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培土生金中药联合西医常规疗法治疗支气管哮喘缓解期肺脾两虚证的Meta分析及GRADE质量评价
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作者 余荣祥 宋德胤 《江西中医药》 2026年第1期45-49,共5页
目的:系统评价培土生金中药联合西医常规疗法治疗支气管哮喘缓解期肺脾两虚证的疗效以及证据质量,为临床决策及疾病指南制订提供循证依据。方法:检索中国知网(CNKI)、万方数据库(Wangfang)、Pubmed、Web of Science等8大中英文数据库,由... 目的:系统评价培土生金中药联合西医常规疗法治疗支气管哮喘缓解期肺脾两虚证的疗效以及证据质量,为临床决策及疾病指南制订提供循证依据。方法:检索中国知网(CNKI)、万方数据库(Wangfang)、Pubmed、Web of Science等8大中英文数据库,由2名研究者独立进行文献筛选、信息提取、偏倚风险评估及方法学质量评价,并对纳入研究的总有效率、中医证候积分、第一秒用力呼气容积(FEV1)、第一秒用力呼气容积/用力肺活量(FEV1/FVC)、哮喘控制测试(ACT)评分等结局指标进行Meta分析,最终依照GRADE评估证据质量。结果:共纳入14项研究,合计1263例患者。结果显示:(1)培土生金中药联合常规西医疗法可有效改善患者总有效率,降低患者中医证候积分,改善患者FEV1水平、FEV1/FVC及ACT评分。(2)总有效率证据质量较优,可信度高,其余指标证据质量较低,尚待更多高质量的研究支持以提升证据级别。结论:培土生金中药联合西医常规疗法治疗支气管哮喘缓解期肺脾两虚证优于单用西医常规治疗,且在总有效率上证据质量较高,具有一定的循证学意义。 展开更多
关键词 支气管哮喘 缓解期 肺脾两虚证 培土生金 中药 META分析 grade评价
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Additive Manufacturing of Functionally Graded Lattice Structures for Personalized Below-Knee Prosthetic Dampers
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作者 Guy O'Keefe Naser A.Alsaleh +3 位作者 Mahmoud A.El-Sayed A.Jiménez Sabbah Ataya Khamis Essa 《Chinese Journal of Polymer Science》 2026年第1期173-188,I0014,共17页
Functionally graded cellular structures(FGCSs)have a multitude of applications to a wide range of industries.Utilising the ever-progressing technology of additive manufacturing(AM),FGCSs can be applied to control mate... Functionally graded cellular structures(FGCSs)have a multitude of applications to a wide range of industries.Utilising the ever-progressing technology of additive manufacturing(AM),FGCSs can be applied to control material grading and achieve the desired mechanical properties.The current study explores the design and optimisation of FGCSs for AM,with a focus on improving the compression and impact performance of below knee(BK)prosthetic limbs made of thermoplastic polyurethane(TPU).A multiscale research methodology integrating topology optimization(TO),finite element analysis(FEA),and design of experiments(Do E)was adopted to optimise lattice structures in terms of stiffness and lightweight properties.Two-unit cell designs were considered in the study:Schwarz P gyroid and body-centered cubic(BCC).Response surface methodology(RSM)was implemented to analyse the effect of minimum and maximum cell wall thickness,cell size,and unit cell type on the mechanical performance of TPU FGCS structures.The results indicated that a Schwarz P FGCS structure with cell size,minimum and maximum cell wall thickness of 6,0.9 and 2.8 mm,respectively,could be optimal for a compromise between performance and weight.In this optimized case,stiffness and volume fraction values of 684 N/mm and 0.64 were obtained,respectively.The study also presents a proof-of-concept design for a BK prosthetic damper,highlighting the potential of FGCSs to enhance patient comfort,reduce manufacturing costs,and enable personalised designs through 3D scanning and AM.The obtained results could be a step forward towards the incorporation of AM technologies in prosthetics,offering a pathway to lightweight,cost-effective,and functionally tailored solutions. 展开更多
关键词 Additive manufacturing Functionally graded cellular structures Topology optimization PROSTHETICS
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Meshfree Dynamic Analysis of Functionally Graded Rectangular Plates with Varying Thickness in Supersonic Flow and Thermal Environment
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作者 Jinmi Kim Kwangil Ri +1 位作者 Songhun Kwak Unbok Jong 《Acta Mechanica Solida Sinica》 2026年第1期101-120,共20页
In this paper,the free vibration and stationary stochastic response of functionally graded(FG)rectangular plates with varying thickness in supersonic flow and thermal environment are analyzed.Two types of material pro... In this paper,the free vibration and stationary stochastic response of functionally graded(FG)rectangular plates with varying thickness in supersonic flow and thermal environment are analyzed.Two types of material property variations of FG plates with varying thickness are considered:the variation along the direction perpendicular to the mid-surface and that along the direction perpendicular to the bottom surface.Considering the effects of aerodynamic pressure and thermal load,the governing equations of motion of FG plates with varying thickness are derived using Hamilton’s principle within the framework of first-order shear deformation theory.A meshfree Jacobi radial point interpolation(Jacobi-RPI)shape function is constructed by combining the Jacobi polynomials and radial basis to approximate the displacement components of the plate.The accuracy and reliability of the present approach are confirmed through sufficient comparisons with numerical results from the published literature and the finite element software ABAQUS.Finally,the effects of different parameters on the free vibration and stationary stochastic response of FG plates are investigated. 展开更多
