期刊文献+
共找到28,575篇文章
< 1 2 250 >
每页显示 20 50 100
脑深部电刺激伏隔核对海洛因成瘾者抑制控制功能的影响:基于Go/NoGo任务的事件相关电位研究
1
作者 边仁杰 李婉 葛顺楠 《空军军医大学学报》 2026年第2期256-262,共7页
目的探讨脑深部电刺激术(DBS)对药物成瘾患者抑制控制功能的影响。方法采用64导联脑电记录系统,在视觉Go/NoGo任务中对DBS术前和术后患者进行事件相关电位监测,分析N2、P3成分的幅值与潜伏期。结果在8名患者的自身前后对照中,N2潜伏期... 目的探讨脑深部电刺激术(DBS)对药物成瘾患者抑制控制功能的影响。方法采用64导联脑电记录系统,在视觉Go/NoGo任务中对DBS术前和术后患者进行事件相关电位监测,分析N2、P3成分的幅值与潜伏期。结果在8名患者的自身前后对照中,N2潜伏期的抑制效应在PZ电极上有显著差异(P<0.05)。术前与术后组间P3波幅比较显示,FZ电极存在显著差异(P<0.05);抑制效应在FZ、FCZ、CZ电极上的术前与术后组均差异显著(P<0.05)。P3潜伏期方面,Lapse(术后复吸)在PZ电极的NoGo-P3潜伏期上存在显著差异(P<0.05)。在15例患者的组间对照中,与Go刺激相比,前部脑区(FZ、FCZ、CZ)NoGo刺激诱发的P3波幅更大(P<0.05),这与P3成分参与反应抑制的作用相符。P3d波幅在术前与术后组间显著差异(P<0.05),术后NoGo-P3d波幅高于术前;未复吸患者的P3d波幅大于复吸患者(P<0.05)。结论DBS-NAc治疗可在一定程度上改善海洛因成瘾患者的抑制控制功能,为阐明DBS术后认知功能变化的神经生理机制提供了证据。 展开更多
关键词 脑深部电刺激 物质相关障碍 海洛因依赖 抑制 心理 go/nogo任务 事件相关电位 P300 神经生理学 伏隔核
暂未订购
小麦GSK激酶TaSK41的功能分析及互作蛋白的筛选
2
作者 李灿 张喜伟 +1 位作者 朱博涛 张沛沛 《作物学报》 北大核心 2026年第3期677-687,共11页
植物糖原合成激酶3(GSK3)家族成员SK41在籽粒发育和粒重形成过程中发挥重要作用。为进一步探究TaSK41调控小麦籽粒发育的生物学功能及其潜在的分子机制,本研究分析了TaSK41在不同组织中的表达模式、亚细胞定位、过表达Ta SK41水稻的籽... 植物糖原合成激酶3(GSK3)家族成员SK41在籽粒发育和粒重形成过程中发挥重要作用。为进一步探究TaSK41调控小麦籽粒发育的生物学功能及其潜在的分子机制,本研究分析了TaSK41在不同组织中的表达模式、亚细胞定位、过表达Ta SK41水稻的籽粒表型,以及与TaSK41相互作用的蛋白。q RT-PCR分析表明, Ta SK41在各个组织中均有表达,其中在穗部、早期发育的籽粒、子房以及种皮中的表达量较高。亚细胞定位显示, TaSK41-GFP融合蛋白主要定位于细胞质和细胞核中。Ta SK41过表达转基因水稻株系的千粒重显著降低,粒长和粒宽均显著减小。通过酵母双杂交系统筛选小麦籽粒cDNA文库,共获得17个可能与TaSK41相互作用的候选蛋白。进一步对TaSK41与调控籽粒发育相关基因TaARF4和Ta BSK3的全长互作验证,结果显示, TaSK41能够与小麦生长素响应因子TaARF4的全长蛋白发生相互作用。利用荧光素酶互补系统在体内对其互作关系进行了验证,结果表明, TaSK41-nLUC与TaARF4-cLUC共转化烟草叶片,可观察到荧光信号,这表明它们在体内确实存在互作关系。本研究结果为深入解析Ta SK41调控小麦粒重形成的分子机制提供了重要理论依据。 展开更多
关键词 小麦 粒重 task41 酵母双杂交 互作蛋白
在线阅读 下载PDF
The Continuation Task and the Model-as-Feedback Writing Task in L2 Writing Development:Timing of Model Texts
3
作者 Xiaoyan Zhang 《Chinese Journal of Applied Linguistics》 2026年第1期76-91,160,共17页
This study compares the relative efficacy of the continuation task and the model-as-feedbackwriting (MAFW) task in EFL writing development. Ninety intermediate-level Chinese EFL learnerswere randomly assigned to a con... This study compares the relative efficacy of the continuation task and the model-as-feedbackwriting (MAFW) task in EFL writing development. Ninety intermediate-level Chinese EFL learnerswere randomly assigned to a continuation group, a MAFW group, and a control group, each with30 learners. A pretest and a posttest were used to gauge L2 writing development. Results showedthat the continuation task outperformed the MAFW task not only in enhancing the overall qualityof L2 writing, but also in promoting the quality of three components of L2 writing, namely, content,organization, and language. The finding has important implications for L2 writing teaching andlearning. 展开更多
关键词 continuation task model-as-feedback writing task L2 writing development timing of model texts
在线阅读 下载PDF
MDMOSA:Multi-Objective-Oriented Dwarf Mongoose Optimization for Cloud Task Scheduling
4
作者 Olanrewaju Lawrence Abraham Md Asri Ngadi +1 位作者 Johan Bin Mohamad Sharif Mohd Kufaisal Mohd Sidik 《Computers, Materials & Continua》 2026年第3期2062-2096,共35页
Task scheduling in cloud computing is a multi-objective optimization problem,often involving conflicting objectives such as minimizing execution time,reducing operational cost,and maximizing resource utilization.Howev... Task scheduling in cloud computing is a multi-objective optimization problem,often involving conflicting objectives such as minimizing execution time,reducing operational cost,and maximizing resource utilization.However,traditional approaches frequently rely on single-objective optimization methods which are insufficient for capturing the complexity of such problems.To address this limitation,we introduce MDMOSA(Multi-objective Dwarf Mongoose Optimization with Simulated Annealing),a hybrid that integrates multi-objective optimization for efficient task scheduling in Infrastructure-as-a-Service(IaaS)cloud environments.MDMOSA harmonizes the exploration