In this paper,we study the uniqueness of positive solutions to the following semilinear equations{-Δu=λ|x|^(α)ue^(u^(2)),in B_(1),u=0,onδB_(1)ueu2;in B_(1);u=0;on@B_(1);whereλ>0,α>-2;B_(1)denotes the unit ...In this paper,we study the uniqueness of positive solutions to the following semilinear equations{-Δu=λ|x|^(α)ue^(u^(2)),in B_(1),u=0,onδB_(1)ueu2;in B_(1);u=0;on@B_(1);whereλ>0,α>-2;B_(1)denotes the unit disk in R^(2):By delicate and relatively complicated computation of radial solutions to the above equation and the asymptotic expansion of solutions near the boundary of B_(1),the uniqueness of positive solutions is obtained.The results of this paper extend the uniqueness result for the semilinear equation with critical exponential growth in CHEN et al.(2022)to the case that includes a Henon term.展开更多
Interfacial superconductivity(IS)has been a topic of intense interest in condensed matter physics,due to its unique properties and exotic photoelectrical performance.However,there are few reports about IS systems cons...Interfacial superconductivity(IS)has been a topic of intense interest in condensed matter physics,due to its unique properties and exotic photoelectrical performance.However,there are few reports about IS systems consisting of two insulators.Here,motivated by the emergence of an insulator-metal transition in type-Ⅲ heterostructures and the superconductivity in some“special”two-dimensional(2D)semiconductors via electron doping,we predict that the 2D heterostructure SnSe_(2)/PtTe_(2) is a model system for realizing IS by using firstprinciples calculations.Our results show that due to slight but crucial interlayer charge transfer,SnSe_(2)/PtTe_(2) turns to be a type-Ⅲ heterostructure with metallic properties and shows a superconducting transition with the critical temperature(T_(c))of 3.73 K.Similar to the enhanced electron–phonon coupling(EPC)in the electrondoped SnSe_(2) monolayer,the IS in the SnSe_(2)/PtTe_(2) heterostructure mainly originates from the metallized SnSe_(2) layer.Furthermore,we find that its superconductivity is sensitive to tensile lattice strain,forming a domeshaped superconducting phase diagram.Remarkably,at 7%biaxial tensile strain,the superconducting T_(c) can increase more than twofold(8.80 K),resulting from softened acoustic phonons at the𝑀point and enhanced EPC strength.Our study provides a concrete example for realizing IS in type-Ⅲ heterostructures,which waits for future experimental verification.展开更多
Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and wheth...Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index(BMI).Methods:This retrospective cohort study used electronic health records from the TriNetX U.S.research network.Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis.Following 1:1 propensity score matching,both the GLP-1 RA user and non-user groups included 183,264 patients.The study outcome was defined as a diagnosis of malignant neoplasms.Hazard ratios(HRs)for overall and site-specific cancer risk were estimated using Cox proportional hazards models.Kaplan–Meier analysis and stratified analysis by BMI were performed.Results:Early GLP-1 RA use demonstrated a modest but significant association with reduced overall cancer risk(HR 0.93;95%CI:0.90–0.96).Reduced risks were noted for cancers of the digestive(HR 0.81),respiratory(HR 0.66),and female genital(HR 0.87)systems.In stratified analysis,benefits were more pronounced in patients with BMI≥30,particularly for pancreatic and colorectal cancers.Conclusion:Early initiation of GLP-1 receptor agonists in patients with diagnosed T2DM was associated with a modest reduction in overall cancer risk,particularly among individuals with obesity.These findings highlight the dual metabolic and oncologic value of prompt GLP-1 RA therapy.展开更多
[Objective] The aim was to investigate the effects of fertilizer type on di- rect-seeded rapeseed and to explore effective fertilizing. [Method] Four treatments including different types of fertilizers were set in the...[Objective] The aim was to investigate the effects of fertilizer type on di- rect-seeded rapeseed and to explore effective fertilizing. [Method] Four treatments including different types of fertilizers were set in the test. Growth, photosynthesis and chlorophyll fluorescence parameters at flowering stage such as plant height, stem diameter, shoot and root dry matter, net photosynthesis, light energy conversion effi- ciency （Fv/Fm） and SPAD value, were investigated. The effects of fertilizer treat-ments on the yield of rapeseed were evaluated as well. [Result] Both multi-functional fertilizer and controlled release fertilizer could improve plant height, stem diameter, shoot dry matter, SPAD value, net photosynthesis, non-photochemical quenching （NPQ）, etc., which helped increase yield and stress resistance. [Conclusion] Both multi-functional fertilizer and controlled release fertilizer could improve yield significantly while multi-functional fertilizer （MFF） was better than controlled release fertilizer （CRF）.展开更多
Flowering is essential in any breeding programme, particularly in genetic introgression programmes in which flowering synchronism is required. In this work, 16 sugarcane genotypes were evaluated using three different ...Flowering is essential in any breeding programme, particularly in genetic introgression programmes in which flowering synchronism is required. In this work, 16 sugarcane genotypes were evaluated using three different flowering-inductive photoperiod treatments (30 s, 45 s, and 1 min of a daily photoperiod decrease from 12 h 55 of light). Each genotype was planted in 43 L pots (equal proportion of soil, sand, and substrate) with three tillers per pot. Plants with 4 to 6 internodes were placed in a photoperiod facility with three controlled chambers, each chamber containing all 16 genotypes (one treatment per chamber). The temperature range (21°C to 32°C) and humidity were the same for all of the treatments. The flower induction started in September 2010 and ended in April 2011. The plant elongation and flag leaf and inflorescence emergence were recorded and the pollen viability was evaluated by using the iodine staining method. The photoperiod facility provided suitable conditions for flowering, as the plants in the three treatments successfully flowered. The genotypes in the three treatments behaved differently in relation to the date of panicle emergence, with the treatment of 45 s showing better results. The results here presented contribute to synchronise flowering for desired sugarcane crosses, particularly those from introgression programmes between commercial cultivars and species from the Saccharum complex.展开更多