关键词 Functionally graded plate Jacobi radial point interpolation Free vibration Stochastic response Varying thickness
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温胆汤加减方治疗不稳定型心绞痛疗效的Meta分析及GRADE评价
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作者 刘雅恬 辛亚然 +2 位作者 武攀 谭绍坤 范新发 《中医药临床杂志》 2026年第3期542-550,共9页
目的:系统评价温胆汤联合常规西药治疗不稳定型心绞痛的有效性及安全性。方法:检索中国知网、万方、维普、中国生物医学文献数据库和PubMed、Embase、Cochrane Library英文数据库,自建库至2025年3月关于温胆汤联合西医常规疗法治疗不稳... 目的:系统评价温胆汤联合常规西药治疗不稳定型心绞痛的有效性及安全性。方法:检索中国知网、万方、维普、中国生物医学文献数据库和PubMed、Embase、Cochrane Library英文数据库,自建库至2025年3月关于温胆汤联合西医常规疗法治疗不稳定型心绞痛的随机对照试验,根据纳入排除标准筛选文献并提取数据。应用Rev-Man5.4.1软件进行Meta分析,参照Cochrane风险评估工具对所纳入研究质量进行评估,通过GRADE证据分级系统对纳入研究质量进行评价。结果:纳入11篇文献,共计1018例患者,治疗组512例,对照组506例。分析结果表明,相较于单纯应用西药治疗,联用温胆汤明显改善患者心绞痛疗效[OR=4.19,95%CI(2.79,6.27),P<0.00001]、心电图改善率[OR=2.56,95%CI(1.68,3.88),P<0.0001]、总胆固醇水平[MD=-0.41,95%CI(-0.54,-0.28),P<0.00001]、炎性因子[MD_(hs-CRP)=-0.45,95%CI(-0.55,-0.35),P<0.00001;MD_(TNF-α)=-2.16,95%CI(-2.63,-1.69),P<0.00001;MD_(IL-6)=-2.25,95%CI(-2.58,-1.92),P<0.00001;MD_(CRP)=-1.62,95%CI(-3.27,0.44),P<0.00001]、中医证候疗效[OR=4.36,95%CI(2.41,7.89),P<0.00001]、血浆同型半胱氨酸水平[MD=-1.32,95%CI(-2.93,-0.29),P=0.11]、中医证候积分[MD=-4.13,95%CI(-4.48,-3.77),P<0.00001]。GRADE证据分级表明心绞痛有效率、心电图改善率证据级别为低级;总胆固醇水平、hs-CRP、TNF-α、IL-6、CRP、中医证候疗效、血浆同型半胱氨酸水平、中医证候积分的证据级别为极低级。结论:常规西药联用温胆汤在提高不稳定型心绞痛患者的临床疗效方面具有显著优势,有效性及安全性方面均优于单纯西药治疗,值得推荐临床应用。 展开更多
关键词 温胆汤 不稳定型心绞痛 META分析 grade评价
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Slope grade difference of cropland spatial pattern in China
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作者 ZHU Panping PENG Qiuzhi +4 位作者 XING Shuang YANG Guanhui XU Jin QIN Zijun JIN Changlei 《Journal of Mountain Science》 2026年第2期798-812,共15页
China's requisition-compensation balance strategy has dramatically reshaped cropland spatial patterns,drawing multidisciplinary research attention.However,existing studies predominantly emphasize horizontal distri... China's requisition-compensation balance strategy has dramatically reshaped cropland spatial patterns,drawing multidisciplinary research attention.However,existing studies predominantly emphasize horizontal distribution,overlooking the significant influence of slope gradient on cropland spatial patterns.This paper proposes a slope location quotient(SLQ)index that reflects the relative advantage of cropland distribution and explores the slope grade difference of cropland spatial patterns in China at the county scale.The analysis adopts 30-m resolution digital elevation model with land cover data,taking 2672 counties with cropland ratio>1%as study units.The temporal scope covers 1990 and 2020,with slope gradients categorized into five grades:0°~2°,2°~6°,6°~15°,15°~25°,and 25°~90°.Results show that:1)The inverse correlation between cropland area and slope gradient remained stable throughout the study period,with the variation in cropland area frequency across slope grades being less than 1%.2)The spatial patterns of SLQ in 1990 and 2020 both transited stepwise with slope gradient,while≤2°and>6°slopes exhibited opposing patterns.3)The mean absolute variation of SLQ during 1990-2020 increased with slope gradient(R2=0.926,p<0.01).Particularly for slope grades>15°,the mean absolute variation reached 0.26(for 15°~25°)and 0.43(for 25°~90°),respectively,and displayed a distinct southward-increasing and northwarddecreasing pattern.This study offers novel slopegradient perspectives for analyzing cropland spatial patterns.To enhance cropland protection benefits,reversing the steep cropland SLQ surge in southern China is recommended. 展开更多
关键词 Cropland spatial pattern Slope grade difference Slope location quotient(SLQ) China
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High-performance thermomagnetic generation in low-grade waste heat recovery
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作者 Haodong Chen Hu Zhang +4 位作者 Mingze Liu Kaiming Qiao Lichen Wang Fengxia Hu Baogen Shen 《Chinese Physics B》 2026年第2期25-41,共17页
