Objective： To investigate the involvement of pulmonary function impairment in ulcerative colitis（UC）, and explore a scientific basis for the Chinese medicine（CM） theory of exterior-interior correlation between L...Objective： To investigate the involvement of pulmonary function impairment in ulcerative colitis（UC）, and explore a scientific basis for the Chinese medicine（CM） theory of exterior-interior correlation between Lung（Fei） and Large intestine（Dachang）. Methods： Totally 120 patients with a diagnosis of UC were recruited and the demographics, clinical data, and blood samples were collected. C-reactive protein（CRP） and erythrocyte sedimentation rate（ESR） concentrations were measured. Every patient accepted pulmonary function test and took chest radiograph（CXR）. Results： Pulmonary function abnormalities were present in 72 of 120 patients. The median（interquartile range） vital capacity（VC）, forced vital capacity（FVC）, forced expiratory volume in 1 s（FEV_1）, carbon monoxide diffusion capacity（DL_∞） of lung, total lung capacity（TLC） and functional residual volume（FRV） were decreased in distal UC and pancolitis compared with ulcerative prochitis（P〈0.0005）. Male patients had increased VC, FEV_1/FVC, and residual volume（RV）/TLC compared with female（P〈0.0005）, but decreased DLCO and carbon monoxide iffusion capacity（KCO） of lung/alveolar ventilation（P〈0.0005）. Age was strongly correlated with RV（Spearman rank correlation coefficient（rs）=–0.57, P〈0.0001）, and RV/TLC（rs=0.48, P〈0.0001）. Age was also correlated with FEV_1/FVC（rs=–0.29, P=0.001）, forced expiratory flow in 75% vital capacity（FEF75%, rs=–0.20, P=0.03）, DLCO（rs=–0.21, P=0.02）, TLC（rs=–0.25, P=0.006）, and FRV（rs=–0.28, P=0.002）. The course of disease was correlated with FEF75%（rs=–0.18, P=0.049） and KCO（rs=–0.19, P=0.036）. Chest radiograph abnormalities were presented in 38 of 120. Pulmonary symptoms were presented in 10 of 120. Other extraintestinal complications were presented in 21 of 120. Conclusions： Pulmonary function impairment was more frequently than other extraintestinal complications in UC patients, which may be affected by sex, age, extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine.展开更多
Human lung growth involves complex processes.Previous studies have suggested associations of prenatal ambient ozone(O_(3))exposure with impaired lung function,but the causal relationships remain unclear.In this cross-...Human lung growth involves complex processes.Previous studies have suggested associations of prenatal ambient ozone(O_(3))exposure with impaired lung function,but the causal relationships remain unclear.In this cross-sectional cohort study,pulmonary function tests were conducted on recruited participants.Prenatal exposure to the maximum daily 8 h average of daily O_(3)(MDA8 O_(3))and other environmental factors were estimated.Generalized linear model,generalized propensity score,and inverse probability weighting were used to investigate the causal relationship between MDA8 O_(3) and impaired lung function.Finally,a total of 1058 children were included.Each 10μg/m^(3) increase in MDA8 O_(3) during the entire pregnancy,the first trimester,and the third trimester was positively associated with the risk of impaired lung function in childhood,with odd ratios and 95%confidence intervals of 1.52(95%CI:1.06−2.18),1.22(95%CI:1.06−1.41),and 1.47(95%CI:1.19−1.83),respectively.The associations for participants exposed to a high ambient temperature(TM),low relative humidity(RH),and low residential greenness during the pregnancy were higher.Prenatal exposure to higher MDA8 O_(3) concentrations may cause impaired lung function in childhood.The adverse influence of the presence of O_(3) may be amplified by elevated ambient TM and attenuated by RH and residential greenness.展开更多
基金Supported by the National Basic Research Program,Ministry of Science and Technology,China(No.2009CB522705)
文摘Objective： To investigate the involvement of pulmonary function impairment in ulcerative colitis（UC）, and explore a scientific basis for the Chinese medicine（CM） theory of exterior-interior correlation between Lung（Fei） and Large intestine（Dachang）. Methods： Totally 120 patients with a diagnosis of UC were recruited and the demographics, clinical data, and blood samples were collected. C-reactive protein（CRP） and erythrocyte sedimentation rate（ESR） concentrations were measured. Every patient accepted pulmonary function test and took chest radiograph（CXR）. Results： Pulmonary function abnormalities were present in 72 of 120 patients. The median（interquartile range） vital capacity（VC）, forced vital capacity（FVC）, forced expiratory volume in 1 s（FEV_1）, carbon monoxide diffusion capacity（DL_∞） of lung, total lung capacity（TLC） and functional residual volume（FRV） were decreased in distal UC and pancolitis compared with ulcerative prochitis（P〈0.0005）. Male patients had increased VC, FEV_1/FVC, and residual volume（RV）/TLC compared with female（P〈0.0005）, but decreased DLCO and carbon monoxide iffusion capacity（KCO） of lung/alveolar ventilation（P〈0.0005）. Age was strongly correlated with RV（Spearman rank correlation coefficient（rs）=–0.57, P〈0.0001）, and RV/TLC（rs=0.48, P〈0.0001）. Age was also correlated with FEV_1/FVC（rs=–0.29, P=0.001）, forced expiratory flow in 75% vital capacity（FEF75%, rs=–0.20, P=0.03）, DLCO（rs=–0.21, P=0.02）, TLC（rs=–0.25, P=0.006）, and FRV（rs=–0.28, P=0.002）. The course of disease was correlated with FEF75%（rs=–0.18, P=0.049） and KCO（rs=–0.19, P=0.036）. Chest radiograph abnormalities were presented in 38 of 120. Pulmonary symptoms were presented in 10 of 120. Other extraintestinal complications were presented in 21 of 120. Conclusions： Pulmonary function impairment was more frequently than other extraintestinal complications in UC patients, which may be affected by sex, age, extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine.
基金supported by the National Natural Science Foundation of China(42175181 and 42375180)the Natural Science Foundation of Guangdong Province(2024A1515012088)the Guangdong Natural Science Foundation General Program(2025A1515011676).
文摘Human lung growth involves complex processes.Previous studies have suggested associations of prenatal ambient ozone(O_(3))exposure with impaired lung function,but the causal relationships remain unclear.In this cross-sectional cohort study,pulmonary function tests were conducted on recruited participants.Prenatal exposure to the maximum daily 8 h average of daily O_(3)(MDA8 O_(3))and other environmental factors were estimated.Generalized linear model,generalized propensity score,and inverse probability weighting were used to investigate the causal relationship between MDA8 O_(3) and impaired lung function.Finally,a total of 1058 children were included.Each 10μg/m^(3) increase in MDA8 O_(3) during the entire pregnancy,the first trimester,and the third trimester was positively associated with the risk of impaired lung function in childhood,with odd ratios and 95%confidence intervals of 1.52(95%CI:1.06−2.18),1.22(95%CI:1.06−1.41),and 1.47(95%CI:1.19−1.83),respectively.The associations for participants exposed to a high ambient temperature(TM),low relative humidity(RH),and low residential greenness during the pregnancy were higher.Prenatal exposure to higher MDA8 O_(3) concentrations may cause impaired lung function in childhood.The adverse influence of the presence of O_(3) may be amplified by elevated ambient TM and attenuated by RH and residential greenness.
