More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unme...More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet clinical need for a diseasemodifying therapy.展开更多
Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior ...Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior and time-varying meshing stiffness(TVMS)of spiral bevel gear pair with cracked tooth.The tooth is sliced,and the contact points on slices are computed using roll angle surfaces.Considering the geometric complexity of crack surface,a set of procedures is formulated to generate spatial crack and determine crack parameters for contact points.According to the positional relationship between contact point and crack path,each sliced tooth is modeled as a non-uniform cantilever beam with varying reduced effective load-bearing tooth thickness.Then the compliance model of the cracked tooth is established to perform contact analysis,along with TVMS calculations utilizing three different models.By employing spiral bevel gear pairs with distinct types of cracks as examples,the accuracy and efficiency of the developed approach are validated via comparative analyses with finite element analysis(FEA)outcomes.Furthermore,the investigation on effects of cracks shows that tooth cracks can induce alterations in meshing performance of both entire gear pair and individual tooth pairs,including not only cracked tooth pair but also adjacent non-cracked tooth pairs.Hence,the proposed model can serve as a useful tool for analyzing the variations in contact behavior and meshing stiffness of spiral bevel gears due to different cracks.展开更多
Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD i...Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD is increasing,affecting up to 20%of the Western European population.This trend was particularly pronounced in high-risk occupational sectors,including healthcare,food services,metal and construction workers,and hairdressers[1].The skin sensitization adverse outcome pathway(AOP)comprises 11 elements,with four designated key events(KEs):formation of proteinhapten complexes(KE-1),inflammatory keratinocyte response(KE-2),dendritic cell(DC)activation(KE-3),and T-cell proliferation(KE-4)[2].As there is no cure for ACD,preventive strategies are of great relevance.In addition to avoiding exposure,preventive measures,such as the use of latex gloves,barrier creams,emollients,and moisturizers,often have limited effectiveness[3].展开更多
Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of...Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of overlying shallow foundations.In this study,the undrained bearing capacity of shallow foundations resting on inhomogeneous and anisotropic clay layers subjected to oblique-eccentric combined loading is investigated through a comprehensive series of finite element limit analysis(FELA)based on the well-established lower-bound theorem and second-order cone programming(SOCP).The heterogeneity of normally consolidated(NC)clays is simulated by adopting a well-known general model of undrained shear strength increasing linearly with depth.In contrast,for overconsolidated(OC)clays,the variation of undrained shear strength with depth is considered to follow a bilinear trend.Furthermore,the inherent anisotropy is accounted for by adopting different values of undrained shear strength along different directions within the soil medium,employing an iterative-based algorithm.The results of numerical simulations are utilized to investigate the influences of natural soil heterogeneity and inherent anisotropy on the ultimate bearing capacity,failure envelope,and failure mechanism of shallow foundations subjected to the various combinations of vertical-horizontal(V-H)and vertical-moment(V-M)loads.展开更多
This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with d...This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with different air injection slot configura- tions are measured by using a five-hole probe at the cascade outlets. Ink-trace flow visualization is performed to obtain the flow details around the air injection slots. The static pressure distribution is clarified with pressure taps on the endwalls. The...展开更多
There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-1...There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-194 loaded in gelatin nanosphere were injected into the muscle atrophy model to realize controlled release.展开更多
A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and f...A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and filter the signal,and the time-frequency domain evolution of induced charge signals is analyzed during coal failure experiments.The quantitative relationships between the induced electric charge and stress-strain energy,and ultimately,between induced electric charge and coal deformation/failure,are revealed.Ultimately,the electric charge sensor exhibits high signal collection frequency and high sensitivity,and the FIR low-pass filter constructed in MATLAB effectively denoises and filters induced charge signals.The main frequency range of the white noise is 50-500 Hz,and the main frequency of the charge signal induced by coal deformation and failure is concentrated in the range of 0-50 Hz.The optimal distances for monitoring cubic and cylindrical raw coal samples using this sensor are 9 mm and 11 mm,respectively.Notably,strain energy is released faster when it can dissipate more readily,and induced charge pulses become denser when more intense signals produce large fluctuations.A method is proposed to identify coal deformation and failure based on changes in the induced electric charge.This study provides a new means of monitoring the early warning signs of dynamic coal mine disasters.Based on our experimental results and conclusions,a new method is proposed to identify coal deformation and failure based on changes in the induced electric charge.The precursor to the moment of coal failure can be identified by monitoring the amplitude of the induced charge,the dynamic trend of fluctuation,and the cumulative number of induced electric charge pulses during the process of coal deformation.展开更多
Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failur...Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failure of roadway support,thus threatening the safety of the roadway.In this paper,the variable angle shear test of drilled specimens under the action of static and dynamic loads is used to study the evolution of mechanical parameters of the specimens and their influence on the plastic zone of the sur-rounding rock.The shear strength decreases linearly with the increase of drilling diameter.With the increase of pre-static load level and dynamic load amplitude,the cohesion first increases and then decreases,and the internal friction angle decreases.Moreover,the shear failure surface changes from rough to smooth.The reasons include that the static load enhances the tooth cutting effect and the repeated friction of cracks caused by the dynamic load.Borehole pressure relief leads to an increase in the radius of the plastic zone of the surrounding rock following a quadratic function.The research results of this paper provide a theoretical basis for designing drilling unloading parameters and supporting parameters for rock burst roadways.展开更多
Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalyti...Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalytic processes[1–3].Based on the different metal loading sites,these bifunctional catalysts can be categorized as follows:(a)metal species loaded on the outer surface of zeolite crystals,(b)metal species encapsulated within the channels or cavities of zeolites,and(c)metal species incorporated into the zeolite framework(Fig.1).Metal species in type(b)and(c)samples are stabilized by the zeolite frameworks,resulting in excellent thermal and hydrothermal stability during catalytic reactions,especially under harsh conditions,as well as unique shape-selectivity.However,the complex synthesis procedures make large-scale preparation of these catalysts impractical.In contrast,a type(a)sample can be achieved via the simple impregnation;nevertheless,migration of metal species and their aggregation into larger particles often occur during the calcination and reduction processes.展开更多
MnO2 loaded weak basic anion exchange resin D301 （Anion exchange resin, macroreticular weak basic styrene） as adsorbent has been prepared and applied to the removal of cadmium. The adsorption characteristics have be...MnO2 loaded weak basic anion exchange resin D301 （Anion exchange resin, macroreticular weak basic styrene） as adsorbent has been prepared and applied to the removal of cadmium. The adsorption characteristics have been investigated with respect to effect of pH, equilibrium isotherms, removal kinetic data, and interference of the coexisting ions. The results indicated that the Cd^2＋ could be efficiently removed using MnO2 loaded D301 resin in the pH range of 3-8 from aqueous solutions with the co-existence of high concentration of alkali and alkaline-earth metals ions. The saturate adsorption capacity of the Cd^2＋ was 77.88 mg/g. The adsorption process followed the pseudo first-order kinetics. The equilibrium data obtained in this study accorded excellently with the Langmuir adsorption isotherm.展开更多
The analytical method based on "Hertz theory on normal contact of elastic solids" and the numerical method based on finite element method (FEM) calculating the contact stress of face-gear drive with spur inv...The analytical method based on "Hertz theory on normal contact of elastic solids" and the numerical method based on finite element method (FEM) calculating the contact stress of face-gear drive with spur involute pinion were introduced, and their relative errors are below 10%, except edge contact, which turns out that these two methods can compute contact stress of face-gear drive correctly and effectively. An agreement of the localized bearing contact stress is gotten for these two methods, making sure that the calculation results of FEM are reliable. The loaded meshing simulations of multi-tooth FEM model were developed, and the determination of the transmission error and the maximal load distribution factor of face-gear drive under torques were given. A formula for the maximal load distribution factor was proposed. By introducing the maximal load distribution factor in multi-tooth contact zone, a method for calculating the maximal contact stress in multi-tooth contact can be given. Compared to FEM, the results of these formulae are proved to be reliable, and the relative errors are below 10%.展开更多
It is confirmed that tandem-blade configurations have potential to enlarge the flow turning in two-dimension(2D) studies. However, the potential of tandem blades to enlarge the design space for highly loaded axial com...It is confirmed that tandem-blade configurations have potential to enlarge the flow turning in two-dimension(2D) studies. However, the potential of tandem blades to enlarge the design space for highly loaded axial compressors was rarely investigated in open literatures. The present work aims to show the capability of tandem blades to break the loading limit of conventional blades for highly loaded compressors. The 2D models of the maximum static pressure rise derived in previous work were validated by a large amount experimental data, which showed a good agreement. An E parameter was defined to evaluate the stall margin of compressor based on the theoretical models, which indicated that the tandem blade was able to increase the loading limit of axial compressors. A single-blade stage with a loading coefficient of 0.46(based on the blade tip rotating speed) was designed as the baseline case under the guidance of the E parameter. A tandem-blade stage was then designed by ensuring that the velocity triangles were similar to the single-blade stage. The performances of both stages were investigated experimentally. The results showed that the maximum efficiency of the tandem-blade stage was 92.8%, 1% higher than the single;the stall margin increased from 16.9% to 22.3%. Besides, the maximum pressure rise of tandem rotors was beyond the loading limit of 2D single-blade cascades, which confirmed the potential of tandem blades to break the loading limit of axial compressors.展开更多
A developed stereo particle image velocimetry(stereo-PIV) system was proposed to measure three-dimensional(3D) soil deformation around a laterally loaded pile in sand.The stereo-PIV technique extended 2D measurement t...A developed stereo particle image velocimetry(stereo-PIV) system was proposed to measure three-dimensional(3D) soil deformation around a laterally loaded pile in sand.The stereo-PIV technique extended 2D measurement to 3D based on a binocular vision model,where two cameras with a well geometrical setting were utilized to image the same object simultaneously.This system utilized two open software packages and some simple programs in MATLAB,which can easily be adjusted to meet user needs at a low cost.The failure planes form an angle with the horizontal line,which are measured at 27°-29°,approximately three-fourths of the frictional angle of soil.The edge of the strain wedge formed in front of the pile is an arc,which is slightly different from the straight line reported in the literature.The active and passive influence zones are about twice and six times of the diameter of the pile,respectively.The test demonstrates the good performance and feasibility of this stereo-PIV system for more advanced geotechnical testing.展开更多