Thermomagnetic generation(TMG),a heat-to-electricity conversion technology based on the thermomagnetic effect,offers high reliability and broad adaptability to diverse heat sources.By exploiting the temperature-depend... Thermomagnetic generation(TMG),a heat-to-electricity conversion technology based on the thermomagnetic effect,offers high reliability and broad adaptability to diverse heat sources.By exploiting the temperature-dependent magnetization of thermomagnetic materials,TMG converts thermal energy into electrical energy through cyclic changes in magnetic flux based on Faraday's law.The performance of TMG systems is largely governed by the intrinsic properties of the working materials and the design of device architecture.Ideal TMG materials exhibit sharp and reversible magnetization transitions near the operating temperature,low thermal hysteresis,and high thermal conductivity.Device configurations can be broadly categorized into active and passive systems:active TMG devices rely on controlled thermal cycling and optimized magnetic circuits for enhanced output,whereas passive devices utilize self-actuated mechanical motion to generate electricity.In this topical review,we provide a comprehensive overview of recent advances in TMG materials and device configurations.Furthermore,we discuss future development trends and offer perspectives on experimental strategies to advance this field. 展开更多
关键词 low grade waste heat thermal energy recovery thermomagnetic generation
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Evaluating Large Language Model Adherence to Targeted Fifth‐Grade Readability Standards in Patient Educationon Chronic Conditions
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作者 Faheed Shafau Chase Wahl +1 位作者 Marcus Kado Garrett Miedema 《Chronic Diseases and Translational Medicine》 2026年第1期73-74,共2页
To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using... To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using AI;often,they will prompt AI with questions before even stepping into a physi-cian's office.The question lies in whether the information produced by AI is reliable and if this information is concise and easy to read across all patient populations. 展开更多
关键词 large languagemodels llms especially fifth grade readability standards artificial intelligence large language models patient education chronic conditions prompt ai READABILITY
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Thermal Vibrations and Buckling Analysis of Bidirectional Functionally Graded Beams Under Axial and Transverse Temperature Gradients
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作者 Haizhou Liu Yang Zhao +2 位作者 Fangtong Luo Hao Tian Weihua Xie 《Acta Mechanica Solida Sinica》 2026年第2期152-165,共14页
Bidirectional functionally graded(BDFG)beams are a promising solution for spacecraft structures subjected to extreme thermal and vibrational environments due to their superior thermal performance and design flexibilit... Bidirectional functionally graded(BDFG)beams are a promising solution for spacecraft structures subjected to extreme thermal and vibrational environments due to their superior thermal performance and design flexibility.Therefore,developing an efficient and highly convergent thermal vibration analysis method for BDFG beams under complex temperature fields is of paramount importance.This paper proposes a Chebyshev spectral method based on Reddy’s higher-order shear deformation theory(HSDT)to investigate the thermoelastic vibrations of BDFG beams.The material properties are temperature-dependent and vary with both thickness and length.The proposed method is validated by comparing the results with those in the existing literature.The analysis reveals that the critical buckling temperature rise is primarily influenced by the ceramic content,but thermal buckling can be mitigated by adjusting the material distribution.A trade-off exists between suppressing thermal buckling and relaxing thermal stresses,necessitating a balanced approach.The titanium alloy BDFG beam offers a broader design envelope compared to the metal-ceramic BDFG beam.The method presented in this study will provide theoretical support and guidance for the design of BDFG beams. 展开更多
关键词 Thermal buckling Chebyshev spectral approach Bidirectional functionally graded beams Axial temperature rise Higher-order shear deformation theory
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Development of Ti/Pt Periodically Modulated Graded Materials:Toward Structural Optimization and Controllable Pressure-Strain Rate Functionality
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作者 JIANG Yuda ZHANG Ruizhi +6 位作者 LIU Shuaixiong ZHOU Yiheng GUO Chengcheng CHEN Han ZHANG Jian LUO Guoqiang SHEN Qiang 《Journal of Wuhan University of Technology(Materials Science)》 2026年第2期333-345,共13页
