Remembrance activities can support the Culture of Care(CoC)in Laboratory Animal Science(LAS)not only by promoting a culture of respect,gratitude and thankfulness for animal life but also by helping the emotional proce...Remembrance activities can support the Culture of Care(CoC)in Laboratory Animal Science(LAS)not only by promoting a culture of respect,gratitude and thankfulness for animal life but also by helping the emotional processing and healing of lab animal researchers and animal facility staff.Even though remembrance activities are practiced in many parts of the world,we did not come across any reported cases in Sri Lanka before 2022.Therefore,here,we report on the various remembrance activities and practices observed within our local scientific community.展开更多
On the occasion of the New Year,I would like to extend my sincere gratitude and New Year greetings to the experts,scholars,author teams,and readers who have long supported the development of Animal Models and Experime...On the occasion of the New Year,I would like to extend my sincere gratitude and New Year greetings to the experts,scholars,author teams,and readers who have long supported the development of Animal Models and Experimental Medicine(AMEM).Over the past year,we have faced challenges together and achieved breakthroughs in academic influence,internationalization,and fulfilling social respon-sibilities.Looking ahead,we are filled with confidence as we strive to build an important bridge connecting laboratory animal science and technology with academic research.展开更多
Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreov...Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,she is the senior scientist of Institute of Laboratory Animal Sciences(ILAS),CAMS&PUMC.She is also the Vice-President of the Asian Federation of Laboratory Animal Science Associations(AFLAS).展开更多
Chuan Qin,MD.PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreov...Chuan Qin,MD.PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,she is the senior scientist of Institute of LaboratoryAnimal Sciences(ILAS),CAMS & PUMC.展开更多
Chuan Qin,MD,PhD,is the President of the Chinese Associaon for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover...Chuan Qin,MD,PhD,is the President of the Chinese Associaon for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,she is the senior scienst of Instute of Laboratory Animal Sciences(ILAS),CAMS&PUMC.She is also the Vice-President of the Asian Federaon of Laboratory Animal Science Associaons(AFLAS),a board member of the Internaonal Council for Laboratory Animal Science(ICLAS),and Chairman of the Naonal Standardizaon Technical Commiee of Laboratory Animals.In addion to Animal Models and Experimental Medicine,Prof.Qin is also the Editor-in-Chief of Acta Laboratorium Animalis Sciena Sinica and Chinese Journal of Comparave Medicine.展开更多
Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC).More...Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC).Moreover,she is the senior scientist of Institute of Laboratory Animal Sciences(ILAS),CAMS& PUMC.She is also the Vice-President of the Asian Federation of Laboratory Animal Science Associations(AFLAS),a board member of the International Council for Laboratory Animal Science(ICLAS),and Chairman of the National Standardization Technical Committee of Laboratory Animals.In addition to Animal Models and Experimental Medicine,Prof.Qin is also the Editor-in-Chief of Acta Laboratorium Animalis Scientia Sinica and Chinese Journal of Comparative Medicine.展开更多
Editorial message Every advancement in the field of laboratory animal science and technology,from exploring basic mechanisms to validating the development of new drugs,and from establishing disease models to respondin...Editorial message Every advancement in the field of laboratory animal science and technology,from exploring basic mechanisms to validating the development of new drugs,and from establishing disease models to responding to public health emergencies,strengthens the foundation for human health and well-being,serving as an important cornerstone for promoting global scientific innovation.For this reason.展开更多
Malaysia's commemoration of the second Asia Laboratory Animal Day(ALAD)in 2025 marked a notable step forward in strengthening national and regional laboratory animal science,ethical governance,and humane research ...Malaysia's commemoration of the second Asia Laboratory Animal Day(ALAD)in 2025 marked a notable step forward in strengthening national and regional laboratory animal science,ethical governance,and humane research practices.Celebrated a day earlier on 28 November,an initiative led by the Laboratory Animal Science Association of Malaysia(LASAM),comprised a coordinated three-month programme from September to November.A series of targeted activities were conducted,including professional exchange visits,competency-based rodent care and use workshops,refinement-centred blood sampling training,and institutional lectures on ethics and welfare.These engagements involved researchers,technicians,ethics committee members,and undergraduate trainees;reflecting ALAD's aim of fostering ethical awareness and technical proficiency across all levels of research personnel.A major highlight of the campaign was the signing of a Memorandum of Understanding between LASAM and Universiti Teknologi MARA(UiTM),strengthening long-term collaboration in training,welfare standard harmonisation,and shared ethical governance.The programme also delivered measurable outcomes:over 92%of participants improved their understanding of the 3Rs and humane endpoints,more than 95%attained competency in basic rodent handling,and national interest in laboratory animal science increased,as reflected by rising LASAM membership.Malaysia's ALAD initiatives emphasise the importance of grassroots engagement,refinement-based training,and strong institutional partnerships in advancing ethical and humane science.The country's experience provides a replicable framework for other Asian regions seeking to enhance welfare capacity,harmonise standards,and cultivate responsible research communities.Malaysia remains committed to supporting ALAD's ongoing mission to advance scientific integrity and animal welfare across Asia.展开更多
