With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Techn...With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.展开更多
Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembol...Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembolization agents.Herein,we incorporated the superstable homogeneous iodinated formulation technology(SHIFT),simultaneously utilizing an enhanced solvent form in a carbon dioxide supercritical fluid environment,to encapsulate radionuclides(such as^(131)I,^(177)Lu,or^(18)F)with lipiodol for the preparation of radiolipiodol.The resulting radiolipiodol exhibited exceptional stability and ultra-high labeling efficiency(≥99%)and displayed notable intratumoral radionuclide retention and in vivo stability more than 2 weeks following locoregional injection in subcutaneous tumors in mice and orthotopic liver tumors in rats and rabbits.Given these encouraging findings,^(18)F was authorized as a radiotracer in radiolipiodol for clinical trials in HCC patients,and showed a favorable tumor accumulation,with a tumor-to-liver uptake ratio of≥50 and minimal radionuclide leakage,confirming the feasibility of SHIFT for TARE applications.In the context of transforming from preclinical to clinical screening,the preparation of radiolipiodol by SHIFT represents an innovative physical strategy for radionuclide encapsulation.Hence,this work offers a reliable and efficient approach for TARE in HCC,showing considerable promise for clinical application(ChiCTR2400087731).展开更多
文摘With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.
基金supported by the Major State Basic Research Development Program of China(No.2023YFB3810000)the National Natural Science Foundation of China(NSFC)(Nos.82402501,81925019,81801817,82360360,U22A20333 and U24A20525)+3 种基金Natural Science Foundation of Guangxi(No.2023GXNSFAA026023,China)Central Government Guided Local Science and Technology Development Fund Projects(No.2023ZYZX1090,China)Nanchong Science and Technology Bureau basic research platform project(No.23JCYJPT0043,China)China Postdoctoral Science Foundation,(Nos.2023MD734156 and 2024M763915).
文摘Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembolization agents.Herein,we incorporated the superstable homogeneous iodinated formulation technology(SHIFT),simultaneously utilizing an enhanced solvent form in a carbon dioxide supercritical fluid environment,to encapsulate radionuclides(such as^(131)I,^(177)Lu,or^(18)F)with lipiodol for the preparation of radiolipiodol.The resulting radiolipiodol exhibited exceptional stability and ultra-high labeling efficiency(≥99%)and displayed notable intratumoral radionuclide retention and in vivo stability more than 2 weeks following locoregional injection in subcutaneous tumors in mice and orthotopic liver tumors in rats and rabbits.Given these encouraging findings,^(18)F was authorized as a radiotracer in radiolipiodol for clinical trials in HCC patients,and showed a favorable tumor accumulation,with a tumor-to-liver uptake ratio of≥50 and minimal radionuclide leakage,confirming the feasibility of SHIFT for TARE applications.In the context of transforming from preclinical to clinical screening,the preparation of radiolipiodol by SHIFT represents an innovative physical strategy for radionuclide encapsulation.Hence,this work offers a reliable and efficient approach for TARE in HCC,showing considerable promise for clinical application(ChiCTR2400087731).