Plants acclimate to drought optimizing the trade-off between biomass production and water loss while ensuring their survival and reproduction. Plants also modify their growth or phenology as complementary strategies i...Plants acclimate to drought optimizing the trade-off between biomass production and water loss while ensuring their survival and reproduction. Plants also modify their growth or phenology as complementary strategies in response to stress. Despite evidence of an interaction between flowering time and plant growth response to environmental stresses, this interaction in response to drought is under debate. To contribute to the analysis of this interaction, leaf growth of 35 genetically modified lines of Arabidopsis thaliana and their common wild-type, Col-0 was analyzed by a quantitative multi-scale phenotyping approach from cellular to whole plant scale both in well-watered and soil moderate water deficit conditions. These genotypes were selected for the various physiological functions potentially altered by their genetic modification and that could interact with plant growth and/or their drought responses. In all genotypes, leaf expansion decreased in response to drought both at the whole rosette and the individual leaf levels. Additionally, epidermal cell area and/or epidermal cell number decreased in response to the drought treatment. In contrast, the number of rosette leaves was reduced in only half of the genotypes and leaf growth duration was only modified in 4 of them. Despite long photoperiod conditions, the duration of the vegetative phase, i.e. the time elapsed between germination and flowering stage, varied from 12 to 27 days among genotypes under well watered conditions. Our analyses revealed that the differences of flowering time observed in well-watered condition impacted the leaf area response to drought. Early-flowering genotypes slightly decreased their final leaf number, but strongly reduced their individual leaf area compared with the late-flowering ones. This result underlines the difficulty to analyze plant response to environmental stresses when genotypes with different flowering dates are compared.展开更多
OBJECTIVE: To determine the efficacy of a fermented buckwheat flower and leaf extract(EFBFL) for the reduction of blood glucose and lipid dysregulation in spontaneously obese type 2 diabetic db/db mice, and to explore...OBJECTIVE: To determine the efficacy of a fermented buckwheat flower and leaf extract(EFBFL) for the reduction of blood glucose and lipid dysregulation in spontaneously obese type 2 diabetic db/db mice, and to explore the possible mechanisms involved.METHODS: Forty 9-week-old male db/db mice were randomly allocated to a high-dose EFBFL group(EFBFL-H), a low-dose EFBFL group(EFBFL-L),a metformin hydrochloride positive control group(MEG), and a db/db control group(MG), and there was also a db/m negative control group(NCG)(n =10). Oral glucose tolerance tests(OGTT) were performed after 7 weeks of treatment. At the end of 8 weeks of treatment, random blood glucose(RBG),glycosylated hemoglobin(Hb Alc), fasting plasma glucose(FPG), fasting serum insulin(FINS), triglyceride(TG), serum total cholesterol(TC), free fatty acids(FFA), high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol(LDL-c) were measured, the homeostasis model assessment-insulin resistance(HOMA-IR) was calculated. Immunohistochemistry and western blotting measured the expression of glucose transporter4(GLUT4) and peroxisome proliferator-activated receptor γ(PPAR-γ) by in skeletal muscle.RESULTS: The MG mice had a significantly increased in RBG, Hb Alc, the HOMA-IR level, the serum of TG, TC, LDL-c, but a decreased in glucose tolerance and the protein expression of GLUT4 and PPAR-γ compared with the NCG. Compared with the MG, EFBFL groups significantly decreased RBG, Hb Alc, and the HOMA-IR level, increased glucose tolerance. Meanwhile EFBFL groups reduced the serum TG, TC, and LDL-c in a dose-dependent manner. In addition, EFBFL increased the protein expression of GLUT4 and PPAR-γ in the skeletal muscle of db/db mice.There was significant difference between the MG group and EFBFL groups.CONCLUSION: These findings suggest that EFBFL has anti-diabetic effects in db/db mice, ameliorating glucose intolerance, lipid dysregulation, and insulin resistance.展开更多
For the first time, 658 herbarium specimens planted from the 15 decorative flower plants in the conditions of the Tashkent Region were collected. From them, disease separation including of 65 types of fungi 9 form and...For the first time, 658 herbarium specimens planted from the 15 decorative flower plants in the conditions of the Tashkent Region were collected. From them, disease separation including of 65 types of fungi 9 form and 1 variation were determined. They were: 4 classes, 7 sections, 11 families and 30 categories.展开更多