We used hydrodynamic simulations and shock wave propagation theories to analyze the behavior of shock waves within Ti/Pt periodically modulated graded structures and their integration layers.The effects of the total n... We used hydrodynamic simulations and shock wave propagation theories to analyze the behavior of shock waves within Ti/Pt periodically modulated graded structures and their integration layers.The effects of the total number of periodic layers,the total thickness of graded materials and loading velocity on the integration layer thickness and behavior of pressure-strain rate were systematically investigated.The results reveal that,by adjusting the total number of periodically modulated layers,the total thickness of graded materials and loading velocity the pressure amplitudes of the reflected compressive and rarefaction waves at different interfaces of Ti/Pt periodically modulated graded materials can be precisely controlled.Furthermore,empirical structural design criteria for Ti/Pt periodically modulated graded materials are established.The thickness ratio variation between adjacent Ti/Pt layers in the periodic structure must exceed 0.32.After the collaborative design of the integration layer,Ti/Pt periodically modulated graded materials can achieve a controllable loading function with pressures ranging from 1.4 to 144 GPa and strain rates from 3.8×10^(4) to 1.7×10^(7) s^(–1).The outcomes of this research provide a theoretical and simulation basis for the optimized design of periodically modulated graded materials to be utilized in ramp compression experiments. 展开更多
关键词 Ti/Pt periodically modulated graded material hydrodynamic simulation wave propagation integration layer controllable pressure-strain rate loading
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Bending Analysis of Functionally Graded Material and Cracked Homogeneous Thin Plates Using Meshfree Numerical Manifold Method
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作者 Shouyang Huang Hong Zheng +2 位作者 Xuguang Yu Ziheng Li Zhiwei Pan 《Computer Modeling in Engineering & Sciences》 2026年第3期304-340,共37页
Functionally graded material(FGM)plates are widely used in various engineering structures owing to their tailor-made mechanical properties,whereas cracked homogeneous plates constitute a canonical setting in fracture ... Functionally graded material(FGM)plates are widely used in various engineering structures owing to their tailor-made mechanical properties,whereas cracked homogeneous plates constitute a canonical setting in fracture mechanics analysis.These two classes of problems respectively embody material non-uniformity and geometric discontinuity,thereby imposing more stringent requirements on numerical methods in terms of high-order field continuity and accurate defect representation.Based on the classical Kirchhoff-Love plate theory,a numerical manifold method(MLS-NMM)incorporating moving least squares(MLS)interpolation is developed for bending analysis of FGM plates and fracture simulation of homogeneous plates with defects.The method constructs an H^(2)-regular approximation with high-order continuous weighting functions and,combined with the separation of mathematical and physical covers,establishes a unified framework that accurately handles material gradients and cracks without mesh reconstruction.For the crack tip,a singular physical cover incorporating the Williams asymptotic field is introduced to achieve local enrichment,enabling the natural capture of displacement discontinuity and stress singularity.Stress intensity factors are extracted using the interaction integral method,and the dimensionless J-integral shows a maximum relative error below 1.2%compared with the reference solution.Numerical results indicate that MLS-NMM exhibits excellent convergence performance:using 676 mathematical nodes,the nondimensional central deflection of both FGM and homogeneous plates agrees with reference solutions with a maximum relative error below 0.81%,and no shear locking occurs.A systematic analysis reveals that for a simply supported on all four edges(SSSS)FGM square plate with a/h=10,the nondimensional central deflection increases by 212%as the gradient index nrises from 0 to 5.For a homogeneous plate containing a central crack with c/a=0.6,the nondimensional central deflection increases by approximately 46%compared with the intact plate.Under weak boundary constraints(e.g.,SFSF),the deformation is markedly amplified,with the deflection reaching more than three times that under strong constraints(SCSC).The proposed method provides an efficient,reconstruction-free numerical tool for high-accuracy bending and fracture analyses of FGM and cracked thin-plate structures. 展开更多
