Routine exposure to inorganic nanoparticles （NPs） that are incorporated into consumer products such as foods/drinks, packaging materials, pharmaceuticals, and personal care products （e.g. cosmetics, sunscreens, sha...Routine exposure to inorganic nanoparticles （NPs） that are incorporated into consumer products such as foods/drinks, packaging materials, pharmaceuticals, and personal care products （e.g. cosmetics, sunscreens, shampoos） occurs on a daily basis. The standard everyday use of these products facilitates interactions between the incorporated inorganic NPs, mammalian tissues （e.g. skin, gastrointestinal tract, oral cavity）, and the community of microbes that resides on these tissues. Changes to the microbiome have been linked to the initiation/ progression of many diseases and there is a growing interest focused on understanding how inorganic NPs can initiate these changes. As these mechanisms are revealed and defined, it may be possible to rationally design microbiota- modulating therapies based on inorganic NPs. In this article, we will： （i） provide a background on inorganic NPs that are commonly found in consumer products such as those that incorporate titanium, zinc, silver, silica, or iron, （ii） discuss how NP properties, microbiota composition, and the physiological microenvironment can mediate the effects that inorganic NPs have on the microbiota, and （iii） highlight opportunities for inorganic NP therapies that are designed to interact with, and navigate, the microbiome.展开更多
Optical tweezers system has emerged as an efficient tool to manipulate tiny particles in a non-invasive way.Trapping stiffness,as an essential parameter of an optical potential well,represents the trapping stability.A...Optical tweezers system has emerged as an efficient tool to manipulate tiny particles in a non-invasive way.Trapping stiffness,as an essential parameter of an optical potential well,represents the trapping stability.Additionally,trapping inorganic nanoparticles such as metallic nanoparticles or other functionalized inorganic nanoparticles is important due to their properties of good stability,high conductivity,tolerable toxicity,etc.,which makes it an ideal detection strategy for bio-sensing,force calculation,and determination of particle and environmental properties.However,the trapping stiffness measurement(TSM)methods of inorganic nanoparticles have rarely been analyzed and summarized.Here,in this review,the principle and methods of TSM are analyzed.We also systematically summarize the progress in acquiring inorganic particles trapping stiffness and its promising applications.In addition,we provide prospects of the energy and environment applications of optical tweezering technique and TSM.Finally,the challenges and future directions of achieving the nanoparticles trapping stiffness are discussed.展开更多
The purpose of this study was to examine the changes of cancer cell in ultrastructure after inorganic crystal nanoparticles （ICN） absorption. HAP and TiO2 nanoparticles were incubated with the Bet- 7402 cells for 1 ...The purpose of this study was to examine the changes of cancer cell in ultrastructure after inorganic crystal nanoparticles （ICN） absorption. HAP and TiO2 nanoparticles were incubated with the Bet- 7402 cells for 1 h and 8 h respectively. Then, cancer cells were collected and examined under transmission electron microscope （TEM）. In cytoplasm, nanoparticle were contained in some vacuoles. Some death features of cell appear. The experimental results indicated that ICN can induce cancer cells death.展开更多
Gold nanoparticles with different morphologies, such as spindle, octahedron, and decahedron were obtained by using different molar ratios of HAuCl4/HEPES in the presence and absence of surfactants at room temperature....Gold nanoparticles with different morphologies, such as spindle, octahedron, and decahedron were obtained by using different molar ratios of HAuCl4/HEPES in the presence and absence of surfactants at room temperature.These nanoparticles were characterized by X-ray diffraction（XRD）, transmission electron microscopy（TEM）, high-resolution transmission electron microscopy（HRTEM）, scanning electron microcopy（SEM）, energy-dispersive X-rays analysis（EDX）, and selected area electron diffraction（SAED）.The kinetics of the formation of gold nanoparticles in HEPES buffer was studied by UV-visible spectrophotometer.The formation of gold nanoparticles was strongly dependent on the concentration of HEPES and pH value.The surfactants play a crucial role in the size and shape controlled synthesis of gold nanoparticles.展开更多
