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Moving mirror speed compound control of the Fourier transform spectrometer based on T-method
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作者 HUANG Ying DUAN Juan +2 位作者 GUO Qian DING Lei HUA Jian-Wen 《红外与毫米波学报》 北大核心 2026年第1期137-147,共11页
傅里叶变换光谱仪是一种精密的红外探测仪器,它采用迈克尔逊式干涉分光方式,动镜是其中一个核心部件。动镜运动速度的均匀性和稳定性直接影响了后续干涉图的质量,所以必须对动镜进行高精度的运动控制。对于某些动镜低速应用场合的傅里... 傅里叶变换光谱仪是一种精密的红外探测仪器,它采用迈克尔逊式干涉分光方式,动镜是其中一个核心部件。动镜运动速度的均匀性和稳定性直接影响了后续干涉图的质量,所以必须对动镜进行高精度的运动控制。对于某些动镜低速应用场合的傅里叶光谱仪,常规的M法测速已经不能满足测速精度的要求了。另外,动镜低速运动时,速度稳定性更容易受外界力学扰动的影响。基于动镜低速运动的平稳性需求,文中对基于T法测速的动镜运动控制技术进行了研究,提出了求取速度实测值和速度期望值的高精度算法,并通过建立被控对象的数学模型和动力学方程,得到速度前馈控制量,进而设计了基于速度前馈的复合速度控制器。该设计的动镜速度控制算法由FPGA硬件平台实现,并应用于傅里叶光谱仪实验平台。实验结果表明,采用T法测速控制系统获得动镜运动匀速区速度峰峰值误差是0.0182,速度均方根值误差是0.0027。为测试文中动镜速度控制系统的抗干扰能力,在干涉仪安装平台动镜运动方向分别施加5 mg、7.5 mg、10 mg的正弦激励力,在每个给定量级的激励力下,进行了2~200 Hz频率范围内各频率点的扫描,实验结果表明,速度峰峰值误差和速度均方根值误差和正弦激励的幅值基本成正比例关系。在5 mg时各频率点的力学激励下,速度峰峰值误差最大是0.0724,速度均方根值误差最大是0.0225。从光谱稳定度和红外焦平面探测器采样间隔误差综合分析,5mg量级时的动镜速度均匀性可以满足系统这两方面需求,使得傅里叶光谱仪在微振动环境应用时也具有一定的抗干扰能力。该设计为傅里叶光谱仪低速高平稳性动镜速度控制的实现提供了一种技术途径,同时也使得傅里叶光谱仪有了更广阔的应用场景。 展开更多
关键词 傅里叶光谱仪 速度控制 t法测速 速度前馈 速度均匀性
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dPCR方法动态监测T790M突变在EGFR阳性非小细胞肺癌耐药治疗中的指导作用
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作者 姚铠涛 曾小芸 +3 位作者 连逸恺 林建雄 王双玲 魏丹娜 《分子诊断与治疗杂志》 2026年第1期131-134,共4页
目的本研究旨在探讨使用数字PCR(dPCR)方法动态监测血浆EGFR T790M突变的可行性,并评估基于血浆T790M突变检测的早期干预是否可作为EGFR突变非小细胞肺癌患者EGFR-TKI转换治疗的最佳时机。方法初筛2021年7月至2023年12月在汕头大学医学... 目的本研究旨在探讨使用数字PCR(dPCR)方法动态监测血浆EGFR T790M突变的可行性,并评估基于血浆T790M突变检测的早期干预是否可作为EGFR突变非小细胞肺癌患者EGFR-TKI转换治疗的最佳时机。方法初筛2021年7月至2023年12月在汕头大学医学院第二附属医院75例接受埃克替尼治疗的EGFR阳性Ⅳ期NSCLC患者,T790M突变率为53.3%,最终纳入40例患者。试验组(n=18)在血浆检测到T790M突变后更换第三代EGFR-TKI治疗,对照组(n=22)在影像学进展及T790M突变后更换EGFR-TKI治疗。比较两组的临床疗效、无进展生存期(PFS)及不良反应。结果试验组的客观缓解率(ORR)为72.2%,对照组为68.2%,两组差异无统计学意义(P>0.05)。试验组的疾病控制率(DCR)为94.4%,对照组为81.9%,差异无统计学意义(P>0.05)。试验组的中位PFS显著长于对照组,差异有统计学意义(14.8个月vs 10.3个月,P=0.024)。两组的不良反应均为1~2级,皮疹、腹泻及肝功能异常的发生率比较,差异无统计学意义(P>0.05)。结论使用dPCR动态监测血浆EGFR T790M突变,可较影像学更早识别一代EGFR-TKI耐药,从而及时转换三代EGFR-TKI治疗,延缓疾病进展,是一种经济且临床可行的策略。 展开更多
关键词 非小细胞肺癌 EGFR t790m 数字PCR 三代酪氨酸激酶抑制剂
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阿美替尼治疗获得性EGFR T790M突变晚期肺腺癌的临床疗效研究
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作者 曹婷婷 李红岩 +7 位作者 陈玲 李建伟 安跃振 张一擎 王明 卢泽芬 田文静 王秋桐 《中国新药与临床杂志》 北大核心 2026年第2期116-122,共7页
目的分析比较阿美替尼与化疗治疗获得性表皮生长因子受体(EGFR)T790M突变晚期肺腺癌的疗效及安全性。方法回顾性收集2021年1月至2023年6月接受阿美替尼或化疗治疗晚期肺腺癌患者资料。根据治疗方案分为阿美替尼组和化疗组。主要终点指... 目的分析比较阿美替尼与化疗治疗获得性表皮生长因子受体(EGFR)T790M突变晚期肺腺癌的疗效及安全性。方法回顾性收集2021年1月至2023年6月接受阿美替尼或化疗治疗晚期肺腺癌患者资料。根据治疗方案分为阿美替尼组和化疗组。主要终点指标为无进展生存期,次要终点指标为客观缓解率、疾病控制率、总生存期。采用Cox回归分析预后相关影响因素。结果共86例患者纳入分析,阿美替尼组46例,化疗组40例。阿美替尼组客观缓解率显著高于化疗组(52%vs.22%,P=0.009),2组疾病控制率无显著差异(83%vs.65%,P=0.062),阿美替尼组中位无进展生存期(13个月vs.8个月,P<0.001)和中位总生存期(28个月vs.19个月,P<0.001)均显著高于化疗组。基线有脑转移是影响患者无进展生存期和总生存期的独立危险因素(HR=2.887,95%CI:1.101~7.570;HR=3.087,95%CI:1.325~7.191)。2组不良反应发生率无显著差异(P>0.05)。结论对于携带获得性EGFR T790M突变的晚期肺腺癌患者,阿美替尼在无进展生存期和总生存期方面均优于化疗,且表现出良好的安全性。 展开更多
关键词 阿美替尼 EGFR t790m突变 肺腺癌 疗效
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血浆ctDNA EGFR-T790M对晚期非小细胞肺癌患者接受EGFR-TKI治疗的预后价值
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作者 郭顺坡 郭雨帅 +1 位作者 邓兴艳 李咏梅 《临床肿瘤学杂志》 2026年第3期242-247,共6页
目的探讨多重微滴数字聚合酶链式反应(ddPCR)检测血浆循环肿瘤DNA(ctDNA)中表皮生长因子受体T790M(EGFR-T790M)的实用性,及其对晚期非小细胞肺癌(NSCLC)患者接受EGFR酪氨酸激酶抑制剂(TKI)治疗预后的影响。方法前瞻性纳入2019年8月至202... 目的探讨多重微滴数字聚合酶链式反应(ddPCR)检测血浆循环肿瘤DNA(ctDNA)中表皮生长因子受体T790M(EGFR-T790M)的实用性,及其对晚期非小细胞肺癌(NSCLC)患者接受EGFR酪氨酸激酶抑制剂(TKI)治疗预后的影响。方法前瞻性纳入2019年8月至2022年12月于我院接受吉非替尼、厄洛替尼或阿法替尼治疗的EGFR-TKI致敏突变晚期NSCLC(ⅢB~Ⅳ期)患者133例。于TKI治疗前采集血浆标本,此后每3个月采集1次。采用单基因ddPCR对血浆ctDNA中EGFR-T790M突变进行基因分型。随访至2024年12月31日。采用Kaplan-Meier法绘制总生存期(OS)曲线,并对生存差异进行Log-rank检验。结果经一线EGFR-TKI治疗后,113例(84.96%)患者出现疾病进展,其中79例(69.91%)接受二次肿瘤组织活检,组织T790M突变率为51.90%(41/79);同期血浆ddPCR检测T790MctDNA阳性率为46.84%(37/79)。ddPCR与二次组织活检结果一致性良好,灵敏度为80.49%,特异度为89.47%;ddPCR额外检出8例T790M ctDNA阳性患者。34例未行二次组织活检的患者中,ddPCR检出T790M ctDNA阳性率为44.12%。自血浆EGFR-T790M ctDNA阳性至临床诊断疾病进展的中位时间间隔为1.38(0.35,4.15)个月。15例仅经ddPCR检出T790MctDNA阳性患者的中位OS为28.29(12.96,33.57)个月;其中11例(57.89%)服用奥希替尼,OS显著延长(38.57个月vs.9.17个月,Log-rankχ^(2)=11.365,P=0.001)。结论基于血浆ddPCR的EGFR-T790M ctDNA基因分型是一项有效技术,可用于监测1/2代EGFR-TKI治疗晚期NSCLC患者的EGFR-T790M突变状态,优化患者管理。 展开更多