Water insufficiency is the hampering feature of crop sustainability,especially in arid and semi-arid regions.So,the effectual usage of all water resources especially underground brackish water represents the core prio...Water insufficiency is the hampering feature of crop sustainability,especially in arid and semi-arid regions.So,the effectual usage of all water resources especially underground brackish water represents the core priority in Saudi Arabia.The present study aimed to recognize the influence of different types of water irrigation(tap water as a control,salinized well water,and magnetized salinized well water)with or without soil amendments(soil without any amendment as a control,peat-moss,ferrous sulfate,and peat-moss plus ferrous sulfate)on petunia plant growth and flowering as well as ion content.Irrigating Petunia plants with saline well water adversely affected growth and flowering as compared to tap water and magnetized saline well water.Additionally,plants irrigated with magnetized water showed a significant enhancement in all the studied vegetative and flowering growth parameters as compared to those irrigated with salinized well water.Furthermore,mineral contents and survival of Petunia plants irrigated with magnetized well water were higher than those irrigated with tap water.Irrigation with magnetized well water significantly reduced levels of Na+and Cl−ions in leaves of Petunia plants indicating the role of magnetization in alleviating harmful effects of salinity.In conclusion,we recommend the utilization of magnetized saline well water for irrigating Petunia plants either alone or in combination with soil amendments(peat moss plus ferrous sulfate).展开更多
BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and lo...BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain controversial.AIM To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ CC.METHODS This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to 2021.Based on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic control.DFS,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk factors.RESULTS Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.展开更多
Hylocereus polyrhizus,also known as pitaya or dragon fruit,is a climbing cactus grown worldwide because of its excellent performance under drought stress and appealing red-purple fruits.In practice,accelerating flower...Hylocereus polyrhizus,also known as pitaya or dragon fruit,is a climbing cactus grown worldwide because of its excellent performance under drought stress and appealing red-purple fruits.In practice,accelerating flower formation and inducing more flowers usually result in higher yield.However,the genes for this purpose have not been well characterized in pitaya.Previously,FLOWERING BHLHs(FBHs)have been identified as positive regulators of flower formation.In the present work,a total of eight FBHs were identified in pitaya.This is a greater number than in beet and spinach,possibly because of the recent whole-genome duplication that occurred in the pitaya genome.The phylogenetic tree indicated that the FBHs could be divided into three groups.In TYPEⅡ,the genes of Caryophyllales encode atypical FBHs and are generated by dispersed duplication.The K_(a)/K_(s) ratios indicated that HpFBHs are under purifying selection.Promoter and expression analysis of HpFBHs revealed that they are spatiotemporally activated in flower-related tissues and responsive to multiple abiotic stresses.These results indicated that HpFBHs are involved in the flower formation of pitaya.Therefore,typical HpFBH1/3 from TYPEⅡI and an atypical HpFBH8 from TYPEⅡwere selected for functional verification.HpFBH3 was found to heterodimerize with HpFBH1 in the nucleus using subcellular localization,yeast two-hybrid and luciferase complementation assays.With bioinformatic analysis,all HpFBHs were predicted to transactivate downstream genes via binding to the E-boxes,which were frequently detected in the promoters of HpCOs,HpFTs and HpSOC1s.RNA-Seq datasets showed that these flowering accelerators were expressed in coordination with HpFBH3.Yeast one-hybrid and dual-luciferase reporter assays further verified that HpFBH3 transactivated HpCO7 by selectively binding to the E-boxes in the promoter.Moreover,ectopic overexpression of HpFBH3 accelerated flower formation in Arabidopsis.In summary,this study systematically characterized the typical HpFBHs,especially HpFBH3,as positive regulators of flower formation,which could be target genes for the genetic improvement of pitaya.展开更多
BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis th...BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.展开更多
Flowering is one of the most important phenological periods,as it determines the timing of fruit maturation and seed dispersal.To date,both nitric oxide(NO)and DNA demethylation have been reported to regulate flowerin...Flowering is one of the most important phenological periods,as it determines the timing of fruit maturation and seed dispersal.To date,both nitric oxide(NO)and DNA demethylation have been reported to regulate flowering in plants.However,there is no compelling experimental evidence for a relationship between NO and DNA demethylation during plant flowering.In this study,an NO donor and a DNA methylation inhibitor were used to investigate the involvement of DNA demethylation in NO-mediated tomato(Solanum lycopersicum cv.Micro-Tom)flowering.The results showed that the promoting effect of NO on tomato flowering was dose-dependent,with the greatest positive effect observed at 10μmol L^(-1) of the NO donor S-nitrosoglutathione(GSNO).Treatment with 50μmol L^(-1) of the DNA methylation inhibitor 5-azacitidine(5-AzaC)also significantly promoted tomato flowering.Moreover,GSNO and 5-AzaC increased the peroxidase(POD)and catalase(CAT)activities and cytokinin(CTK)and proline contents,while they reduced the gibberellic acid(GA3)and indole-3-acetic acid(IAA)contents.Co-treatment with GSNO and 5-AzaC accelerated the positive effects of GSNO and 5-AzaC in promoting tomato flowering.Meanwhile,compared with a GSNO or 5-AzaC treatment alone,co-treatment with GSNO+5-AzaC significantly increased the global DNA demethylation levels in different tissues of tomato.The results also indicate that DNA demethylation may be involved in NO-induced flowering.The expression of flowering genes was significantly altered by the GSNO+5-AzaC treatment.Five of these flowering induction genes,ARGONAUTE 4(AGO4A),SlSP3D/SINGLE FLOWER TRUSS(SFT),MutS HOMOLOG 1(MSH1),ZINC FINGER PROTEIN 2(ZFP2),and FLOWERING LOCUS D(FLD),were selected as candidate genes for further study.An McrBC-PCR analysis showed that DNA demethylation of the SFT gene in the apex and the FLD gene in the stem might be involved in NO-induced flowering.Therefore,this study shows that NO might promote tomato flowering by mediating the DNA demethylation of flowering induction genes,and it provides direct evidence for a synergistic effect of NO and DNA demethylation in promoting tomato flowering.展开更多