Bone cement has the capacity to release antibiotic molecules if any antibiotic is included in it, and these elution properties are improved as cement porosity is increased. In vitro studies have shown high local antib...Bone cement has the capacity to release antibiotic molecules if any antibiotic is included in it, and these elution properties are improved as cement porosity is increased. In vitro studies have shown high local antibiotic concentration for many hours or few days after its use. Antibiotic loaded bone cement(ALBC) is helpful when treating an infection in total knee arthroplasty(TKA) revision surgery. The purpose of this paper was to review the evidence for the routine use of ALBC in TKA in the literature, its pros and cons. Many authors have recommended the use of ALBC also in primary TKA for infection prophylaxis, but the evidence based on data from National Registries, randomized clinical trials and meta-analysis suggest a protective effect of ALBC against infection when used in hips, but not(or only mild) in knees. A possible explanation to this finding is that the duration and quantity of locally elevated antibiotic levels after surgery are smaller in TKA, due to the smaller amount of cement used for fixation in TKA-only a layer in the bone surface. There are some concerns about the routine use of ALBC in primary TKA as prophylaxis against infection: Firstly, there is a risk of hypersensivity or toxicity even when the chance is highly improbable. Secondly, there is a reduction in the mechanical properties of the cement, but this can be probably neglected if the antibiotic is used in low doses, not more than 1 g per 40 g cement package. Another significant concern is the increased economic cost, which could be overlooked if there were enough savings in treating fewer prosthetic infections. Finally, there is also a risk of selection of antibiotic-resistant strains of bacteria and this could be the main concern. If used, the choice of the antibiotic mixed in ALBC should consider microbiological aspects(broad antimicrobial spectrum and low rate of resistant bacteria), physical and chemical aspects(thermal stability, high water solubility), pharmacological characteristics(low risk to allergic reactions or toxicity) and economic aspects(not too expensive). The most commonly used antibiotics in ALBC are gentamicin, tobramycin and vancomycin. In conclusion, there is a paucity of randomized clinical trials in the use of ALBC in primary TKAs and the actual evidence of the effect of ALBC in reducing the risk of infection is insufficient. This, in addition to concerns about patient safety, risks of increase in the antibiotic resistance of microorganisms and the increase in costs in the procedure, lead us to recommend a cautious use of ALBC, perhaps only in high-risk patients(immunocompromised, morbidly obese, diabetic and patients with previous history of fracture or infection around the knee) unless the benefits of ALBC use were fully proven. Meanwhile, the rigorous use of peri-operative prophylactic systemic antibiotics and adoption of efficient antiseptic procedures and improved surgical techniques must be considered the gold standard in infection prevention in TKA surgery.展开更多
Skidding which occurs when rolling element entering into the loaded zone is prone to cause wear and incipient failure to the raceways and rolling elements. This paper presents a dynamic model to investigate the skiddi...Skidding which occurs when rolling element entering into the loaded zone is prone to cause wear and incipient failure to the raceways and rolling elements. This paper presents a dynamic model to investigate the skidding of a rolling element bearing under radial load when the rolling element is entering into the load zone. In this dynamic model, the effects of the contact forces, friction forces on the rolling element-race and rolling element-cage interfaces, gravity, and the centrifugal forces of rolling elements are taken into consideration. The Hertzian contact theory is applied to calculate the non-linear contact forces. The Coulomb friction law is used to calculate the friction forces. The differential equations of rotational motion of the rolling element with regard to its central axis and the central axis of the outer ring are established respectively. The dynamic equations are then solved by using a fourth-order Runge-Kutta algorithm. The skidding characteristics of rolling element at the entry into the loaded zone are exposed, and the effects of the operating parameters on skidding behavior are carefully investigated.展开更多
Nano-silver loaded montmorillonite （Ag-MMT） was prepared by ion-exchange and then a UV-photoreduction two-step approach was applied. The silver content in Ag-MMT determined by Volhard method was about 6.4 wt%. The m...Nano-silver loaded montmorillonite （Ag-MMT） was prepared by ion-exchange and then a UV-photoreduction two-step approach was applied. The silver content in Ag-MMT determined by Volhard method was about 6.4 wt%. The morphology and structure of as-synthesized Ag-MMT were characterized by scanning electron microscopy （SEM） and X-ray diffraction （XRD）. The results showed that the Ag nanoparticles were spherical and their diameters were about 15-20 nm. Moreover, the structure of MMT did not change. The minimum inhibition concentration （MIC） of Ag-MMT was 100×10-6 and the sterilizing efficiency （SE） of Ag-MMT was approximately 100% against Escherichia coli ATCC 11229 （E. coli. In addition, the slow release property of silver in Ag-MMT was also demonstrated.展开更多