Inorganic/organic nanohybrids composed of arrayed TiO_2 nanotubes（Ti NTs）/porphyrin nanoparticles（NPs） have been fabricated via a wet chemical approach. The inorganic component, particularly the arrayed one-dimens...Inorganic/organic nanohybrids composed of arrayed TiO_2 nanotubes（Ti NTs）/porphyrin nanoparticles（NPs） have been fabricated via a wet chemical approach. The inorganic component, particularly the arrayed one-dimensional（1D） nanostructures, provides high charge-carrier mobility and rapid charge transport. The organic component exhibits extensive visible light absorption and good solution processability. Additionally, the geometric restraint by supramolecular assembly renders an improved photostability. A combination of these two components could thus allow for an efficient solar energy conversion. In this work, a colloid of porphyrin NPs prepared by a solvent exchange method is coated on anodic Ti NTs by means of a dip-coating treatment to form inorganic/organic hybrids. The hybrids exhibit an improvement on solar absorption and a significant enhancement on photocurrent generation at a small bias compared with individual component. Herein, the inorganic/organic nanohybrids are proved to be excellent photoanodes highly responsive to visible light and thus pave a way to discover new inorganic/organic assemblies for high-performance optoelectronic applications, as well as for device integration.展开更多
Here,we report a comprehensive study on the characterization of cotton biomass residue,its conversion into carbon-based materials via pyrolysis,and its application as an electrochemical sensor for ascorbic acid(AA).Th...Here,we report a comprehensive study on the characterization of cotton biomass residue,its conversion into carbon-based materials via pyrolysis,and its application as an electrochemical sensor for ascorbic acid(AA).The compositions,morphologies,and structures of the resulting materials were investigated using XRD,FTIR,TGA,SEM,and EDS.Pyrolysis was carried out in an air atmosphere at different temperatures(300℃ and 400℃)and durations(1,60,and 240min),leading to the transformation of lignocellulosic cotton residue into carbon-basedmaterials embedded with inorganic nanoparticles,including carbonates,sulfates,chlorates,and phosphates of potassium,calcium,and magnesium.These inorganic nanoparticles exhibited irregular shapes with sizes ranging from 50 to 150 nm.The pyrolysis conditions significantly influenced both the mass ratio and the crystallinity of the inorganic phases,with treatment at 400℃ for 60 min resulting in enhanced crystallinity and an inorganic content of 54.4%.The cotton biomass-based nanomaterials were used in the construction of carbon paste electrodes(CPEs)and evaluated in PBS for AA oxidation.The electrocatalytic performance increased with the inorganic nanoparticle content.Among all,the sample pyrolyzed at 400℃ for 60 min demonstrated the highest sensitivity(3.31±0.16μA(mmol⋅L^(−1)),along with low limits of detection(2.90±1.87μmol⋅L^(−1))and quantification(9.66±6.23μmol⋅L^(−1)).These promising sensor characteristics highlight the potential of cotton biomass residue as a renewable source of electroactive nanomaterials,considering the simplicity of the carbon material preparation process and the ease of electrode fabrication.展开更多
Acute kidney injury(AKI)is a serious kidney disease without specific medications currently except for expensive dialysis treatment.Some potential drugs are limited due to their high hydrophobicity,poor in vivo stabili...Acute kidney injury(AKI)is a serious kidney disease without specific medications currently except for expensive dialysis treatment.Some potential drugs are limited due to their high hydrophobicity,poor in vivo stability,low bioavailability and possible adverse effects.Besides,kidney-targeted drugs are not common and small molecules are cleared too quickly to achieve effective drug concentrations in injured kidneys.These problems limit the development of pharmacological therapy for AKI.Nanotherapeutics based on nanotechnology have been proved to be an emerging and promising treatment strategy for AKI,which may solve the pharmacological therapy dilemma.More and more nanotherapeutics with different physicochemical properties are developed to efficiently deliver drugs,increase accumulation and control release of drugs in injury kidneys and also directly as effective antioxidants.Here,we discuss the recent nanotherapeutics applied in the treatment and prevention of AKI with improved effectiveness and few side effects.展开更多
The hybrid Janus nanomaterials have captured considerable attention since the asymmetric structure can combine the properties of each component and display synergistic applications.However,the precise design of the sp...The hybrid Janus nanomaterials have captured considerable attention since the asymmetric structure can combine the properties of each component and display synergistic applications.However,the precise design of the specific hybrid Janus nanostructures still remains a formidable challenge.Here,we for the first time report the fabrication of novel and highly uniform inorganic/organic hybrid Janus nanotubes via disassembling the mesoporous inorganic nanoparticles(NPs)/polystyrene-block-poly(4-vinylpyridine)(PS-b-P4VP)hybrid sheets,which are generated through the in situ reduction of functional metal precursors on the prepared PS-b-P4VP mesoporous scaffolds.More importantly,the internal pore size of the hybrid Janus nanotubes can be precisely tuned by readily controlling the swelling time of the PS-b-P4VP sheet-like assemblies in a selective solvent for P4VP domains,thus generating the particular inorganic/organic hybrid Janus nanotubes with adjustable inner diameter size.We believe that our finding will provide an efficient and universal route to fabricate the particular inorganic/organic hybrid nanotubes for hierarchical functional devices and nanomaterials.展开更多