关键词 晚期非小细胞肺癌 循环肿瘤DNA糖核酸 液滴数字PCR 表皮生长因子受体t790m突变 生存预后
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Mie-T矩阵耦合的沙尘多次散射效应表征与Monte Carlo验证
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作者 汤牧云 朝克夫 +1 位作者 华文成 崔存森 《中国光学(中英文)》 北大核心 2026年第1期85-95,共11页
为精确量化沙尘天气对城市光电系统可见光传输的衰减影响,本研究以呼和浩特地区为例,构建了融合非球形粒子修正的光传输预测模型。基于Mie散射理论,结合本地沙尘样品的扫描电镜与能谱分析数据,计算三基色红绿蓝波段的沙尘粒子消光特性;... 为精确量化沙尘天气对城市光电系统可见光传输的衰减影响,本研究以呼和浩特地区为例,构建了融合非球形粒子修正的光传输预测模型。基于Mie散射理论,结合本地沙尘样品的扫描电镜与能谱分析数据,计算三基色红绿蓝波段的沙尘粒子消光特性;进而采用T矩阵法对非球形粒子的散射参数进行修正,并利用Monte Carlo方法模拟光子的多次散射过程,系统比较单次与多次散射模型下的衰减率差异。结果表明,单次散射模型会系统性高估衰减率,蓝光波段最大误差达18.3%;经多次散射修正后,衰减率平均降低12.4%。在本例中,能见度为400 m,蓝光衰减率约为95 dB/km,显著高于红光的衰减率(约70 dB/km)。本研究构建的混合模型显著提升了沙尘环境下可见光衰减的预测精度,明确多次散射效应的关键影响,为城市光电系统在沙尘天气下的可见光传输提供了可靠的理论依据与数据支持。 展开更多
关键词 沙尘天气 消光系数 mIE散射理论 t矩阵法 monte Carlo模拟 可见光
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WITHDRAWAL:Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models
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《Acta Geologica Sinica(English Edition)》 2025年第2期625-625,共1页
WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphol... WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094. 展开更多
关键词 fractal models morphological division nmr t spectra methods fractal models acta irreducible water saturation nmr t spectra
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3D anisotropic modeling and identification for airborne EM systems based on the spectral-element method 被引量:4
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作者 黄鑫 殷长春 +3 位作者 曹晓月 刘云鹤 张博 蔡晶 《Applied Geophysics》 SCIE CSCD 2017年第3期419-430,461,462,共14页
The airborne electromagnetic (AEM) method has a high sampling rate and survey flexibility. However, traditional numerical modeling approaches must use high-resolution physical grids to guarantee modeling accuracy, e... The airborne electromagnetic (AEM) method has a high sampling rate and survey flexibility. However, traditional numerical modeling approaches must use high-resolution physical grids to guarantee modeling accuracy, especially for complex geological structures such as anisotropic earth. This can lead to huge computational costs. To solve this problem, we propose a spectral-element (SE) method for 3D AEM anisotropic modeling, which combines the advantages of spectral and finite-element methods. Thus, the SE method has accuracy as high as that of the spectral method and the ability to model complex geology inherited from the finite-element method. The SE method can improve the modeling accuracy within discrete grids and reduce the dependence of modeling results on the grids. This helps achieve high-accuracy anisotropic AEM modeling. We first introduced a rotating tensor of anisotropic conductivity to Maxwell's equations and described the electrical field via SE basis functions based on GLL interpolation polynomials. We used the Galerkin weighted residual method to establish the linear equation system for the SE method, and we took a vertical magnetic dipole as the transmission source for our AEM modeling. We then applied fourth-order SE calculations with coarse physical grids to check the accuracy of our modeling results against a 1D semi-analytical solution for an anisotropic half-space model and verified the high accuracy of the SE. Moreover, we conducted AEM modeling for different anisotropic 3D abnormal bodies using two physical grid scales and three orders of SE to obtain the convergence conditions for different anisotropic abnormal bodies. Finally, we studied the identification of anisotropy for single anisotropic abnormal bodies, anisotropic surrounding rock, and single anisotropic abnormal body embedded in an anisotropic surrounding rock. This approach will play a key role in the inversion and interpretation of AEM data collected in regions with anisotropic geology. 展开更多