Shortage in phosphorus （P） resources and P wastewater pollution is considered as a serious problem worldwide. The application of modified biochar for P recovery from wastewater and reuse of recovered P as agricultur...Shortage in phosphorus （P） resources and P wastewater pollution is considered as a serious problem worldwide. The application of modified biochar for P recovery from wastewater and reuse of recovered P as agricultural fertilizer is a preferred process. This work aims to develop a calcium and magnesium loaded biochar （Ca-Mg/biochar） application for P recovery from biogas fermentation liquid. The physico-chemical characterization, adsorption efficiency, adsorption selectivity, and postsorption availability of Ca-Mg/biochar were investigated. The synthesized Ca-Mg/biochar was rich in organic functional groups and in CaO and MgO nanoparticles. With the increase in synthesis temperature, the yield decreased, C content increased, H content decreased, N content remained the same basically, and BET surface area increased. The P adsorption of Ca-Mg/biochar could be accelerated by nano-CaO and nano-MgO particles and reached equilibrium after 360min. The process was endothermic, spontaneous, and showed an increase in the disorder of the solid-liquid interface. Moreover, it could be fitted by the Freundlich model. The maximum P adsorption amounts were 294.22, 315.33, and 326.63 mg/g. The P adsorption selectivity of Ca-Mg/biochar could not be significantly influenced by the typical pH level of biogas fermentation liquid. The nano-CaO and nano-MgO particles of Ca-Mg/biochar could reduce the negative interaction effects of coexisting ions. The P releasing amounts of postsorption Ca-Mg/biochar were in the order of Ca-Mg/B600 〉 Ca-Mg/B4S0 〉 Ca-Mg/B300. Results revealed that postsorption Ca-Mg/biochar can continually release P and is more suitable for an acid environment.展开更多
In order to improve turbine internal efficiency and lower manufacturing cost, a new highly loaded rotating blade has been developed. The 3D optimization design method based on artificial neural network and genetic alg...In order to improve turbine internal efficiency and lower manufacturing cost, a new highly loaded rotating blade has been developed. The 3D optimization design method based on artificial neural network and genetic algorithm is adopted to construct the blade shape. The blade is stacked by the center of gravity in radial direction with five sections. For each blade section, independent suction and pressure sides are constructed from the camber line using Bezier curves. Three-dimensional flow analysis is carried out to verify the performance of the new blade. It is found that the new blade has improved the blade performance by 0.5%. Consequently, it is verified that the new blade is effective to improve the turbine internal efficiency and to lower the turbine weight and manufacturing cost by reducing the blade number by about 15%.展开更多
Bimetallic oxides composites have received an increasing attention as promising adsorbents for aqueous phosphate (P) removal in recent years. In this study, a novel magnetic composite MZLCO was prepared by hybridizing...Bimetallic oxides composites have received an increasing attention as promising adsorbents for aqueous phosphate (P) removal in recent years. In this study, a novel magnetic composite MZLCO was prepared by hybridizing amorphous Zr-La (carbonate) oxides (ZLCO) with nano-FeOthrough a one-pot solvothermal method for efficient phosphate adsorption. Our optimum sample of MZLCO-45 exhibited a high Langmuir maximum adsorption capacity of 96.16 mg P/g and performed well even at low phosphate concentration. The phosphate adsorption kinetics by MZLCO-45 fitted well with the pseudo-second-order model, and the adsorption capacity could reach 79% of the ultimate value within the first 60 min. The phosphate adsorption process was highly p H-dependent, and MZLCO-45 performed well over a wide p H range of 2.0-8.0. Moreover, MZLCO-45 showed a strong selectivity to phosphate in the presence of competing ions (Cl^(-), NO_(3)^(-), SO_(4)^(2-), HCO_(3)^(-), Ca^(2+), and Mg^(2+)) and a good reusability using the eluent of Na OH/Na Cl mixture, then 64% adsorption capacity remained after ten recycles. The initial 2.0 mg P/L in municipal wastewater and surface water could be efficiently reduced to below 0.1mg P/L by 0.07 g/L MZLCO-45, and the phosphate removal efficiencies were 95.7% and 96.21%, respectively. Phosphate adsorption mechanisms by MZLCO-45 could be attributed to electrostatic attraction and the inner-sphere complexation via ligand exchange forming Zr/La-O-P, -OH and CO_(3)^(2-)groups on MZLCO-45 surface played important roles in the ligand exchange process. The existence of oxygen vacancies could accelerate the phosphate absorption rate of the MZLCO-45 composites.展开更多
基金funded by The Michael J.Fox Foundation for Parkinson’s Research(grant numbers:17244 and 023410)Science Foundation Ireland(grant number:19/FFP/6554)(to ED)。
文摘More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet clinical need for a diseasemodifying therapy.
基金co-supported by the National Natural Science Foundation of China (No. 52175104)the Postdoctoral Fellowship Program of CPSF (No. GZC20233008)
文摘Tooth cracks may occur in spiral bevel gear transmission system of the aerospace equipment.In this study,an accurate and efficient loaded tooth contact analysis(LTCA)model is developed to predict the contact behavior and time-varying meshing stiffness(TVMS)of spiral bevel gear pair with cracked tooth.The tooth is sliced,and the contact points on slices are computed using roll angle surfaces.Considering the geometric complexity of crack surface,a set of procedures is formulated to generate spatial crack and determine crack parameters for contact points.According to the positional relationship between contact point and crack path,each sliced tooth is modeled as a non-uniform cantilever beam with varying reduced effective load-bearing tooth thickness.Then the compliance model of the cracked tooth is established to perform contact analysis,along with TVMS calculations utilizing three different models.By employing spiral bevel gear pairs with distinct types of cracks as examples,the accuracy and efficiency of the developed approach are validated via comparative analyses with finite element analysis(FEA)outcomes.Furthermore,the investigation on effects of cracks shows that tooth cracks can induce alterations in meshing performance of both entire gear pair and individual tooth pairs,including not only cracked tooth pair but also adjacent non-cracked tooth pairs.Hence,the proposed model can serve as a useful tool for analyzing the variations in contact behavior and meshing stiffness of spiral bevel gears due to different cracks.