Flexible aqueous zinc-air batteries with high energy density and safety have garnered significant attention.Gel polymer electrolytes have emerged as the preferred option over conventional liquid electrolytes due to th...Flexible aqueous zinc-air batteries with high energy density and safety have garnered significant attention.Gel polymer electrolytes have emerged as the preferred option over conventional liquid electrolytes due to their ability to prevent electrolyte leakage.In this study,a composite PANa-PVP-TiO_(2)(NH_(2))hydrogel with high alkaline resistance and ionic conductivity is designed,where the inorganic TiO_(2)(NH_(2))nanoparticles are evenly distributed and integrated into the organic dual network of polyacrylate sodium and polyvinyl pyrrolidone.The organic-inorganic hybrid structure enhances the absorption and retention capabilities for electrolyte solution,leading to impressive ionic conductivity of the gel polymer electrolyte throughout the operation of flexible aqueous zinc-air batteries.Additionally,the incorporation of TiO_(2)(NH_(2))nanoparticles and the dual network construction effectively strengthen the mechanical strength and flexibility of the gel polymer electrolyte,suppressing by-products and zinc dendrite formation.The enhancements lead to the extended cycling longevity of zinc symmetric batteries and excellent power density,as well as the prolonged cycle life of flexible aqueous zinc-air batteries.展开更多
The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with o...The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary.Herein,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)loading.We further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting.Moreover,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting effect.The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.展开更多
Aerogel is a nanoporous solid material with ultrahigh porosity,ultralow density,and thermal conductivity,which is considered to be one of the most promising high-performance insulation materials today.However,traditio...Aerogel is a nanoporous solid material with ultrahigh porosity,ultralow density,and thermal conductivity,which is considered to be one of the most promising high-performance insulation materials today.However,traditional pure inorganic aerogels(i.e.,silica aerogel)exhibit inherent structural brittleness,making their processing and handling difficult,and their manufacturing costs are relatively high,which limits their large-scale practical use.The recently developed aerogel based on polymer nanofibers has ultralow thermal conductivity and density,excellent elasticity,and designable multifunction.More importantly,one-dimensional polymer nanofibers are directly used as building blocks to construct the network of aerogels via a gelation-free process.This greatly simplifies the aerogel preparation process,thereby bringing opportunities for large-scale aerogel applications.The aggregation of inorganic nanomaterials and polymer nanofibers is considered to be a very attractive strategy for obtaining highly flexible,easily available,and multifunctional composite aerogels.Therefore,this review summarizes the recent advances in novel aerogels through the hybrid aggregation of inorganic nanomaterials and polymeric fibers for thermal insulation.The main processing routes,porous microstructure,mechanical properties,and thermal properties and applications of these aerogels are highlighted.In addition,various future challenges faced by these aerogels in thermal insulation applications are discussed in this review.展开更多
Ultrasound(US) imaging in combination with US contrast agents(UCAs) is a powerful tool in the modern biomedical field because of its high spatial resolution, easy access to patients and minimum invasiveness.The microb...Ultrasound(US) imaging in combination with US contrast agents(UCAs) is a powerful tool in the modern biomedical field because of its high spatial resolution, easy access to patients and minimum invasiveness.The microbubble-based UCAs have been widely used in clinical diagnosis; however, they are only limited to the blood pool imaging and not applicable to the tissue-penetrated imaging due to their large particle size and structural instability. Inorganic nanoparticles(NPs), such as silica,gold and Fe x O y, featured with both satisfactory echogenic properties and structural stability have the potential to be used as a new generation of UCAs. In this review, we present the most recent progresses in the tailored construction of inorganic UCAs and their biomedical applications in the US imaging-involved fields. Firstly, the typical inorganic NPs with different structures including solid, hollow and multiple-layer forms will be comprehensively introduced in terms of their structure design,physicochemical property, US imaging mechanism and diverse applications; secondly, the recent progress in exploring the gas-generating inorganic NP system for US imaging purpose will be reviewed, and these intelligent UCAs are multifunctional for simultaneous US imaging and disease therapy; thirdly, several nanocomposite platforms newly constructed by combining inorganic UCAs with other functional components will be presented anddiscussed. These multifunctional NPs are capable of further enhancing the imaging resolution by providing more comprehensive anatomical information simultaneously.Last but not the least, the design criteria for developing promising UCAs to satisfy both clinical demands and optimized US imaging capability will be discussed and summarized in this review.展开更多
