N^(6)-methyladenosine RNA methylation,an essential post-transcriptional modification,dynamically regulates RNA metabolism and plays a crucial role in neuronal function.Growing evidence suggests that dysregulated N^(6)...N^(6)-methyladenosine RNA methylation,an essential post-transcriptional modification,dynamically regulates RNA metabolism and plays a crucial role in neuronal function.Growing evidence suggests that dysregulated N^(6)-methyladenosine modification contributes to the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,and amyotrophic lateral sclerosis.However,the precise mechanisms by which N^(6)-methyladenosine modification influences these conditions remain unclear.This review summarizes the role of m6A modification and its associated regulators in neurodegeneration,focusing on their involvement in key pathological processes.In Alzheimer’s disease,m6A modification contributes to synaptic dysfunction,mitochondrial damage,and neuronal apoptosis.Evidence from APP/PS1,5xFAD,tau transgenic,and Drosophila models demonstrates that regulators such as methyltransferase-like 3 and fat mass and obesity-associated protein influence Alzheimer’s disease progression through neuroinflammation,circular RNAs dysregulation,and autophagy-related mechanisms.In Parkinson’s disease,altered N^(6)-methyladenosine regulator expression affects dopaminergic neuron survival and stress responses by modulating mRNA stability and autophagy-related lncRNAs.In multiple sclerosis and amyotrophic lateral sclerosis,N^(6)-methyladenosine affects immune activation,myelin repair,and the regulation of disease-associated genes such as TDP-43.Beyond N^(6)-methyladenosine,other RNA methylation modifications-such as m1A,m5C,m7G,uracil,and pseudouridine-are implicated in neurodegenerative diseases through their regulation of mitochondrial function,RNA metabolism,and neuronal stress responses.Additionally,N^(6)-methyladenosine exhibits cell type-specific functions:in microglia,it regulates inflammatory activation and phagocytic function;in astrocytes,it modulates metabolic homeostasis and glutamate-associated neurotoxicity;in neurons,it affects synaptic function and neurodegeneration-related gene expression;and in adult neural stem cells,it controls differentiation,neurogenesis,and cognitive plasticity.Recently,several small-molecule inhibitors targeting methyltransferase-like 3 or fat mass and obesity-associated protein have been developed to modulate N^(6)-methyladenosine modification,providing new opportunities for disease intervention,with the targeting of N⁶-methyladenosine-related pathways emerging as a promising therapeutic strategy.However,challenges persist in optimizing the specificity and delivery of these therapeutic approaches.展开更多
In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectr...In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectrum given by Code for Seismic Design of Buildings (GB50011-2001). Sometimes, there may be a remarkable difference be-tween them. If the PCS is lower than the corresponding code design response spectrum (CDS), the seismic fortifi-cation criterion for the key projects would be lower than that for the general industry and civil buildings. In the paper, the relation between PCS and CDS is discussed by using the ideal simple potential seismic source. The re-sults show that in the most areas influenced mainly by the potential sources of the epicentral earthquakes and the regional earthquakes, PCS is generally lower than CDS in the long periods. We point out that the long-period re-sponse spectra of the code should be further studied and combined with the probability method of seismic zoning as much as possible. Because of the uncertainties in SSE, it should be prudent to use the long-period response spectra given by SSE for key projects when they are lower than CDS.展开更多
利用1989—1996年滇西地震预报实验场绝对重力和相对重力观测资料,采用逐年差分和多年累积的方法,分析滇西地震预报实验场内部不同时间尺度的重力场演变特征及其与丽江地震在时空上的对应关系,结果表明:①1992年以前,研究区内部重力场...利用1989—1996年滇西地震预报实验场绝对重力和相对重力观测资料,采用逐年差分和多年累积的方法,分析滇西地震预报实验场内部不同时间尺度的重力场演变特征及其与丽江地震在时空上的对应关系,结果表明:①1992年以前,研究区内部重力场变化平稳,1993年出现局部变化,1995年变化急剧加大,震后快速反向调整,变化量值基本与震前多年累积相当,重力场演化特征与丽江地震存在高度时空对应关系,表明该时段重力场变化为丽江地震的孕震特征。②研究区差分及累积重力场动态演化过程中,在川滇菱形块体与滇西块体边界产生重力变化梯度带,表明这2个块体构造活动剧烈。③沿红河断裂带出现(-60~90)×10-8 m/s 2的重力变化高梯度带,其走向与红河断裂构造高度一致,反映区域重力场变化受主要活动构造控制,是地下深部壳幔物质运移的表现。展开更多
Long non coding RNAs(lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell’s transcriptional output, demonstrate functional att...Long non coding RNAs(lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell’s transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlled expression, RNA processing and editing, dosage compensation, genomic imprinting, conserved evolutionary traits etc. These long non coding variants are well associated with pathogenicity of various diseases including the neurological disorders like Alzheimer’s disease, schizophrenia, Huntington’s disease, Parkinson’s disease etc. Neurological disorders are widespread and there knowing the underlying mechanisms become crucial. The lncRNAs take part in the pathogenesis by a plethora of mechanisms like decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. Detailed knowledge of the role of lncRNAs can help to use them further as novel biomarkers for therapeutic aspects. Here, in this review we discuss regulation and functional roles of lncRNAs in eight neurological diseases and psychiatric disorders, and the mechanisms by which they act. With these, we try to establish their roles as potential markers and viable diagnostic tools in these disorders.展开更多
