Luminex多重检测技术检测血清IL-4、IL-5、IL-6、IL-13、IL-23、IL-33水平。采用Spearman相关性分析评价CSU患者的生物标志物与其他参数的相关性,logistic回归分析CSU发生的影响因素。结果CSU组患者血清MRGPRX2水平高于对照组[2.41(0,11.51)ng/mL vs 0(0,2.86)ng/mL,P=0.015],IL-23水平高于对照组[0.09(0.04,0.56)pg/mL vs 0.05(0.03,0.08)pg/mL,P=0.033]。两组受试者其他细胞因子水平差异无统计学意义。重度和非重度CSU患者MRGPRX2及细胞因子水平差异无统计学意义。相关性分析结果显示,CSU患者的血清MRGPRX2水平与IL-4(r=0.345,P=0.010)、IL-6(r=0.395,P=0.003)水平正相关。Logistic回归分析显示,血清MRGPRX2≥0.055 ng/mL、IL-23≥0.135 pg/mL是CSU发生的独立危险因素(P<0.05)。结论CSU患者血清MRGPRX2和IL-23水平升高,二者可能参与CSU发病。
