针对含光伏(photovoltaic,PV)、电动汽车(electric vehicle,EV)及家庭电器负荷的智能社区,以车入户(vehicle to home,V2H)的形式将EV纳入家庭需求响应框架,利用EV的双向输能特性并考虑EV充/放电带来的电池容量退化成本,协同PV、电网的...针对含光伏(photovoltaic,PV)、电动汽车(electric vehicle,EV)及家庭电器负荷的智能社区,以车入户(vehicle to home,V2H)的形式将EV纳入家庭需求响应框架,利用EV的双向输能特性并考虑EV充/放电带来的电池容量退化成本,协同PV、电网的实时电价和用户需求的可容忍时延,基于Lyapunov优化理论提出随机环境下V2H用户的EV充/放电调度策略和每户家庭的负荷响应策略,最小化家庭用户的长期平均购电成本。并提出一种智能社区在线能量交易方案,旨在最小化智能社区总的购电成本、最大限度提高社区能源利用率。理论分析和仿真结果表明,所提算法无需实时电价、PV出力、用户负荷需求的先验概率信息,仅基于当前系统状态就可使优化目标趋于最优值,实现家庭用户的能量调度和家庭用户之间的能量共享,减少家庭购电成本,提高用户之间能量交易的灵活性。展开更多
This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-fiel...This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.展开更多
A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.展开更多
In order to solve the springback problem in sheet metal forming, the trial and error method is a widely used method in the factory, which is time-consuming and costly for its non-direction and non-quantitative. Finite...In order to solve the springback problem in sheet metal forming, the trial and error method is a widely used method in the factory, which is time-consuming and costly for its non-direction and non-quantitative. Finite element simulation is an e ective method to predict the springback of complex shape parts, but its precision is sensitive to the simulation model, particularly material model and boundary conditions. In this paper, the simple iterative method is introduced to establish the iterative compensation algorithm, and the convergence criterion of iterative parameters is put forward. In addition, the new algorithm is applied to the V-free bending and stretch-bending processes, and the convergence of curvature and bending angle is proved theoretically and verified experimentally. At the same time,the iterative compensation experiments for plane bending show that, the new method can predict the next compensaantido tnh ev atlaureg ebta cseurdv oatnu trhe ew sitphri tnhgeb earcrko ro fo fe laecshs ttehsat,n s0 o. 5 th%a ta rteh eo btatraigneet db aefntedri n2 g-3 a nitgelrea tiwoitnhs.t Thhei se rrreosre aorf clhe sps rtohpaons e±s 0 a.1%new iterative compensation algorithm to predict springback in sheet metal forming process, where each compensation value depends only on the iteration parameter di erence before and after springback for the same forming process of same material.展开更多
The H9N2 subtype avian influenza virus(AIV)continues to propagate and undergo evolution within China,thereby posing a significant threat to the poultry industry.This study encompassed the collection of 436 samples and...The H9N2 subtype avian influenza virus(AIV)continues to propagate and undergo evolution within China,thereby posing a significant threat to the poultry industry.This study encompassed the collection of 436 samples and swabs in East China over the period spanning 2018 to 2019,from which 31 strains of the H9N2 subtype viruses were isolated and purified.We revealed that the HA and NA genes of the 31 isolates categorized within the Y280 branch,while the PB2 and M genes were associated with the G1 branch,and the remaining genes aligned with the F/98 branch.Despite this alignment,antigenic mapping demonstrated differences between the 2018 and 2019 strains,with the early vaccine strains displaying low serological reactivity toward these isolates.Notably,the CK/SH/49/19 isolate exhibited lethality in mice,characterized by a PB2 E627V mutation and a HA deletion at amino acid position 217.Mechanistically,in vitro studies showed that the influenza virus CK/SH/49/19 carrying PB2627V and HA 217M mutations displayed enhanced replication capacity,attributed to the heightened activity of the polymerase with PB2627V.Moreover,the absence of the amino acid at the HA 217 site obstructed viral adsorption and internalization,resulted in lower activation pH,and impeded the virus budding process.Critically,in vivo experiments revealed that CK/SH/49/19(PB2627V,HA 217Δ)triggered a robust activation of interferon response and interferon-stimulated genes.This study furnished a theoretical foundation for the scientific prevention and control strategies against H9N2 subtype avian influenza.展开更多