关键词 Kirchhoff-love plate theory functionally graded materials moving least squares interpolation numerical manifold method bending analysis fracture mechanics stress intensity factor
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Size effect on the thermal fracture behavior of collinear interface cracks in functionally graded coating/substrate structures
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作者 Huameng WANG Zhangna XUE +1 位作者 Jianlin LIU Z.T.CHEN 《Applied Mathematics and Mechanics(English Edition)》 2026年第2期325-346,共22页
When micro/nano-scale gradient coatings are subject to large thermal gradients or high heat fluxes,the spatial size effect cannot be ignored.It is important to understand how the size effect influences the thermal fra... When micro/nano-scale gradient coatings are subject to large thermal gradients or high heat fluxes,the spatial size effect cannot be ignored.It is important to understand how the size effect influences the thermal fracture behavior of functionally graded coating/substrate structures.This study aims at analyzing the transient thermal fracture behavior of collinear interface cracks in functionally graded coating/substrate structures based on the nonlocal dual-phase-lag heat conduction model.By means of integral transform techniques,the mixed boundary problem is transformed into a set of singular integral equations,which are solved by the Chebyshev polynomials.The effects of the nonlocal parameter,coating thickness,crack spacing,and non-homogeneous parameters on the temperature and stress intensity factors(SIFs)are examined.The numerical results show that these parameters play an essential role in controlling the thermal fracture behavior of the structures,especially at micro/nano-scales. 展开更多
关键词 nonlocal dual-phase-lag heat conduction collinear interface crack functionally graded coating stress intensity factor(SIF)
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New Insight to Large Deformation Analysis of Thick-Walled Axisymmetric Functionally Graded Hyperelastic Ellipsoidal Pressure Vessel Structures:A Comparison between FEM and PINNs
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作者 Azhar G.Hamad Nasser Firouzi Yousef S.Al Rjoub 《Computers, Materials & Continua》 2026年第5期403-430,共28页
The accurate mechanical analysis of thick-walled pressure vessel structures composed of advanced materials,such as hyperelastic and functionally graded materials(FGMs),is critical for ensuring their safety and optimiz... The accurate mechanical analysis of thick-walled pressure vessel structures composed of advanced materials,such as hyperelastic and functionally graded materials(FGMs),is critical for ensuring their safety and optimizing their design.However,conventional numerical methods can face challenges with the non-linearities inherent in hyperelasticity and the complex spatial variations in FGMs.This paper presents a novel hybrid numerical approach combining Physics-Informed Neural Networks(PINNs)with Finite Element Method(FEM)derived data for the robust analysis of thick-walled,axisymmetric,heterogeneous,hyperelastic pressure vessels with elliptical geometries.A PINN framework incorporating neo-Hookean constitutive relations is developed in MATLAB.To enhance training efficiency and accuracy,the PINN’s loss function is augmented with displacement data obtained from high-fidelity FEM simulations performed in ANSYS.The methodology is rigorously validated by comparing PINN-predicted displacement and von Mises stress fields against ANSYS benchmarks for various scenarios of FGMconfigurations(with material properties varying according to a power law)subjected to internal and external pressurization.The results demonstrate excellent agreement between the proposed hybrid PINN-FEMapproach and conventional FEMsolutions across all test cases,accurately capturing complex deformation patterns and stress concentrations.This study highlights the potential of data-augmented PINNs as an effective and accurate computational tool for tackling complex solid mechanics problems involving non-linearmaterials and significant heterogeneity,offering a promising avenue for future research in engineering design and analysis. 展开更多
关键词 Finite elementmethod(FEM) physics-informed neural networks(PINNs) HYPERELASTICITY functionally graded materials(FGMs) pressure vessels hybrid numerical methods axisymmetric analysis
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Moderately large amplitude forced vibration of sandwich functionally graded auxetic beams:an analytical approach