关键词 Spectral-element method ANISOtROPY frequency-domain AEm GLL interpolation basis function forward m odeling
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基于METTL14-m^(6)A-FOXO3A信号通路介导的细胞自噬探讨补肾强督方抑制炎症治疗强直性脊柱炎的机制研究 被引量:1
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作者 吴琳 李松倍 +2 位作者 苏晓庆 韩天然 李泽光 《海南医科大学学报》 北大核心 2025年第2期94-101,共8页
目的:观察补肾强督方对T淋巴细胞METTL14-m^(6)A-FOXO3A信号通路介导的细胞自噬的影响,从而明确其抑制炎症、治疗强制性脊柱炎的分子机制。方法:使用Jurkat细胞,采用抗CD3联合抗CD28抗体诱导24 h构建细胞模型,并给予补肾强督方含药血清... 目的:观察补肾强督方对T淋巴细胞METTL14-m^(6)A-FOXO3A信号通路介导的细胞自噬的影响,从而明确其抑制炎症、治疗强制性脊柱炎的分子机制。方法:使用Jurkat细胞,采用抗CD3联合抗CD28抗体诱导24 h构建细胞模型,并给予补肾强督方含药血清和METTL14重组蛋白进行干预。采用ELISA法检测炎症因子(IL-23和IL-17A)和氧化应激指标的水平,流式细胞术检测ROS水平,Western blot法检测自噬相关蛋白、METTL14和FOXO3A的表达,RT-qPCR检测METTL14和FOXO3A的表达,斑点杂交实验检测FOXO3A的m^(6)A甲基化水平。结果:与模型组比较,补肾强督方显著降低Jurkat细胞上清中IL-23、IL-17A和MDA的含量与ROS的水平,增加SOD和GSH-Px的活性,差异均具有统计学意义(P<0.01)。此外,补肾强督方能显著上调Jurkat细胞中Beclin-1、FOXO3A和METTL14蛋白和基因的表达和增加LC3Ⅱ/LC3Ⅰ的比值,下调p62蛋白的表达,与模型组比较差异均具有统计学意义(P<0.01)。在此基础之上,与模型组比较,补肾强督方能显著上调Jurkat细胞FOXO3A的m^(6)A甲基化水平,差异均具有统计学意义(P<0.01)。结论:补肾强督方通过METTL14介导的FOXO3A的m^(6)A甲基化修饰促进T细胞自噬,从而达到治疗强直性脊柱炎的作用。 展开更多
关键词 补肾强督方 t淋巴细胞 mEttL14 FOXO3A m^(6)A甲基化修饰
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采用VSG控制的T型三电平通用平均电路模型
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作者 李先允 程煜 +2 位作者 程爽 梁自鑫 郑雨萱 《电源学报》 北大核心 2026年第2期80-90,共11页
采用传统的三相脉宽调制PWM(pulse width modulation)逆变器的构网型光伏系统存在谐波大、效率低等问题,并且目前针对构网型虚拟同步发电机VSG(virtual synchronous generator)控制的主要建模研究未考虑逆变器拓扑本身和多电平变流器对... 采用传统的三相脉宽调制PWM(pulse width modulation)逆变器的构网型光伏系统存在谐波大、效率低等问题,并且目前针对构网型虚拟同步发电机VSG(virtual synchronous generator)控制的主要建模研究未考虑逆变器拓扑本身和多电平变流器对系统稳定性的影响。T型三电平具有谐波小、开关损耗小等优点,因此提出1种应用于构网型VSG的通用T型三电平状态空间平均模型,将电路中的开关器件平均后利用受控源代替形成等效受控源电路,并建立完整的状态空间方程进行稳定性分析。最后通过仿真与实验验证所建等效受控源模型与实际电路的适应性。结果表明,基于受控源的VSG数学模型的输出特性与实际模型一致,且具有良好的稳定性。 展开更多
关键词 VSG控制 t型三电平 等效受控源法 动态建模 参与因子法
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宫颈癌TNM分期与预后相关性分析 被引量:1
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作者 陈锦元 蒋祎 《世界肿瘤研究》 2025年第1期45-51,共7页
目的:基于SEER数据库的宫颈癌患者影响因素分析,分析影响宫颈癌预后的相关因素,为宫颈癌患者预后恢复及治疗提供科学参考依据。方法:利用SEER数据库初步筛查宫颈癌相关数据,从中下载所有符合研究的宫颈癌患者的不同病理分型的数据,选用... 目的:基于SEER数据库的宫颈癌患者影响因素分析,分析影响宫颈癌预后的相关因素,为宫颈癌患者预后恢复及治疗提供科学参考依据。方法:利用SEER数据库初步筛查宫颈癌相关数据,从中下载所有符合研究的宫颈癌患者的不同病理分型的数据,选用第八期T,N,M分期对数据的T,N,M分期进行整理,标准化,筛选,筛选条件为患者第八期T,N,M分期明确,有符合要求的观察结局,如死亡或存活。通过筛查出的患者的不同病理分型的数据,运用SPSS26.0统计软件进行统计描述,采用Kaplan-Meier法。描绘生存曲线并估计患者的生存率,死亡率。生存时间分布的组间比较采用Log-Rank检验,对分析结果中P α = 0.05,以P Objective: Study on the prognostic risk model of cervical cancer patients based on SEER database, analyze the relevant factors affecting the prognosis of cervical cancer, and provide scientific reference for the prognosis recovery and treatment of cervical cancer patients. Methods: The SEER database was used to preliminarily screen the data related to cervical cancer, download the data of different pathological types of cervical cancer patients in line with the study, and select the eighth stage T, N, M to sort out, standardize and screen the T, N and M stages of the data. The screening conditions were that the eighth stage T, N and M stages of patients were clear, and there were satisfactory observed outcomes, such as death or survival. Through the data of different pathological types of patients screened, spss26 0 statistical software for statistical description, using Kaplan Meier method. Draw the survival curve and estimate the survival rate and mortality of patients. The inter group comparison of survival time distribution adopts log rank test to conduct multi factor Cox analysis on the variables with