capabilities of the biologically inspired Dwarf Mongoose Optimization(DMO)with the exploitation strengths of Simulated Annealing(SA),achieving a balanced search process.The algorithm aims to optimize task allocation by reducing makespan and financial cost while improving system resource utilization.We evaluate MDMOSA through extensive simulations using the real-world Google Cloud Jobs(GoCJ)dataset within the CloudSim environment.Comparative analysis against benchmarked algorithms such as SMOACO,MOTSGWO,and MFPAGWO reveals that MDMOSA consistently achieves superior performance in terms of scheduling efficiency,cost-effectiveness,and scalability.These results confirm the potential of MDMOSA as a robust and adaptable solution for resource scheduling in dynamic and heterogeneous cloud computing infrastructures. 展开更多
关键词 Cloud computing MULTI-OBJECTIVE task scheduling dwarf mongoose optimization METAHEURISTIC
在线阅读 下载PDF
Unpacking the Role of Grammarly in Iterative Continuation Tasks to Develop L2 Grammar Learning Strategies,Grit,and Competence
5
作者 Jianling Zhan Chuyi Zhou 《Chinese Journal of Applied Linguistics》 2026年第1期112-132,161,共22页
The iterative continuation task(ICT)requires English as a foreign language(EFL)learners to read a segment and write a continuation that aligns with the preceding segment of an English novel with successive turns,offer... The iterative continuation task(ICT)requires English as a foreign language(EFL)learners to read a segment and write a continuation that aligns with the preceding segment of an English novel with successive turns,offering exposure to diverse grammatical structures and opportunities for contextualized usage.Given the importance of integrating technology into second language(L2)writing and the critical role that grammar plays in L2 writing development,automated written corrective feedback provided by Grammarly has gained significant attention.This study investigates the impact of Grammarly on grammar learning strategies,grammar grit,and grammar competence among EFL college students engaged in ICT.This study employed a mixed-methods sequential exploratory design;56 participants were divided into an experimental group(n=28),receiving Grammarly feedback for ICT,and a control group(n=28),completing ICT without Grammarly feedback.Quantitative results revealed that both groups showed improvements in L2 grammar learning strategies,grit and competence.For the experimental group,significant differences were observed across all variables of L2 grammar learning strategies,grit,and competence between pre-and post-tests.For the control group,significant differences were only observed in the affective dimension of grammar learning strategies,Consistency of Interest(COI)of grammar grit,and grammar competence.However,the control group presented a significantly higher improvement in grammar competence.Qualitative analysis showed both positive and negative perceptions of Grammarly.The pedagogical implications of integrating Grammarly and ICT for L2 grammar development are discussed. 展开更多
关键词 grammar learning strategies grammar grit grammar competence iterative continuation tasks Grammarly
在线阅读 下载PDF
DRL-Based Task Scheduling and Trajectory Control for UAV-Assisted MEC Systems
6
作者 Sai Xu Jun Liu +1 位作者 Shengyu Huang Zhi Li 《Computers, Materials & Continua》 2026年第3期1349-1364,共16页