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作者 F.M.NASREKANI H.EIPAKCHI 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期99-114,共16页
Sandwich functionally graded(FG)auxetic beams are extensively utilized in aerospace,automotive,and biomedical industries due to their excellent strength-toweight ratio,impact resistance,and tunable mechanical properti... Sandwich functionally graded(FG)auxetic beams are extensively utilized in aerospace,automotive,and biomedical industries due to their excellent strength-toweight ratio,impact resistance,and tunable mechanical properties.The integration of FG materials with auxetic structures enhances their adaptability in advanced engineering applications.However,understanding their dynamic behavior under external excitations is essential for optimal design and structural reliability.Nonlinear interactions in such structures pose significant challenges in vibration analysis,necessitating robust analytical methods.This study presents a closed-form solution for the nonlinear forced vibration analysis of sandwich FG auxetic beams,offering an accurate and efficient method for predicting their dynamic response.The beam consists of two FG face sheets with material properties varying through the thickness and a re-entrant honeycomb auxetic core with an adjustable Poisson's ratio.The governing nonlinear equations of motion are derived using the first-order shear deformation theory(FSDT),the modified Gibson model,and the von Kármán relations,formulated through Hamilton's principle.A closed-form solution is obtained via the Galerkin method and multiple-scale technique.The results demonstrate that FG layers enable control of the overweight and dynamic response amplitude,with positive power law indexes reducing weight.Comparisons with finite element results confirm the accuracy of the proposed formulation. 展开更多
关键词 functionally graded(FG)auxetic beam nonlinear forced vibration closedform solution multiple-scale method first-order shear deformation theory(FSDT)
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Core GRADE方法学体系:GRADE证据质量评价与指南制定核心方法
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作者 曾力楠 贺彤 +9 位作者 李海龙 邹锟 杨春松 刁莎 刘丹 陈哲 倪晓凤 程晓 陈婧婧 张伶俐 《中国医院用药评价与分析》 2025年第11期1281-1285,1290,共6页
为解决推荐分级的评估、制订与评价(GRADE)分级标准在应用过程中出现的操作日趋复杂、方法间不一致的问题,有必要制定更为简洁、高效的证据质量评价体系,Core GRADE方法学体系应运而生。Core GRADE方法学体系提供了临床问题构建方法、... 为解决推荐分级的评估、制订与评价(GRADE)分级标准在应用过程中出现的操作日趋复杂、方法间不一致的问题,有必要制定更为简洁、高效的证据质量评价体系,Core GRADE方法学体系应运而生。Core GRADE方法学体系提供了临床问题构建方法、证据质量评价方法(包括证据质量评价目标判定,证据不精确性、不一致性、偏倚风险、间接性、发表偏倚的评价方法)及从证据到推荐意见形成方法。同时,Core GRADE方法学体系建议使用结果总结表对证据进行汇总,并介绍了指南制定者与卫生技术评估者将证据转化为推荐意见或决策的核心方法。Core GRADE方法学体系为系统评价、临床指南及卫生技术评估中的证据质量评价与推荐意见形成提供了更高效、实用的方法。 展开更多
关键词 grade 系统评价 临床指南 卫生技术评估 证据质量 推荐意见
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Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma:Comparison with conventional diffusion-weighted imaging 被引量:38
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作者 Shao-Cheng Zhu Yue-Hua Liu +4 位作者 Yi Wei Lin-Lin Li She-Wei Dou Ting-Yi Sun Da-Peng Shi 《World Journal of Gastroenterology》 SCIE CAS 2018年第8期929-940,共12页
AIM To compare intravoxel incoherent motion(IVIM)-derived parameters with conventional diffusion-weighted imaging(DWI) parameters in predicting the histological grade of hepatocellular carcinoma(h CC) and to evaluate ... AIM To compare intravoxel incoherent motion(IVIM)-derived parameters with conventional diffusion-weighted imaging(DWI) parameters in predicting the histological grade of hepatocellular carcinoma(h CC) and to evaluate the correlation between the parameters and the histological grades.METHODS A retrospective study was performed. Sixty-two patients with surgically confirmed h CCs underwent diffusion-weighted magnetic resonance imaging with twelve b values(10-1200 s/mm^2). The apparent diffusion coefficient(ADC), pure diffusion coefficient(D), pseudo-diffusion coefficient(D*), and perfusion fraction(f) were calculated by two radiologists. The IVIM and conventional DWI parameters were compared among the different grades by using analysis of variance(ANOVA) and the Kruskal-Wallis test. Receiver operating characteristic(ROC) analysis was performed to evaluate the diagnostic efficiency of distinguishing between low-grade(grade 1, G1) and high-grade(grades 2 and 3, G2 and G3) hC C. The correlation between the parameters and the histological grades was assessed by using the Spearman correlation test. Bland-Altman analysis was used to evaluate the reproducibility of the two radiologists' measurements.RESULTS The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of HCCs were statistically