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture....Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.展开更多
Collagen is a class of mammalian extracellular matrix of the main structural proteins,widely present in the skin,bone,muscle and other tissues and it plays a role in supporting,repairing,and protecting tissue cells.Na...Collagen is a class of mammalian extracellular matrix of the main structural proteins,widely present in the skin,bone,muscle and other tissues and it plays a role in supporting,repairing,and protecting tissue cells.Natural source extraction and artificial synthesis provide a rich source of collagen.As a macromolecular material,collagen has good application potential in cosmetics,pharmaceutical,medical and food industries.Collagen has generated a great deal of interest in the cosmetic industry due to its abundance,strength,and direct correlation with skin aging.Collagen is widely used in cosmetics due to its unique structure,good biocompatibility and low antigenicity,as well as rich biological functions.To enhance the youthfulness and health of the user,the cosmetic industry adds collagen to products such as eye creams,face creams,and nutritional supplements,and uses it in medical aesthetic techniques such as tissue fillers,skin replacement,and soft skin enhancement.This paper mainly reviews the sources and types of collagen used in cosmetics industry,then introduces the effects of collagen in cosmetics and prospects the development prospects of collagen in dermatologic and cosmetic fields.展开更多
Two sharp Chernoff type inequalities are derived for star bodies in R2,one is an extension of the dual Chernoff-Ou-Pan inequality,and the other is the reverse Chernoff type inequality.Furthermore,we establish a genera...Two sharp Chernoff type inequalities are derived for star bodies in R2,one is an extension of the dual Chernoff-Ou-Pan inequality,and the other is the reverse Chernoff type inequality.Furthermore,we establish a generalized dual symmetric mixed Chernoff inequality for two planar star bodies.As a direct consequence,a new proof of the dual symmetric mixed isoperimetric inequality is presented.展开更多
Tibetan turnip and oilseeds are the most important vegetables cultivated in the Qinghai-Tibet Plateau.Our field observations identified a dominant early-bolting phenotype at the vegetative growth stage in the Tibetan ...Tibetan turnip and oilseeds are the most important vegetables cultivated in the Qinghai-Tibet Plateau.Our field observations identified a dominant early-bolting phenotype at the vegetative growth stage in the Tibetan turnip,which was possibly due to cross-pollination contamination from nearby oilseeds.We performed genetic and molecular experiments to explore the main reason for early bolting.We first analyzed gene expression and genomic sequence variation of turnip and oilseed BraFLC2,a gene that acts as a key repressor of flowering in turnip in a dosage-dependent manner.We found that the differences in flowering time and life habits between turnip and oilseeds were closely correlated with the genetic variations in BraFLC2.We further identified that the early-bolting turnip was the hybrid between turnip and oilseeds by selecting BraFLC2 as a testing gene.Furthermore,using an artificial hybridization experiment,we found that the heterozygote and low levels of BraFLC2 expression promoted early bolting in hybrid plants.These findings indicate that early-bolting in turnip is caused by cross-pollination contamination from oilseeds under human agricultural activities.We propose a strategy of strict seed screening,cultivation isolation and turnip breeding to ensure high quality and yield.展开更多
Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods W...Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen,China.Patients were categorized into 6 groups based on baseline fasting plasma glucose(FPG)levels and diabetes duration(from the date of diabetes diagnosis to the baseline date)to examine their combined effects on subsequent MI.Cox proportional hazards regression models were used,with further stratification by age,sex,and comorbidities to assess potential interactions.Results Over a median follow-up of 2.4 years,2,110 patients experienced MI.Compared to those with optimal glycemic control(FPG<6.1 mmol/L)and shorter diabetes duration(<10 years),the fullyadjusted hazard ratio(HR)(95%Confidence Interval[95%CI])for those with a diabetes duration of≥10 years and FPG>8.0 mmol/L was 1.93(95%CI:1.59,2.36).The combined effects of FPG and diabetes duration on MI were largely similar across different age,sex,and comorbidity groups,although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial fibrillation.Conclusion Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and T2D.Tailored management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.展开更多
基金Supported by the Natural Science Foundation of China(12571122,12061010)。
文摘In this paper,we study the uniqueness of positive solutions to the following semilinear equations{-Δu=λ|x|^(α)ue^(u^(2)),in B_(1),u=0,onδB_(1)ueu2;in B_(1);u=0;on@B_(1);whereλ>0,α>-2;B_(1)denotes the unit disk in R^(2):By delicate and relatively complicated computation of radial solutions to the above equation and the asymptotic expansion of solutions near the boundary of B_(1),the uniqueness of positive solutions is obtained.The results of this paper extend the uniqueness result for the semilinear equation with critical exponential growth in CHEN et al.(2022)to the case that includes a Henon term.
