Objective To observe the therapeutic difference in treatment of Irishmen with discogenic low back pain （arthritis of cold-damp syndrome type） between heat-sensitive acupoint and acupuncture. Methods Eighty-two patie...Objective To observe the therapeutic difference in treatment of Irishmen with discogenic low back pain （arthritis of cold-damp syndrome type） between heat-sensitive acupoint and acupuncture. Methods Eighty-two patients were randomly assigned to the heat-sensitive group （43 cases） and the acupuncture group （39 cases）. Corresponding heat-sensitive points in the lumbosacral area were selected in the heat-sensitive group. Then moxibustion was performed at the heat-sensitive acupoint, thus conducting the moxibustion sensation. The treatment was ended when the sensation conduction was finished. If there appeared no moxibustion sensation, moxibustion at the corresponding painful point was lasted for 30 min. Needling was performed in the acupuncture group at corresponding Jiájǐ（夹 脊 EX-B 2）, Back-shu point, Wěizhōng （委中 BL 40）; matching points included Huántiào （环跳 GB 30）, Fēngshì（风市 GB 31）, Yánglíngquán （阳陵泉 GB 34）, Zhìbiān （秩边 BL 54）, etc. The waste was irradiated with TDP after needling, with the maintaining time of 30 min. The treatment was carried out twice weekly, four weeks as one therapeutic course. The therapeutic effect was statistically calculated after 8-week treatment. Results Nineteen cases were clinically cured, 20 improved, 4 failed, and the effective rate 90.7%（39/43） in the heat-sensitive group, while 9 clinically cured, 25 improved, 5 failed, and the effective rate 87.2%（34/39） in the acupuncture group. Signif icant difference was shown in the clinically cured case by 2 test （P0.05）. Conclusion Heat-sensitive acupoint was superior to traditional acupuncture in treatment Irishmen with discogenic low back pain.展开更多
Objective To compare the effects between acupuncture combined with moxibustion on heat-sensitive acupoints and acupuncture on irritable bowel syndrome with diarrhea （IBS-D）. Methods Sixty-four cases were randomly di...Objective To compare the effects between acupuncture combined with moxibustion on heat-sensitive acupoints and acupuncture on irritable bowel syndrome with diarrhea （IBS-D）. Methods Sixty-four cases were randomly divided into an acupuncture and moxibustion group （n=32） and an acupuncture group （n=32）. Conventional acupuncture at Tiānshū （天枢 ST 14）, Zúsānlǐ （足三里 ST 36）, Gōngsūn （公孙 SP 4） and other acupoints was used in the two groups, and moxibustion on heat-sensitive acupoints was added in the acupuncture and moxibustion group. The treatment frequency was 5 times a week, and 4 weeks were a course. After 2 courses, the therapeutic effect was evaluated. Results The clinical symptom scores after treatment in two groups decreased obviously than those before treatment （both P〈0.01）. The cured and markedly effective rate in the acupuncture and moxibustion group was 87.5% （28/32）, and that in the acupuncture group was 37.5% （12/32）, so the effect in the acupuncture and moxibustion group was better than that in the acupuncture group （P〈0.01）. The improvement of all kinds of symptom scores in the acupuncture and moxibustion group was all better than that in the acupuncture group （all P〈0.05）. Conclusion The clinical effect of acupuncture combined with moxibustion on heat-sensitive acupoints on IBS-D is better than that of acupuncture.展开更多
Objective:To observe the clinical effect of electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion on knee osteoarthritis and its effect on blood lipid level,polyprotein polysaccharide enz...Objective:To observe the clinical effect of electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion on knee osteoarthritis and its effect on blood lipid level,polyprotein polysaccharide enzyme-4(a disintegrin and metalloprotease with thrombospondin motifs,ADAMTS-4,matrix metalloproteinase-3(matrix metalloproteinase-3,);and MMPs-3)Impact.Methods:80 patients were randomly divided into two groups,40 cases per group,Treatment and control groups,The treatment group was given electroacupuncture combined with heat-sensitive moxibustion,Six times a week,Continuous