Symbiotic nitrogen fixation in members of the Fabaceae family is highly efficient and beneficial for global agriculture,but not all species in this family form root nodules with rhizobial bacteria.Nodulation mainly oc...Symbiotic nitrogen fixation in members of the Fabaceae family is highly efficient and beneficial for global agriculture,but not all species in this family form root nodules with rhizobial bacteria.Nodulation mainly occurs in plants belonging to the Papilionoideae and Caesalpinioideae subfamilies(Tederso0 et al.,2018;van Velzen et al.,2019).Nodulation mechanisms in Fabaceae are well studied(Yang et al.,2022),and genomic comparisons of nodulating and non-nodulating host species can provide valuable insights into the evolutionary and genetic basis of this key process.展开更多
Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in m...Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in modern cardiovascular practice.The authors conducted a retrospective analysis involving 2050 elderly patients(aged≥75 years)undergoing successful percutaneous coronary intervention(PCI).展开更多
In recent years,with the increasing attention to issues related to carbon emissions,such as carbon tariffs and government netzero carbon emission policies,carbon emissions have become an important indicator that is be...In recent years,with the increasing attention to issues related to carbon emissions,such as carbon tariffs and government netzero carbon emission policies,carbon emissions have become an important indicator that is being prioritized by governments worldwide.The Google Environmental Insights Explorer(EIE)tool has been developed to facilitate the collection and integration of data in this context.This study focuses on Tainan City and utilizes EIE to analyze greenhouse gas emissions from transportation.By using EIE,the study obtains data on greenhouse gas emissions from transportation activities in Tainan City.EIE utilizes data collected by Google and simulation functions to estimate data based on actual measurements of transportation activities.This tool saves time and resources by eliminating the need for on-site investigations while providing data that closely represent the real emissions from transportation activities in urban areas.Transportation vehicles contribute to greenhouse gas emissions in two ways:through direct combustion of fossil fuels and through the consumption of electricity in electric vehicles(EVs).The level of greenhouse gas emissions in a city’s transportation industry depends on factors such as transportation modes,fuel types,fleet age and energy efficiency,total distance traveled,and annual mileage.EIE estimates the greenhouse gas emissions from Tainan City’s transportation industry in 2022 to be 3,320,000 metric tons,including emissions from buses,motorcycles,cars,walking,railways,bicycles,and other modes of transportation.展开更多
With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th...With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether they are physiological or pathological.展开更多
Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized b...Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).展开更多
When attending a symposium on private businesses on 17 February,Chinese President Xi Jinping underscored the immense opportunities within China’s private economy.He stated that the private sector enjoys broad prospec...When attending a symposium on private businesses on 17 February,Chinese President Xi Jinping underscored the immense opportunities within China’s private economy.He stated that the private sector enjoys broad prospects and great potential on the new journey in the new era,and that it is a prime time for private businesses and entrepreneurs to give full play to their capabilities.展开更多
Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response ...Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response to axonal injury,autophagy is upregulated to facilitate the removal of cellular debris and support the recycling of essential components needed for regeneration.展开更多
The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strat...The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).展开更多
Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising ...Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising among Asian populations. Studies comparing areal bone mineral density and fracture across races generally indicate lower bone mineral density in Asian individuals including the Chinese, but this does not reflect their relatively low risk of non-vertebral fractures. In contrast, the Chinese have relatively high vertebral fracture rates similar to that of Caucasians. The paradoxically low risk for some types of fractures among the Chinese despite their low areal bone mineral density has been elucidated in part by recent advances in skeletal imaging. New techniques for assessing bone quality non-invasively demonstrate that the Chinese compensate for smaller bone size by differences in hip geometry and microstructural skeletal organization. Studies evaluating factors influencing racial differences in bone remodeling, as well as bone acquisition and loss, may further elucidate racial variation in bone microstructure. Advances in understanding the microstructure of the Chinese skeleton have not only helped to explain the epidemiology of fracture in the Chinese, but may also provide insight into the epidemiology of fracture in other races as well.展开更多
Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3...Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time,展开更多
The North China Craton(NCC)is a classic case of the destruction of an ancient craton,in that it records the loss of more than 100 km of ancient refractory lithospheric mantle during the Mesozoic(e.g.,Menzies et al.,19...The North China Craton(NCC)is a classic case of the destruction of an ancient craton,in that it records the loss of more than 100 km of ancient refractory lithospheric mantle during the Mesozoic(e.g.,Menzies et al.,1993).This展开更多
Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin, China, with an exploration history of several years. Recent exploration has preliminarily indicated that the Ordovician ...Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin, China, with an exploration history of several years. Recent exploration has preliminarily indicated that the Ordovician carbonate formations in this area have some oil and gas potential. Carbonate microfacies provides material basis for reservoir development, seal formation and hydrocarbon generation. Therefore, this work utilized the standard microfacies （SMF） types to study the microfacies of the Ordovician formations in the Yubei area in order to provide theoretical basis for the next exploration.展开更多
Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the ea...Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D＇s role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution, however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol （as if often the case）, thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are analyzed using the biomarker 25（OH）D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating 25（OH）D concentration of at least 100 nmol. L-1 （40 ng. mL-1）. Because ,an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation （and trophoblast invasion）; however, this question remains unanswered. Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of supplementation, taking into account a variety of lifestyles, body types, baseline vitamin D status, and maternal and fetal vitamin D receptor （VDR） and vitamin D binding protein （VDBP） genotypes. Determining the role of vitamin D in nonclassical, immune pathways continues to be a challenge that once answered will substantiate recommendations and public health policies.展开更多
Objective The lateral extrusion of southeastern edge of the crustal materials around the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of-1300 km latitudinal crustal convergence in...Objective The lateral extrusion of southeastern edge of the crustal materials around the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of-1300 km latitudinal crustal convergence in the Tibetan Plateau, since the collision of India and Eurasia in the Paleogene. Two end-member models were used to describe the process of lateral extrusion of crustal material on the southeastern edge of the Tibetan Plateau. The ＂tectonic escape＂ model suggests the Indochina Block, Chuandian Fragment and Shan-Thai Block have experienced lateral extrusion along strike-slip fault systems, and the ＂crustal flow＂ model suggests that the upper crust has undergone southeastward escape in the form of ductile deformation, driven by viscous lower crustal flow channels. In addition, the GPS observations surrounding the Tibetan Plateau indicate that crustal materials currently experience clockwise rotation around the Eastern Himalaya syntaxis. This work conducted paleomagnetic studies in the Cretaceous and Paleogene red-beds along the southeastern margin of Tibetan Plateau,展开更多
Remote sensing has played a pivotal role in our understanding of the geometry of dykes and dyke swarms on Earth,Venus and Mars(West and Ernst,1991;Mege and Masson,1995;Ernst et al.,2005).Since the 1970’s
The restricted neurogenesis limits the brain ability to overcome neuronal cell death following ischemic lesion：Failure of the damaged brain to regenerate following cerebral ischemia results in functional deficits tho...The restricted neurogenesis limits the brain ability to overcome neuronal cell death following ischemic lesion：Failure of the damaged brain to regenerate following cerebral ischemia results in functional deficits those are most often irreversible and can further deteriorate,causing mortality and severe disability,progressive memory loss and cognitive impairments,known as dementia.展开更多
基金supported by the National Natural Science Foundation of China(No.32160142)Guangxi Natural Science Foundation(No.2023GXNSFDA026034)+3 种基金State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(SKLCUSAb202302)to H.W.,the National Natural Science Foundation of China(No.32460062)to Y.L.,and 1+9 Leading the Charge with Open Competition'project of Sichuan Academy of Agricultural Sciences(1+9KJGG010)Fruit tree breeding project in Sichuan Province(2021YFYZ0023)to H.X.