基金support was provided by the European Regional Development Fund(ERDF),through the Centro 2020 Regional Operational Programme,Portugal(Project No.:CENTRO-01-0145-FEDER-000012(HealthyAging2020))through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation and Portuguese National Funds via Fundaçao para a Ciencia e a Tecnologia,Portugal(Project Nos.:POCI-01-0145-FEDER-029369 UIDB/04539/2020,iBiMED UIDB/04501/2020,DOI identifier https://doi.org/10.54499/UIDB/04501/2020 and project reference UIDP/04501/2020,DOI identifier https://doi.org/10.54499/UIDP/04501/2020,and LA/P/0058/2020)supported by Fundaçao para a Ciencia e a Tecnologia through the individual PhD fellowships,Portugal(Grant Nos.:PD/BDE/142926/2018 and SFRH/BD/110717/2015)。
文摘Skin sensitization is a common adverse effect of a wide range of small reactive chemicals,leading to allergic contact dermatitis(ACD),the most frequent manifestation of immunotoxicity in humans.The prevalence of ACD is increasing,affecting up to 20%of the Western European population.This trend was particularly pronounced in high-risk occupational sectors,including healthcare,food services,metal and construction workers,and hairdressers[1].The skin sensitization adverse outcome pathway(AOP)comprises 11 elements,with four designated key events(KEs):formation of proteinhapten complexes(KE-1),inflammatory keratinocyte response(KE-2),dendritic cell(DC)activation(KE-3),and T-cell proliferation(KE-4)[2].As there is no cure for ACD,preventive strategies are of great relevance.In addition to avoiding exposure,preventive measures,such as the use of latex gloves,barrier creams,emollients,and moisturizers,often have limited effectiveness[3].
文摘Clay deposits typically exhibit significant degrees of heterogeneity and anisotropy in their strength and stiffness properties.Such non-monotonic responses can significantly impact the stability analysis and design of overlying shallow foundations.In this study,the undrained bearing capacity of shallow foundations resting on inhomogeneous and anisotropic clay layers subjected to oblique-eccentric combined loading is investigated through a comprehensive series of finite element limit analysis(FELA)based on the well-established lower-bound theorem and second-order cone programming(SOCP).The heterogeneity of normally consolidated(NC)clays is simulated by adopting a well-known general model of undrained shear strength increasing linearly with depth.In contrast,for overconsolidated(OC)clays,the variation of undrained shear strength with depth is considered to follow a bilinear trend.Furthermore,the inherent anisotropy is accounted for by adopting different values of undrained shear strength along different directions within the soil medium,employing an iterative-based algorithm.The results of numerical simulations are utilized to investigate the influences of natural soil heterogeneity and inherent anisotropy on the ultimate bearing capacity,failure envelope,and failure mechanism of shallow foundations subjected to the various combinations of vertical-horizontal(V-H)and vertical-moment(V-M)loads.
基金National Natural Science Foundation of China (50876023)Chinese Specialized Research Fund for the Doctoral Pro-gram of Higher Education (20060213007)National Basic Research Program of China (2007CB210100)
文摘This article experimentally studies the effects of air injection near the blade trailing edge on flow separation and losses in a highly loaded linear compressor cascade. Aerodynamic parameters of eight cascades with different air injection slot configura- tions are measured by using a five-hole probe at the cascade outlets. Ink-trace flow visualization is performed to obtain the flow details around the air injection slots. The static pressure distribution is clarified with pressure taps on the endwalls. The...
文摘There is still no effective therapy for muscle atrophy.It found that miR-194 was significantlydownregulated in muscle atrophy model.miR-194 could promote muscle differentiation,and also inhibit ubiquitin ligases.miR-194 loaded in gelatin nanosphere were injected into the muscle atrophy model to realize controlled release.
基金supported by the National Key Research and Development Project of the National Natural Science Foundation(Grant No.2022YFC3004605)the National Natural Science Foundation of China Youth Science Fund(Grant No.52104087).
文摘A coal-loaded charge induction monitoring system is developed to effectively forecast the dynamic disasters caused by coal failure.Specifically,a digital finite impulse response(FIR)filter is designed to denoise and filter the signal,and the time-frequency domain evolution of induced charge signals is analyzed during coal failure experiments.The quantitative relationships between the induced electric charge and stress-strain energy,and ultimately,between induced electric charge and coal deformation/failure,are revealed.Ultimately,the electric charge sensor exhibits high signal collection frequency and high sensitivity,and the FIR low-pass filter constructed in MATLAB effectively denoises and filters induced charge signals.The main frequency range of the white noise is 50-500 Hz,and the main frequency of the charge signal induced by coal deformation and failure is concentrated in the range of 0-50 Hz.The optimal distances for monitoring cubic and cylindrical raw coal samples using this sensor are 9 mm and 11 mm,respectively.Notably,strain energy is released faster when it can dissipate more readily,and induced charge pulses become denser when more intense signals produce large fluctuations.A method is proposed to identify coal deformation and failure based on changes in the induced electric charge.This study provides a new means of monitoring the early warning signs of dynamic coal mine disasters.Based on our experimental results and conclusions,a new method is proposed to identify coal deformation and failure based on changes in the induced electric charge.The precursor to the moment of coal failure can be identified by monitoring the amplitude of the induced charge,the dynamic trend of fluctuation,and the cumulative number of induced electric charge pulses during the process of coal deformation.