but its application is constrained by hepatotoxicity.This study aimed to investigate the feasibility of reducing AAEO’s toxicity through storage and to evaluate changes in chemical composition,toxicity,and bioactivit...but its application is constrained by hepatotoxicity.This study aimed to investigate the feasibility of reducing AAEO’s toxicity through storage and to evaluate changes in chemical composition,toxicity,and bioactivity.Methods:Gas chromatography-mass spectrometry was used to analyze compositional changes during storage.Zebrafish acute toxicity tests and the liver-specific transgenic zebrafish model Tg(fabp10:EGFP)were used to assess toxicity.Antimicrobial,analgesic,and antioxidant assays evaluated variations in bioactivity.Results:Over the 150-day storage period,gas chromatography-mass spectrometry analysis identified 39 components.Zebrafish acute toxicity tests showed that the LD50 of AAEO stored for 0,30,60,90,120,and 150 days were 0.10μL·mL^(-1),0.10μL·mL^(-1),0.10μL·mL^(-1),0.11μL·mL^(-1),0.13μL·mL^(-1),and 0.14μL·mL^(-1),respectively,demonstrating a 40%reduction in acute toxicity after 150 days of storage.Using the liver-specific green fluorescent transgenic Tg(fabp10:EGFP)zebrafish model,the inhibition rates of AAEO on hepatic fluorescence intensity were measured at 68.5%,43.5%,42.6%,37.8%,34.6%,and 31.9% at different time points,confirming reduced hepatotoxicity after storage.Additionally,the antioxidant and analgesic activities of AAEO were significantly enhanced(p<0.05)after storage,while the antibacterial activity decreased(p<0.05).Conclusions:After storage,AAEO significantly reduces hepatotoxicity,with a 40% decrease in acute toxicity after 150 days.Meanwhile,the antioxidant and analgesic activities of AAEO increase,while its antibacterial activity decreases after storage.展开更多
Boris numerical scheme due to its long-time stability,accuracy and conservative properties has been widely applied in many studies of magnetized plasmas.Such algorithms conserve the phase space volume and hence provid...Boris numerical scheme due to its long-time stability,accuracy and conservative properties has been widely applied in many studies of magnetized plasmas.Such algorithms conserve the phase space volume and hence provide accurate charge particle orbits.However,this algorithm does not conserve the energy in some special electromagnetic configurations,particularly for long simulation times.Here,we empirically analyze the energy behavior of Boris algorithm by applying it to a 2D autonomous Hamiltonian.The energy behavior of the Boris method is found to be strongly related to the integrability of our Hamiltonian system.We find that if the invariant tori is preserved under Boris discretization,the energy error can be bounded for an exponentially long time,otherwise the said error will show a linear growth.On the contrary,for a non-integrable Hamiltonian system,a random walk pattern has been observed in the energy error.展开更多
A fast motion estimation algorithm for variable block-size using the ＂line scan and block merge procedure＂ is proposed for airborne image compression modules.Full hardware implementation via FPGA is discussed in det...A fast motion estimation algorithm for variable block-size using the ＂line scan and block merge procedure＂ is proposed for airborne image compression modules.Full hardware implementation via FPGA is discussed in detail.The proposed pipelined architecture based on the line scan algorithm is capable of calculating the required 41 motion vectors of various size blocks supported by H.264 within a 16 × 16 block in parallel.An adaptive rate distortion cost function is used for various size block decision.The motion vectors of adjacent small blocks are merged to predict the motion vectors of larger blocks for reducing computation.Experimental results show that our proposed method has lower computational complexity than full search algorithm with slight quality decrease and little bit rate increase.Due to the high real-time processing speed it can be easily realized in hardware.展开更多
文摘针对含光伏(photovoltaic,PV)、电动汽车(electric vehicle,EV)及家庭电器负荷的智能社区,以车入户(vehicle to home,V2H)的形式将EV纳入家庭需求响应框架,利用EV的双向输能特性并考虑EV充/放电带来的电池容量退化成本,协同PV、电网的实时电价和用户需求的可容忍时延,基于Lyapunov优化理论提出随机环境下V2H用户的EV充/放电调度策略和每户家庭的负荷响应策略,最小化家庭用户的长期平均购电成本。并提出一种智能社区在线能量交易方案,旨在最小化智能社区总的购电成本、最大限度提高社区能源利用率。理论分析和仿真结果表明,所提算法无需实时电价、PV出力、用户负荷需求的先验概率信息,仅基于当前系统状态就可使优化目标趋于最优值,实现家庭用户的能量调度和家庭用户之间的能量共享,减少家庭购电成本,提高用户之间能量交易的灵活性。
基金supported by the Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2025ZD005100)by Beijing Geolight Technology Co.,Ltd.under the project“The Impact of Strong Ground Motion on Buildings”(YF-202520).