treatment for 4 weeks;The control group was given intraarticular sodium hyaluronate,Once a week,continuous treatment for 4 weeks.Results:During the treatment period,Visual analogue scale visual analogue scale,VAS)show a downward trend,Intra-group comparisons,Differences were statistically significant(P<0.05);After 2 weeks of treatment,4 weeks of treatment and 2 weeks of follow-up,All the scores in the treatment group were lower than those in the control group(P<0.05).After treatment in two groups(The Western Ontario and Mc Master Universities Osteoarthritis Index,)of osteoarthritis index,University of Western Ontario WOMAC)The scores of each item decreased significantly,treatment group was better than the control group(P<0.05).After four weeks of treatment,(Total cholesterol,)Total cholesterol TC,triglycerides(Triglyceride,);and TG,LDL(Low density lipoprotein,);and LDL-C)A decrease in content,High density lipoprotein High density lipoprotein,HDL-C)Increased content,and the improvement was better than that of the control group(P<0.05).After treatment,the ADAMTS-4,MMPs-3 content decreased,Intergroup comparisons,Differences were statistically significant(P<0.05);The effective rate in the treatment group was 87.5%,The control rate was 60%,treatment group was more effective(P<0.05).Conclusions:Electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion can obviously improve the symptoms of knee osteoarthritis patients,Regulate blood lipids,High security,It is worth popularizing in clinic.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
Objective To explore the possibility of infrared objective display of the heat-sensitive （HS） acupoint. Methods In 79 cases of lumbar intervertebral disc protrusion （LIDP） patients, infrared thermograms of the lum...Objective To explore the possibility of infrared objective display of the heat-sensitive （HS） acupoint. Methods In 79 cases of lumbar intervertebral disc protrusion （LIDP） patients, infrared thermograms of the lumbar and back region were taken with a thermal texture maps（TTM） method at a natural state, followed by a heat-sensitive detection with moxibustion method [moxibustion was given at Yaoyangguan （腰阳关GV 3） area for 10 min]. The cases with thermal diffusion and heat transfer on the Yaoyangguan （腰阳关GV 3） area were recorded after ceasing of the suspended moxibustion. Then the infrared thermograms were taken by TTM for the second time, and the changes of infrared thermograms of the waist-back region before and after moxibustion were recorded. Finally, the differences between moxibustion and infrared detection methods in the heat-sensitive state on Yaoyangguan （腰阳关GV 3） area were compared in the LIDP patients. Results Before moxibustion, the infrared radiation intensity most displayed high-temperature characteristics on the Yaoyangguan （腰阳关GV 3） area in the LIDP patients. Compared with the moxibustion method, the sensitivity（true positive rate） was 86.4%, the specificity （true negative rate） was 70.0%, and the accuracy was 82.3%; after moxibustion at the Yaoyangguan （腰阳关GV 3） area, the infrared radiation enhanced area obviously extended vertically along the medial waist-back （the Governor Vessel） or horizontally along the Belt Vessel. Compared with the moxibustion method, the sensitivity （true positive rate） was 79.7%, the specificity （true negative rate） was 75.0% and the accuracy was 78.5%. Conclusion The HS state of Yaoyangguan （腰阳关GV 3） area in the LIDP patients can be objectively displayed by the infrared imaging to a certain extent; moxibustion at the HS acupoint produces the thermal phenomena, such as thermal expansion and heat transfer, which can be objectively displayed to a certain extent by the infrared imaging apart from the subjective feeling of the subject.展开更多
针对菇房内杏鲍菇表型参数测量任务中,由于扫描设备视角受限,扫描的杏鲍菇点云出现残缺问题,基于AdaPoinTr(Adaptive geometry-aware point transformers)提出了改进的SwinPoinTr模型,实现了对残缺杏鲍菇点云的准确补全和杏鲍菇表型参...针对菇房内杏鲍菇表型参数测量任务中,由于扫描设备视角受限,扫描的杏鲍菇点云出现残缺问题,基于AdaPoinTr(Adaptive geometry-aware point transformers)提出了改进的SwinPoinTr模型,实现了对残缺杏鲍菇点云的准确补全和杏鲍菇表型参数的测量。该方法在使用提出的特征重塑模块的基础上,构建具有几何感知能力的层次化Transformer编码模块,提高了模型对输入点云的利用率和模型捕捉点云细节特征的能力。然后基于泊松重建方法完成了补全点云表面重建,并测量到杏鲍菇表型参数。实验结果表明,本文所提算法在残缺杏鲍菇点云补全任务中,模型倒角距离为1.316×10^(-4),地球移动距离为21.3282,F1分数为87.87%。在表型参数估测任务中,模型对杏鲍菇菌高、体积、表面积估测结果的决定系数分别为0.9582、0.9596、0.9605,均方根误差分别为4.4213 mm、10.8185 cm^(3)、7.5778 cm^(2)。结果证实了该研究方法可以有效地补全残缺的杏鲍菇点云,可以为菇房内杏鲍菇表型参数测量提供基础。展开更多
Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medi...Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medical（CBM） database, Chinese Science and Technology Periodical Database（VIP）, Wan Fang Data, Pubmed and Cochrane Library were retrieved to search the randomized controlled trials（RCT） on heat-sensitive moxibustion in treatment of CSR, and Meta analysis was conducted by applying Rev Man 5.3 software. Results Eventually, 10 papers were included in this study, including 1008 subjects. Meta analysis result showed： the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.13, 95%CI（1.06, 1.21）, Z=3.54, P=0.000 4]; the cure rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.80, 95%CI（1.52, 2.13）, Z=6.82, P〈0.000 01]; the improvement of short-form Mc Gill pain questionnaire（SF-MPQ） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–4.44, 95%CI（–6.38,-2.50）, Z=4.49, P〈0.000 01]; visual analogue scale（VAS） of treatment group was lower than that of control group, and the difference was statistically significant [MD=-0.36, 95%CI（-0.50, –0.23）, Z=5.42, P〈0.00001]; and the improvement of interleukin-6（IL-6） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–7.32, 95%CI（-11.49, –3.14）, Z=3.44, P=0.000 6]. Conclusion It is indicated from the Meta analysis result that the clinical efficacy of heat-sensitive moxibustion or acupuncture combined with heat-sensitive moxibustion in treatment of CSR is superior to that of simple acupuncture or traditional suspended moxibustion, providing a new therapeutic method for treatment of CSR. However, the abovementioned conclusion still needs to be confirmed through randomized blind controlled trials with high quality and large sample size since the sample size of included studies was small, and the quality was low.展开更多
Objective To compare the clinical efficacy between electroacupuncture combined with heat-sensitive moxibustion and western medicine for treatment of premature ovarian failure. Methods Eighty patients were randomly div...Objective To compare the clinical efficacy between electroacupuncture combined with heat-sensitive moxibustion and western medicine for treatment of premature ovarian failure. Methods Eighty patients were randomly divided into an electroacupuncture combined with heat-sensitive moxibustion group（group A, n=40） and a western medicine group（group B, n=40）. Zǐgōng（子宫 EX-CA 1）, Xuèhǎi（血海 SP 10）, Gānshū（肝俞 BL 18） and Shènshū（肾俞 BL 23） were selected in group A, and acupuncture combined with heat-sensitive moxibustion were carried out. Climen was taken orally in group B. The score changes of menstrual cycle, tidal fever and sweatiness, emotional excitement, soreness and weakness of waist and knees, dizziness and tinnitus, as well as the cured and markedly effective rate of the patients in the two groups before and after two courses of treatment were compared. Results The cured and markedly effective rate of group A was 72.5%（29/40）, which was superior to that of group B（37.5%, 15/40）（ P〈0.05）. The symptom scores were improved significantly in the two groups after treatment（all P〈0.05）, and the improvement in group A was superior to that in group B（all P〈0.05）. Conclusion The efficacy of electroacupuncture combined with heat-sensitive moxibustion is superior to that of conventional western medicine in treatment of premature ovarian failure.展开更多
