In this work,we investigate the impact of the whole small recess offset on DC and RF characteristics of InP high electron mobility transistors(HEMTs).L_(g)=80 nm HEMTs are fabricated with a double-recessed gate proces...In this work,we investigate the impact of the whole small recess offset on DC and RF characteristics of InP high electron mobility transistors(HEMTs).L_(g)=80 nm HEMTs are fabricated with a double-recessed gate process.We focus on their DC and RF responses,including the maximum transconductance(g_(m_max)),ON-resistance(R_(ON)),current-gain cutoff frequency(f_(T)),and maximum oscillation frequency(f_(max)).The devices have almost same RON.The g_(m_max) improves as the whole small recess moves toward the source.However,a small gate to source capacitance(C_(gs))and a small drain output conductance(g_(ds))lead to the largest f_(T),although the whole small gate recess moves toward the drain leads to the smaller g_(m_max).According to the small-signal modeling,the device with the whole small recess toward drain exhibits an excellent RF characteristics,such as f_(T)=372 GHz and f_(max)=394 GHz.This result is achieved by paying attention to adjust resistive and capacitive parasitics,which play a key role in high-frequency response.展开更多
目的探讨肿瘤蛋白p53诱导的核蛋白2(tumor protein p53 inducible nuclear protein 2,TP53INP2)和溶质载体有机阴离子转运蛋白家族成员2A1(solute carrier organic anion transporter family member 2A1,SLCO2A1)在分化型甲状腺癌(diffe...目的探讨肿瘤蛋白p53诱导的核蛋白2(tumor protein p53 inducible nuclear protein 2,TP53INP2)和溶质载体有机阴离子转运蛋白家族成员2A1(solute carrier organic anion transporter family member 2A1,SLCO2A1)在分化型甲状腺癌(differentiated thyroid carcinoma,DTC)中的表达及其与临床病理特征和预后的关系。方法选取2024年3月至5月于南京医科大学第三附属医院行甲状腺癌根治术的DTC患者80例,比较TP53INP2和SLCO2A1在DTC患者的癌组织、癌旁组织及淋巴结转移组织中的表达,分析其与DTC患者临床病理特征之间的关系。从癌症基因组图谱(The Cancer GenomeAtlas,TCGA)数据库下载正常人甲状腺和DTC组织的表达矩阵、临床病理参数及预后资料,使用R软件进行基因集变异分析(gene set variation analysis,GSVA),分析GSVA评分与DTC患者临床病理特征及预后之间的关系。采用Kaplan-Meier法分析基因集GSVA评分与DTC患者无进展生存(progress free survive,PFS)之间的关系。采用Cox单因素及多因素分析探讨影响DTC患者预后的因素。结果DTC患者癌组织及淋巴结转移组织中的TP53INP2和SLCO2A1表达显著降低(P<0.05)。GSVA评分与肿瘤侵袭、淋巴结转移、远处转移和病理类型显著相关(P<0.05)。GSVA评分低的DTC患者的PFS率显著低于GSVA评分高者(P=0.002)。Cox多因素分析结果显示肿瘤侵袭及GSVA评分低均是导致DTC患者预后不良的独立影响因素(P<0.05)。结论TP53INP2和SLCO2A1在DTC组织中表达降低,其表达降低与肿瘤侵袭、淋巴结转移、远处转移及不良预后有关,或可成为DTC患者预后判断的潜在靶点。展开更多
The development of InGaAs/InP single-photon avalanche photodiodes(SPADs)necessitates the utiliza-tion of a two-element diffusion technique to achieve accurate manipulation of the multiplication width and the dis-tribu...The development of InGaAs/InP single-photon avalanche photodiodes(SPADs)necessitates the utiliza-tion of a two-element diffusion technique to achieve accurate manipulation of the multiplication width and the dis-tribution of its electric field.Regarding the issue of accurately predicting the depth of diffusion in InGaAs/InP SPAD,simulation analysis and device development were carried out,focusing on the dual diffusion behavior of zinc atoms.A formula of X_(j)=k√t-t_(0)+c to quantitatively predict the diffusion depth is obtained by fitting the simulated twice-diffusion depths based on a two-dimensional(2D)model.The 2D impurity morphologies and the one-dimensional impurity profiles for the dual-diffused region are characterized by using scanning electron micros-copy and secondary ion mass spectrometry as a function of the diffusion depth,respectively.InGaAs/InP SPAD devices with different dual-diffusion conditions are also fabricated,which show breakdown behaviors well consis-tent with the simulated results under the same junction geometries.The dark count rate(DCR)of the device de-creased as the multiplication width increased,as indicated by the results.DCRs of 2×10^(6),1×10^(5),4×10^(4),and 2×10^(4) were achieved at temperatures of 300 K,273 K,263 K,and 253 K,respectively,with a bias voltage of 3 V,when the multiplication width was 1.5µm.These results demonstrate an effective prediction route for accu-rately controlling the dual-diffused zinc junction geometry in InP-based planar device processing.展开更多
基金Supported by the Terahertz Multi User RF Transceiver System Development Project(Z211100004421012).