基金supported by the National Key R&D Program of China (Grant Nos.2022YFA1403103 and 2019YFA0308603)the National Natural Science Foundation of China (Grant No.12304167)the Shandong Provincial Natural Science Foundation of China (Grant No.ZR2023QA020)。
文摘Interfacial superconductivity(IS)has been a topic of intense interest in condensed matter physics,due to its unique properties and exotic photoelectrical performance.However,there are few reports about IS systems consisting of two insulators.Here,motivated by the emergence of an insulator-metal transition in type-Ⅲ heterostructures and the superconductivity in some“special”two-dimensional(2D)semiconductors via electron doping,we predict that the 2D heterostructure SnSe_(2)/PtTe_(2) is a model system for realizing IS by using firstprinciples calculations.Our results show that due to slight but crucial interlayer charge transfer,SnSe_(2)/PtTe_(2) turns to be a type-Ⅲ heterostructure with metallic properties and shows a superconducting transition with the critical temperature(T_(c))of 3.73 K.Similar to the enhanced electron–phonon coupling(EPC)in the electrondoped SnSe_(2) monolayer,the IS in the SnSe_(2)/PtTe_(2) heterostructure mainly originates from the metallized SnSe_(2) layer.Furthermore,we find that its superconductivity is sensitive to tensile lattice strain,forming a domeshaped superconducting phase diagram.Remarkably,at 7%biaxial tensile strain,the superconducting T_(c) can increase more than twofold(8.80 K),resulting from softened acoustic phonons at the𝑀point and enhanced EPC strength.Our study provides a concrete example for realizing IS in type-Ⅲ heterostructures,which waits for future experimental verification.
基金financial support fromthe Chung Shan Medical University Hospital,Taiwan(CSH-2022-A-009).
文摘Background:To determine whether initiating a glucagon-like peptide-1 receptor agonist(GLP-1 RA)within 3 months of type 2 diabetes(T2DM)diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index(BMI).Methods:This retrospective cohort study used electronic health records from the TriNetX U.S.research network.Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis.Following 1:1 propensity score matching,both the GLP-1 RA user and non-user groups included 183,264 patients.The study outcome was defined as a diagnosis of malignant neoplasms.Hazard ratios(HRs)for overall and site-specific cancer risk were estimated using Cox proportional hazards models.Kaplan–Meier analysis and stratified analysis by BMI were performed.Results:Early GLP-1 RA use demonstrated a modest but significant association with reduced overall cancer risk(HR 0.93;95%CI:0.90–0.96).Reduced risks were noted for cancers of the digestive(HR 0.81),respiratory(HR 0.66),and female genital(HR 0.87)systems.In stratified analysis,benefits were more pronounced in patients with BMI≥30,particularly for pancreatic and colorectal cancers.Conclusion:Early initiation of GLP-1 receptor agonists in patients with diagnosed T2DM was associated with a modest reduction in overall cancer risk,particularly among individuals with obesity.These findings highlight the dual metabolic and oncologic value of prompt GLP-1 RA therapy.
基金Supported by National Natural Science Foundation of China (31101124)National Modern Rapeseed Industry Technology SystemCentral Public-interest Scientific Institution Basal Research Fund (1610172009003)~~
文摘[Objective] The aim was to investigate the effects of fertilizer type on di- rect-seeded rapeseed and to explore effective fertilizing. [Method] Four treatments including different types of fertilizers were set in the test. Growth, photosynthesis and chlorophyll fluorescence parameters at flowering stage such as plant height, stem diameter, shoot and root dry matter, net photosynthesis, light energy conversion effi- ciency （Fv/Fm） and SPAD value, were investigated. The effects of fertilizer treat-ments on the yield of rapeseed were evaluated as well. [Result] Both multi-functional fertilizer and controlled release fertilizer could improve plant height, stem diameter, shoot dry matter, SPAD value, net photosynthesis, non-photochemical quenching （NPQ）, etc., which helped increase yield and stress resistance. [Conclusion] Both multi-functional fertilizer and controlled release fertilizer could improve yield significantly while multi-functional fertilizer （MFF） was better than controlled release fertilizer （CRF）.
文摘Flowering is essential in any breeding programme, particularly in genetic introgression programmes in which flowering synchronism is required. In this work, 16 sugarcane genotypes were evaluated using three different flowering-inductive photoperiod treatments (30 s, 45 s, and 1 min of a daily photoperiod decrease from 12 h 55 of light). Each genotype was planted in 43 L pots (equal proportion of soil, sand, and substrate) with three tillers per pot. Plants with 4 to 6 internodes were placed in a photoperiod facility with three controlled chambers, each chamber containing all 16 genotypes (one treatment per chamber). The temperature range (21°C to 32°C) and humidity were the same for all of the treatments. The flower induction started in September 2010 and ended in April 2011. The plant elongation and flag leaf and inflorescence emergence were recorded and the pollen viability was evaluated by using the iodine staining method. The photoperiod facility provided suitable conditions for flowering, as the plants in the three treatments successfully flowered. The genotypes in the three treatments behaved differently in relation to the date of panicle emergence, with the treatment of 45 s showing better results. The results here presented contribute to synchronise flowering for desired sugarcane crosses, particularly those from introgression programmes between commercial cultivars and species from the Saccharum complex.