In scenarios where ground-based cloud computing infrastructure is unavailable,unmanned aerial vehicles(UAVs)act as mobile edge computing(MEC)servers to provide on-demand computation services for ground terminals.To ad... In scenarios where ground-based cloud computing infrastructure is unavailable,unmanned aerial vehicles(UAVs)act as mobile edge computing(MEC)servers to provide on-demand computation services for ground terminals.To address the challenge of jointly optimizing task scheduling and UAV trajectory under limited resources and high mobility of UAVs,this paper presents PER-MATD3,a multi-agent deep reinforcement learning algorithm with prioritized experience replay(PER)into the Centralized Training with Decentralized Execution(CTDE)framework.Specifically,PER-MATD3 enables each agent to learn a decentralized policy using only local observations during execution,while leveraging a shared replay buffer with prioritized sampling and centralized critic during training to accelerate convergence and improve sample efficiency.Simulation results show that PER-MATD3 reduces average task latency by up to 23%,improves energy efficiency by 21%,and enhances service coverage compared to state-of-the-art baselines,demonstrating its effectiveness and practicality in scenarios without terrestrial networks. 展开更多
关键词 Mobile edge computing deep reinforcement learning task offloading resource allocation trajectory control
在线阅读 下载PDF
Multi-Objective Enhanced Cheetah Optimizer for Joint Optimization of Computation Offloading and Task Scheduling in Fog Computing
7
作者 Ahmad Zia Nazia Azim +5 位作者 Bekarystankyzy Akbayan Khalid J.Alzahrani Ateeq Ur Rehman Faheem Ullah Khan Nouf Al-Kahtani Hend Khalid Alkahtani 《Computers, Materials & Continua》 2026年第3期1559-1588,共30页
The cloud-fog computing paradigm has emerged as a novel hybrid computing model that integrates computational resources at both fog nodes and cloud servers to address the challenges posed by dynamic and heterogeneous c... The cloud-fog computing paradigm has emerged as a novel hybrid computing model that integrates computational resources at both fog nodes and cloud servers to address the challenges posed by dynamic and heterogeneous computing networks.Finding an optimal computational resource for task offloading and then executing efficiently is a critical issue to achieve a trade-off between energy consumption and transmission delay.In this network,the task processed at fog nodes reduces transmission delay.Still,it increases energy consumption,while routing tasks to the cloud server saves energy at the cost of higher communication delay.Moreover,the order in which offloaded tasks are executed affects the system’s efficiency.For instance,executing lower-priority tasks before higher-priority jobs can disturb the reliability and stability of the system.Therefore,an efficient strategy of optimal computation offloading and task scheduling is required for operational efficacy.In this paper,we introduced a multi-objective and enhanced version of Cheeta Optimizer(CO),namely(MoECO),to jointly optimize the computation offloading and task scheduling in cloud-fog networks to minimize two competing objectives,i.e.,energy consumption and communication delay.MoECO first assigns tasks to the optimal computational nodes and then the allocated tasks are scheduled for processing based on the task priority.The mathematical modelling of CO needs improvement in computation time and convergence speed.Therefore,MoECO is proposed to increase the search capability of agents by controlling the search strategy based on a leader’s location.The adaptive step length operator is adjusted to diversify the solution and thus improves the exploration phase,i.e.,global search strategy.Consequently,this prevents the algorithm from getting trapped in the local optimal solution.Moreover,the interaction factor during the exploitation phase is also adjusted based on the location of the prey instead of the adjacent Cheetah.This increases the exploitation capability of agents,i.e.,local search capability.Furthermore,MoECO employs a multi-objective Pareto-optimal front to simultaneously minimize designated objectives.Comprehensive simulations in MATLAB demonstrate that the proposed algorithm obtains multiple solutions via a Pareto-optimal front and achieves an efficient trade-off between optimization objectives compared to baseline methods. 展开更多
关键词 Computation offloading task scheduling cheetah optimizer fog computing optimization resource allocation internet of things