文摘In this work,we investigate the impact of the whole small recess offset on DC and RF characteristics of InP high electron mobility transistors(HEMTs).L_(g)=80 nm HEMTs are fabricated with a double-recessed gate process.We focus on their DC and RF responses,including the maximum transconductance(g_(m_max)),ON-resistance(R_(ON)),current-gain cutoff frequency(f_(T)),and maximum oscillation frequency(f_(max)).The devices have almost same RON.The g_(m_max) improves as the whole small recess moves toward the source.However,a small gate to source capacitance(C_(gs))and a small drain output conductance(g_(ds))lead to the largest f_(T),although the whole small gate recess moves toward the drain leads to the smaller g_(m_max).According to the small-signal modeling,the device with the whole small recess toward drain exhibits an excellent RF characteristics,such as f_(T)=372 GHz and f_(max)=394 GHz.This result is achieved by paying attention to adjust resistive and capacitive parasitics,which play a key role in high-frequency response.
基金Supported by the National Natural Science Foundation of China(12027805,62171136,62174166,U2241219)the Science and Technology Commission of Shanghai Municipality(2019SHZDZX01,22JC1402902)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB43010200)。
基金Supported by the National Natural Science Foundation of China(NSFC)(62174166,11991063,U2241219)Shanghai Municipal Science and Technology Major Project(2019SHZDZX01,22JC1402902)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB43010200)。
文摘目的探讨肿瘤蛋白p53诱导的核蛋白2(tumor protein p53 inducible nuclear protein 2,TP53INP2)和溶质载体有机阴离子转运蛋白家族成员2A1(solute carrier organic anion transporter family member 2A1,SLCO2A1)在分化型甲状腺癌(differentiated thyroid carcinoma,DTC)中的表达及其与临床病理特征和预后的关系。方法选取2024年3月至5月于南京医科大学第三附属医院行甲状腺癌根治术的DTC患者80例,比较TP53INP2和SLCO2A1在DTC患者的癌组织、癌旁组织及淋巴结转移组织中的表达,分析其与DTC患者临床病理特征之间的关系。从癌症基因组图谱(The Cancer GenomeAtlas,TCGA)数据库下载正常人甲状腺和DTC组织的表达矩阵、临床病理参数及预后资料,使用R软件进行基因集变异分析(gene set variation analysis,GSVA),分析GSVA评分与DTC患者临床病理特征及预后之间的关系。采用Kaplan-Meier法分析基因集GSVA评分与DTC患者无进展生存(progress free survive,PFS)之间的关系。采用Cox单因素及多因素分析探讨影响DTC患者预后的因素。结果DTC患者癌组织及淋巴结转移组织中的TP53INP2和SLCO2A1表达显著降低(P<0.05)。GSVA评分与肿瘤侵袭、淋巴结转移、远处转移和病理类型显著相关(P<0.05)。GSVA评分低的DTC患者的PFS率显著低于GSVA评分高者(P=0.002)。Cox多因素分析结果显示肿瘤侵袭及GSVA评分低均是导致DTC患者预后不良的独立影响因素(P<0.05)。结论TP53INP2和SLCO2A1在DTC组织中表达降低,其表达降低与肿瘤侵袭、淋巴结转移、远处转移及不良预后有关,或可成为DTC患者预后判断的潜在靶点。
基金Supported by Shanghai Natural Science Foundation(22ZR1472600).
文摘The development of InGaAs/InP single-photon avalanche photodiodes(SPADs)necessitates the utiliza-tion of a two-element diffusion technique to achieve accurate manipulation of the multiplication width and the dis-tribution of its electric field.Regarding the issue of accurately predicting the depth of diffusion in InGaAs/InP SPAD,simulation analysis and device development were carried out,focusing on the dual diffusion behavior of zinc atoms.A formula of X_(j)=k√t-t_(0)+c to quantitatively predict the diffusion depth is obtained by fitting the simulated twice-diffusion depths based on a two-dimensional(2D)model.The 2D impurity morphologies and the one-dimensional impurity profiles for the dual-diffused region are characterized by using scanning electron micros-copy and secondary ion mass spectrometry as a function of the diffusion depth,respectively.InGaAs/InP SPAD devices with different dual-diffusion conditions are also fabricated,which show breakdown behaviors well consis-tent with the simulated results under the same junction geometries.The dark count rate(DCR)of the device de-creased as the multiplication width increased,as indicated by the results.DCRs of 2×10^(6),1×10^(5),4×10^(4),and 2×10^(4) were achieved at temperatures of 300 K,273 K,263 K,and 253 K,respectively,with a bias voltage of 3 V,when the multiplication width was 1.5µm.These results demonstrate an effective prediction route for accu-rately controlling the dual-diffused zinc junction geometry in InP-based planar device processing.