statistical significance of P α = 0.05, P < 0.05. Result: (1) Kaplan Meier univariate analysis: different pathological stages of T stage, N stage and M stage have an impact on the survival of patients, which is statistically significant (P < 0.05), and can affect the survival of patients to varying degrees. (2) Cox multivariate analysis: T stage, N stage and M stage were independent prognostic factors affecting the survival time of patients. Conclusion: Different T, N and M pathological stages of different cervical cancer patients can affect the prognosis of cervical cancer patients to varying degrees. They have a significant impact on the mortality and survival rate of cervical cancer patients, and can provide relevant basis for the development and improvement of the treatment scheme of cervical cancer. 展开更多
关键词 SEER数据库 宫颈癌 t N m病理分期 预后 影响因素分析
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M2-TAMs源性TGF-β1抑制CD8^(+)T细胞免疫功能并促进食管癌进展
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作者 陈素芳 任祎琳 +7 位作者 杨凯歌 井玉莹 陈凯 段余钡 罗成华 王良海 杨兰 胡建明 《中国病理生理杂志》 北大核心 2025年第5期851-860,共10页
目的:探讨食管癌肿瘤微环境中M2样肿瘤相关巨噬细胞(M2-like tumor-associated macrophages,M2-TAMs)介导CD8^(+)T细胞的免疫抑制作用。方法:多重荧光免疫组化分析食管癌组织免疫细胞分布情况;建立体外共培养体系,流式细胞术及活死细胞... 目的:探讨食管癌肿瘤微环境中M2样肿瘤相关巨噬细胞(M2-like tumor-associated macrophages,M2-TAMs)介导CD8^(+)T细胞的免疫抑制作用。方法:多重荧光免疫组化分析食管癌组织免疫细胞分布情况;建立体外共培养体系,流式细胞术及活死细胞染色检测M2-TAMs对CD8^(+)T细胞功能的影响;GEPIA数据库分析PDCD1表达在食管癌患者预后中的价值以及编码基因的表达相关性;免疫组化检测食管癌组织中转化生长因子β1(transforming growth factor-β1,TGF-β1)的表达情况;流式细胞术和酶联免疫法检测加入TGF-β1抑制剂后CD8^(+)T细胞的PD-1、IFN-γ和TNF-α的表达。结果:与早期(I期)食管癌患者相比,中晚期(II~IV期)患者肿瘤组织中CD4^(+)T细胞、CD8^(+)T细胞、Tregs及M2-TAMs浸润数量存在动态变化且相互之间具有显著相关性(P<0.05),M2-TAMs与Tregs的分布与患者不良预后正相关(P<0.05);CD8^(+)T细胞分布与患者不良预后负相关(P<0.05);而CD4^(+)T细胞分布与患者临床预后无显著相关性(P>0.05)。CD8^(+)T细胞与M2-TAMs共培养后CD107a、颗粒酶B、IFN-γ和TNF-α表达水平显著下降(均P<0.01);且M2-TAMs处理后CD8^(+)T细胞与食管癌细胞共培养后,食管癌细胞凋亡减少。PDCD1的高表达与患者的预后不良具有显著相关性(P<0.05),CD8A与PDCD1、TGF-β1与CD274基因表达之间具有显著相关性(P<0.01)。TGF-β1与CD163+细胞的免疫浸润及食管癌的发生发展具有相关性;M2-TAMs与CD8^(+)T细胞共培养体系中加入TGF-β1抑制剂后,CD8^(+)T细胞的PD-1表达显著下调,IFN-γ和TNF-α分泌显著增多(P<0.01)。结论:食管癌肿瘤微环境中M2-TAMs源性TGF-β1抑制CD8^(+)T细胞的抗肿瘤活性。 展开更多
关键词 食管癌 肿瘤微环境 m2样肿瘤相关巨噬细胞 CD8^(+)t细胞 转化生长因子β1
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Weaning methods affect ruminal methanogenic archaea composition and diversity in Holstein calves 被引量:5
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作者 DONG Li-feng MA Jun-nan +1 位作者 TU Yan DIAO Qi-yu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第5期1080-1092,共13页
The objective of the present study was to examine the effect of different weaning methods on the ruminal methanogenic archaea composition and diversity in Holstein calves.Thirty-six newborn Holstein bull calves were a... The objective of the present study was to examine the effect of different weaning methods on the ruminal methanogenic archaea composition and diversity in Holstein calves.Thirty-six newborn Holstein bull calves were assigned to 1 of 3 treatments:(1)conventional weaning(d 56)and fed a high proportion of solid feed(CWS);(2)conventional weaning(d 56)and fed a high proportion of liquid feed(CWL);(3)early weaning(d 42)and fed with a high proportion of solid feed(EWS).High-throughput sequencing of the methyl coenzyme M reductase(mcr A)gene,which encodes theα-subunit of methyl coenzyme M reductase-the enzyme that catalyzes the final step in methanogenesis was used to determine the composition and diversity of rumen methanogens.No significant difference(P>0.05)was observed for operational taxonomic units(OTUs)or richness indices,but diversity indices increased(P<0.05)for calves fed high dietary solids.Predominant families across the three treatments were Methanobacteriaceae,Thermoplasmataceae and Methanomassiliicoccaceae.Calves in the EWS treatment had a higher(P<0.05)relative abundance of Methanobrevibacter sp.strain AbM4 and Methanosphaera