OBJECTIVE: To systematically evaluate the effectiveness and safety of heat-sensitive moxibustion(HSM)onasthma.METHODS: Large databases in China and overseas were searched by electronic and manual means to collect info...OBJECTIVE: To systematically evaluate the effectiveness and safety of heat-sensitive moxibustion(HSM)onasthma.METHODS: Large databases in China and overseas were searched by electronic and manual means to collect information on randomized controlled trials(RCTs).Two evaluators independently extracted data and evaluated the quality of RCTs according to Cochrane Review Handbook v5.0. RevMan v5.0.20 was used for statisticalanalyses.RESULTS: Fourteen RCTs involving 637 patients were collected.Thirteen RCTs compared the effects of HSM and Western Medicine. After 3-month treatment and after 6-month follow-up, there was no significant difference in effective rate [relative risk(RR)=1.01, 95% CI(0.92, 1.12), and 1.12,(0.93, 1.36),respectively], in the asthma control test score of asthma symptoms [weighted mean difference(WMD)=﹣1.54, 95% CI(﹣3.54, 0.47), and 1.41,(﹣0.48, 3.29), respectively] and in the forced expiratory volumein 1 second(FEV1)and peak expiratory flow(PEF). One RCT compared the effect of HSM with warm-suspended moxibustion. After 6-month follow-up, there was a significant difference in FEV1 and PEF [WMD=0.51, 95% CI(0.10, 0.92), and 1.78,(1.06, 2.50), respectively]. After 3-month treatment,there was no significant difference between the two groups. One RCT compared the effect of HSM with acupoint application. After 3-month treatment, there was no significant difference in the effectiverate[RR=0.68,95%CI(0.42,1.12)].CONCLUSION: HSM did not show superiority to conventional Western Medicine and acupoint application in terms of curative effects, and may be superior to warm-suspended moxibustion with regard to long-term curative effects. Because of low quality of the included RCTs, this conclusion must be bolstered with higher-quality RCTs.展开更多
Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfus...Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui （DU14） for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury.展开更多
Objective:To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019(COVID-19)of the ordinary type.Methods:A total of 42 patients with COVID-19 of the...Objective:To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019(COVID-19)of the ordinary type.Methods:A total of 42 patients with COVID-19 of the ordinary type were adopted.Shenque(神阙CV8)and Tianshu(天枢ST25)were selected.Heat-sensitive moxibustion was operated according to the required standard,40 min to 60 min each time,once daily.Before and after moxibustion,the improvements in clinical symptoms were evaluated,such as chest oppression,poor appetite,lassitude and negative emotions.Results:(1)The number of cases and the incidence was 21 cases(50.0%),24 cases(57.1%)and 26 cases(61.9%)for chest oppression,poor appetite and lassitude before heat-sensitive moxibustion.The number of cases was reduced to be 10 cases(23.8%),7 cases(16.7%)and 4 cases(9.5%)after the 1 st treatment of heat-sensitive moxibustion for chest oppression,poor appetite,and lassitude.It was reduced to be 11 cases(26.2%),8 cases(19.0%)and 4 cases(9.5%)after the 2 nd treatment of moxibustion and it was reduced to be 18 cases(42.9%),10 cases(23.8%)and 6 cases(14.3%)after the 3 rd treatment of moxibustion.The incidences of the symptoms were all reduced obviously as compared with those before treatment.(2)Before treatment with heat-sensitive moxibustion,there were 24 cases of negative emotions(57.1%).It was reduced to be 16 cases(38.1%),11 cases(26.2%)and 3 cases(7.1%)after the 1 st,2 nd and 3 rd treatment of heat-sensitive moxibustion successively.The incidences were all reduced obviously as compared with those before treatment.(3)After the 1 st treatment,the active acceptance rate of heat-sensitive moxibustion was 100%(42/42)in the patients,higher than 11.9%(5/42)before treatment.Conclusion:Adjuvant treatment with heat-sensitive moxibustion effectively relieves the symptoms of COVID-19 such as chest oppression,poor appetite and lassitude,and alleviates the negative emotions,such as tension and anxiety.This therapy improves the therapeutic effect of COVID-19 and deserves to be promoted in clinical practice.展开更多