significant(P < 0.001). The D* and f values had no significant differences among the different histological grades of h CC(P > 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performance in differentiating the low-grade h CC from the high-grade h CC, with areas under the curve(AUCs) of 0.909 and 0.843, respectively, measured by radiologist 1 and of 0.911 and 0.852, respectively, measured by radiologist 2. The following significant correlations were obtained between the ADC, D, and D~* values and the histological grades: r =-0.619(P < 0.001), r =-0.628(P < 0.001), and r =-0.299(P = 0.018), respectively, as measured by radiologist 1; r =-0.622(P < 0.001), r =-0.633(P < 0.001), and r =-0.303(P = 0.017), respectively, as measured by radiologist 2. The intra-class correlation coefficient(ICC) values between the two observers were 0.996 for ADC, 0.997 for D, 0.996 for D*, and 0.992 for f values, which indicated excellent interobserver agreement in the measurements between the two observers.CONCLUSION The IVIM-derived D and ADC values show better diagnostic performance in differentiating high-grade hC C from low-grade hC C, and there is a moderate to good correlation between the ADC and D values and the histological grades. 展开更多
关键词 Intravoxel INCOHERENT motion Diffusionweighted imaging HEPATOCELLULAR CARCINOMA PATHOLOGICAL DIFFERENTIATION grade
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Optimum Weight Design of Functionally Graded Material Gears 被引量:8
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作者 JING Shikai ZHANG He +1 位作者 ZHOU Jingtao SONG Guohua 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第6期1186-1193,共8页
Traditional gear weight optimization methods consider gear tooth number, module, face width or other dimension parameters of gear as design variables. However, due to the complicated form and geometric features peculi... Traditional gear weight optimization methods consider gear tooth number, module, face width or other dimension parameters of gear as design variables. However, due to the complicated form and geometric features peculiar to the gear, there will be large amounts of design parameters in gear design, and the influences of gear parameters changing on gear trains, transmission system and the whole equipment have to be taken into account, which increases the complexity of optimization problem. This paper puts forward to apply functionally graded materials(FGMs) to gears and then conduct the optimization. According to the force situation of gears, the material distribution form of FGM gears is determined. Then based on the performance parameters analysis of FGMs and the practical working demands for gears, a multi-objective optimization model is formed. Finally by using the goal driven optimization(GDO) method, the optimal material distribution is achieved, which makes gear weight and the maximum deformation be minimum and the maximum bending stress do not exceed the allowable stress. As an example, the applying of FGM to automotive transmission gear is conducted to illustrate the optimization design process and the result shows that under the condition of keeping the normal working performance of gear, the method achieves in greatly reducing the gear weight. This research proposes a FGM gears design method that is able to largely reduce the weight of gears by optimizing the microscopic material parameters instead of changing the macroscopic dimension parameters of gears, which reduces the complexity of gear weight optimization problem. 展开更多
关键词 GEARS optimum weight design functionally graded materials material distribution additive manufacturing
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Lightweight topology optimization of graded lattice structures with displacement constraints based on an independent continuous mapping method 被引量:4
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作者 Nan Wei Hongling Ye +2 位作者 Xing Zhang Weiwei Wang Yunkang Sui 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2022年第4期128-138,I0003,共12页