基金supported by the National Natural Science Foundation of China(Nos.52374100,52525401,and 52304150)Outstanding Young Talent Project of Shanxi Province(No.SJYC2024301)Research Project Supported by Shanxi Scholarship Council of China(No.2023-041).
文摘Borehole pressure relief helps prevent rock bursts.However,this may change the physical and mechan-ical properties of the surrounding rock,affect the variation of the plastic zone of the roadway,and lead to the failure of roadway support,thus threatening the safety of the roadway.In this paper,the variable angle shear test of drilled specimens under the action of static and dynamic loads is used to study the evolution of mechanical parameters of the specimens and their influence on the plastic zone of the sur-rounding rock.The shear strength decreases linearly with the increase of drilling diameter.With the increase of pre-static load level and dynamic load amplitude,the cohesion first increases and then decreases,and the internal friction angle decreases.Moreover,the shear failure surface changes from rough to smooth.The reasons include that the static load enhances the tooth cutting effect and the repeated friction of cracks caused by the dynamic load.Borehole pressure relief leads to an increase in the radius of the plastic zone of the surrounding rock following a quadratic function.The research results of this paper provide a theoretical basis for designing drilling unloading parameters and supporting parameters for rock burst roadways.
基金financially supported by the National Key R&D Program of China(2024YFE0101100)the National Natural Science Foundation of China(22475112,22305132,22305155)+1 种基金the China Postdoctoral Science Foundation(2023M732323)the Postdoctoral Fellowship Program of CPSF(GZC20231679).
文摘Metal(oxide)-zeolite bifunctional catalysts have been the subject of considerable attention from researchers in both academic and industry,due to their superior activity and stability in various heterogeneous catalytic processes[1–3].Based on the different metal loading sites,these bifunctional catalysts can be categorized as follows:(a)metal species loaded on the outer surface of zeolite crystals,(b)metal species encapsulated within the channels or cavities of zeolites,and(c)metal species incorporated into the zeolite framework(Fig.1).Metal species in type(b)and(c)samples are stabilized by the zeolite frameworks,resulting in excellent thermal and hydrothermal stability during catalytic reactions,especially under harsh conditions,as well as unique shape-selectivity.However,the complex synthesis procedures make large-scale preparation of these catalysts impractical.In contrast,a type(a)sample can be achieved via the simple impregnation;nevertheless,migration of metal species and their aggregation into larger particles often occur during the calcination and reduction processes.
基金Project supported by Shanghai Municipal Committee of Science andTechnology(No.05JC14059)the National Natural Science Foun-dation of China(No.50478103)
文摘MnO2 loaded weak basic anion exchange resin D301 （Anion exchange resin, macroreticular weak basic styrene） as adsorbent has been prepared and applied to the removal of cadmium. The adsorption characteristics have been investigated with respect to effect of pH, equilibrium isotherms, removal kinetic data, and interference of the coexisting ions. The results indicated that the Cd^2＋ could be efficiently removed using MnO2 loaded D301 resin in the pH range of 3-8 from aqueous solutions with the co-existence of high concentration of alkali and alkaline-earth metals ions. The saturate adsorption capacity of the Cd^2＋ was 77.88 mg/g. The adsorption process followed the pseudo first-order kinetics. The equilibrium data obtained in this study accorded excellently with the Langmuir adsorption isotherm.
基金Project(50875263) supported by the National Natural Science Foundation of ChinaProject(2011CB706800) supported by the National Basic Research Program of ChinaProject(2010ssxt172) supported by the Natural Science Foundation of Hunan Province,China
文摘The analytical method based on "Hertz theory on normal contact of elastic solids" and the numerical method based on finite element method (FEM) calculating the contact stress of face-gear drive with spur involute pinion were introduced, and their relative errors are below 10%, except edge contact, which turns out that these two methods can compute contact stress of face-gear drive correctly and effectively. An agreement of the localized bearing contact stress is gotten for these two methods, making sure that the calculation results of FEM are reliable. The loaded meshing simulations of multi-tooth FEM model were developed, and the determination of the transmission error and the maximal load distribution factor of face-gear drive under torques were given. A formula for the maximal load distribution factor was proposed. By introducing the maximal load distribution factor in multi-tooth contact zone, a method for calculating the maximal contact stress in multi-tooth contact can be given. Compared to FEM, the results of these formulae are proved to be reliable, and the relative errors are below 10%.