As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewe...As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewed commitment to ethical and scientific excellence in animal-based research.Throughout 2025,PALAS has continued to strengthen the laboratory animal science community by advancing education,capacity building,policy advocacy,and regional cooperation.These efforts underscore PALAS’vital role in shaping a culture of responsible animal research aligned with international standards.展开更多
Objective: To investigate the potential of superparamagnetic iron oxide particles (SPIO) in MR imaging for the differentiation between hyperplastic and metastatic lymph node. Methods: Animal models of malignant lymph ...Objective: To investigate the potential of superparamagnetic iron oxide particles (SPIO) in MR imaging for the differentiation between hyperplastic and metastatic lymph node. Methods: Animal models of malignant lymph node metastasis were established in 6 New-Zealand rabbits by a unilateral intra-muscular injection of VX2 carcinoma cells, and models of hyperplastic lymph nodes were induced in another 6 rabbits by a unilateral intra-muscular injection of egg yolk emulsion. MR images of the lymph nodes were obtained before and 12 h after interstitial injection of SPIO. Image results were analyzed and compared with pathological findings. Results: On unenhanced images, the signal intensity of hyperplastic and metastatic lymph nodes did not differ significantly. After administration of SPIO, the signal intensity of both hyperplastic and metastatic lymph nodes remained unchanged on T1-weighted SE images. On T2-weighted SE images, the signal intensity of hyperplastic lymph nodes decreased heterogeneously, while that of all metastatic ones remained unchanged. On T2-weighted GRE images, the signal intensity of hyperplastic lymph nodes decreased significantly and homogeneously, while that of 4 metastatic ones remained unchanged and that of the rest 2 decreased heterogeneously. Conclusion: SPIO-enhanced MR imaging may enable the differentiation between the hyperplastic and metastatic lymph nodes.展开更多
Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance o...Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance of these activities mandatory for any experiment and professional working in this area. Assigning the severity of a research experiment is the result of an analysis of records of observations of the animal’s behavior, and clinical signs. The aim of this study was to describe the importance of carrying out a severity assessment associated with clinical and behavioral monitoring of rodents and rabbits during experimentation to maintain the welfare of these animals undergoing scientific research. Methods: The literature search was carried out using the following terms: “Monitoring”;“Humane endpoints”;“Animal welfare”, “Rodents”;“Rabbits”, and as connectors “and”;“or”, in the following databases: PubMed;LILACS/BIREME and SciELO. Results: A total of 987 articles were identified in the databases, and 20 of these studies were included in this review. Conclusions: Humane endpoint protocols and procedure severity tables are of the utmost importance, both from an ethical point and to refine the results of research conducted on laboratory animals. They should be drawn up jointly by the teams responsible for the project and the maintenance of the animals during the research period, and the data obtained should be published so that the scientific community can have access to it, helping to disseminate these practices, as well as helping to draw up new procedures. Monitoring and evaluating the welfare and clinical condition of animals undergoing scientific research procedures is the responsibility of the professors, researchers, veterinarians, and animal facility coordinators. The Ethics Committee on the Use of Animals must monitor all the activities conducted with the animals, by inspecting the experimental procedures and the physical environment of the laboratory animal facility where the animals are housed.展开更多
Editorial Message:Asia Laboratory Animal Day:Origin and Founding Mission—Paying Tribute to the Silent Contributors in Scientific Research In the journey of advancing human scientific progress and health well-being,la...Editorial Message:Asia Laboratory Animal Day:Origin and Founding Mission—Paying Tribute to the Silent Contributors in Scientific Research In the journey of advancing human scientific progress and health well-being,laboratory animals serve as indispensable silent contributors.To commemorate their contributions and advocate for welfare principles,the“Asia Laboratory Animal Day”was established.This initiative is the result of collaborative efforts among various laboratory animal organizations across Asia,forming a crucial link in connecting scientific research ethics and humanistic care throughout the continent.展开更多
The FELASA 2025 Congress,themed“Reducing Severity in Animal Research,”convened global experts in laboratory animal sciences to discuss ethical advancements,welfare standards,and innovative practices.Key sessions hig...The FELASA 2025 Congress,themed“Reducing Severity in Animal Research,”convened global experts in laboratory animal sciences to discuss ethical advancements,welfare standards,and innovative practices.Key sessions highlighted the integration of the 3R principles(Replacement,Reduction,Refinement),with presentations addressing challenges in immunology,AI-driven animal monitoring,and aseptic surgical techniques.Notable lectures,including Prof.Stasinos Stavrianeas'exploration of zoology's origins and Dr.David Anderson's award-winning talk on squid welfare,emphasized cultural relevance and ethical responsibility.The congress also prioritized sustainability through waste-reduction measures and digital tools like an official app for enhanced networking.Exhibitions showcased cutting-edge technologies,while workshops fostered hands-on skill development.By advocating openness and interdisciplinary collaboration,FELASA 2025 aimed to advance humane and scientifically rigorous animal research practices globally.展开更多
文摘Remembrance activities can support the Culture of Care(CoC)in Laboratory Animal Science(LAS)not only by promoting a culture of respect,gratitude and thankfulness for animal life but also by helping the emotional processing and healing of lab animal researchers and animal facility staff.Even though remembrance activities are practiced in many parts of the world,we did not come across any reported cases in Sri Lanka before 2022.Therefore,here,we report on the various remembrance activities and practices observed within our local scientific community.