stadtmanae,while calves in the CWL treatment had a higher(P<0.05)abundance of Methanosphaera sp.strain SM9.A positive(P<0.05)relationship was identified between butyrate and Methanobrevibacter sp.strain AbM4.In conclusion,the composition and diversity of methanogens in the rumen of Holstein calves varied under the different weaning methods.This study identified a positive relationship between butyrate and Methanobrevibacter sp.strain AbM4,potentially reflecting correlations between ruminal fermentation variables and methanogenesis function.These in-depth analyses provide further understanding of weaning methods for intensified production systems. 展开更多
关键词 calf methyl COENZYmE m reductase(mcrA)gene mEtHANOGENIC archaea DIVERSItY rumen fermentation WEANING methodS
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Synthesis and photoluminescent characteristics of Eu3+-doped MMoO4(M=Sr,Ba)nanophosphors by a hydrothermal method 被引量:6
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作者 李宋楚 于立新 +1 位作者 孙家驹 满孝琴 《Journal of Rare Earths》 SCIE EI CAS CSCD 2017年第4期347-355,共9页
The europium ions doped MMoO4 (M=Sr, Ba) nanophosphors were successfully synthesized via a facile hydrothermal method using isopropanol. The relationship between phosphor crystalline phase, morphology, photohtminesc... The europium ions doped MMoO4 (M=Sr, Ba) nanophosphors were successfully synthesized via a facile hydrothermal method using isopropanol. The relationship between phosphor crystalline phase, morphology, photohtminescent properties and hexadecyl trimethyl ammonium bromide (CTAB) concentration, pH value in precursor solution was investigated. The results indi- cated that the morphology and photoluminescent properties were strongly influenced by CTAB concentration and pH value in precursor solution. In SrMoO4:Eu3+ hosts, the phosphor surface tended to become smoother as the concentration of CTAB was increased; while particles tended to agglomerate as increasing pH value. The relative intensity ratio of charge transfer band to Eu3+ characteristic emission peaks of MMoO4:Eu3+ (M=Sr, Ba) was changed as CTAB concentration and pH value changed. The emission spectra of MMoO4:Eu3+ (M=Sr, Ba) could be adjusted by CTAB concentration and pH value due to their impacts on the structure. It was im- portant that the different morphologies and photoluminescent properties of MMoO4:Eu3+ (M=Sr, Ba) could be obtained by the facile hydrothermal method and modulated by changing CTAB concentration and pH value. 展开更多
关键词 mmoO4:Eu3+ m=Sr Ba) hydrothermal method morphology photoluminescent properties CtAB concentration pH value rare earths
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30 m先张折线预应力T梁斜截面抗裂性能足尺试验研究 被引量:1
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作者 陶敬林 李星泽 +3 位作者 余丁浩 李钢 魏明光 裴辉腾 《工业建筑》 2025年第8期176-184,共9页
先张折线预应力T梁具有承载能力高、适用跨径大等特点,在桥梁工程中具有广泛的应用前景。对于预应力梁,其开裂与否是判断其是否仍处在正常工作状态的重要标志,尤其对于先张法构件,由于其预应力主要通过钢绞线与混凝土之间的黏结力传递,... 先张折线预应力T梁具有承载能力高、适用跨径大等特点,在桥梁工程中具有广泛的应用前景。对于预应力梁,其开裂与否是判断其是否仍处在正常工作状态的重要标志,尤其对于先张法构件,由于其预应力主要通过钢绞线与混凝土之间的黏结力传递,一旦开裂将导致内部预应力筋直接与腐蚀介质接触,并使得两者之间黏结性能降低,进而直接影响其耐久性和安全性。依托实际工程设计了一种新型30 m先张折线预应力T梁,并通过足尺试验与有限元数值分析对其在剪跨比λ=2.5条件下的梁端斜截面抗裂性能进行研究,试验采用分级加载方式。结果表明:裂缝首先在梁端上翼板底部与靠近加载截面下翼缘底侧出现,随后在加载截面附近受拉区以及梁端腹板上部大范围斜向发展,且主要集中于加载点与支点连线两侧。实测试验梁段开裂剪力值为1766 kN,该梁设计剪力为962.6 kN,实测值与设计值比值为1.835,表明该新型T梁具有较好的抗裂性能。基于此,进一步提出该梁的有限元数值计算模型,结果表明在开裂荷载下其对腹板应变分布的预测与实测结果基本一致,可为该新型预应力T梁的斜截面抗裂验算提供参考。 展开更多
关键词 先张法 预应力 混凝土t 抗裂性能 抗剪试验
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Method of reverberation ray matrix for static analysis of planar framed structures composed of anisotropic Timoshenko beam members 被引量:2
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作者 Jiao ZHANG Guohua NIE 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2015年第2期233-242,共10页