文摘Plants acclimate to drought optimizing the trade-off between biomass production and water loss while ensuring their survival and reproduction. Plants also modify their growth or phenology as complementary strategies in response to stress. Despite evidence of an interaction between flowering time and plant growth response to environmental stresses, this interaction in response to drought is under debate. To contribute to the analysis of this interaction, leaf growth of 35 genetically modified lines of Arabidopsis thaliana and their common wild-type, Col-0 was analyzed by a quantitative multi-scale phenotyping approach from cellular to whole plant scale both in well-watered and soil moderate water deficit conditions. These genotypes were selected for the various physiological functions potentially altered by their genetic modification and that could interact with plant growth and/or their drought responses. In all genotypes, leaf expansion decreased in response to drought both at the whole rosette and the individual leaf levels. Additionally, epidermal cell area and/or epidermal cell number decreased in response to the drought treatment. In contrast, the number of rosette leaves was reduced in only half of the genotypes and leaf growth duration was only modified in 4 of them. Despite long photoperiod conditions, the duration of the vegetative phase, i.e. the time elapsed between germination and flowering stage, varied from 12 to 27 days among genotypes under well watered conditions. Our analyses revealed that the differences of flowering time observed in well-watered condition impacted the leaf area response to drought. Early-flowering genotypes slightly decreased their final leaf number, but strongly reduced their individual leaf area compared with the late-flowering ones. This result underlines the difficulty to analyze plant response to environmental stresses when genotypes with different flowering dates are compared.
基金Supported by a Grant from the Scientific Research Project of Hebei Provincial Administration for Traditional Chinese Medicine(Protective Effects and Mechanism of Extract from Fermented Buckwheat Flower and Leaf on Kidney in TypeⅡDiabetic db/db Mice,No.2017083)the Key Project Plan of Medical Science Research in Hebei Province in 2018(Protective Effects and Mechanism of Extract From Fermented Buckwheat Flower and Leaf on IsletβCells,No.201810736)。
文摘OBJECTIVE: To determine the efficacy of a fermented buckwheat flower and leaf extract(EFBFL) for the reduction of blood glucose and lipid dysregulation in spontaneously obese type 2 diabetic db/db mice, and to explore the possible mechanisms involved.METHODS: Forty 9-week-old male db/db mice were randomly allocated to a high-dose EFBFL group(EFBFL-H), a low-dose EFBFL group(EFBFL-L),a metformin hydrochloride positive control group(MEG), and a db/db control group(MG), and there was also a db/m negative control group(NCG)(n =10). Oral glucose tolerance tests(OGTT) were performed after 7 weeks of treatment. At the end of 8 weeks of treatment, random blood glucose(RBG),glycosylated hemoglobin(Hb Alc), fasting plasma glucose(FPG), fasting serum insulin(FINS), triglyceride(TG), serum total cholesterol(TC), free fatty acids(FFA), high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol(LDL-c) were measured, the homeostasis model assessment-insulin resistance(HOMA-IR) was calculated. Immunohistochemistry and western blotting measured the expression of glucose transporter4(GLUT4) and peroxisome proliferator-activated receptor γ(PPAR-γ) by in skeletal muscle.RESULTS: The MG mice had a significantly increased in RBG, Hb Alc, the HOMA-IR level, the serum of TG, TC, LDL-c, but a decreased in glucose tolerance and the protein expression of GLUT4 and PPAR-γ compared with the NCG. Compared with the MG, EFBFL groups significantly decreased RBG, Hb Alc, and the HOMA-IR level, increased glucose tolerance. Meanwhile EFBFL groups reduced the serum TG, TC, and LDL-c in a dose-dependent manner. In addition, EFBFL increased the protein expression of GLUT4 and PPAR-γ in the skeletal muscle of db/db mice.There was significant difference between the MG group and EFBFL groups.CONCLUSION: These findings suggest that EFBFL has anti-diabetic effects in db/db mice, ameliorating glucose intolerance, lipid dysregulation, and insulin resistance.
文摘For the first time, 658 herbarium specimens planted from the 15 decorative flower plants in the conditions of the Tashkent Region were collected. From them, disease separation including of 65 types of fungi 9 form and 1 variation were determined. They were: 4 classes, 7 sections, 11 families and 30 categories.
基金funded by Abdulaziz City for Science and Technology,Saudi Arabia(Grant Research No.1-17-04-001-0021).
文摘Water insufficiency is the hampering feature of crop sustainability,especially in arid and semi-arid regions.So,the effectual usage of all water resources especially underground brackish water represents the core priority in Saudi Arabia.The present study aimed to recognize the influence of different types of water irrigation(tap water as a control,salinized well water,and magnetized salinized well water)with or without soil amendments(soil without any amendment as a control,peat-moss,ferrous sulfate,and peat-moss plus ferrous sulfate)on petunia plant growth and flowering as well as ion content.Irrigating Petunia plants with saline well water adversely affected growth and flowering as compared to tap water and magnetized saline well water.Additionally,plants irrigated with magnetized water showed a significant enhancement in all the studied vegetative and flowering growth parameters as compared to those irrigated with salinized well water.Furthermore,mineral contents and survival of Petunia plants irrigated with magnetized well water were higher than those irrigated with tap water.Irrigation with magnetized well water significantly reduced levels of Na+and Cl−ions in leaves of Petunia plants indicating the role of magnetization in alleviating harmful effects of salinity.In conclusion,we recommend the utilization of magnetized saline well water for irrigating Petunia plants either alone or in combination with soil amendments(peat moss plus ferrous sulfate).