文摘Symbiotic nitrogen fixation in members of the Fabaceae family is highly efficient and beneficial for global agriculture,but not all species in this family form root nodules with rhizobial bacteria.Nodulation mainly occurs in plants belonging to the Papilionoideae and Caesalpinioideae subfamilies(Tederso0 et al.,2018;van Velzen et al.,2019).Nodulation mechanisms in Fabaceae are well studied(Yang et al.,2022),and genomic comparisons of nodulating and non-nodulating host species can provide valuable insights into the evolutionary and genetic basis of this key process.
文摘Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in modern cardiovascular practice.The authors conducted a retrospective analysis involving 2050 elderly patients(aged≥75 years)undergoing successful percutaneous coronary intervention(PCI).
文摘In recent years,with the increasing attention to issues related to carbon emissions,such as carbon tariffs and government netzero carbon emission policies,carbon emissions have become an important indicator that is being prioritized by governments worldwide.The Google Environmental Insights Explorer(EIE)tool has been developed to facilitate the collection and integration of data in this context.This study focuses on Tainan City and utilizes EIE to analyze greenhouse gas emissions from transportation.By using EIE,the study obtains data on greenhouse gas emissions from transportation activities in Tainan City.EIE utilizes data collected by Google and simulation functions to estimate data based on actual measurements of transportation activities.This tool saves time and resources by eliminating the need for on-site investigations while providing data that closely represent the real emissions from transportation activities in urban areas.Transportation vehicles contribute to greenhouse gas emissions in two ways:through direct combustion of fossil fuels and through the consumption of electricity in electric vehicles(EVs).The level of greenhouse gas emissions in a city’s transportation industry depends on factors such as transportation modes,fuel types,fleet age and energy efficiency,total distance traveled,and annual mileage.EIE estimates the greenhouse gas emissions from Tainan City’s transportation industry in 2022 to be 3,320,000 metric tons,including emissions from buses,motorcycles,cars,walking,railways,bicycles,and other modes of transportation.
基金Clévio Nóbrega’s laboratory is funded by the Cure CSB projectthe Viljem Julijan Association for Children with Rare Diseases(Slovenia)+1 种基金the Algarve Biomedical Center Research Institute(ABC-Ri)funded by CRESC Algarve 2020(Operation Code:ALG-01-0145-FEDER-072586)(to CN)。
文摘With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether they are physiological or pathological.
基金supported by NEI/NIH R01 EY030513NIAMS/NIH R21-AR076035Multi-PI Team Science grant from Presbyterian Health Foundation。
文摘Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).
文摘When attending a symposium on private businesses on 17 February,Chinese President Xi Jinping underscored the immense opportunities within China’s private economy.He stated that the private sector enjoys broad prospects and great potential on the new journey in the new era,and that it is a prime time for private businesses and entrepreneurs to give full play to their capabilities.
文摘Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response to axonal injury,autophagy is upregulated to facilitate the removal of cellular debris and support the recycling of essential components needed for regeneration.
基金supported by the Third National Census of Livestock and Poultry Genetic Resources(K4050422227)the 2020 Scientist plus Engineer program of Shaanxi Province of Chinathe Central Guidance on Local Science and Technology Development Fund(K3030922098).
文摘The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).
基金supported by NIH grants K23 AR053507, a National Osteoporosis Foundation grant, and the Mary and David Hoar Fellowship Program of the New York Community Trust and the New York Academy of Medicine
文摘Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising among Asian populations. Studies comparing areal bone mineral density and fracture across races generally indicate lower bone mineral density in Asian individuals including the Chinese, but this does not reflect their relatively low risk of non-vertebral fractures. In contrast, the Chinese have relatively high vertebral fracture rates similar to that of Caucasians. The paradoxically low risk for some types of fractures among the Chinese despite their low areal bone mineral density has been elucidated in part by recent advances in skeletal imaging. New techniques for assessing bone quality non-invasively demonstrate that the Chinese compensate for smaller bone size by differences in hip geometry and microstructural skeletal organization. Studies evaluating factors influencing racial differences in bone remodeling, as well as bone acquisition and loss, may further elucidate racial variation in bone microstructure. Advances in understanding the microstructure of the Chinese skeleton have not only helped to explain the epidemiology of fracture in the Chinese, but may also provide insight into the epidemiology of fracture in other races as well.