In this paper,it has proposed a realtime implementation of low-density paritycheck(LDPC)decoder with less complexity used for satellite communication on FPGA platform.By adopting a(2048.4096)irregular quasi-cyclic(QC)...In this paper,it has proposed a realtime implementation of low-density paritycheck(LDPC)decoder with less complexity used for satellite communication on FPGA platform.By adopting a(2048.4096)irregular quasi-cyclic(QC)LDPC code,the proposed partly parallel decoding structure balances the complexity between the check node unit(CNU)and the variable node unit(VNU)based on min-sum(MS)algorithm,thereby achieving less Slice resources and superior clock performance.Moreover,as a lookup table(LUT)is utilized in this paper to search the node message stored in timeshare memory unit,it is simple to reuse and save large amount of storage resources.The implementation results on Xilinx FPGA chip illustrate that,compared with conventional structure,the proposed scheme can achieve at last 28.6%and 8%cost reduction in RAM and Slice respectively.The clock frequency is also increased to 280 MHz without decoding performance deterioration and convergence speed reduction.展开更多
Plasma disruption is often an unavoidable aspect of tokamak operations. It may cause severe damage to in-vessel components such as the vacuum vessel conductors, the first wall and the divertor target plates. Two types...Plasma disruption is often an unavoidable aspect of tokamak operations. It may cause severe damage to in-vessel components such as the vacuum vessel conductors, the first wall and the divertor target plates. Two types of disruption, the hot-plasma vertical displacement event and the major disruption with a cold-plasma vertical displacement event, are simulated by the DINA code for HL-2M. The time evolutions of the plasma current, the halo current, the magnetic axis, the minor radius, the elongation as well as the electromagnetic force and eddy currents on the vacuum vessel during the thermal quench and the current quench are investigated. By comparing the electromagnetic forces before and after the disruption, we find that the disruption causes great damage to the vacuum vessel conductors. In addition, the hot-plasma vertical displacement event is more dangerous than the major disruption with the cold-plasma vertical displacement event.展开更多
The Galileo E1 open service （OS） and the global positioning system （GPS） L1C are intending to use the multiplexed binary offset carrier （MBOC） modulation in E1/L1 band, including both pilot and data components. ...The Galileo E1 open service （OS） and the global positioning system （GPS） L1C are intending to use the multiplexed binary offset carrier （MBOC） modulation in E1/L1 band, including both pilot and data components. The impact of data and pilot codes cross-correlation on the distortion of the discriminator function （i.e., the S-curve） is investigated, when only the pilot （or data） components of MBOC signals are tracked. It is shown that the modulation schemes and the receiver configuration （e.g., the correlator spacing） strongly affect the S-curve bias. In this paper, two methods are proposed to optimize the data/pilot code pairs of Galileo E1 OS and GPS L1C. The optimization goal is to obtain the minimum average S-curve bias when tracking only the pilot components a the specific correlator spacing. Figures of merit, such as S-curve bias, correlation loss and code tracking variance have been adopted for analyzing and comparing the un-optimized and optimized code pairs. Simulation results show that the optimized data/pilot code pairs could significantly mitigate the intra-channel codes cross-correlation, and then improve the code tracking performance of MBOC signals.展开更多
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report...Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.展开更多
Multiple access interference (MAI) is the most serious interference in spectral phase encoding optical code division multiple access (SPE OCDMA) systems. This paper focuses on the behavior of MAI in SPE OCDMA systems ...Multiple access interference (MAI) is the most serious interference in spectral phase encoding optical code division multiple access (SPE OCDMA) systems. This paper focuses on the behavior of MAI in SPE OCDMA systems with pseudorandom coding. The statistical expectation of multi access interference (MAI) is derived and plotted. The results confirm that MAI can be suppressed effectively by pseudorandom coding with m sequences.展开更多
基金supported by the National Nature Science Foundation of China(General Program),Nos.82271237,82071218(both to JC),and 82230042(to ZY)the Foundation of Key Laboratory of Neurology,Hebei Medical University,Ministry of Education,China,No.2023001(to JC).