在线阅读 下载PDF
Dynamic Reconnaissance Task Planning for Multi-UAV Based on Learning-Enhanced Pigeon-Inspired Optimization
8
作者 Yalan Peng Haibin Duan 《Journal of Beijing Institute of Technology》 2026年第1期53-62,共10页
In dynamic and uncertain reconnaissance missions,effective task assignment and path planning for multiple unmanned aerial vehicles(UAVs)present significant challenges.A stochastic multi-UAV reconnaissance scheduling p... In dynamic and uncertain reconnaissance missions,effective task assignment and path planning for multiple unmanned aerial vehicles(UAVs)present significant challenges.A stochastic multi-UAV reconnaissance scheduling problem is formulated as a combinatorial optimization task with nonlinear objectives and coupled constraints.To solve the non-deterministic polynomial(NP)-hard problem efficiently,a novel learning-enhanced pigeon-inspired optimization(L-PIO)algorithm is proposed.The algorithm integrates a Q-learning mechanism to dynamically regulate control parameters,enabling adaptive exploration–exploitation trade-offs across different optimization phases.Additionally,geometric abstraction techniques are employed to approximate complex reconnaissance regions using maximum inscribed rectangles and spiral path models,allowing for precise cost modeling of UAV paths.The formal objective function is developed to minimize global flight distance and completion time while maximizing reconnaissance priority and task coverage.A series of simulation experiments are conducted under three scenarios:static task allocation,dynamic task emergence,and UAV failure recovery.Comparative analysis with several updated algorithms demonstrates that L-PIO exhibits superior robustness,adaptability,and computational efficiency.The results verify the algorithm's effectiveness in addressing dynamic reconnaissance task planning in real-time multi-UAV applications. 展开更多
关键词 unmanned aerial vehicle(UAV) pigeon-inspired optimization reinforcement learning dynamic task planning coverage path planning
在线阅读 下载PDF
Energy Aware Task Scheduling of IoT Application Using a Hybrid Metaheuristic Algorithm in Cloud Computing
9
作者 Ahmed Awad Mohamed Eslam Abdelhakim Seyam +4 位作者 Ahmed R.Elsaeed Laith Abualigah Aseel Smerat Ahmed M.AbdelMouty Hosam E.Refaat 《Computers, Materials & Continua》 2026年第3期1786-1803,共18页
In recent years,fog computing has become an important environment for dealing with the Internet of Things.Fog computing was developed to handle large-scale big data by scheduling tasks via cloud computing.Task schedul... In recent years,fog computing has become an important environment for dealing with the Internet of Things.Fog computing was developed to handle large-scale big data by scheduling tasks via cloud computing.Task scheduling is crucial for efficiently handling IoT user requests,thereby improving system performance,cost,and energy consumption across nodes in cloud computing.With the large amount of data and user requests,achieving the optimal solution to the task scheduling problem is challenging,particularly in terms of cost and energy efficiency.In this paper,we develop novel strategies to save energy consumption across nodes in fog computing when users execute tasks through the least-cost paths.Task scheduling is developed using modified artificial ecosystem optimization(AEO),combined with negative swarm operators,Salp Swarm Algorithm(SSA),in order to competitively optimize their capabilities during the exploitation phase of the optimal search process.In addition,the proposed strategy,Enhancement Artificial Ecosystem Optimization Salp Swarm Algorithm(EAEOSSA),attempts to find the most suitable solution.The optimization that combines cost and energy for multi-objective task scheduling optimization problems.The backpack problem is also added to improve both cost and energy in the iFogSim implementation as well.A comparison was made between the proposed strategy and other strategies in terms of time,cost,energy,and productivity.Experimental results showed that the proposed strategy improved energy consumption,cost,and time over other algorithms.Simulation results demonstrate that the proposed algorithm increases the average cost,average energy consumption,and mean service time in most scenarios,with average reductions of up to 21.15%in cost and 25.8%in energy consumption. 展开更多