基金supported in part by grants EY01545 and by core grant EY03040the Arnold and Mabel Beckman Foundationan unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness Inc.,New York,NY
文摘Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time,
文摘The North China Craton(NCC)is a classic case of the destruction of an ancient craton,in that it records the loss of more than 100 km of ancient refractory lithospheric mantle during the Mesozoic(e.g.,Menzies et al.,1993).This
基金funded by the National Natural Science Foundation of China(grant No.41572117)Technological&Developmental Department of China Petroleum&Chemical Corporation(grants No.P13040 and P14128)China Geological Survey(grant No.DD20160175-1-1)
文摘Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin, China, with an exploration history of several years. Recent exploration has preliminarily indicated that the Ordovician carbonate formations in this area have some oil and gas potential. Carbonate microfacies provides material basis for reservoir development, seal formation and hydrocarbon generation. Therefore, this work utilized the standard microfacies （SMF） types to study the microfacies of the Ordovician formations in the Yubei area in order to provide theoretical basis for the next exploration.
基金Funded in part by NIH/NICHD R01 HD043921the Thrasher Research Fund+1 种基金NIH/NCATS UL1 RR029882UL1 TR000062
文摘Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D＇s role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution, however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol （as if often the case）, thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are analyzed using the biomarker 25（OH）D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating 25（OH）D concentration of at least 100 nmol. L-1 （40 ng. mL-1）. Because ,an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation （and trophoblast invasion）; however, this question remains unanswered. Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of supplementation, taking into account a variety of lifestyles, body types, baseline vitamin D status, and maternal and fetal vitamin D receptor （VDR） and vitamin D binding protein （VDBP） genotypes. Determining the role of vitamin D in nonclassical, immune pathways continues to be a challenge that once answered will substantiate recommendations and public health policies.
基金supported by the National Natural Science Foundation of China(grants No.41202162 and 41572183)
文摘Objective The lateral extrusion of southeastern edge of the crustal materials around the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of-1300 km latitudinal crustal convergence in the Tibetan Plateau, since the collision of India and Eurasia in the Paleogene. Two end-member models were used to describe the process of lateral extrusion of crustal material on the southeastern edge of the Tibetan Plateau. The ＂tectonic escape＂ model suggests the Indochina Block, Chuandian Fragment and Shan-Thai Block have experienced lateral extrusion along strike-slip fault systems, and the ＂crustal flow＂ model suggests that the upper crust has undergone southeastward escape in the form of ductile deformation, driven by viscous lower crustal flow channels. In addition, the GPS observations surrounding the Tibetan Plateau indicate that crustal materials currently experience clockwise rotation around the Eastern Himalaya syntaxis. This work conducted paleomagnetic studies in the Cretaceous and Paleogene red-beds along the southeastern margin of Tibetan Plateau,
文摘Remote sensing has played a pivotal role in our understanding of the geometry of dykes and dyke swarms on Earth,Venus and Mars(West and Ernst,1991;Mege and Masson,1995;Ernst et al.,2005).Since the 1970’s
文摘The restricted neurogenesis limits the brain ability to overcome neuronal cell death following ischemic lesion：Failure of the damaged brain to regenerate following cerebral ischemia results in functional deficits those are most often irreversible and can further deteriorate,causing mortality and severe disability,progressive memory loss and cognitive impairments,known as dementia.