Inorganic nanocarriers are potent candidates for delivering conventional anticancer drugs,nucleic acid-based therapeutics,and imaging agents,influencing their blood half-lives,tumor targetability,and bioactivity.In ad...Inorganic nanocarriers are potent candidates for delivering conventional anticancer drugs,nucleic acid-based therapeutics,and imaging agents,influencing their blood half-lives,tumor targetability,and bioactivity.In addition to the high surface area-to-volume ratio,they exhibit excellent scalability in synthesis,controllable shape and size,facile surface modification,inertness,stability,and unique optical and magnetic properties.However,only a limited number of inorganic nanocarriers have been so far approved for clinical applications due to burst drug release,poor target specificity,and toxicity.To overcome these barriers,understanding the principles involved in loading therapeutic and imaging molecules into these nanoparticles(NPs)and the strategies employed in enhancing sustainability and targetability of the resultant complexes and ensuring the release of the payloads in extracellular and intracellular compartments of the target site is of paramount importance.Therefore,we will shed light on various loading mechanisms harnessed for different inorganic NPs,particularly involving physical entrapment into porous/hollow nanostructures,ionic interactions with native and surface-modified NPs,covalent bonding to surface-functionalized nanomaterials,hydrophobic binding,affinity-based interactions,and intercalation through co-precipitation or anion exchange reaction.展开更多
Psoriasis is an autoimmune disease marked by excessive keratinocyte proliferation and aberrant activation of immune cells,resulting in clinical manifestations such as erythema,pruritus,and skin scaling.Although curren...Psoriasis is an autoimmune disease marked by excessive keratinocyte proliferation and aberrant activation of immune cells,resulting in clinical manifestations such as erythema,pruritus,and skin scaling.Although current treatments such as biologics,immunosuppressants,and phototherapy have demonstrated certain therapeutic efficacy,their application remains constrained by systemic side effects,limited drug permeability,and reduced long-term tolerability.Furthermore,the high relapse rate and suboptimal patient compliance contribute to considerable physical and psychological burdens.In recent years,nanomedicines have emerged as a promising therapeutic strategy for psoriasis due to their unique physicochemical properties,including small size,high payload,controllable release,and targeted delivery.By selectively modulating key cellular components,cytokines,and signaling pathways involved in the pathogenesis of psoriasis,nanomedicines have shown potential to achieve targeted,synergistic,and sustained therapeutic effects that are often difficult to attain with conventional formulations.This review aims to summarize recent advances in nanomedicine-based therapies for psoriasis,focusing on diverse therapeutic targets,thereby offering novel perspectives and directions for future development in this field.展开更多
Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inh...Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor （VEGF）-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.展开更多
文摘Routine exposure to inorganic nanoparticles （NPs） that are incorporated into consumer products such as foods/drinks, packaging materials, pharmaceuticals, and personal care products （e.g. cosmetics, sunscreens, shampoos） occurs on a daily basis. The standard everyday use of these products facilitates interactions between the incorporated inorganic NPs, mammalian tissues （e.g. skin, gastrointestinal tract, oral cavity）, and the community of microbes that resides on these tissues. Changes to the microbiome have been linked to the initiation/ progression of many diseases and there is a growing interest focused on understanding how inorganic NPs can initiate these changes. As these mechanisms are revealed and defined, it may be possible to rationally design microbiota- modulating therapies based on inorganic NPs. In this article, we will： （i） provide a background on inorganic NPs that are commonly found in consumer products such as those that incorporate titanium, zinc, silver, silica, or iron, （ii） discuss how NP properties, microbiota composition, and the physiological microenvironment can mediate the effects that inorganic NPs have on the microbiota, and （iii） highlight opportunities for inorganic NP therapies that are designed to interact with, and navigate, the microbiome.