文摘This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.
基金supported by the National Natural Science Foundation of China(32273037 and 32102636)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)+4 种基金Laboratory of Lingnan Modern Agriculture Project(NT2021007)the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098)the 111 Center(D20008)the double first-class discipline promotion project(2023B10564003)the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
文摘A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.
基金Supported by Hebei Provincial Natural Science Foundation of in China(Grant Nos.E2015203244,E2016203266)Program for the Youth Top-notch Talents of Hebei Province
文摘In order to solve the springback problem in sheet metal forming, the trial and error method is a widely used method in the factory, which is time-consuming and costly for its non-direction and non-quantitative. Finite element simulation is an e ective method to predict the springback of complex shape parts, but its precision is sensitive to the simulation model, particularly material model and boundary conditions. In this paper, the simple iterative method is introduced to establish the iterative compensation algorithm, and the convergence criterion of iterative parameters is put forward. In addition, the new algorithm is applied to the V-free bending and stretch-bending processes, and the convergence of curvature and bending angle is proved theoretically and verified experimentally. At the same time,the iterative compensation experiments for plane bending show that, the new method can predict the next compensaantido tnh ev atlaureg ebta cseurdv oatnu trhe ew sitphri tnhgeb earcrko ro fo fe laecshs ttehsat,n s0 o. 5 th%a ta rteh eo btatraigneet db aefntedri n2 g-3 a nitgelrea tiwoitnhs.t Thhei se rrreosre aorf clhe sps rtohpaons e±s 0 a.1%new iterative compensation algorithm to predict springback in sheet metal forming process, where each compensation value depends only on the iteration parameter di erence before and after springback for the same forming process of same material.
基金supported by National Natural Science Foundation of China[Grant number:32272992(JP),31772775(JP)]National Key Research and Development Program of China[Grant number:2021YFD1800205(JP)].
文摘The H9N2 subtype avian influenza virus(AIV)continues to propagate and undergo evolution within China,thereby posing a significant threat to the poultry industry.This study encompassed the collection of 436 samples and swabs in East China over the period spanning 2018 to 2019,from which 31 strains of the H9N2 subtype viruses were isolated and purified.We revealed that the HA and NA genes of the 31 isolates categorized within the Y280 branch,while the PB2 and M genes were associated with the G1 branch,and the remaining genes aligned with the F/98 branch.Despite this alignment,antigenic mapping demonstrated differences between the 2018 and 2019 strains,with the early vaccine strains displaying low serological reactivity toward these isolates.Notably,the CK/SH/49/19 isolate exhibited lethality in mice,characterized by a PB2 E627V mutation and a HA deletion at amino acid position 217.Mechanistically,in vitro studies showed that the influenza virus CK/SH/49/19 carrying PB2627V and HA 217M mutations displayed enhanced replication capacity,attributed to the heightened activity of the polymerase with PB2627V.Moreover,the absence of the amino acid at the HA 217 site obstructed viral adsorption and internalization,resulted in lower activation pH,and impeded the virus budding process.Critically,in vivo experiments revealed that CK/SH/49/19(PB2627V,HA 217Δ)triggered a robust activation of interferon response and interferon-stimulated genes.This study furnished a theoretical foundation for the scientific prevention and control strategies against H9N2 subtype avian influenza.