We consider the problem of inducing withdrawal reflex on a test subject by exposing the subject’s skin to an electromagnetic beam. Heat-sensitive nociceptors in the skin are activated wherever the temperature is abov...We consider the problem of inducing withdrawal reflex on a test subject by exposing the subject’s skin to an electromagnetic beam. Heat-sensitive nociceptors in the skin are activated wherever the temperature is above the activation temperature. Withdrawal reflex occurs when the activated volume reaches a threshold. Previously we studied static beams with 3 types of power density distribution: Gaussian, super-Gaussian, and flat-top. We found that the flaptop is the best and the Gaussian is the worst in their performance with regard to 1) minimizing the time to withdrawal reflex, 2) minimizing the energy consumption and 3) minimizing the maximum temperature increase. The less-than-desirable performance of Gaussian beams is attributed to the uneven distribution of power density resulting in low energy efficiency: near the beam center the high power density does not contribute proportionally to increasing the activated volume;outside the beam effective radius the low power density fails to activate nociceptors. To overcome the drawbacks of Gaussian beams, in this study, we revolve a Gaussian beam around a fixed point to make the power density more uniformly distributed. We optimize the performance over two parameters: the spot size of static beam and the radius of beam revolution. We find that in comparison with a static Gaussian beam, a revolving Gaussian beam can reduce the energy consumption, and at the same time lower the maximum temperature.展开更多
文摘Objective To observe the therapeutic difference in treatment of Irishmen with discogenic low back pain （arthritis of cold-damp syndrome type） between heat-sensitive acupoint and acupuncture. Methods Eighty-two patients were randomly assigned to the heat-sensitive group （43 cases） and the acupuncture group （39 cases）. Corresponding heat-sensitive points in the lumbosacral area were selected in the heat-sensitive group. Then moxibustion was performed at the heat-sensitive acupoint, thus conducting the moxibustion sensation. The treatment was ended when the sensation conduction was finished. If there appeared no moxibustion sensation, moxibustion at the corresponding painful point was lasted for 30 min. Needling was performed in the acupuncture group at corresponding Jiájǐ（夹 脊 EX-B 2）, Back-shu point, Wěizhōng （委中 BL 40）; matching points included Huántiào （环跳 GB 30）, Fēngshì（风市 GB 31）, Yánglíngquán （阳陵泉 GB 34）, Zhìbiān （秩边 BL 54）, etc. The waste was irradiated with TDP after needling, with the maintaining time of 30 min. The treatment was carried out twice weekly, four weeks as one therapeutic course. The therapeutic effect was statistically calculated after 8-week treatment. Results Nineteen cases were clinically cured, 20 improved, 4 failed, and the effective rate 90.7%（39/43） in the heat-sensitive group, while 9 clinically cured, 25 improved, 5 failed, and the effective rate 87.2%（34/39） in the acupuncture group. Signif icant difference was shown in the clinically cured case by 2 test （P0.05）. Conclusion Heat-sensitive acupoint was superior to traditional acupuncture in treatment Irishmen with discogenic low back pain.
文摘Objective To compare the effects between acupuncture combined with moxibustion on heat-sensitive acupoints and acupuncture on irritable bowel syndrome with diarrhea （IBS-D）. Methods Sixty-four cases were randomly divided into an acupuncture and moxibustion group （n=32） and an acupuncture group （n=32）. Conventional acupuncture at Tiānshū （天枢 ST 14）, Zúsānlǐ （足三里 ST 36）, Gōngsūn （公孙 SP 4） and other acupoints was used in the two groups, and moxibustion on heat-sensitive acupoints was added in the acupuncture and moxibustion group. The treatment frequency was 5 times a week, and 4 weeks were a course. After 2 courses, the therapeutic effect was evaluated. Results The clinical symptom scores after treatment in two groups decreased obviously than those before treatment （both P〈0.01）. The cured and markedly effective rate in the acupuncture and moxibustion group was 87.5% （28/32）, and that in the acupuncture group was 37.5% （12/32）, so the effect in the acupuncture and moxibustion group was better than that in the acupuncture group （P〈0.01）. The improvement of all kinds of symptom scores in the acupuncture and moxibustion group was all better than that in the acupuncture group （all P〈0.05）. Conclusion The clinical effect of acupuncture combined with moxibustion on heat-sensitive acupoints on IBS-D is better than that of acupuncture.