Based on the method of reverberation ray matrix(MRRM), a reverberation matrix for planar framed structures composed of anisotropic Timoshenko(T) beam members containing completely hinged joints is developed for st... Based on the method of reverberation ray matrix(MRRM), a reverberation matrix for planar framed structures composed of anisotropic Timoshenko(T) beam members containing completely hinged joints is developed for static analysis of such structures.In the MRRM for dynamic analysis, amplitudes of arriving and departing waves for joints are chosen as unknown quantities. However, for the present case of static analysis, displacements and rotational angles at the ends of each beam member are directly considered as unknown quantities. The expressions for stiffness matrices for anisotropic beam members are developed. A corresponding reverberation matrix is derived analytically for exact and unified determination on the displacements and internal forces at both ends of each member and arbitrary cross sectional locations in the structure. Numerical examples are given and compared with the finite element method(FEM) results to validate the present model. The characteristic parameter analysis is performed to demonstrate accuracy of the present model with the T beam theory in contrast with errors in the usual model based on the Euler-Bernoulli(EB) beam theory. The resulting reverberation matrix can be used for exact calculation of anisotropic framed structures as well as for parameter analysis of geometrical and material properties of the framed structures. 展开更多
关键词 planar framed structure ANISOtROPIC timenshenko(t beam stiffness matrix method of reverberation ray matrix(mRRm static analysis
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Determination of Fe^(2+)/Fe^(3+)Ratios of Magnetite using Different Methods:A Case Study from the Qimantag Metallogenic Belt 被引量:2
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作者 YI Liwen LI Qiuping +2 位作者 LU Anhuai GU Xiangping CHI Guoxiang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2022年第6期2135-2147,共13页
Determination of Fe^(2+)/Fe^(3+)ratios from metallogenic belts to explore controlling physical and chemical conditions of rock formation is of great significance.In order to explore magnetite Fe^(2+)/Fe^(3+)ratios of ... Determination of Fe^(2+)/Fe^(3+)ratios from metallogenic belts to explore controlling physical and chemical conditions of rock formation is of great significance.In order to explore magnetite Fe^(2+)/Fe^(3+)ratios of the Qimantag metallogenic belt,part of the Eastern Kunlun orogenic belt in the northeastern margin of the Qinghai–Tibetan plateau,western Central Orogenic Belt of China,and overcome the limitation of the traditional electronic probe,five different measurement methods are proposed and their respective advantages and disadvantages evaluated,with the composition data of the magnetite obtained using electron probe microanalysis(EPMA).The direct oxygen measurement method has a significant impact on the determination results of FeO and Fe2O3,but the accuracy and uniformity of the results are low.The valence method(Flank method)based on the spectral intensity ratio of Lαto Lβfor iron is also unreliable for FeO and Fe_(2)O^(3)measurements because it is difficult to establish a relationship between Lβ/Lα,the spectral intensity ratio,and the Fe^(2+)/Fe^(3+)content ratio.In comparison,the charge difference method,the surplus-oxygen method and the Mössbauer spectrum method are still the most favorable.Mössbauer spectroscopy,with its isomer movement particularly sensitive to the oxidation state of iron,yields results closer to 0.5,which is relatively reliable.Earlier magnetite deposits are located in intrusions or contact zones and formed by magmatic fluids with high Fe2+/Fe3+ratios,whereas later magnetite deposits are farther away from intrusions and have low Fe^(2+)/Fe^(3+)ratios.The transformation mechanism of hematite and magnetite in the Qimantage metallogenic belt is also studied.No large volume changes,such as pore filling and shrinkage fracture,were detected in the metallogenic belt,and the transformation mechanism is more similar to a reoxidation and reduction mechanism. 展开更多
