Flexible di(ethyloxy-ether) was introduced into the aromstic copolyesters and copely(ester-amide)s to reduce the melting point of resulting polymers. The liquid crystallinity was proved by PLM observation and WAXD stu...Flexible di(ethyloxy-ether) was introduced into the aromstic copolyesters and copely(ester-amide)s to reduce the melting point of resulting polymers. The liquid crystallinity was proved by PLM observation and WAXD study. The melting point was greatly reduced, to 200℃ or even lower in some cases, and the molecular weight was satisfactorily high as reflected by inherent viscosity.The copolyester showed better crystallinity and liquid crystallinity than corresponding copely(ester-amide) with similar monomer compogition.展开更多
在J2EE开发中,程序员经常需要面对如何将程序元素组装成类聚的应用程序,如何有效地管理组件和组件间的相互调用装载,成为应用程序开发的重要任务,IOC(Inversion of Control,控制反转)框架的发展,满足了这个方面的需求。文中讨论了IOC模...在J2EE开发中,程序员经常需要面对如何将程序元素组装成类聚的应用程序,如何有效地管理组件和组件间的相互调用装载,成为应用程序开发的重要任务,IOC(Inversion of Control,控制反转)框架的发展,满足了这个方面的需求。文中讨论了IOC模式的基本概论I、OC问题的产生,比较了IOC模式与工厂模式的区别以及IOC的发展意义,重点给出了IOC框架设计的两种设计方案:动态IOC和静态IOC的实现,最后比较了两种方案的优缺点。展开更多
在软件开发中，我们经常需要面对如何将程序元素组装成类聚的应用程序，如何有效地管理组件和组件间的相互调用装载．成为应用程序开发的重要任务，IOC（Inversion of Control，控制反转）框架的发展，满足了这个方面的需求。文中讨论了...在软件开发中，我们经常需要面对如何将程序元素组装成类聚的应用程序，如何有效地管理组件和组件间的相互调用装载．成为应用程序开发的重要任务，IOC（Inversion of Control，控制反转）框架的发展，满足了这个方面的需求。文中讨论了IOC模式的基本概论、控制反转（IOC）的基本原理、CastleIOC容器配置构建，重点介绍了IOC的分析与实现。展开更多
Previous studies have reported a neuroprotective effect of 8-hydroxy-2-（di-n-propylamino）tetralin （8-OH-DPAT） against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal in...Previous studies have reported a neuroprotective effect of 8-hydroxy-2-（di-n-propylamino）tetralin （8-OH-DPAT） against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats. 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature.展开更多
New highly stereoregular 2, 3 -di- O-(p-azidobenzyl )-(1 →5 ) - α-D -ribofuranan was synthesized byselective ring-opening polymerization of 1, 4-anhydro-2, 3 - di-O -(p-azidobenzyl )-α-D -ribopyranose(ADABR) using ...New highly stereoregular 2, 3 -di- O-(p-azidobenzyl )-(1 →5 ) - α-D -ribofuranan was synthesized byselective ring-opening polymerization of 1, 4-anhydro-2, 3 - di-O -(p-azidobenzyl )-α-D -ribopyranose(ADABR) using phosphorus pentafluoride or tin tetrachloride as catalyst at low temperature indichloromethane. The monomer was obtained by the reaction of p - bromomethyl -phenyleneazide with 1, 4 -anhydro-α-D-ribose in DMF. The structure of poly(ADANR) was identified by specific rotation and ^(13)C-NMR spectroscopy. Acid chloride-AgCl_4 complex catalyst such as CH_2=C(CH_3)C^+OClO_4^- used in thepolymerization resulted in polymers with mixed structures, i.e. (1→5)-α-D-ribofuranosidic and (1→4)-β-D-ribopyranosidic units. However, with C_6H_5C^+OClO_4^- as catalyst, pure (1→5)-α-D-ribofuranan was obtained.The effects of catalyst, polymerization temperature and time on polymer stereoregularity were examined, andthe mechanism of the ring-opening polymerization was discussed.展开更多
目的:建立药用丁基橡胶塞中添加剂[抗氧剂264(2,6-二叔丁基-4-甲基苯酚,简称BHT)和硫化剂可提取硫]的含量测定方法。方法:以二氯甲烷-无水乙醇为提取溶剂,利用高效液相色谱法对药用丁基橡胶塞的BHT和可提取硫含量进行测定,以含0.1%三氟...目的:建立药用丁基橡胶塞中添加剂[抗氧剂264(2,6-二叔丁基-4-甲基苯酚,简称BHT)和硫化剂可提取硫]的含量测定方法。方法:以二氯甲烷-无水乙醇为提取溶剂,利用高效液相色谱法对药用丁基橡胶塞的BHT和可提取硫含量进行测定,以含0.1%三氟乙酸的乙腈-含0.1%三氟乙酸的水(90∶10)为流动相,流速1.0 m L·min^(-1),检测波长280 nm。结果:抗氧剂BHT的线性检测范围0.41~103.00μg·mL^(-1)(r^2=1.000),可提取硫的线性检测范围0.10~103.50μg·mL^(-1)(r^2=0.999 9),BHT和可提取硫的平均回收率分别为95.2%和86.8%。测定7批药用胶塞中BHT与可提取硫含量范围分别为4~206μg·g^(-1)和1~143μg·g^(-1)。结论:本文建立的检测方法经方法学验证,可用于考察药用丁基橡胶塞中BHT和可提取硫的含量及质量控制。展开更多
文摘Flexible di(ethyloxy-ether) was introduced into the aromstic copolyesters and copely(ester-amide)s to reduce the melting point of resulting polymers. The liquid crystallinity was proved by PLM observation and WAXD study. The melting point was greatly reduced, to 200℃ or even lower in some cases, and the molecular weight was satisfactorily high as reflected by inherent viscosity.The copolyester showed better crystallinity and liquid crystallinity than corresponding copely(ester-amide) with similar monomer compogition.