基金supported by the National Natural Science Foundation of China(62275164,61905145,62275168)National Key Research and Development Program of China(No.2022YFA1200116)+1 种基金Guangdong Natural Science Foundation and Province Project(2021A1515011916)Shenzhen Science and Technology Planning Project(ZDSYS20210623092006020).
文摘Optical tweezers system has emerged as an efficient tool to manipulate tiny particles in a non-invasive way.Trapping stiffness,as an essential parameter of an optical potential well,represents the trapping stability.Additionally,trapping inorganic nanoparticles such as metallic nanoparticles or other functionalized inorganic nanoparticles is important due to their properties of good stability,high conductivity,tolerable toxicity,etc.,which makes it an ideal detection strategy for bio-sensing,force calculation,and determination of particle and environmental properties.However,the trapping stiffness measurement(TSM)methods of inorganic nanoparticles have rarely been analyzed and summarized.Here,in this review,the principle and methods of TSM are analyzed.We also systematically summarize the progress in acquiring inorganic particles trapping stiffness and its promising applications.In addition,we provide prospects of the energy and environment applications of optical tweezering technique and TSM.Finally,the challenges and future directions of achieving the nanoparticles trapping stiffness are discussed.
文摘The purpose of this study was to examine the changes of cancer cell in ultrastructure after inorganic crystal nanoparticles （ICN） absorption. HAP and TiO2 nanoparticles were incubated with the Bet- 7402 cells for 1 h and 8 h respectively. Then, cancer cells were collected and examined under transmission electron microscope （TEM）. In cytoplasm, nanoparticle were contained in some vacuoles. Some death features of cell appear. The experimental results indicated that ICN can induce cancer cells death.
基金supports from the Program for Excellent Talents of the Department of Education of Hubei Province, China (No. Q20081504)the Area of Excellence Scheme administered by the University Grant Committee and the University of Hong Kong (No.AoE/ P-10/ 01)
文摘Gold nanoparticles with different morphologies, such as spindle, octahedron, and decahedron were obtained by using different molar ratios of HAuCl4/HEPES in the presence and absence of surfactants at room temperature.These nanoparticles were characterized by X-ray diffraction（XRD）, transmission electron microscopy（TEM）, high-resolution transmission electron microscopy（HRTEM）, scanning electron microcopy（SEM）, energy-dispersive X-rays analysis（EDX）, and selected area electron diffraction（SAED）.The kinetics of the formation of gold nanoparticles in HEPES buffer was studied by UV-visible spectrophotometer.The formation of gold nanoparticles was strongly dependent on the concentration of HEPES and pH value.The surfactants play a crucial role in the size and shape controlled synthesis of gold nanoparticles.
基金the National Natural Science Foundation of China (Nos. 51503014 and 51501008)the Beijing Higher Education Young Elite Teacher Project (No. YETP0419)
文摘Inorganic/organic nanohybrids composed of arrayed TiO_2 nanotubes（Ti NTs）/porphyrin nanoparticles（NPs） have been fabricated via a wet chemical approach. The inorganic component, particularly the arrayed one-dimensional（1D） nanostructures, provides high charge-carrier mobility and rapid charge transport. The organic component exhibits extensive visible light absorption and good solution processability. Additionally, the geometric restraint by supramolecular assembly renders an improved photostability. A combination of these two components could thus allow for an efficient solar energy conversion. In this work, a colloid of porphyrin NPs prepared by a solvent exchange method is coated on anodic Ti NTs by means of a dip-coating treatment to form inorganic/organic hybrids. The hybrids exhibit an improvement on solar absorption and a significant enhancement on photocurrent generation at a small bias compared with individual component. Herein, the inorganic/organic nanohybrids are proved to be excellent photoanodes highly responsive to visible light and thus pave a way to discover new inorganic/organic assemblies for high-performance optoelectronic applications, as well as for device integration.