基金the support of National Natural Science Foundation of China(Nos.51806004 and 51790511)National Science and Technology Major Project,China(No.2017-Ⅱ-0001-0013)。
文摘It is confirmed that tandem-blade configurations have potential to enlarge the flow turning in two-dimension(2D) studies. However, the potential of tandem blades to enlarge the design space for highly loaded axial compressors was rarely investigated in open literatures. The present work aims to show the capability of tandem blades to break the loading limit of conventional blades for highly loaded compressors. The 2D models of the maximum static pressure rise derived in previous work were validated by a large amount experimental data, which showed a good agreement. An E parameter was defined to evaluate the stall margin of compressor based on the theoretical models, which indicated that the tandem blade was able to increase the loading limit of axial compressors. A single-blade stage with a loading coefficient of 0.46(based on the blade tip rotating speed) was designed as the baseline case under the guidance of the E parameter. A tandem-blade stage was then designed by ensuring that the velocity triangles were similar to the single-blade stage. The performances of both stages were investigated experimentally. The results showed that the maximum efficiency of the tandem-blade stage was 92.8%, 1% higher than the single;the stall margin increased from 16.9% to 22.3%. Besides, the maximum pressure rise of tandem rotors was beyond the loading limit of 2D single-blade cascades, which confirmed the potential of tandem blades to break the loading limit of axial compressors.
基金Project(104244) supported by the Natural Sciences and Engineering Research Council of Canada
文摘A developed stereo particle image velocimetry(stereo-PIV) system was proposed to measure three-dimensional(3D) soil deformation around a laterally loaded pile in sand.The stereo-PIV technique extended 2D measurement to 3D based on a binocular vision model,where two cameras with a well geometrical setting were utilized to image the same object simultaneously.This system utilized two open software packages and some simple programs in MATLAB,which can easily be adjusted to meet user needs at a low cost.The failure planes form an angle with the horizontal line,which are measured at 27°-29°,approximately three-fourths of the frictional angle of soil.The edge of the strain wedge formed in front of the pile is an arc,which is slightly different from the straight line reported in the literature.The active and passive influence zones are about twice and six times of the diameter of the pile,respectively.The test demonstrates the good performance and feasibility of this stereo-PIV system for more advanced geotechnical testing.
文摘Bone cement has the capacity to release antibiotic molecules if any antibiotic is included in it, and these elution properties are improved as cement porosity is increased. In vitro studies have shown high local antibiotic concentration for many hours or few days after its use. Antibiotic loaded bone cement(ALBC) is helpful when treating an infection in total knee arthroplasty(TKA) revision surgery. The purpose of this paper was to review the evidence for the routine use of ALBC in TKA in the literature, its pros and cons. Many authors have recommended the use of ALBC also in primary TKA for infection prophylaxis, but the evidence based on data from National Registries, randomized clinical trials and meta-analysis suggest a protective effect of ALBC against infection when used in hips, but not(or only mild) in knees. A possible explanation to this finding is that the duration and quantity of locally elevated antibiotic levels after surgery are smaller in TKA, due to the smaller amount of cement used for fixation in TKA-only a layer in the bone surface. There are some concerns about the routine use of ALBC in primary TKA as prophylaxis against infection: Firstly, there is a risk of hypersensivity or toxicity even when the chance is highly improbable. Secondly, there is a reduction in the mechanical properties of the cement, but this can be probably neglected if the antibiotic is used in low doses, not more than 1 g per 40 g cement package. Another significant concern is the increased economic cost, which could be overlooked if there were enough savings in treating fewer prosthetic infections. Finally, there is also a risk of selection of antibiotic-resistant strains of bacteria and this could be the main concern. If used, the choice of the antibiotic mixed in ALBC should consider microbiological aspects(broad antimicrobial spectrum and low rate of resistant bacteria), physical and chemical aspects(thermal stability, high water solubility), pharmacological characteristics(low risk to allergic reactions or toxicity) and economic aspects(not too expensive). The most commonly used antibiotics in ALBC are gentamicin, tobramycin and vancomycin. In conclusion, there is a paucity of randomized clinical trials in the use of ALBC in primary TKAs and the actual evidence of the effect of ALBC in reducing the risk of infection is insufficient. This, in addition to concerns about patient safety, risks of increase in the antibiotic resistance of microorganisms and the increase in costs in the procedure, lead us to recommend a cautious use of ALBC, perhaps only in high-risk patients(immunocompromised, morbidly obese, diabetic and patients with previous history of fracture or infection around the knee) unless the benefits of ALBC use were fully proven. Meanwhile, the rigorous use of peri-operative prophylactic systemic antibiotics and adoption of efficient antiseptic procedures and improved surgical techniques must be considered the gold standard in infection prevention in TKA surgery.
基金Sponsored by the National Natural Science Key Foundation of China(Grant No.51035008)the Twelfth Five-Year Plan Period Program(Grant No.2011BAF09B01)
文摘Skidding which occurs when rolling element entering into the loaded zone is prone to cause wear and incipient failure to the raceways and rolling elements. This paper presents a dynamic model to investigate the skidding of a rolling element bearing under radial load when the rolling element is entering into the load zone. In this dynamic model, the effects of the contact forces, friction forces on the rolling element-race and rolling element-cage interfaces, gravity, and the centrifugal forces of rolling elements are taken into consideration. The Hertzian contact theory is applied to calculate the non-linear contact forces. The Coulomb friction law is used to calculate the friction forces. The differential equations of rotational motion of the rolling element with regard to its central axis and the central axis of the outer ring are established respectively. The dynamic equations are then solved by using a fourth-order Runge-Kutta algorithm. The skidding characteristics of rolling element at the entry into the loaded zone are exposed, and the effects of the operating parameters on skidding behavior are carefully investigated.