文摘On the occasion of the New Year,I would like to extend my sincere gratitude and New Year greetings to the experts,scholars,author teams,and readers who have long supported the development of Animal Models and Experimental Medicine(AMEM).Over the past year,we have faced challenges together and achieved breakthroughs in academic influence,internationalization,and fulfilling social respon-sibilities.Looking ahead,we are filled with confidence as we strive to build an important bridge connecting laboratory animal science and technology with academic research.
文摘Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,she is the senior scientist of Institute of Laboratory Animal Sciences(ILAS),CAMS&PUMC.She is also the Vice-President of the Asian Federation of Laboratory Animal Science Associations(AFLAS).
文摘Chuan Qin,MD.PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,she is the senior scientist of Institute of LaboratoryAnimal Sciences(ILAS),CAMS & PUMC.
文摘Chuan Qin,MD,PhD,is the President of the Chinese Associaon for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,she is the senior scienst of Instute of Laboratory Animal Sciences(ILAS),CAMS&PUMC.She is also the Vice-President of the Asian Federaon of Laboratory Animal Science Associaons(AFLAS),a board member of the Internaonal Council for Laboratory Animal Science(ICLAS),and Chairman of the Naonal Standardizaon Technical Commiee of Laboratory Animals.In addion to Animal Models and Experimental Medicine,Prof.Qin is also the Editor-in-Chief of Acta Laboratorium Animalis Sciena Sinica and Chinese Journal of Comparave Medicine.
文摘Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC).Moreover,she is the senior scientist of Institute of Laboratory Animal Sciences(ILAS),CAMS& PUMC.She is also the Vice-President of the Asian Federation of Laboratory Animal Science Associations(AFLAS),a board member of the International Council for Laboratory Animal Science(ICLAS),and Chairman of the National Standardization Technical Committee of Laboratory Animals.In addition to Animal Models and Experimental Medicine,Prof.Qin is also the Editor-in-Chief of Acta Laboratorium Animalis Scientia Sinica and Chinese Journal of Comparative Medicine.
文摘Editorial message Every advancement in the field of laboratory animal science and technology,from exploring basic mechanisms to validating the development of new drugs,and from establishing disease models to responding to public health emergencies,strengthens the foundation for human health and well-being,serving as an important cornerstone for promoting global scientific innovation.For this reason.
文摘Malaysia's commemoration of the second Asia Laboratory Animal Day(ALAD)in 2025 marked a notable step forward in strengthening national and regional laboratory animal science,ethical governance,and humane research practices.Celebrated a day earlier on 28 November,an initiative led by the Laboratory Animal Science Association of Malaysia(LASAM),comprised a coordinated three-month programme from September to November.A series of targeted activities were conducted,including professional exchange visits,competency-based rodent care and use workshops,refinement-centred blood sampling training,and institutional lectures on ethics and welfare.These engagements involved researchers,technicians,ethics committee members,and undergraduate trainees;reflecting ALAD's aim of fostering ethical awareness and technical proficiency across all levels of research personnel.A major highlight of the campaign was the signing of a Memorandum of Understanding between LASAM and Universiti Teknologi MARA(UiTM),strengthening long-term collaboration in training,welfare standard harmonisation,and shared ethical governance.The programme also delivered measurable outcomes:over 92%of participants improved their understanding of the 3Rs and humane endpoints,more than 95%attained competency in basic rodent handling,and national interest in laboratory animal science increased,as reflected by rising LASAM membership.Malaysia's ALAD initiatives emphasise the importance of grassroots engagement,refinement-based training,and strong institutional partnerships in advancing ethical and humane science.The country's experience provides a replicable framework for other Asian regions seeking to enhance welfare capacity,harmonise standards,and cultivate responsible research communities.Malaysia remains committed to supporting ALAD's ongoing mission to advance scientific integrity and animal welfare across Asia.