关键词 iron mAGNEtItE direct oxygen measurement flank-charge difference-surplus-oxygen methods mössbauer spectra Qimantage
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奥希替尼在T790M阳性非小细胞肺癌老年患者靶向治疗中的临床效果及对肿瘤标志物的影响
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作者 李碧峰 施雄文 林文笔 《临床合理用药》 2025年第32期71-73,共3页
目的 观察奥希替尼在T790M阳性非小细胞肺癌(NSCLC)老年患者靶向治疗中的临床效果及对肿瘤标志物的影响。方法 回顾性选取2020年1月—2024年12月厦门市中医院收治的NSCLC患者50例,依据治疗方案不同分为靶向联合组和常规化疗组,各25例。... 目的 观察奥希替尼在T790M阳性非小细胞肺癌(NSCLC)老年患者靶向治疗中的临床效果及对肿瘤标志物的影响。方法 回顾性选取2020年1月—2024年12月厦门市中医院收治的NSCLC患者50例,依据治疗方案不同分为靶向联合组和常规化疗组,各25例。常规化疗组依据患者实际和意愿情况选择以下3种化疗方案:AP(注射用培美曲塞二钠、顺铂注射液或卡铂注射液)、GP(注射用盐酸吉西他滨、顺铂注射液或卡铂注射液)、TP(紫杉醇注射液、顺铂注射液或卡铂注射液),靶向联合组在常规化疗组基础上加用甲磺酸奥希替尼片。2组均以21 d为1个周期,连续治疗2个周期。比较2组近期疗效,治疗前后营养指标[体质指数(BMI)、白蛋白(Alb)]、肿瘤标志物[细胞角质蛋白19片段抗原21-1(CYFRA21-1)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)]、生存质量[卡氏功能状态评分(KPS)],不良反应。结果 靶向联合组疾病控制率为84.00%,与常规化疗组的60.00%比较差异无统计学意义(χ^(2)=3.579,P=0.059)。治疗2个周期后,2组BMI与血清Alb水平降低(P<0.01),但组间比较无统计学差异(P>0.05);2组血清CYFRA21-1、CEA、CA19-9水平降低,且靶向联合组低于常规化疗组(P<0.01);常规化疗组KPS评分降低,但靶向联合组高于常规化疗组(P<0.01),靶向联合组KPS评分与治疗前比较无统计学差异(P>0.05)。靶向联合组与常规化疗组消化道反应、血小板降低、神经毒性、皮肤反应、白细胞异常发生率比较均无统计学差异(P>0.05)。结论 在常规化疗基础上联合奥希替尼治疗老年NSCLC患者,抗肿瘤效果略佳,且联合用药不增加不良反应,患者耐受性更佳,对改善患者生存质量具有更大优势。 展开更多
关键词 非小细胞肺癌 t790m阳性 奥希替尼 化疗 免疫功能 肿瘤标志物
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A decomposition method of nuclear magnetic resonance T2 spectrum for identifying fluid properties 被引量:5
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作者 ZHONG Jibin YAN Ronghui +3 位作者 ZHANG Haitao FENG Yihan LI Nan LIU Xingjun 《Petroleum Exploration and Development》 2020年第4期740-752,共13页
Based on analysis of NMR T2 spectral characteristics,a new method for identifying fluid properties by decomposing T2 spectrum through signal analysis has been proposed.Because T2 spectrum satisfies lognormal distribut... Based on analysis of NMR T2 spectral characteristics,a new method for identifying fluid properties by decomposing T2 spectrum through signal analysis has been proposed.Because T2 spectrum satisfies lognormal distribution on transverse relaxation time axis,the T2 spectrum can be decomposed into 2 to 5 independent component spectra by fitting the T2 spectrum with Gauss functions.By analyzing the free relaxation response characteristics of crude oil and formation water,the dynamic response characteristics of the core mutual drive between oil and water,the petrophysical significance of each component spectrum is clarified.T2 spectrum can be decomposed into clay bound water component spectrum,capillary bound fluid component spectrum,micropores fluid component spectrum and macropores fluid component spectrum.According to the nature of crude oil in the target area,the distribution range of T2 component spectral peaks of oil-bearing reservoir is 165-500 ms on T2 time axis.This range can be used to accurately identify fluid properties.This method has high adaptability in identifying complex oil and water layers in low porosity and permeability reservoirs. 展开更多
关键词 nuclear magnetic resonance free relaxation t2 spectrum decomposition method fitted t2 spectrum component spectrum fluid identification
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An unsupervised clustering method for nuclear magnetic resonance transverse relaxation spectrums based on the Gaussian mixture model and its application 被引量:3
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作者 GE Xinmin XUE Zong’an +6 位作者 ZHOU Jun HU Falong LI Jiangtao ZHANG Hengrong WANG Shuolong NIU Shenyuan ZHAO Ji’er 《Petroleum Exploration and Development》 CSCD 2022年第2期339-348,共10页