基金supported by grants from the National Natural Science Foundation of China(82074026)the National Interdisciplinary Innovation Team of Traditional Chinese Medicine(ZYYCXTD-D-202209).
文摘but its application is constrained by hepatotoxicity.This study aimed to investigate the feasibility of reducing AAEO’s toxicity through storage and to evaluate changes in chemical composition,toxicity,and bioactivity.Methods:Gas chromatography-mass spectrometry was used to analyze compositional changes during storage.Zebrafish acute toxicity tests and the liver-specific transgenic zebrafish model Tg(fabp10:EGFP)were used to assess toxicity.Antimicrobial,analgesic,and antioxidant assays evaluated variations in bioactivity.Results:Over the 150-day storage period,gas chromatography-mass spectrometry analysis identified 39 components.Zebrafish acute toxicity tests showed that the LD50 of AAEO stored for 0,30,60,90,120,and 150 days were 0.10μL·mL^(-1),0.10μL·mL^(-1),0.10μL·mL^(-1),0.11μL·mL^(-1),0.13μL·mL^(-1),and 0.14μL·mL^(-1),respectively,demonstrating a 40%reduction in acute toxicity after 150 days of storage.Using the liver-specific green fluorescent transgenic Tg(fabp10:EGFP)zebrafish model,the inhibition rates of AAEO on hepatic fluorescence intensity were measured at 68.5%,43.5%,42.6%,37.8%,34.6%,and 31.9% at different time points,confirming reduced hepatotoxicity after storage.Additionally,the antioxidant and analgesic activities of AAEO were significantly enhanced(p<0.05)after storage,while the antibacterial activity decreased(p<0.05).Conclusions:After storage,AAEO significantly reduces hepatotoxicity,with a 40% decrease in acute toxicity after 150 days.Meanwhile,the antioxidant and analgesic activities of AAEO increase,while its antibacterial activity decreases after storage.
基金Abdullah Zafar acknowledges the Chinese Scholarship Council(CSC)to support him as the 2015 CSC awardee(CSC No.2015GXZQ56).
文摘Boris numerical scheme due to its long-time stability,accuracy and conservative properties has been widely applied in many studies of magnetized plasmas.Such algorithms conserve the phase space volume and hence provide accurate charge particle orbits.However,this algorithm does not conserve the energy in some special electromagnetic configurations,particularly for long simulation times.Here,we empirically analyze the energy behavior of Boris algorithm by applying it to a 2D autonomous Hamiltonian.The energy behavior of the Boris method is found to be strongly related to the integrability of our Hamiltonian system.We find that if the invariant tori is preserved under Boris discretization,the energy error can be bounded for an exponentially long time,otherwise the said error will show a linear growth.On the contrary,for a non-integrable Hamiltonian system,a random walk pattern has been observed in the energy error.
基金Supported by the Aviation Science Fund of China(2009ZC15001)
文摘A fast motion estimation algorithm for variable block-size using the ＂line scan and block merge procedure＂ is proposed for airborne image compression modules.Full hardware implementation via FPGA is discussed in detail.The proposed pipelined architecture based on the line scan algorithm is capable of calculating the required 41 motion vectors of various size blocks supported by H.264 within a 16 × 16 block in parallel.An adaptive rate distortion cost function is used for various size block decision.The motion vectors of adjacent small blocks are merged to predict the motion vectors of larger blocks for reducing computation.Experimental results show that our proposed method has lower computational complexity than full search algorithm with slight quality decrease and little bit rate increase.Due to the high real-time processing speed it can be easily realized in hardware.