This paper presents a novel topology optimization method to design graded lattice structures to minimize the volume subject to displacement constraints based on the independent continuous mapping(ICM)method.First,the ... This paper presents a novel topology optimization method to design graded lattice structures to minimize the volume subject to displacement constraints based on the independent continuous mapping(ICM)method.First,the effective elastic properties of graded unit cells are analyzed by the strain energy-based homogenization method.A surrogate model using quartic polynomial interpolation is built to map the independent continuous topological variable to the effective elastic matrix of the unit cell and set up the relationship between the macroscale structure and microscale unit cells.Second,a lightweight topology optimization model is established,which can be transformed into an explicitly standard quadratic programming problem by sensitivity analysis and solved by dual sequential quadratic programming.Third,several numerical examples demonstrate that graded lattice structures have a better lightweight effect than uniform lattice structures,which validates the effectiveness and feasibility of the proposed method.The results show that graded lattice structures become lighter with increasing displacement constraints.In addition,some diverse topological configurations are obtained.This method provides a reference for the graded lattice structure design and expands the application of the ICM method. 展开更多
关键词 Topology optimization.graded lattice structures ICM method Displacement constraints Effective properties
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Improvement of Grain Size and Dome Height of Microalloyed Steels Using Taguchi Method Based on Grey Relational Grade in Controlled Rolling 被引量:2
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作者 Mohsen Ayaz Daavood Mirahmadi Khaki Nasrollah Bani Mostafa Arab 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2013年第12期115-123,共9页
An efficient approach was introduced for improving the condition of major controlled rolling process pa- rameters of roughing, finishing and coiling temperatures and optimizing these parameters to obtain minimum grain... An efficient approach was introduced for improving the condition of major controlled rolling process pa- rameters of roughing, finishing and coiling temperatures and optimizing these parameters to obtain minimum grain size and maximum dome height simultaneously. Taguchi method combined with grey relational analysis was applied to achieve optimum grain size and dome height during controlled rolling process. For this purpose, four levels for the above temperatures were chosen and sixteen experiments were conducted based on orthogonal array of Taguchi meth- od. Based on Taguchi approach, signal-to-noise (S/N) ratios were calculated and used in order to obtain the opti- mum levels for every input parameter. Analysis of variance revealed that finishing and coiling temperatures have the maximum effect on the grain size and dome height of microalloyed steels. The confirmation tests with the optimal levels of parameters indicated that the grain size and dome height of controlled rolled microalloyed steels can be im- proved effectively through this approach. 展开更多
关键词 controlled rolling microalloyed steel dome height grain size Taguchi method grey relational grade
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A Note on the Height of Transitive Depth-One Graded Lie Algebras Generated by Their Local Parts
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作者 Thomas B. Gregory 《Advances in Pure Mathematics》 2014年第6期242-243,共2页
For a transitive depth-one graded Lie algebra over a field of characteristic greater than two, a limit on the degree of the highest gradation space is determined.
关键词 gradeD LIE ALGEBRAS
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加载口服中成药干预冠状动脉慢血流现象的Meta分析及GRADE证据评价
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作者 陈佳萍 商钰 +4 位作者 刘红旭 来晓磊 李享 尚菊菊 周慧文 《中西医结合心脑血管病杂志》 2025年第6期801-811,共11页
目的:系统评价加载口服中成药干预冠状动脉慢血流现象(CSFP)的疗效与安全性。方法:通过检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、EMbase、the Cochrane Library、Wed of Science数据库自建库至2022年12月1日收录的... 目的:系统评价加载口服中成药干预冠状动脉慢血流现象(CSFP)的疗效与安全性。方法:通过检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、EMbase、the Cochrane Library、Wed of Science数据库自建库至2022年12月1日收录的加载口服中成药干预CSFP病人的随机对照试验。采用Cochrane偏倚风险评估工具及改良Jadad量表评价文献质量。采用RevMan 5.3及Stata 17.0对主要结局指标[校正的心肌梗死溶栓试验帧数(cTFC)、心肌梗死溶栓试验(TIMI)血流3级发生率、冠状动脉微血管阻力指数(IMR)]、次要结局指标[超敏C反应蛋白(hs-CRP)、西雅图心绞痛量表(SAQ)评分]及不良反应发生率进行Meta分析。应用GRADEpro GDT评价证据质量。结果:共纳入20项研究,涉及1417例病人。纳入研究的文献质量普遍较低。Meta分析结果显示,与对照组比较,试验组cTFC[MD=-8.57,95%C(I-12.60,-4.54),P<0.0001]、IMR[MD=-4.15,95%C(I-5.60,-2.69),P<0.00001]和hs-CRP[MD=-1.57,95%C(I-1.81,-1.33),P<0.00001]降低,TIMI血流3级发生率[RR=2.04,95%C(I 1.66,2.50),P<0.00001]和SAQ评分[MD=67.93,95%C(I 54.24,81.63),P<0.00001]增加。安全性方面,两组不良反应发生率比较,差异无统计学意义(P>0.05)。GRADE分级显示TIMI血流3级发生率为中级,cTFC、hs-CRP、SAQ评分、不良反应发生率为低级,IMR为极低级。结论:现有证据表明,与西医常规治疗相比,加载口服中成药可进一步改善CSFP病人的冠状动脉血流、冠状动脉微血管功能及生活质量,抑制炎症反应。 展开更多
关键词 冠状动脉慢血流现象 中成药 校正的心肌梗死溶栓试验帧数 冠状动脉微血管阻力指数 META分析 grade分级
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