基金Clinical Medical Research Project of Wuhan Municipal Health and Family Planning Commission(No.WZ20Q12)Major project of the National Natural Science Foundation of China"Clinical Application Research on Different Functional States of Acupoints"(No.81590955)。
文摘Objective:To observe the clinical effect of electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion on knee osteoarthritis and its effect on blood lipid level,polyprotein polysaccharide enzyme-4(a disintegrin and metalloprotease with thrombospondin motifs,ADAMTS-4,matrix metalloproteinase-3(matrix metalloproteinase-3,);and MMPs-3)Impact.Methods:80 patients were randomly divided into two groups,40 cases per group,Treatment and control groups,The treatment group was given electroacupuncture combined with heat-sensitive moxibustion,Six times a week,Continuous treatment for 4 weeks;The control group was given intraarticular sodium hyaluronate,Once a week,continuous treatment for 4 weeks.Results:During the treatment period,Visual analogue scale visual analogue scale,VAS)show a downward trend,Intra-group comparisons,Differences were statistically significant(P<0.05);After 2 weeks of treatment,4 weeks of treatment and 2 weeks of follow-up,All the scores in the treatment group were lower than those in the control group(P<0.05).After treatment in two groups(The Western Ontario and Mc Master Universities Osteoarthritis Index,)of osteoarthritis index,University of Western Ontario WOMAC)The scores of each item decreased significantly,treatment group was better than the control group(P<0.05).After four weeks of treatment,(Total cholesterol,)Total cholesterol TC,triglycerides(Triglyceride,);and TG,LDL(Low density lipoprotein,);and LDL-C)A decrease in content,High density lipoprotein High density lipoprotein,HDL-C)Increased content,and the improvement was better than that of the control group(P<0.05).After treatment,the ADAMTS-4,MMPs-3 content decreased,Intergroup comparisons,Differences were statistically significant(P<0.05);The effective rate in the treatment group was 87.5%,The control rate was 60%,treatment group was more effective(P<0.05).Conclusions:Electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion can obviously improve the symptoms of knee osteoarthritis patients,Regulate blood lipids,High security,It is worth popularizing in clinic.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
基金Supported by National Natural Science Fund:30760320National Key Basic Research Development Project("973" Project):2009 CB 522902Jiangxi Provincial 2007 Key Science and Technique Innovation Project
文摘Objective To explore the possibility of infrared objective display of the heat-sensitive （HS） acupoint. Methods In 79 cases of lumbar intervertebral disc protrusion （LIDP） patients, infrared thermograms of the lumbar and back region were taken with a thermal texture maps（TTM） method at a natural state, followed by a heat-sensitive detection with moxibustion method [moxibustion was given at Yaoyangguan （腰阳关GV 3） area for 10 min]. The cases with thermal diffusion and heat transfer on the Yaoyangguan （腰阳关GV 3） area were recorded after ceasing of the suspended moxibustion. Then the infrared thermograms were taken by TTM for the second time, and the changes of infrared thermograms of the waist-back region before and after moxibustion were recorded. Finally, the differences between moxibustion and infrared detection methods in the heat-sensitive state on Yaoyangguan （腰阳关GV 3） area were compared in the LIDP patients. Results Before moxibustion, the infrared radiation intensity most displayed high-temperature characteristics on the Yaoyangguan （腰阳关GV 3） area in the LIDP patients. Compared with the moxibustion method, the sensitivity（true positive rate） was 86.4%, the specificity （true negative rate） was 70.0%, and the accuracy was 82.3%; after moxibustion at the Yaoyangguan （腰阳关GV 3） area, the infrared radiation enhanced area obviously extended vertically along the medial waist-back （the Governor Vessel） or horizontally along the Belt Vessel. Compared with the moxibustion method, the sensitivity （true positive rate） was 79.7%, the specificity （true negative rate） was 75.0% and the accuracy was 78.5%. Conclusion The HS state of Yaoyangguan （腰阳关GV 3） area in the LIDP patients can be objectively displayed by the infrared imaging to a certain extent; moxibustion at the HS acupoint produces the thermal phenomena, such as thermal expansion and heat transfer, which can be objectively displayed to a certain extent by the infrared imaging apart from the subjective feeling of the subject.