基金financial support of Brazilian agencies FAPESC/ACAFE,CAPES,CNPq and Nationals Institutes of Science and Technology of Carbon Nanomaterials(INCT-Nanocarbon,421701/2017-0)Nanomaterials for Life(INCT Nano Life,406079/2022-6)+2 种基金J.P.M.C.A.acknowledges his scientific initiation(PIBIT)grant from CNPq,D.O.S.thanks CAPES for his post-doctoral grant(PNPD/CAPES 2017-2019)J.A.is grateful for his grant from CNPq(CNPq 303633/2023-9)the financial support from FAPESC through various projects(contracts:2018TR1546,2023TR001521 and 2024TR002662).
文摘Here,we report a comprehensive study on the characterization of cotton biomass residue,its conversion into carbon-based materials via pyrolysis,and its application as an electrochemical sensor for ascorbic acid(AA).The compositions,morphologies,and structures of the resulting materials were investigated using XRD,FTIR,TGA,SEM,and EDS.Pyrolysis was carried out in an air atmosphere at different temperatures(300℃ and 400℃)and durations(1,60,and 240min),leading to the transformation of lignocellulosic cotton residue into carbon-basedmaterials embedded with inorganic nanoparticles,including carbonates,sulfates,chlorates,and phosphates of potassium,calcium,and magnesium.These inorganic nanoparticles exhibited irregular shapes with sizes ranging from 50 to 150 nm.The pyrolysis conditions significantly influenced both the mass ratio and the crystallinity of the inorganic phases,with treatment at 400℃ for 60 min resulting in enhanced crystallinity and an inorganic content of 54.4%.The cotton biomass-based nanomaterials were used in the construction of carbon paste electrodes(CPEs)and evaluated in PBS for AA oxidation.The electrocatalytic performance increased with the inorganic nanoparticle content.Among all,the sample pyrolyzed at 400℃ for 60 min demonstrated the highest sensitivity(3.31±0.16μA(mmol⋅L^(−1)),along with low limits of detection(2.90±1.87μmol⋅L^(−1))and quantification(9.66±6.23μmol⋅L^(−1)).These promising sensor characteristics highlight the potential of cotton biomass residue as a renewable source of electroactive nanomaterials,considering the simplicity of the carbon material preparation process and the ease of electrode fabrication.
基金supported by New Century 151 Talent Project of Zhejiang ProvinceJoint Institute of Lishui Hospital and Zhejiang University for nanomaterials and nanotechnology。
文摘Acute kidney injury(AKI)is a serious kidney disease without specific medications currently except for expensive dialysis treatment.Some potential drugs are limited due to their high hydrophobicity,poor in vivo stability,low bioavailability and possible adverse effects.Besides,kidney-targeted drugs are not common and small molecules are cleared too quickly to achieve effective drug concentrations in injured kidneys.These problems limit the development of pharmacological therapy for AKI.Nanotherapeutics based on nanotechnology have been proved to be an emerging and promising treatment strategy for AKI,which may solve the pharmacological therapy dilemma.More and more nanotherapeutics with different physicochemical properties are developed to efficiently deliver drugs,increase accumulation and control release of drugs in injury kidneys and also directly as effective antioxidants.Here,we discuss the recent nanotherapeutics applied in the treatment and prevention of AKI with improved effectiveness and few side effects.
基金financially supported by the National Natural Science Foundation of China for General Program(No.22072143)and Major Program(No.51433009)。
文摘The hybrid Janus nanomaterials have captured considerable attention since the asymmetric structure can combine the properties of each component and display synergistic applications.However,the precise design of the specific hybrid Janus nanostructures still remains a formidable challenge.Here,we for the first time report the fabrication of novel and highly uniform inorganic/organic hybrid Janus nanotubes via disassembling the mesoporous inorganic nanoparticles(NPs)/polystyrene-block-poly(4-vinylpyridine)(PS-b-P4VP)hybrid sheets,which are generated through the in situ reduction of functional metal precursors on the prepared PS-b-P4VP mesoporous scaffolds.More importantly,the internal pore size of the hybrid Janus nanotubes can be precisely tuned by readily controlling the swelling time of the PS-b-P4VP sheet-like assemblies in a selective solvent for P4VP domains,thus generating the particular inorganic/organic hybrid Janus nanotubes with adjustable inner diameter size.We believe that our finding will provide an efficient and universal route to fabricate the particular inorganic/organic hybrid nanotubes for hierarchical functional devices and nanomaterials.
