Elsberg syndrome, or HSV-2 lumbosacral radiculitis, is a rare and underrecognized neurologic condition that mimics cauda equina syndrome (CES). It typically presents with symptoms such as urinary retention, saddle ane...Elsberg syndrome, or HSV-2 lumbosacral radiculitis, is a rare and underrecognized neurologic condition that mimics cauda equina syndrome (CES). It typically presents with symptoms such as urinary retention, saddle anesthesia, and bowel incontinence. This case report describes a 59-year-old immunosuppressed male with idiopathic pulmonary fibrosis who developed Elsberg syndrome due to re-activation of latent HSV-2. The patient experienced progressive lower extremity sensory deficits and genitourinary dysfunction, culminating in a vesiculopustular rash. Diagnosis was confirmed via cerebrospinal fluid analysis and PCR testing of skin lesions. Despite early imaging findings being unremarkable, subsequent MRI revealed enhancement of the conus medullaris and cauda equina. Treatment with intravenous acyclovir, corticosteroids, and supportive therapy led to gradual functional improvement, though sensory deficits and neuropathy persisted. This case highlights the diagnostic challenges and importance of clinical suspicion for HSV-2 reactivation in immunosuppressed patients, as well as considerations for long-term symptom management.展开更多
目的:了解江苏省男男性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunoddficiency virus,HIV)感染者的梅毒及单纯疱疹病毒Ⅱ型(herpes simplex virus 2,HSV-2)的感染情况及影响因素。方法:2012年3～6月在南...目的:了解江苏省男男性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunoddficiency virus,HIV)感染者的梅毒及单纯疱疹病毒Ⅱ型(herpes simplex virus 2,HSV-2)的感染情况及影响因素。方法:2012年3～6月在南京、镇江市整群抽取HIV阳性的MSM 264例,对其进行随访问卷调查,并回顾其病例报告时的问卷信息。静脉血采集进行梅毒和HSV-2检测。结果:264例MSM中梅毒感染率为29.55%(78/264),其中现症梅毒感染率为13.64%(36/264),HSV-2型特异性IgG抗体阳性率为28.03%(74/264)。多因素Logistic回归分析结果显示与现症梅毒感染有统计学意义的因素为感染前6个月内同性性伴数>3人、HSV-2阳性;与HSV-2感染有统计学意义的因素为年龄>35岁、本县区户籍、现症梅毒感染和接受安全套发放服务。结论:应探索新的干预模式和检测策略,以应对梅毒和HSV-2在MSM人群中的传播和流行。展开更多
目的设计单纯疱疹病毒2型(HSV-2)诊断芯片的O ligo探针。方法利用BLA ST软件对HSV-2的DNA序列进行序列比对,得到有意义的特异序列;用生物学软件O ligo6.0设计特异性高、Tm值相近、长度均一的O ligo探针。结果获得13条60-m er O ligo探...目的设计单纯疱疹病毒2型(HSV-2)诊断芯片的O ligo探针。方法利用BLA ST软件对HSV-2的DNA序列进行序列比对,得到有意义的特异序列;用生物学软件O ligo6.0设计特异性高、Tm值相近、长度均一的O ligo探针。结果获得13条60-m er O ligo探针。结论利用BLA ST系统和生物学软件O ligo6.0设计HSV-2诊断芯片的探针,可为后期打印成DNA芯片,用于HSV-2的检测打下基础。展开更多
文摘Elsberg syndrome, or HSV-2 lumbosacral radiculitis, is a rare and underrecognized neurologic condition that mimics cauda equina syndrome (CES). It typically presents with symptoms such as urinary retention, saddle anesthesia, and bowel incontinence. This case report describes a 59-year-old immunosuppressed male with idiopathic pulmonary fibrosis who developed Elsberg syndrome due to re-activation of latent HSV-2. The patient experienced progressive lower extremity sensory deficits and genitourinary dysfunction, culminating in a vesiculopustular rash. Diagnosis was confirmed via cerebrospinal fluid analysis and PCR testing of skin lesions. Despite early imaging findings being unremarkable, subsequent MRI revealed enhancement of the conus medullaris and cauda equina. Treatment with intravenous acyclovir, corticosteroids, and supportive therapy led to gradual functional improvement, though sensory deficits and neuropathy persisted. This case highlights the diagnostic challenges and importance of clinical suspicion for HSV-2 reactivation in immunosuppressed patients, as well as considerations for long-term symptom management.
文摘目的:了解江苏省男男性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunoddficiency virus,HIV)感染者的梅毒及单纯疱疹病毒Ⅱ型(herpes simplex virus 2,HSV-2)的感染情况及影响因素。方法:2012年3～6月在南京、镇江市整群抽取HIV阳性的MSM 264例,对其进行随访问卷调查,并回顾其病例报告时的问卷信息。静脉血采集进行梅毒和HSV-2检测。结果:264例MSM中梅毒感染率为29.55%(78/264),其中现症梅毒感染率为13.64%(36/264),HSV-2型特异性IgG抗体阳性率为28.03%(74/264)。多因素Logistic回归分析结果显示与现症梅毒感染有统计学意义的因素为感染前6个月内同性性伴数>3人、HSV-2阳性;与HSV-2感染有统计学意义的因素为年龄>35岁、本县区户籍、现症梅毒感染和接受安全套发放服务。结论:应探索新的干预模式和检测策略,以应对梅毒和HSV-2在MSM人群中的传播和流行。
文摘目的设计单纯疱疹病毒2型(HSV-2)诊断芯片的O ligo探针。方法利用BLA ST软件对HSV-2的DNA序列进行序列比对,得到有意义的特异序列;用生物学软件O ligo6.0设计特异性高、Tm值相近、长度均一的O ligo探针。结果获得13条60-m er O ligo探针。结论利用BLA ST系统和生物学软件O ligo6.0设计HSV-2诊断芯片的探针,可为后期打印成DNA芯片,用于HSV-2的检测打下基础。