基金Supported by Anhui Provincial Colleges science research platform team building program:2015TD033Provincial demonstrating experiment and practice training center:20100541
文摘Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medical（CBM） database, Chinese Science and Technology Periodical Database（VIP）, Wan Fang Data, Pubmed and Cochrane Library were retrieved to search the randomized controlled trials（RCT） on heat-sensitive moxibustion in treatment of CSR, and Meta analysis was conducted by applying Rev Man 5.3 software. Results Eventually, 10 papers were included in this study, including 1008 subjects. Meta analysis result showed： the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.13, 95%CI（1.06, 1.21）, Z=3.54, P=0.000 4]; the cure rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.80, 95%CI（1.52, 2.13）, Z=6.82, P〈0.000 01]; the improvement of short-form Mc Gill pain questionnaire（SF-MPQ） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–4.44, 95%CI（–6.38,-2.50）, Z=4.49, P〈0.000 01]; visual analogue scale（VAS） of treatment group was lower than that of control group, and the difference was statistically significant [MD=-0.36, 95%CI（-0.50, –0.23）, Z=5.42, P〈0.00001]; and the improvement of interleukin-6（IL-6） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–7.32, 95%CI（-11.49, –3.14）, Z=3.44, P=0.000 6]. Conclusion It is indicated from the Meta analysis result that the clinical efficacy of heat-sensitive moxibustion or acupuncture combined with heat-sensitive moxibustion in treatment of CSR is superior to that of simple acupuncture or traditional suspended moxibustion, providing a new therapeutic method for treatment of CSR. However, the abovementioned conclusion still needs to be confirmed through randomized blind controlled trials with high quality and large sample size since the sample size of included studies was small, and the quality was low.
基金Supported by Nanchang Municipal Guiding Science and Technology Planning Project:H.K.Z.[2016]No.96,item 19
文摘Objective To compare the clinical efficacy between electroacupuncture combined with heat-sensitive moxibustion and western medicine for treatment of premature ovarian failure. Methods Eighty patients were randomly divided into an electroacupuncture combined with heat-sensitive moxibustion group（group A, n=40） and a western medicine group（group B, n=40）. Zǐgōng（子宫 EX-CA 1）, Xuèhǎi（血海 SP 10）, Gānshū（肝俞 BL 18） and Shènshū（肾俞 BL 23） were selected in group A, and acupuncture combined with heat-sensitive moxibustion were carried out. Climen was taken orally in group B. The score changes of menstrual cycle, tidal fever and sweatiness, emotional excitement, soreness and weakness of waist and knees, dizziness and tinnitus, as well as the cured and markedly effective rate of the patients in the two groups before and after two courses of treatment were compared. Results The cured and markedly effective rate of group A was 72.5%（29/40）, which was superior to that of group B（37.5%, 15/40）（ P〈0.05）. The symptom scores were improved significantly in the two groups after treatment（all P〈0.05）, and the improvement in group A was superior to that in group B（all P〈0.05）. Conclusion The efficacy of electroacupuncture combined with heat-sensitive moxibustion is superior to that of conventional western medicine in treatment of premature ovarian failure.
基金Supported by the National Science and Technology-supported program in the eleventh 5-year plan(No.2006BAI12B04-2)the National 973 Basic Research Program(No.2009CB522902)the State Natural Science Fund(No.81202854)
文摘OBJECTIVE: To systematically evaluate the effectiveness and safety of heat-sensitive moxibustion(HSM)onasthma.METHODS: Large databases in China and overseas were searched by electronic and manual means to collect information on randomized controlled trials(RCTs).Two evaluators independently extracted data and evaluated the quality of RCTs according to Cochrane Review Handbook v5.0. RevMan v5.0.20 was used for statisticalanalyses.RESULTS: Fourteen RCTs involving 637 patients were collected.Thirteen RCTs compared the effects of HSM and Western Medicine. After 3-month treatment and after 6-month follow-up, there was no significant difference in effective rate [relative risk(RR)=1.01, 95% CI(0.92, 1.12), and 1.12,(0.93, 1.36),respectively], in the asthma control test score of asthma symptoms [weighted mean difference(WMD)=﹣1.54, 95% CI(﹣3.54, 0.47), and 1.41,(﹣0.48, 3.29), respectively] and in the forced expiratory volumein 1 second(FEV1)and peak expiratory flow(PEF). One RCT compared the effect of HSM with warm-suspended moxibustion. After 6-month follow-up, there was a significant difference in FEV1 and PEF [WMD=0.51, 95% CI(0.10, 0.92), and 1.78,(1.06, 2.50), respectively]. After 3-month treatment,there was no significant difference between the two groups. One RCT compared the effect of HSM with acupoint application. After 3-month treatment, there was no significant difference in the effectiverate[RR=0.68,95%CI(0.42,1.12)].CONCLUSION: HSM did not show superiority to conventional Western Medicine and acupoint application in terms of curative effects, and may be superior to warm-suspended moxibustion with regard to long-term curative effects. Because of low quality of the included RCTs, this conclusion must be bolstered with higher-quality RCTs.