基金supported by the National Natural Science Foundation of China(Grant Nos.51872147,22136003)the Project of Hubei Provincial Department of Education(Grant No.D20221202)+1 种基金the 111 Project(Grant No.D20015)the Hubei Provincial Natural Science Foundation of China(Grant Nos.2022CFA065,2022CFB820).
文摘Flexible aqueous zinc-air batteries with high energy density and safety have garnered significant attention.Gel polymer electrolytes have emerged as the preferred option over conventional liquid electrolytes due to their ability to prevent electrolyte leakage.In this study,a composite PANa-PVP-TiO_(2)(NH_(2))hydrogel with high alkaline resistance and ionic conductivity is designed,where the inorganic TiO_(2)(NH_(2))nanoparticles are evenly distributed and integrated into the organic dual network of polyacrylate sodium and polyvinyl pyrrolidone.The organic-inorganic hybrid structure enhances the absorption and retention capabilities for electrolyte solution,leading to impressive ionic conductivity of the gel polymer electrolyte throughout the operation of flexible aqueous zinc-air batteries.Additionally,the incorporation of TiO_(2)(NH_(2))nanoparticles and the dual network construction effectively strengthen the mechanical strength and flexibility of the gel polymer electrolyte,suppressing by-products and zinc dendrite formation.The enhancements lead to the extended cycling longevity of zinc symmetric batteries and excellent power density,as well as the prolonged cycle life of flexible aqueous zinc-air batteries.
基金This work was financially supported by the National Natural Science Foundation of China(Nos.31930067,31525009,31800797,and 31771096)the National Key Research and Development Program of China(Nos.2017YFC1103502 and 2016YFA0201402)+2 种基金the China Postdoctoral Science Foundation funded project(No.2018M631094)the Postdoctoral Innovation Talents Support Program(No.BX20180207)1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD18002).
文摘The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary.Herein,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)loading.We further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting.Moreover,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting effect.The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.
基金National Natural Science Foundation of China,Grant/Award Numbers:51873166,51873165Program of Hubei Technology InnovationInternational Collaboration,Grant/Award Number:2017AHB065+1 种基金Hubei Province Central Government Guides Local Science and Technology Development Projects,Grant/Award Number:2018ZYYD057Applied Fundamental Research Program of Wuhan Municipal Science and Technology Bureau,Grant/Award Number:2017060201010165。
文摘Aerogel is a nanoporous solid material with ultrahigh porosity,ultralow density,and thermal conductivity,which is considered to be one of the most promising high-performance insulation materials today.However,traditional pure inorganic aerogels(i.e.,silica aerogel)exhibit inherent structural brittleness,making their processing and handling difficult,and their manufacturing costs are relatively high,which limits their large-scale practical use.The recently developed aerogel based on polymer nanofibers has ultralow thermal conductivity and density,excellent elasticity,and designable multifunction.More importantly,one-dimensional polymer nanofibers are directly used as building blocks to construct the network of aerogels via a gelation-free process.This greatly simplifies the aerogel preparation process,thereby bringing opportunities for large-scale aerogel applications.The aggregation of inorganic nanomaterials and polymer nanofibers is considered to be a very attractive strategy for obtaining highly flexible,easily available,and multifunctional composite aerogels.Therefore,this review summarizes the recent advances in novel aerogels through the hybrid aggregation of inorganic nanomaterials and polymeric fibers for thermal insulation.The main processing routes,porous microstructure,mechanical properties,and thermal properties and applications of these aerogels are highlighted.In addition,various future challenges faced by these aerogels in thermal insulation applications are discussed in this review.