文摘N^(6)-methyladenosine RNA methylation,an essential post-transcriptional modification,dynamically regulates RNA metabolism and plays a crucial role in neuronal function.Growing evidence suggests that dysregulated N^(6)-methyladenosine modification contributes to the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,and amyotrophic lateral sclerosis.However,the precise mechanisms by which N^(6)-methyladenosine modification influences these conditions remain unclear.This review summarizes the role of m6A modification and its associated regulators in neurodegeneration,focusing on their involvement in key pathological processes.In Alzheimer’s disease,m6A modification contributes to synaptic dysfunction,mitochondrial damage,and neuronal apoptosis.Evidence from APP/PS1,5xFAD,tau transgenic,and Drosophila models demonstrates that regulators such as methyltransferase-like 3 and fat mass and obesity-associated protein influence Alzheimer’s disease progression through neuroinflammation,circular RNAs dysregulation,and autophagy-related mechanisms.In Parkinson’s disease,altered N^(6)-methyladenosine regulator expression affects dopaminergic neuron survival and stress responses by modulating mRNA stability and autophagy-related lncRNAs.In multiple sclerosis and amyotrophic lateral sclerosis,N^(6)-methyladenosine affects immune activation,myelin repair,and the regulation of disease-associated genes such as TDP-43.Beyond N^(6)-methyladenosine,other RNA methylation modifications-such as m1A,m5C,m7G,uracil,and pseudouridine-are implicated in neurodegenerative diseases through their regulation of mitochondrial function,RNA metabolism,and neuronal stress responses.Additionally,N^(6)-methyladenosine exhibits cell type-specific functions:in microglia,it regulates inflammatory activation and phagocytic function;in astrocytes,it modulates metabolic homeostasis and glutamate-associated neurotoxicity;in neurons,it affects synaptic function and neurodegeneration-related gene expression;and in adult neural stem cells,it controls differentiation,neurogenesis,and cognitive plasticity.Recently,several small-molecule inhibitors targeting methyltransferase-like 3 or fat mass and obesity-associated protein have been developed to modulate N^(6)-methyladenosine modification,providing new opportunities for disease intervention,with the targeting of N⁶-methyladenosine-related pathways emerging as a promising therapeutic strategy.However,challenges persist in optimizing the specificity and delivery of these therapeutic approaches.
基金Shanghai Science & Technology Development Foundation (022512065) and Shanghai Construction Technology Development Foundation (A0206101).
文摘In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectrum given by Code for Seismic Design of Buildings (GB50011-2001). Sometimes, there may be a remarkable difference be-tween them. If the PCS is lower than the corresponding code design response spectrum (CDS), the seismic fortifi-cation criterion for the key projects would be lower than that for the general industry and civil buildings. In the paper, the relation between PCS and CDS is discussed by using the ideal simple potential seismic source. The re-sults show that in the most areas influenced mainly by the potential sources of the epicentral earthquakes and the regional earthquakes, PCS is generally lower than CDS in the long periods. We point out that the long-period re-sponse spectra of the code should be further studied and combined with the probability method of seismic zoning as much as possible. Because of the uncertainties in SSE, it should be prudent to use the long-period response spectra given by SSE for key projects when they are lower than CDS.