关键词 Energy-efficient tasks internet of things(IoT) cloud fog computing artificial ecosystem-based optimization salp swarm algorithm cloud computing
在线阅读 下载PDF
高血压脑出血血清Nogo-A、Adropin、CysC水平与近期预后的关系分析 被引量:2
10
作者 吴中华 王炬 +1 位作者 娄平阳 王成光 《罕少疾病杂志》 2025年第5期25-26,共2页
目的探究高血压脑出血患者血清神经轴突生长抑制因子A(Nogo-A)、Adropin、胱抑素C(Cys C)水平的检测意义。方法80例高血压脑出血患者被纳入本院治疗作为研究组,另选取42例单纯高血压患者为对照组。比较两组血清Nogo-A、Adropin和Cys C水... 目的探究高血压脑出血患者血清神经轴突生长抑制因子A(Nogo-A)、Adropin、胱抑素C(Cys C)水平的检测意义。方法80例高血压脑出血患者被纳入本院治疗作为研究组,另选取42例单纯高血压患者为对照组。比较两组血清Nogo-A、Adropin和Cys C水平,根据改良Rankin量表将研究组分为预后良好组(n=49)及预后不良组(n=31),并对上述指标进行比较,以Logistic回归分析对上述指标与患者近期预后的关系进行分析。结果研究组Nogo-A、Cys C水平高于对照组,Adropin水平低于对照组,差异显著(P<0.05)。预后不良组Nogo-A、Cys C水平高于预后良好组,Adropin水平低于预后良好组,差异显著(P<0.05)。NogoA≥157.918ng/m L、Adropin<2.068ng/m L、Cys C<2.354mg/L是预测患者预后不良的危险因素。结论血清Nogo-A、Cys C、Adropin均与高血压脑出血的发生及出血量有密切关联,且三者对患者预后均有预测价值。 展开更多
关键词 高血压脑出血 神经轴突生长抑制因子A Adropin蛋白 胱抑素C
暂未订购
基于Nogo-B/RhoA信号通路研究左金丸对DSS诱导溃疡性结肠炎小鼠巨噬细胞极化的作用及机制
11
作者 曾诚 刘璐 +5 位作者 申盼 吕旭涵 张彩霞 张磊昌 王海燕 葛巍 《药物评价研究》 北大核心 2025年第12期3428-3438,共11页
目的观察左金丸对葡聚糖硫酸钠(DSS)诱导溃疡性结肠炎小鼠巨噬细胞极化和Nogo-B/RhoA信号通路的影响。方法将40只C57BL/6J雄性小鼠随机分为对照组、模型组、左金丸(0.3 g·kg^(-1))组及美沙拉嗪肠溶片(5-ASA,300 mg·kg^(-1))组... 目的观察左金丸对葡聚糖硫酸钠(DSS)诱导溃疡性结肠炎小鼠巨噬细胞极化和Nogo-B/RhoA信号通路的影响。方法将40只C57BL/6J雄性小鼠随机分为对照组、模型组、左金丸(0.3 g·kg^(-1))组及美沙拉嗪肠溶片(5-ASA,300 mg·kg^(-1))组,每组10只。除对照组外,其余各组采用“2.3%DSS(第1~7天)—自由饮水(第8~14天)—2.3%DSS(第15~21天)”制备小鼠实验性结肠炎模型。造模第8天开始ig给药,持续14 d。每天定时监测小鼠体质量,计算每日疾病活动指数(DAI);造模第22天,观察小鼠一般情况和结肠病理变化;采用酶联免疫吸附试验(ELISA)检测小鼠结肠组织肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)和白细胞介素-10(IL-10)含量;采用流式细胞术检测结肠组织CD11b^(+)F4/80^(+)细胞中MHC-Ⅱ^(+)、CD64^(+)、CD206^(+)、CD209^(+)表达水平;采用Western blotting法测定结肠组织内质网膜蛋白4B(Nogo-B)、Rho关联含卷曲螺旋结合蛋白激酶1(Rock1)和Ras同源家族成员A(RhoA)蛋白表达水平;采用实时荧光定量PCR(q RT-PCR)法测定结肠组织Nogo-B和RhoA m RNA表达水平。结果与模型组比较,左金丸显著改善DSS诱导结肠炎小鼠体质量降低、DAI升高、结肠长度降低、结肠质量降低、结肠指数升高、病理损伤评分升高(P<0.05、0.01);降低结肠组织TNF-α、IL-1β、CD11b^(+)F4/80^(+)MHC-Ⅱ^(+)、CD11b^(+)F4/80^(+)CD64^(+)细胞水平,以及Nogo-B、RhoA、Rock1蛋白和m RNA的表达(P<0.05、0.01);同时提高IL-10、TGF-β1、CD11b^(+)F4/80^(+)CD206^(+)、CD11b^(+)F4/80^(+)CD209^(+)细胞水平(P<0.05、0.01)。结论左金丸对DSS诱导小鼠结肠炎具有明显缓解作用,其作用机制可能与抑制Nogo-B/RhoA信号通路,调控巨噬细胞M1/M2极化,进而恢复促炎/抗炎因子平衡相关。 展开更多
关键词 左金丸 巨噬细胞M1/M2极化 nogo-B/RhoA信号通路 溃疡性结肠炎
原文传递
Dynamic Task Offloading Scheme for Edge Computing via Meta-Reinforcement Learning 被引量:1
12
作者 Jiajia Liu Peng Xie +2 位作者 Wei Li Bo Tang Jianhua Liu 《Computers, Materials & Continua》 2025年第2期2609-2635,共27页
As an important complement to cloud computing, edge computing can effectively reduce the workload of the backbone network. To reduce latency and energy consumption of edge computing, deep learning is used to learn the... As an important complement to cloud computing, edge computing can effectively reduce the workload of the backbone network. To reduce latency and energy consumption of edge computing, deep learning is used to learn the task offloading strategies by interacting with the entities. In actual application scenarios, users of edge computing are always changing dynamically. However, the existing task offloading strategies cannot be applied to such dynamic scenarios. To solve this problem, we propose a novel dynamic task offloading framework for distributed edge computing, leveraging the potential of meta-reinforcement learning (MRL). Our approach formulates a multi-objective optimization problem aimed at minimizing both delay and energy consumption. We model the task offloading strategy using a directed acyclic graph (DAG). Furthermore, we propose a distributed edge computing