To make the quantitative results of nuclear magnetic resonance(NMR) transverse relaxation(T;) spectrums reflect the type and pore structure of reservoir more directly, an unsupervised clustering method was developed t... To make the quantitative results of nuclear magnetic resonance(NMR) transverse relaxation(T;) spectrums reflect the type and pore structure of reservoir more directly, an unsupervised clustering method was developed to obtain the quantitative pore structure information from the NMR T;spectrums based on the Gaussian mixture model(GMM). Firstly, We conducted the principal component analysis on T;spectrums in order to reduce the dimension data and the dependence of the original variables. Secondly, the dimension-reduced data was fitted using the GMM probability density function, and the model parameters and optimal clustering numbers were obtained according to the expectation-maximization algorithm and the change of the Akaike information criterion. Finally, the T;spectrum features and pore structure types of different clustering groups were analyzed and compared with T;geometric mean and T;arithmetic mean. The effectiveness of the algorithm has been verified by numerical simulation and field NMR logging data. The research shows that the clustering results based on GMM method have good correlations with the shape and distribution of the T;spectrum, pore structure, and petroleum productivity, providing a new means for quantitative identification of pore structure, reservoir grading, and oil and gas productivity evaluation. 展开更多
关键词 NmR t2 spectrum Gaussian mixture model expectation-maximization algorithm Akaike information criterion unsupervised clustering method quantitative pore structure evaluation
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The Method for Optimum Design of Water Rocket Flight Stability Performance Conditions Using CAE with T Method and Robust Parameter Design 被引量:2
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作者 Eiji Toma Yoshihiro Ito 《Journal of Applied Mathematics and Physics》 2021年第11期2669-2697,共29页
A water rocket is a rocket system that obtains thrust by injecting water with compressed air of up to about 8 atmospheres. It is usually manufactured using a pressure-resistant PET bottle. The mechanical elements and ... A water rocket is a rocket system that obtains thrust by injecting water with compressed air of up to about 8 atmospheres. It is usually manufactured using a pressure-resistant PET bottle. The mechanical elements and principles contained in the water rocket have much in common with the actual small rocket system, and are suitable as educational and research teaching materials in the field of mechanics. Especially in the field of disaster prevention and mitigation, the use of water rockets is being researched and developed as a rescue tool in the event of a flood or earthquake as a disaster countermeasure. However, since the water rocket is a flying object based on the mechanical principle, it is important to ensure the accuracy and stability of the flight path. In this paper, a mechanical simulator is developed with a numerical calculation program based on the mechanical consideration of water rocket flight performance. In addition, the correlation between the flight distance obtained in the simulation and the estimated flight distance is analyzed by applying a multivariate analysis method and verifying the validity of the flight distance calculated from the result. Based on the verification results, we will apply a statistical optimization method to approach the optimization of flight stability performance conditions for water rockets. 展开更多
关键词 Flying Principle multivariate Analysis t method Robust Parameter Design Flight Stability Energetic SN Ratio
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