基金supported by China National Funds for Distinguished Young Scientists(51225202)the National Natural Science Foundation of China(51402329)+1 种基金Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures(SKL201404)Shanghai Excellent Academic Leaders Program(14XD1403800)
文摘Ultrasound(US) imaging in combination with US contrast agents(UCAs) is a powerful tool in the modern biomedical field because of its high spatial resolution, easy access to patients and minimum invasiveness.The microbubble-based UCAs have been widely used in clinical diagnosis; however, they are only limited to the blood pool imaging and not applicable to the tissue-penetrated imaging due to their large particle size and structural instability. Inorganic nanoparticles(NPs), such as silica,gold and Fe x O y, featured with both satisfactory echogenic properties and structural stability have the potential to be used as a new generation of UCAs. In this review, we present the most recent progresses in the tailored construction of inorganic UCAs and their biomedical applications in the US imaging-involved fields. Firstly, the typical inorganic NPs with different structures including solid, hollow and multiple-layer forms will be comprehensively introduced in terms of their structure design,physicochemical property, US imaging mechanism and diverse applications; secondly, the recent progress in exploring the gas-generating inorganic NP system for US imaging purpose will be reviewed, and these intelligent UCAs are multifunctional for simultaneous US imaging and disease therapy; thirdly, several nanocomposite platforms newly constructed by combining inorganic UCAs with other functional components will be presented anddiscussed. These multifunctional NPs are capable of further enhancing the imaging resolution by providing more comprehensive anatomical information simultaneously.Last but not the least, the design criteria for developing promising UCAs to satisfy both clinical demands and optimized US imaging capability will be discussed and summarized in this review.
文摘Inorganic nanocarriers are potent candidates for delivering conventional anticancer drugs,nucleic acid-based therapeutics,and imaging agents,influencing their blood half-lives,tumor targetability,and bioactivity.In addition to the high surface area-to-volume ratio,they exhibit excellent scalability in synthesis,controllable shape and size,facile surface modification,inertness,stability,and unique optical and magnetic properties.However,only a limited number of inorganic nanocarriers have been so far approved for clinical applications due to burst drug release,poor target specificity,and toxicity.To overcome these barriers,understanding the principles involved in loading therapeutic and imaging molecules into these nanoparticles(NPs)and the strategies employed in enhancing sustainability and targetability of the resultant complexes and ensuring the release of the payloads in extracellular and intracellular compartments of the target site is of paramount importance.Therefore,we will shed light on various loading mechanisms harnessed for different inorganic NPs,particularly involving physical entrapment into porous/hollow nanostructures,ionic interactions with native and surface-modified NPs,covalent bonding to surface-functionalized nanomaterials,hydrophobic binding,affinity-based interactions,and intercalation through co-precipitation or anion exchange reaction.
基金supported by the Chongqing Science and Technology Development Foundation(CSTB 2024NSCQ-KJFZZDX0033).
文摘Psoriasis is an autoimmune disease marked by excessive keratinocyte proliferation and aberrant activation of immune cells,resulting in clinical manifestations such as erythema,pruritus,and skin scaling.Although current treatments such as biologics,immunosuppressants,and phototherapy have demonstrated certain therapeutic efficacy,their application remains constrained by systemic side effects,limited drug permeability,and reduced long-term tolerability.Furthermore,the high relapse rate and suboptimal patient compliance contribute to considerable physical and psychological burdens.In recent years,nanomedicines have emerged as a promising therapeutic strategy for psoriasis due to their unique physicochemical properties,including small size,high payload,controllable release,and targeted delivery.By selectively modulating key cellular components,cytokines,and signaling pathways involved in the pathogenesis of psoriasis,nanomedicines have shown potential to achieve targeted,synergistic,and sustained therapeutic effects that are often difficult to attain with conventional formulations.This review aims to summarize recent advances in nanomedicine-based therapies for psoriasis,focusing on diverse therapeutic targets,thereby offering novel perspectives and directions for future development in this field.
文摘Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor （VEGF）-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.
基金supported by the National Natural Science Foundation of China(61705228 and 62105333)the Key Research Program of the Chinese Academy of Sciences(ZDRW-CN-2021-3)Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(2020ZZ114)。
基金the support from the National Natural Science Foundation of China(NSFC)(U20A20128,52263027,22379060,52173169 and 52222312)the"Double Thousand Plan"Science and Technology Innovation High-end Talent Project of Jiangxi Province(jxsq2019201049)+2 种基金the Natural Science Foundation of Jiangxi Province(20231ZDH04036,20212BAB214055 and 20224ACB204007)China National Postdoctoral Program for Innovative Talents(BX2021117)China Postdoctoral Science Foundation(2021M700060)。