adaptive task offloading algorithm rooted in MRL. This algorithm integrates multiple Markov decision processes (MDP) with a sequence-to-sequence (seq2seq) network, enabling it to learn and adapt task offloading strategies responsively across diverse network environments. To achieve joint optimization of delay and energy consumption, we incorporate the non-dominated sorting genetic algorithm II (NSGA-II) into our framework. Simulation results demonstrate the superiority of our proposed solution, achieving a 21% reduction in time delay and a 19% decrease in energy consumption compared to alternative task offloading schemes. Moreover, our scheme exhibits remarkable adaptability, responding swiftly to changes in various network environments. 展开更多
关键词 Edge computing adaptive META task offloading joint optimization
在线阅读 下载PDF
Nogo-B受体在肺腺癌的表达及其与表皮生长因子受体相关靶向治疗的协同作用研究
13
作者 吴雨晗 王蓓 +2 位作者 王秀红 李洁 钟定荣 《中日友好医院学报》 2025年第3期148-152,F0004,共6页
目的:探讨Nogo-B受体(NgBR)在肺腺癌中的表达特征,评估其在肺腺癌发生发展及表皮生长因子受体(EGFR)靶向治疗耐药中的潜在作用。方法:回顾性研究2016年1月—2020年12月间于中日友好医院接受手术切除且术后病理确诊为肺腺癌的病例。纳入... 目的:探讨Nogo-B受体(NgBR)在肺腺癌中的表达特征,评估其在肺腺癌发生发展及表皮生长因子受体(EGFR)靶向治疗耐药中的潜在作用。方法:回顾性研究2016年1月—2020年12月间于中日友好医院接受手术切除且术后病理确诊为肺腺癌的病例。纳入200例,通过免疫组化和RT-PCR技术检测NgBR和Nogo-B的表达水平,分析其与免疫标记物及常见驱动基因表达的相关性。另选取10例接受EGFR-酪氨酸激酶抑制剂(EGFR-TKI)治疗的病例,探讨NgBR和Nogo-B表达与治疗耐药的关系。结果:NgBR在肺腺癌细胞中的表达高于正常肺泡上皮细胞和细支气管上皮细胞,Nogo-B的表达亦高于正常肺泡上皮细胞,差异均有统计学意义(均P<0.05)。驱动基因检测显示,NgBR表达与EGFR突变相关(P=0.030)。EGFR-TKI治疗后,肿瘤细胞中NgBR表达上调(P=0.042),而Nogo-B表达无明显变化。结论:NgBR促进肺腺癌的发生,还可能与EGFR突变及耐药性相关,为肺腺癌的治疗提供了新的潜在靶点。 展开更多
关键词 肺腺癌 NgBR 表皮生长因子受体 靶向治疗 耐药
暂未订购
Multi-station multi-robot task assignment method based on deep reinforcement learning 被引量:1
14
作者 Junnan Zhang Ke Wang Chaoxu Mu 《CAAI Transactions on Intelligence Technology》 2025年第1期134-146,共13页
This paper focuses on the problem of multi-station multi-robot spot welding task assignment,and proposes a deep reinforcement learning(DRL)framework,which is made up of a public graph attention network and independent... This paper focuses on the problem of multi-station multi-robot spot welding task assignment,and proposes a deep reinforcement learning(DRL)framework,which is made up of a public graph attention network and independent policy networks.The graph of welding spots distribution is encoded using the graph attention network.Independent policy networks with attention mechanism as a decoder can handle the encoded graph and decide to assign robots to different tasks.The policy network is used to convert the large scale welding spots allocation problem to multiple small scale singlerobot welding path planning problems,and the path planning problem is quickly solved through existing methods.Then,the model is trained through reinforcement learning.In addition,the task balancing method is used to allocate tasks to multiple stations.The proposed algorithm is compared with classical algorithms,and the results show that the algorithm based on DRL can produce higher quality solutions. 展开更多
关键词 attention mechanism deep reinforcement learning graph neural network industrial robot task allocation
在线阅读 下载PDF
Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites
15
作者 Kirsty Goncalves Stefan Przyborski 《Neural Regeneration Research》 SCIE CAS 2025年第9期2645-2654,共10页
Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's disease.The accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is be... Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's disease.The accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is believed to induce neuritic abnormalities,including reduced growth,extension,and abnormal growth cone morphology,all of which contribute to decreased connectivity.However,the precise cellular and molecular mechanisms governing this response remain unknown.In this study,we used an innovative approach to demonstrate the effect of amyloid-βon neurite dynamics in both two-dimensional and three-dimensional cultu re systems,in order to provide more physiologically relevant culture geometry.We utilized various methodologies,including the addition of exogenous amyloid-βpeptides to the culture medium,growth substrate coating,and the utilization of human-induced pluripotent stem cell technology,to investigate the effect of endogenous amyloid-βsecretion on neurite outgrowth,thus paving the way for potential future applications in personalized medicine.Additionally,we also explore the involvement of the Nogo signaling cascade in amyloid-β-induced neurite inhibition.We demonstrate that inhibition of downstream ROCK and RhoA components of the Nogo signaling pathway,achieved through modulation with Y-27632(a ROCK inhibitor)and Ibuprofen(a Rho A inhibitor),respectively,can restore and even enhance neuronal connectivity in the presence of amyloid-β.In summary,this study not only presents a novel culture approach that offers insights into the biological process of neurite growth and inhibition,but also proposes a specific mechanism for reduced neural connectivity in the presence of amyloid-βpeptides,along with potential intervention points to restore neurite growth.Thereby,we aim to establish a culture system that has the potential to serve as an assay for measuring preclinical,predictive outcomes of drugs and their ability to promote neurite outgrowth,both generally and in a patient-specific manner. 展开更多
关键词 Alzheimer's disease induced pluripotent stem cell neurite outgrowth neuron nogo Rho A ROCK stem cell three-dimensional culture
暂未订购
Providing Robust and Low-Cost Edge Computing in Smart Grid:An Energy Harvesting Based Task Scheduling and Resource Management Framework 被引量:1
16
作者 Xie Zhigang Song Xin +1 位作者 Xu Siyang Cao Jing 《China Communications》 2025年第2期226-240,共15页
Recently,one of the main challenges facing the smart grid is insufficient computing resources and intermittent energy supply for various distributed components(such as monitoring systems for renewable energy power sta... Recently,one of the main challenges facing the smart grid is insufficient computing resources and intermittent energy supply for various distributed components(such as monitoring systems for renewable energy power stations).To solve the problem,we propose an energy harvesting based task scheduling and resource management framework to provide robust and low-cost edge computing services for smart grid.First,we formulate an energy consumption minimization problem with regard to task offloading,time switching,and resource allocation for mobile devices,which can be decoupled and transformed into a typical knapsack problem.Then,solutions are derived by two different algorithms.Furthermore,we deploy renewable energy and energy storage units at edge servers to tackle intermittency and instability problems.Finally,we design an energy management algorithm based on sampling average approximation for edge computing servers to derive the optimal charging/discharging strategies,number of energy storage units,and renewable energy utilization.The simulation results show the efficiency and superiority of our proposed framework. 展开更多
关键词 edge computing energy harvesting energy storage unit renewable energy sampling average approximation task scheduling
在线阅读 下载PDF
Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction
17
作者 Shi Li Didi Sun 《Computers, Materials & Continua》 SCIE EI 2025年第1期1069-1086,共18页
With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions... With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying reasons.This comprehension is crucial for making informed strategic decisions in various business and societal contexts.However,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause extraction.To address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment mechanisms.The model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause pairs.Second,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among tasks.The proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 score.Experimental results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its effectiveness.This research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-cause pair extraction.However,the study’s limitation lies in the data sources,potentially restricting the generalizability of the findings. 展开更多
