RIG-I样受体(RIG-I like receptors,RLRs)是天然免疫系统中一类重要模式识别受体,在细胞天然免疫应答中发挥重要的作用,LGP2是RLRs家族成员之一,对RLRs信号转导有正向和负向调控的双重作用。LGP2依据感染病毒种类的不同发挥着不同的调...RIG-I样受体(RIG-I like receptors,RLRs)是天然免疫系统中一类重要模式识别受体,在细胞天然免疫应答中发挥重要的作用,LGP2是RLRs家族成员之一,对RLRs信号转导有正向和负向调控的双重作用。LGP2依据感染病毒种类的不同发挥着不同的调控作用,但详细作用机制不明确。随着研究的深入,LGP2在天然免疫应答中的作用愈发重要。本文就近年来对LGP2参与RLRs介导的抗病毒天然免疫应答的调控及在不同病毒感染宿主中所起的作用作一综述,以期为LGP2深入研究提供参考。展开更多
An improved cycle-consistent generative adversarial network(CycleGAN) method for defect data augmentation based on feature fusion and self attention residual module is proposed to address the insufficiency of defect s...An improved cycle-consistent generative adversarial network(CycleGAN) method for defect data augmentation based on feature fusion and self attention residual module is proposed to address the insufficiency of defect sample data for light guide plate(LGP) in production,as well as the problem of minor defects.Two optimizations are made to the generator of CycleGAN:fusion of low resolution features obtained from partial up-sampling and down-sampling with high-resolution features,combination of self attention mechanism with residual network structure to replace the original residual module.Qualitative and quantitative experiments were conducted to compare different data augmentation methods,and the results show that the defect images of the LGP generated by the improved network were more realistic,and the accuracy of the you only look once version 5(YOLOv5) detection network for the LGP was improved by 5.6%,proving the effectiveness and accuracy of the proposed method.展开更多
以京沪高铁深厚地层细粒土固结试验数据为基础,以e-lgp曲线包含分式函数的复合函数表达和土体液限与压缩指数的线性关系为依据,提出了基于土体基本物性指标标准压缩模量E1？2和液限wL推求正常固结原状地基土全压力段压缩模量的简化方法...以京沪高铁深厚地层细粒土固结试验数据为基础,以e-lgp曲线包含分式函数的复合函数表达和土体液限与压缩指数的线性关系为依据,提出了基于土体基本物性指标标准压缩模量E1？2和液限wL推求正常固结原状地基土全压力段压缩模量的简化方法,其适用性得到了京津城际铁路试验数据的验证。结果表明,Harris函数能较好地描述土体压缩的e-lgp曲线特征,E1？2和wL能分别反映曲线低压力段割线斜率和高压力点切线斜率,建立的地基土压缩模量估算方法具有良好精度,其中,100-1 000 k Pa常压力段的误差均值仅为7.89%,高压力段约为13.70%,只在低压力段变异性较大;研究成果提供了缺少e-lgp曲线情况下简便快速获取土体压缩模量的新途径。展开更多
文摘RIG-I样受体(RIG-I like receptors,RLRs)是天然免疫系统中一类重要模式识别受体,在细胞天然免疫应答中发挥重要的作用,LGP2是RLRs家族成员之一,对RLRs信号转导有正向和负向调控的双重作用。LGP2依据感染病毒种类的不同发挥着不同的调控作用,但详细作用机制不明确。随着研究的深入,LGP2在天然免疫应答中的作用愈发重要。本文就近年来对LGP2参与RLRs介导的抗病毒天然免疫应答的调控及在不同病毒感染宿主中所起的作用作一综述,以期为LGP2深入研究提供参考。
基金supported by the Jiangsu Province IUR Cooperation Project (No.BY2021258)the Wuxi Science and Technology Development Fund Project (No.G20212028)。
文摘An improved cycle-consistent generative adversarial network(CycleGAN) method for defect data augmentation based on feature fusion and self attention residual module is proposed to address the insufficiency of defect sample data for light guide plate(LGP) in production,as well as the problem of minor defects.Two optimizations are made to the generator of CycleGAN:fusion of low resolution features obtained from partial up-sampling and down-sampling with high-resolution features,combination of self attention mechanism with residual network structure to replace the original residual module.Qualitative and quantitative experiments were conducted to compare different data augmentation methods,and the results show that the defect images of the LGP generated by the improved network were more realistic,and the accuracy of the you only look once version 5(YOLOv5) detection network for the LGP was improved by 5.6%,proving the effectiveness and accuracy of the proposed method.
文摘以京沪高铁深厚地层细粒土固结试验数据为基础,以e-lgp曲线包含分式函数的复合函数表达和土体液限与压缩指数的线性关系为依据,提出了基于土体基本物性指标标准压缩模量E1？2和液限wL推求正常固结原状地基土全压力段压缩模量的简化方法,其适用性得到了京津城际铁路试验数据的验证。结果表明,Harris函数能较好地描述土体压缩的e-lgp曲线特征,E1？2和wL能分别反映曲线低压力段割线斜率和高压力点切线斜率,建立的地基土压缩模量估算方法具有良好精度,其中,100-1 000 k Pa常压力段的误差均值仅为7.89%,高压力段约为13.70%,只在低压力段变异性较大;研究成果提供了缺少e-lgp曲线情况下简便快速获取土体压缩模量的新途径。