基金supported by the National Natural Science Foundation of China, No. 81060305
文摘Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui （DU14） for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury.
基金Key Research and Development Project of Traditional Chinese Medicine in Jiangxi Province:2020J007。
文摘Objective:To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019(COVID-19)of the ordinary type.Methods:A total of 42 patients with COVID-19 of the ordinary type were adopted.Shenque(神阙CV8)and Tianshu(天枢ST25)were selected.Heat-sensitive moxibustion was operated according to the required standard,40 min to 60 min each time,once daily.Before and after moxibustion,the improvements in clinical symptoms were evaluated,such as chest oppression,poor appetite,lassitude and negative emotions.Results:(1)The number of cases and the incidence was 21 cases(50.0%),24 cases(57.1%)and 26 cases(61.9%)for chest oppression,poor appetite and lassitude before heat-sensitive moxibustion.The number of cases was reduced to be 10 cases(23.8%),7 cases(16.7%)and 4 cases(9.5%)after the 1 st treatment of heat-sensitive moxibustion for chest oppression,poor appetite,and lassitude.It was reduced to be 11 cases(26.2%),8 cases(19.0%)and 4 cases(9.5%)after the 2 nd treatment of moxibustion and it was reduced to be 18 cases(42.9%),10 cases(23.8%)and 6 cases(14.3%)after the 3 rd treatment of moxibustion.The incidences of the symptoms were all reduced obviously as compared with those before treatment.(2)Before treatment with heat-sensitive moxibustion,there were 24 cases of negative emotions(57.1%).It was reduced to be 16 cases(38.1%),11 cases(26.2%)and 3 cases(7.1%)after the 1 st,2 nd and 3 rd treatment of heat-sensitive moxibustion successively.The incidences were all reduced obviously as compared with those before treatment.(3)After the 1 st treatment,the active acceptance rate of heat-sensitive moxibustion was 100%(42/42)in the patients,higher than 11.9%(5/42)before treatment.Conclusion:Adjuvant treatment with heat-sensitive moxibustion effectively relieves the symptoms of COVID-19 such as chest oppression,poor appetite and lassitude,and alleviates the negative emotions,such as tension and anxiety.This therapy improves the therapeutic effect of COVID-19 and deserves to be promoted in clinical practice.
文摘We consider the problem of inducing withdrawal reflex on a test subject by exposing the subject’s skin to an electromagnetic beam. Heat-sensitive nociceptors in the skin are activated wherever the temperature is above the activation temperature. Withdrawal reflex occurs when the activated volume reaches a threshold. Previously we studied static beams with 3 types of power density distribution: Gaussian, super-Gaussian, and flat-top. We found that the flaptop is the best and the Gaussian is the worst in their performance with regard to 1) minimizing the time to withdrawal reflex, 2) minimizing the energy consumption and 3) minimizing the maximum temperature increase. The less-than-desirable performance of Gaussian beams is attributed to the uneven distribution of power density resulting in low energy efficiency: near the beam center the high power density does not contribute proportionally to increasing the activated volume;outside the beam effective radius the low power density fails to activate nociceptors. To overcome the drawbacks of Gaussian beams, in this study, we revolve a Gaussian beam around a fixed point to make the power density more uniformly distributed. We optimize the performance over two parameters: the spot size of static beam and the radius of beam revolution. We find that in comparison with a static Gaussian beam, a revolving Gaussian beam can reduce the energy consumption, and at the same time lower the maximum temperature.
