Moringa oleifera Lam.is a Moringa genus in the Moringaceae family that is high in nutrients and has a wide range of applications.Phenolic compounds are widely found in plants and have various health benefits for the h...Moringa oleifera Lam.is a Moringa genus in the Moringaceae family that is high in nutrients and has a wide range of applications.Phenolic compounds are widely found in plants and have various health benefits for the human body.With its high content and wide variety of phenolic compounds,M.oleifera Lam.has been widely studied for its health benefits.The phenolic compounds in M.oleifera Lam.(MOPCs)can be a potential source of functional food ingredients in pharmaceutical and industrial applications.Numerous studies have shown that MOPCs have antioxidant,anti-obesity,anti-diabetic,and antibacterial effects.Although the research on MOPCs has been gradually increasing,the extraction,isolation,identification,biological activities,and comprehensive application of MOPCs need a more systematic summary and generalization.Therefore,this paper reviews the isolation and extraction methods,structure identification,biological activities,and comprehensive applications to provide a further reference for the research and application of MOPCs.展开更多
People living long-term in areas with UV will cause premature photoaging.An abnormal reduction in autophagy is a key feature of photoaging,and p38 MAPK has been regarded as a key regulator of autophagy.Isothiocyanate ...People living long-term in areas with UV will cause premature photoaging.An abnormal reduction in autophagy is a key feature of photoaging,and p38 MAPK has been regarded as a key regulator of autophagy.Isothiocyanate is one of the main active components of Moringa oleifera Lam.seeds.Studies have reported that M.oleifera Lam.seeds iso thiocyanate(MITC)has anticancer,anti-inflammatory,cardio metabolic repair,nervous system protection,blood lipid regulation and diabetes prevention properties.However,the molecular mechanisms of MITC with protective effects against skin photoaging have not been studied thus far.In this study,we aimed to evaluate the antiphotoaging activity of MITC and to investigate the effect of p38 MAPK-dependent autophagy in vivo and in vitro models of photoaging.In this research we found that MITC can reverse the intracellular reactive oxygen species(ROS)content and inhibit the activation of p38 MAPK to improve the autophagy level,reduce the expression of matrix metalloproteinases(MMPs),and finally protect against photoaging by UV.Our results will uncover the molecular mechanisms of MITC that play a role in the protective effects against skin photoaging,provide helpful information for developing MITC as an anti-photoaging plant material and improve the utilization of M.oleifera Lam.seeds.展开更多
基金supported by Major Project of Science and Technology Department of Yunnan Province(202002AA100005,202102AE090027-2)National Natural Science Foundation of China(82260703)+1 种基金Cassava Industrial Technology System of China(CARS11-YNTY)Yunnan Province Ten Thousand Plan Industrial Technology Talents Project(YNWR-CYJS-2020-010)。
文摘Moringa oleifera Lam.is a Moringa genus in the Moringaceae family that is high in nutrients and has a wide range of applications.Phenolic compounds are widely found in plants and have various health benefits for the human body.With its high content and wide variety of phenolic compounds,M.oleifera Lam.has been widely studied for its health benefits.The phenolic compounds in M.oleifera Lam.(MOPCs)can be a potential source of functional food ingredients in pharmaceutical and industrial applications.Numerous studies have shown that MOPCs have antioxidant,anti-obesity,anti-diabetic,and antibacterial effects.Although the research on MOPCs has been gradually increasing,the extraction,isolation,identification,biological activities,and comprehensive application of MOPCs need a more systematic summary and generalization.Therefore,this paper reviews the isolation and extraction methods,structure identification,biological activities,and comprehensive applications to provide a further reference for the research and application of MOPCs.
基金supported by National Natural Science Foundation of China(82260703)。
文摘People living long-term in areas with UV will cause premature photoaging.An abnormal reduction in autophagy is a key feature of photoaging,and p38 MAPK has been regarded as a key regulator of autophagy.Isothiocyanate is one of the main active components of Moringa oleifera Lam.seeds.Studies have reported that M.oleifera Lam.seeds iso thiocyanate(MITC)has anticancer,anti-inflammatory,cardio metabolic repair,nervous system protection,blood lipid regulation and diabetes prevention properties.However,the molecular mechanisms of MITC with protective effects against skin photoaging have not been studied thus far.In this study,we aimed to evaluate the antiphotoaging activity of MITC and to investigate the effect of p38 MAPK-dependent autophagy in vivo and in vitro models of photoaging.In this research we found that MITC can reverse the intracellular reactive oxygen species(ROS)content and inhibit the activation of p38 MAPK to improve the autophagy level,reduce the expression of matrix metalloproteinases(MMPs),and finally protect against photoaging by UV.Our results will uncover the molecular mechanisms of MITC that play a role in the protective effects against skin photoaging,provide helpful information for developing MITC as an anti-photoaging plant material and improve the utilization of M.oleifera Lam.seeds.