文摘利用1989—1996年滇西地震预报实验场绝对重力和相对重力观测资料,采用逐年差分和多年累积的方法,分析滇西地震预报实验场内部不同时间尺度的重力场演变特征及其与丽江地震在时空上的对应关系,结果表明:①1992年以前,研究区内部重力场变化平稳,1993年出现局部变化,1995年变化急剧加大,震后快速反向调整,变化量值基本与震前多年累积相当,重力场演化特征与丽江地震存在高度时空对应关系,表明该时段重力场变化为丽江地震的孕震特征。②研究区差分及累积重力场动态演化过程中,在川滇菱形块体与滇西块体边界产生重力变化梯度带,表明这2个块体构造活动剧烈。③沿红河断裂带出现(-60~90)×10-8 m/s 2的重力变化高梯度带,其走向与红河断裂构造高度一致,反映区域重力场变化受主要活动构造控制,是地下深部壳幔物质运移的表现。
文摘Long non coding RNAs(lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell’s transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlled expression, RNA processing and editing, dosage compensation, genomic imprinting, conserved evolutionary traits etc. These long non coding variants are well associated with pathogenicity of various diseases including the neurological disorders like Alzheimer’s disease, schizophrenia, Huntington’s disease, Parkinson’s disease etc. Neurological disorders are widespread and there knowing the underlying mechanisms become crucial. The lncRNAs take part in the pathogenesis by a plethora of mechanisms like decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. Detailed knowledge of the role of lncRNAs can help to use them further as novel biomarkers for therapeutic aspects. Here, in this review we discuss regulation and functional roles of lncRNAs in eight neurological diseases and psychiatric disorders, and the mechanisms by which they act. With these, we try to establish their roles as potential markers and viable diagnostic tools in these disorders.
文摘In this paper,it has proposed a realtime implementation of low-density paritycheck(LDPC)decoder with less complexity used for satellite communication on FPGA platform.By adopting a(2048.4096)irregular quasi-cyclic(QC)LDPC code,the proposed partly parallel decoding structure balances the complexity between the check node unit(CNU)and the variable node unit(VNU)based on min-sum(MS)algorithm,thereby achieving less Slice resources and superior clock performance.Moreover,as a lookup table(LUT)is utilized in this paper to search the node message stored in timeshare memory unit,it is simple to reuse and save large amount of storage resources.The implementation results on Xilinx FPGA chip illustrate that,compared with conventional structure,the proposed scheme can achieve at last 28.6%and 8%cost reduction in RAM and Slice respectively.The clock frequency is also increased to 280 MHz without decoding performance deterioration and convergence speed reduction.
基金Supported by the China ITER Plan Project Foundation under Grant Nos 2013GB113001 and 2014GB110004
文摘Plasma disruption is often an unavoidable aspect of tokamak operations. It may cause severe damage to in-vessel components such as the vacuum vessel conductors, the first wall and the divertor target plates. Two types of disruption, the hot-plasma vertical displacement event and the major disruption with a cold-plasma vertical displacement event, are simulated by the DINA code for HL-2M. The time evolutions of the plasma current, the halo current, the magnetic axis, the minor radius, the elongation as well as the electromagnetic force and eddy currents on the vacuum vessel during the thermal quench and the current quench are investigated. By comparing the electromagnetic forces before and after the disruption, we find that the disruption causes great damage to the vacuum vessel conductors. In addition, the hot-plasma vertical displacement event is more dangerous than the major disruption with the cold-plasma vertical displacement event.
基金National Basic Research Program of China(No.2010CB731805)
文摘The Galileo E1 open service （OS） and the global positioning system （GPS） L1C are intending to use the multiplexed binary offset carrier （MBOC） modulation in E1/L1 band, including both pilot and data components. The impact of data and pilot codes cross-correlation on the distortion of the discriminator function （i.e., the S-curve） is investigated, when only the pilot （or data） components of MBOC signals are tracked. It is shown that the modulation schemes and the receiver configuration （e.g., the correlator spacing） strongly affect the S-curve bias. In this paper, two methods are proposed to optimize the data/pilot code pairs of Galileo E1 OS and GPS L1C. The optimization goal is to obtain the minimum average S-curve bias when tracking only the pilot components a the specific correlator spacing. Figures of merit, such as S-curve bias, correlation loss and code tracking variance have been adopted for analyzing and comparing the un-optimized and optimized code pairs. Simulation results show that the optimized data/pilot code pairs could significantly mitigate the intra-channel codes cross-correlation, and then improve the code tracking performance of MBOC signals.
基金supported by the National Natural Science Foundation of China,Nos.82171429,81771384a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
文摘Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.
基金Fund of Science and Technology Develop-ment of Shanghai(No.0 0 JC14 0 5 4
文摘Multiple access interference (MAI) is the most serious interference in spectral phase encoding optical code division multiple access (SPE OCDMA) systems. This paper focuses on the behavior of MAI in SPE OCDMA systems with pseudorandom coding. The statistical expectation of multi access interference (MAI) is derived and plotted. The results confirm that MAI can be suppressed effectively by pseudorandom coding with m sequences.