基金Huazhong University of Science and Technology,China, for the analytical support
文摘Nano-silver loaded montmorillonite （Ag-MMT） was prepared by ion-exchange and then a UV-photoreduction two-step approach was applied. The silver content in Ag-MMT determined by Volhard method was about 6.4 wt%. The morphology and structure of as-synthesized Ag-MMT were characterized by scanning electron microscopy （SEM） and X-ray diffraction （XRD）. The results showed that the Ag nanoparticles were spherical and their diameters were about 15-20 nm. Moreover, the structure of MMT did not change. The minimum inhibition concentration （MIC） of Ag-MMT was 100×10-6 and the sterilizing efficiency （SE） of Ag-MMT was approximately 100% against Escherichia coli ATCC 11229 （E. coli. In addition, the slow release property of silver in Ag-MMT was also demonstrated.
基金supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20120008120013)the National Natural Science Foundation of China (No. 31401944)+2 种基金the Beijing Natural Science Foundation (No. 6144026)the China Scholarship Council (No. 201206355006)the Chinese Universities Scientific Fund of China Agricultural University (No. 2011JS169)
文摘Shortage in phosphorus （P） resources and P wastewater pollution is considered as a serious problem worldwide. The application of modified biochar for P recovery from wastewater and reuse of recovered P as agricultural fertilizer is a preferred process. This work aims to develop a calcium and magnesium loaded biochar （Ca-Mg/biochar） application for P recovery from biogas fermentation liquid. The physico-chemical characterization, adsorption efficiency, adsorption selectivity, and postsorption availability of Ca-Mg/biochar were investigated. The synthesized Ca-Mg/biochar was rich in organic functional groups and in CaO and MgO nanoparticles. With the increase in synthesis temperature, the yield decreased, C content increased, H content decreased, N content remained the same basically, and BET surface area increased. The P adsorption of Ca-Mg/biochar could be accelerated by nano-CaO and nano-MgO particles and reached equilibrium after 360min. The process was endothermic, spontaneous, and showed an increase in the disorder of the solid-liquid interface. Moreover, it could be fitted by the Freundlich model. The maximum P adsorption amounts were 294.22, 315.33, and 326.63 mg/g. The P adsorption selectivity of Ca-Mg/biochar could not be significantly influenced by the typical pH level of biogas fermentation liquid. The nano-CaO and nano-MgO particles of Ca-Mg/biochar could reduce the negative interaction effects of coexisting ions. The P releasing amounts of postsorption Ca-Mg/biochar were in the order of Ca-Mg/B600 〉 Ca-Mg/B4S0 〉 Ca-Mg/B300. Results revealed that postsorption Ca-Mg/biochar can continually release P and is more suitable for an acid environment.
文摘In order to improve turbine internal efficiency and lower manufacturing cost, a new highly loaded rotating blade has been developed. The 3D optimization design method based on artificial neural network and genetic algorithm is adopted to construct the blade shape. The blade is stacked by the center of gravity in radial direction with five sections. For each blade section, independent suction and pressure sides are constructed from the camber line using Bezier curves. Three-dimensional flow analysis is carried out to verify the performance of the new blade. It is found that the new blade has improved the blade performance by 0.5%. Consequently, it is verified that the new blade is effective to improve the turbine internal efficiency and to lower the turbine weight and manufacturing cost by reducing the blade number by about 15%.
基金supported by the Beijing Municipal Science and Technology Project (No. Z181100005518007)the National Key Research and Development Program of China (No. 2017YFC0505303)+1 种基金the National Natural Science Foundation of China (Nos. 51978054 and 51678053)Beijing Municipal Education Commission through the Innovative Transdisciplinary Program ‘Ecological Restoration Engineering’ (No. GJJXK210102)。
文摘Bimetallic oxides composites have received an increasing attention as promising adsorbents for aqueous phosphate (P) removal in recent years. In this study, a novel magnetic composite MZLCO was prepared by hybridizing amorphous Zr-La (carbonate) oxides (ZLCO) with nano-FeOthrough a one-pot solvothermal method for efficient phosphate adsorption. Our optimum sample of MZLCO-45 exhibited a high Langmuir maximum adsorption capacity of 96.16 mg P/g and performed well even at low phosphate concentration. The phosphate adsorption kinetics by MZLCO-45 fitted well with the pseudo-second-order model, and the adsorption capacity could reach 79% of the ultimate value within the first 60 min. The phosphate adsorption process was highly p H-dependent, and MZLCO-45 performed well over a wide p H range of 2.0-8.0. Moreover, MZLCO-45 showed a strong selectivity to phosphate in the presence of competing ions (Cl^(-), NO_(3)^(-), SO_(4)^(2-), HCO_(3)^(-), Ca^(2+), and Mg^(2+)) and a good reusability using the eluent of Na OH/Na Cl mixture, then 64% adsorption capacity remained after ten recycles. The initial 2.0 mg P/L in municipal wastewater and surface water could be efficiently reduced to below 0.1mg P/L by 0.07 g/L MZLCO-45, and the phosphate removal efficiencies were 95.7% and 96.21%, respectively. Phosphate adsorption mechanisms by MZLCO-45 could be attributed to electrostatic attraction and the inner-sphere complexation via ligand exchange forming Zr/La-O-P, -OH and CO_(3)^(2-)groups on MZLCO-45 surface played important roles in the ligand exchange process. The existence of oxygen vacancies could accelerate the phosphate absorption rate of the MZLCO-45 composites.