文摘As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewed commitment to ethical and scientific excellence in animal-based research.Throughout 2025,PALAS has continued to strengthen the laboratory animal science community by advancing education,capacity building,policy advocacy,and regional cooperation.These efforts underscore PALAS’vital role in shaping a culture of responsible animal research aligned with international standards.
文摘Objective: To investigate the potential of superparamagnetic iron oxide particles (SPIO) in MR imaging for the differentiation between hyperplastic and metastatic lymph node. Methods: Animal models of malignant lymph node metastasis were established in 6 New-Zealand rabbits by a unilateral intra-muscular injection of VX2 carcinoma cells, and models of hyperplastic lymph nodes were induced in another 6 rabbits by a unilateral intra-muscular injection of egg yolk emulsion. MR images of the lymph nodes were obtained before and 12 h after interstitial injection of SPIO. Image results were analyzed and compared with pathological findings. Results: On unenhanced images, the signal intensity of hyperplastic and metastatic lymph nodes did not differ significantly. After administration of SPIO, the signal intensity of both hyperplastic and metastatic lymph nodes remained unchanged on T1-weighted SE images. On T2-weighted SE images, the signal intensity of hyperplastic lymph nodes decreased heterogeneously, while that of all metastatic ones remained unchanged. On T2-weighted GRE images, the signal intensity of hyperplastic lymph nodes decreased significantly and homogeneously, while that of 4 metastatic ones remained unchanged and that of the rest 2 decreased heterogeneously. Conclusion: SPIO-enhanced MR imaging may enable the differentiation between the hyperplastic and metastatic lymph nodes.
文摘Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance of these activities mandatory for any experiment and professional working in this area. Assigning the severity of a research experiment is the result of an analysis of records of observations of the animal’s behavior, and clinical signs. The aim of this study was to describe the importance of carrying out a severity assessment associated with clinical and behavioral monitoring of rodents and rabbits during experimentation to maintain the welfare of these animals undergoing scientific research. Methods: The literature search was carried out using the following terms: “Monitoring”;“Humane endpoints”;“Animal welfare”, “Rodents”;“Rabbits”, and as connectors “and”;“or”, in the following databases: PubMed;LILACS/BIREME and SciELO. Results: A total of 987 articles were identified in the databases, and 20 of these studies were included in this review. Conclusions: Humane endpoint protocols and procedure severity tables are of the utmost importance, both from an ethical point and to refine the results of research conducted on laboratory animals. They should be drawn up jointly by the teams responsible for the project and the maintenance of the animals during the research period, and the data obtained should be published so that the scientific community can have access to it, helping to disseminate these practices, as well as helping to draw up new procedures. Monitoring and evaluating the welfare and clinical condition of animals undergoing scientific research procedures is the responsibility of the professors, researchers, veterinarians, and animal facility coordinators. The Ethics Committee on the Use of Animals must monitor all the activities conducted with the animals, by inspecting the experimental procedures and the physical environment of the laboratory animal facility where the animals are housed.
文摘Editorial Message:Asia Laboratory Animal Day:Origin and Founding Mission—Paying Tribute to the Silent Contributors in Scientific Research In the journey of advancing human scientific progress and health well-being,laboratory animals serve as indispensable silent contributors.To commemorate their contributions and advocate for welfare principles,the“Asia Laboratory Animal Day”was established.This initiative is the result of collaborative efforts among various laboratory animal organizations across Asia,forming a crucial link in connecting scientific research ethics and humanistic care throughout the continent.
文摘The FELASA 2025 Congress,themed“Reducing Severity in Animal Research,”convened global experts in laboratory animal sciences to discuss ethical advancements,welfare standards,and innovative practices.Key sessions highlighted the integration of the 3R principles(Replacement,Reduction,Refinement),with presentations addressing challenges in immunology,AI-driven animal monitoring,and aseptic surgical techniques.Notable lectures,including Prof.Stasinos Stavrianeas'exploration of zoology's origins and Dr.David Anderson's award-winning talk on squid welfare,emphasized cultural relevance and ethical responsibility.The congress also prioritized sustainability through waste-reduction measures and digital tools like an official app for enhanced networking.Exhibitions showcased cutting-edge technologies,while workshops fostered hands-on skill development.By advocating openness and interdisciplinary collaboration,FELASA 2025 aimed to advance humane and scientifically rigorous animal research practices globally.