基金Supported by the Leading Innovation Specialist Support Program of Guangdong Provincethe Science and Technology Planning Project of Ganzhou,No.202101074816the National Natural Science Foundation of China,No.82260501.
文摘BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain controversial.AIM To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ CC.METHODS This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to 2021.Based on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic control.DFS,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk factors.RESULTS Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.
基金supported by the National Natural Science Foundation of China(32160681 and 32060663)the National Guidance Foundation for Local Science and Technology Development of China(2023-009)+1 种基金the Guizhou Provincial Basic Research Program(Natural Science)(ZK[2022]YB132)the Foundation of Postgraduate of Guizhou Province,China(YJSKYJJ[2021]057)。
文摘Hylocereus polyrhizus,also known as pitaya or dragon fruit,is a climbing cactus grown worldwide because of its excellent performance under drought stress and appealing red-purple fruits.In practice,accelerating flower formation and inducing more flowers usually result in higher yield.However,the genes for this purpose have not been well characterized in pitaya.Previously,FLOWERING BHLHs(FBHs)have been identified as positive regulators of flower formation.In the present work,a total of eight FBHs were identified in pitaya.This is a greater number than in beet and spinach,possibly because of the recent whole-genome duplication that occurred in the pitaya genome.The phylogenetic tree indicated that the FBHs could be divided into three groups.In TYPEⅡ,the genes of Caryophyllales encode atypical FBHs and are generated by dispersed duplication.The K_(a)/K_(s) ratios indicated that HpFBHs are under purifying selection.Promoter and expression analysis of HpFBHs revealed that they are spatiotemporally activated in flower-related tissues and responsive to multiple abiotic stresses.These results indicated that HpFBHs are involved in the flower formation of pitaya.Therefore,typical HpFBH1/3 from TYPEⅡI and an atypical HpFBH8 from TYPEⅡwere selected for functional verification.HpFBH3 was found to heterodimerize with HpFBH1 in the nucleus using subcellular localization,yeast two-hybrid and luciferase complementation assays.With bioinformatic analysis,all HpFBHs were predicted to transactivate downstream genes via binding to the E-boxes,which were frequently detected in the promoters of HpCOs,HpFTs and HpSOC1s.RNA-Seq datasets showed that these flowering accelerators were expressed in coordination with HpFBH3.Yeast one-hybrid and dual-luciferase reporter assays further verified that HpFBH3 transactivated HpCO7 by selectively binding to the E-boxes in the promoter.Moreover,ectopic overexpression of HpFBH3 accelerated flower formation in Arabidopsis.In summary,this study systematically characterized the typical HpFBHs,especially HpFBH3,as positive regulators of flower formation,which could be target genes for the genetic improvement of pitaya.
基金Supported by The National Natural Science Foundation of China,No.82350127 and No.82241013the Shanghai Natural Science Foundation,No.20ZR1411600+2 种基金the Shanghai Shenkang Hospital Development Center,No.SHDC2020CR4039the Bethune Ethicon Excellent Surgery Foundation,No.CESS2021TC04Xuhui District Medical Research Project of Shanghai,No.SHXH201805.
文摘BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
基金supported by the National Natural Science Foundation of China(32360743,32072559,and31860568)the National Key Research and Development Program,China(2018YFD1000800)the Fostering Foundation for the Excellent Ph D Dissertation of Gansu Agricultural University,China(YB2022004)。
文摘Flowering is one of the most important phenological periods,as it determines the timing of fruit maturation and seed dispersal.To date,both nitric oxide(NO)and DNA demethylation have been reported to regulate flowering in plants.However,there is no compelling experimental evidence for a relationship between NO and DNA demethylation during plant flowering.In this study,an NO donor and a DNA methylation inhibitor were used to investigate the involvement of DNA demethylation in NO-mediated tomato(Solanum lycopersicum cv.Micro-Tom)flowering.The results showed that the promoting effect of NO on tomato flowering was dose-dependent,with the greatest positive effect observed at 10μmol L^(-1) of the NO donor S-nitrosoglutathione(GSNO).Treatment with 50μmol L^(-1) of the DNA methylation inhibitor 5-azacitidine(5-AzaC)also significantly promoted tomato flowering.Moreover,GSNO and 5-AzaC increased the peroxidase(POD)and catalase(CAT)activities and cytokinin(CTK)and proline contents,while they reduced the gibberellic acid(GA3)and indole-3-acetic acid(IAA)contents.Co-treatment with GSNO and 5-AzaC accelerated the positive effects of GSNO and 5-AzaC in promoting tomato flowering.Meanwhile,compared with a GSNO or 5-AzaC treatment alone,co-treatment with GSNO+5-AzaC significantly increased the global DNA demethylation levels in different tissues of tomato.The results also indicate that DNA demethylation may be involved in NO-induced flowering.The expression of flowering genes was significantly altered by the GSNO+5-AzaC treatment.Five of these flowering induction genes,ARGONAUTE 4(AGO4A),SlSP3D/SINGLE FLOWER TRUSS(SFT),MutS HOMOLOG 1(MSH1),ZINC FINGER PROTEIN 2(ZFP2),and FLOWERING LOCUS D(FLD),were selected as candidate genes for further study.An McrBC-PCR analysis showed that DNA demethylation of the SFT gene in the apex and the FLD gene in the stem might be involved in NO-induced flowering.Therefore,this study shows that NO might promote tomato flowering by mediating the DNA demethylation of flowering induction genes,and it provides direct evidence for a synergistic effect of NO and DNA demethylation in promoting tomato flowering.