文摘在J2EE开发中,程序员经常需要面对如何将程序元素组装成类聚的应用程序,如何有效地管理组件和组件间的相互调用装载,成为应用程序开发的重要任务,IOC(Inversion of Control,控制反转)框架的发展,满足了这个方面的需求。文中讨论了IOC模式的基本概论I、OC问题的产生,比较了IOC模式与工厂模式的区别以及IOC的发展意义,重点给出了IOC框架设计的两种设计方案:动态IOC和静态IOC的实现,最后比较了两种方案的优缺点。
文摘在软件开发中，我们经常需要面对如何将程序元素组装成类聚的应用程序，如何有效地管理组件和组件间的相互调用装载．成为应用程序开发的重要任务，IOC（Inversion of Control，控制反转）框架的发展，满足了这个方面的需求。文中讨论了IOC模式的基本概论、控制反转（IOC）的基本原理、CastleIOC容器配置构建，重点介绍了IOC的分析与实现。
基金funded by the Natural Science Foundation of Technology Department of Liaoning Province, No.20032047
文摘Previous studies have reported a neuroprotective effect of 8-hydroxy-2-（di-n-propylamino）tetralin （8-OH-DPAT） against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats. 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature.
文摘New highly stereoregular 2, 3 -di- O-(p-azidobenzyl )-(1 →5 ) - α-D -ribofuranan was synthesized byselective ring-opening polymerization of 1, 4-anhydro-2, 3 - di-O -(p-azidobenzyl )-α-D -ribopyranose(ADABR) using phosphorus pentafluoride or tin tetrachloride as catalyst at low temperature indichloromethane. The monomer was obtained by the reaction of p - bromomethyl -phenyleneazide with 1, 4 -anhydro-α-D-ribose in DMF. The structure of poly(ADANR) was identified by specific rotation and ^(13)C-NMR spectroscopy. Acid chloride-AgCl_4 complex catalyst such as CH_2=C(CH_3)C^+OClO_4^- used in thepolymerization resulted in polymers with mixed structures, i.e. (1→5)-α-D-ribofuranosidic and (1→4)-β-D-ribopyranosidic units. However, with C_6H_5C^+OClO_4^- as catalyst, pure (1→5)-α-D-ribofuranan was obtained.The effects of catalyst, polymerization temperature and time on polymer stereoregularity were examined, andthe mechanism of the ring-opening polymerization was discussed.
文摘目的:建立药用丁基橡胶塞中添加剂[抗氧剂264(2,6-二叔丁基-4-甲基苯酚,简称BHT)和硫化剂可提取硫]的含量测定方法。方法:以二氯甲烷-无水乙醇为提取溶剂,利用高效液相色谱法对药用丁基橡胶塞的BHT和可提取硫含量进行测定,以含0.1%三氟乙酸的乙腈-含0.1%三氟乙酸的水(90∶10)为流动相,流速1.0 m L·min^(-1),检测波长280 nm。结果:抗氧剂BHT的线性检测范围0.41~103.00μg·mL^(-1)(r^2=1.000),可提取硫的线性检测范围0.10~103.50μg·mL^(-1)(r^2=0.999 9),BHT和可提取硫的平均回收率分别为95.2%和86.8%。测定7批药用胶塞中BHT与可提取硫含量范围分别为4~206μg·g^(-1)和1~143μg·g^(-1)。结论:本文建立的检测方法经方法学验证,可用于考察药用丁基橡胶塞中BHT和可提取硫的含量及质量控制。