关键词 Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms
在线阅读 下载PDF
Air-to-ground reconnaissance-attack task allocation for heterogeneous UAV swarm 被引量:1
18
作者 LUO Yuelong JIANG Xiuqiang +1 位作者 ZHONG Suchuan JI Yuandong 《Journal of Systems Engineering and Electronics》 2025年第1期155-175,共21页
A task allocation problem for the heterogeneous unmanned aerial vehicle (UAV) swarm in unknown environments is studied in this paper.Considering that the actual mission environment information may be unknown,the UAV s... A task allocation problem for the heterogeneous unmanned aerial vehicle (UAV) swarm in unknown environments is studied in this paper.Considering that the actual mission environment information may be unknown,the UAV swarm needs to detect the environment first and then attack the detected targets.The heterogeneity of UAVs,multiple types of tasks,and the dynamic nature of task environment lead to uneven load and time sequence problems.This paper proposes an improved contract net protocol (CNP) based task allocation scheme,which effectively balances the load of UAVs and improves the task efficiency.Firstly,two types of task models are established,including regional reconnaissance tasks and target attack tasks.Secondly,for regional reconnaissance tasks,an improved CNP algorithm using the uncertain contract is developed.Through uncertain contracts,the area size of the regional reconnaissance task is determined adaptively after this task assignment,which can improve reconnaissance efficiency and resource utilization.Thirdly,for target attack tasks,an improved CNP algorithm using the fuzzy integrated evaluation and the double-layer negotiation is presented to enhance collaborative attack efficiency through adjusting the assignment sequence adaptively and multi-layer allocation.Finally,the effectiveness and advantages of the improved method are verified through comparison simulations. 展开更多
关键词 unmanned aerial vehicle(UAV)swarm reconnaissance-attack coupled task allocation contract net protocol(CNP) fuzzy integrated evaluation double-layer negotiation
在线阅读 下载PDF
Correction to:Overexpression of Tau Rescues Nogo-66-Induced Neurite Outgrowth Inhibition In Vitro
19
作者 Yu-Chao Zuo Hong-Lian Li +4 位作者 Nan-Xiang Xiong Jian-Ying Shen Yi-Zhi Huang Peng Fu Hong-Yang Zhao 《Neuroscience Bulletin》 2025年第9期1710-1710,共1页
Correction to:Neurosci.Bull.December,2016,32(6):577–584.https://doi.org/10.1007/s12264-016-0068-z In this article,in Fig 5A,the picture of the Vector+Nogo-66 group was incorrect and should have appeared as shown below.
关键词 VITRO OVEREXPRESSION neurite outgrowth TAU nogo INHIBITION
原文传递
Nogo-A/NgR通路对经典致幻剂降低小鼠前脉冲抑制反应的影响
20
作者 曲颖 王悦颖 +1 位作者 孙毅 苏瑞斌 《中国药理学通报》 北大核心 2025年第7期1231-1236,共6页
目的探究神经突生长抑制因子A/神经突生长抑制因子受体(neurite outgrowth inhibitor A/neurite outgrowth inhibitor receptor,Nogo-A/NgR)通路对经典致幻剂降低小鼠前脉冲抑制反应的影响。方法小鼠单次腹腔注射经典致幻剂赛洛西宾、2... 目的探究神经突生长抑制因子A/神经突生长抑制因子受体(neurite outgrowth inhibitor A/neurite outgrowth inhibitor receptor,Nogo-A/NgR)通路对经典致幻剂降低小鼠前脉冲抑制反应的影响。方法小鼠单次腹腔注射经典致幻剂赛洛西宾、2,5-二甲氧基-4-碘苯丙胺(DOI)建立前脉冲抑制(prepulse inhibition,PPI)反应降低动物模型。评价Nogo-A抑制剂NEP1-40提前30 min侧脑室注射预防给药对小鼠PPI的影响;评价赛洛西宾、DOI对Rtn4r全身性敲除小鼠PPI的影响。结果提前30 min注射NEP1-40(1 g·L^(-1),每只5μL,i.c.v)不会对小鼠PPI产生影响,在70、75 dB前脉冲刺激条件下,NEP1-40可以明显上调赛洛西宾诱导的小鼠PPI降低,在70、80 dB前脉冲刺激条件下,NEP1-40可以明显上调DOI诱导的小鼠PPI降低;溶剂组Rtn4r^(-/-)小鼠PPI与野生型无差异,与Rtn4r^(-/-)溶剂组小鼠相比,Rtn4r^(-/-)给药组小鼠PPI有降低趋势,但差异无统计学意义,在70 dB前脉冲刺激条件下,Rtn4r^(-/-)小鼠给药组与野生型小鼠给药组差异有统计学意义。结论Nogo-A/NgR通路参与了经典致幻剂赛洛西宾、DOI对小鼠感觉运动门控的破坏过程。 展开更多
关键词 经典致幻剂 动物模型 前脉冲抑制 nogo-A蛋白 NgR受体 Rtn4r基因敲除
暂未订购
上一页 1 2 250 下一页 到第
使用帮助 返回顶部