基金supported by the National Key Research and Development Project (2021YFA1201404)National Natural Science Foundation of China Major Project (81991514)+6 种基金General Project (82272530, 82372459)Jiangsu Province Medical Innovation Center of Orthopedic Surgery (CXZX202214)Jiangsu Provincial Key Medical Center FoundationJiangsu Provincial Medical Outstanding Talent FoundationJiangsu Provincial Medical Youth Talent FoundationJiangsu Provincial Key Medical Talent Foundationthe Fundamental Research Funds for the Central Universities (14380493, 14380494)
文摘Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.
文摘Collagen is a class of mammalian extracellular matrix of the main structural proteins,widely present in the skin,bone,muscle and other tissues and it plays a role in supporting,repairing,and protecting tissue cells.Natural source extraction and artificial synthesis provide a rich source of collagen.As a macromolecular material,collagen has good application potential in cosmetics,pharmaceutical,medical and food industries.Collagen has generated a great deal of interest in the cosmetic industry due to its abundance,strength,and direct correlation with skin aging.Collagen is widely used in cosmetics due to its unique structure,good biocompatibility and low antigenicity,as well as rich biological functions.To enhance the youthfulness and health of the user,the cosmetic industry adds collagen to products such as eye creams,face creams,and nutritional supplements,and uses it in medical aesthetic techniques such as tissue fillers,skin replacement,and soft skin enhancement.This paper mainly reviews the sources and types of collagen used in cosmetics industry,then introduces the effects of collagen in cosmetics and prospects the development prospects of collagen in dermatologic and cosmetic fields.
基金supported by the Postgraduate Scientic Research Innovation Project of Chongqing Normal University(YKC24010)Chunna Zeng's research was supported by the Major Special Project of the National Natural Science Foundation of China(12141101)+2 种基金the Young Top-Talent program of Chongqing(CQYC2021059145)the Technology Research Foundation of Chongqing Educational committee(KJZD-K202200509)the Natural Science Foundation Project of Chongqing(CSTB2024NSCQ-MSX0937)。
文摘Two sharp Chernoff type inequalities are derived for star bodies in R2,one is an extension of the dual Chernoff-Ou-Pan inequality,and the other is the reverse Chernoff type inequality.Furthermore,we establish a generalized dual symmetric mixed Chernoff inequality for two planar star bodies.As a direct consequence,a new proof of the dual symmetric mixed isoperimetric inequality is presented.
基金supported by the National Natural Science Foundation of China(no.32200306,32170385 and 32070362)the Postdoctoral Directional Training Foundation of Yunnan Province,and the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(no.2019QZKK0502).
文摘Tibetan turnip and oilseeds are the most important vegetables cultivated in the Qinghai-Tibet Plateau.Our field observations identified a dominant early-bolting phenotype at the vegetative growth stage in the Tibetan turnip,which was possibly due to cross-pollination contamination from nearby oilseeds.We performed genetic and molecular experiments to explore the main reason for early bolting.We first analyzed gene expression and genomic sequence variation of turnip and oilseed BraFLC2,a gene that acts as a key repressor of flowering in turnip in a dosage-dependent manner.We found that the differences in flowering time and life habits between turnip and oilseeds were closely correlated with the genetic variations in BraFLC2.We further identified that the early-bolting turnip was the hybrid between turnip and oilseeds by selecting BraFLC2 as a testing gene.Furthermore,using an artificial hybridization experiment,we found that the heterozygote and low levels of BraFLC2 expression promoted early bolting in hybrid plants.These findings indicate that early-bolting in turnip is caused by cross-pollination contamination from oilseeds under human agricultural activities.We propose a strategy of strict seed screening,cultivation isolation and turnip breeding to ensure high quality and yield.
基金supported by the R&D project of Pazhou Lab(Huangpu)under Grant 2023K0610the National Natural Science Foundation of China(Grants 12126602)+4 种基金the National Natural Science Foundation of China(Grants 82030102)the Shenzhen Medical Research Fund(Grants C2302001)the Shenzhen Science and Technology Innovation Committee(No.ZDSYS20200810171403013)the Chinese Postdoctoral Science Foundation(No.2022M721463)the Ministry of Science and Technology of China(Grants 2022YFC3702703).
文摘Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen,China.Patients were categorized into 6 groups based on baseline fasting plasma glucose(FPG)levels and diabetes duration(from the date of diabetes diagnosis to the baseline date)to examine their combined effects on subsequent MI.Cox proportional hazards regression models were used,with further stratification by age,sex,and comorbidities to assess potential interactions.Results Over a median follow-up of 2.4 years,2,110 patients experienced MI.Compared to those with optimal glycemic control(FPG<6.1 mmol/L)and shorter diabetes duration(<10 years),the fullyadjusted hazard ratio(HR)(95%Confidence Interval[95%CI])for those with a diabetes duration of≥10 years and FPG>8.0 mmol/L was 1.93(95%CI:1.59,2.36).The combined effects of FPG and diabetes duration on MI were largely similar across different age,sex,and comorbidity groups,although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial fibrillation.Conclusion Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and T2D.Tailored management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.
