Apple is a most important fruit tree and contains various nutrients and health-promoting compounds.Fruit color is an important factor in terms of consumer preference and determined by anthocyanin content(Winkel-Shirle...Apple is a most important fruit tree and contains various nutrients and health-promoting compounds.Fruit color is an important factor in terms of consumer preference and determined by anthocyanin content(Winkel-Shirley,2001;Jiang et al.2020).Anthocyanin is synthesized on the cytosolic surface of the endoplasmic reticulum(Gomez et al.2009;Francisco et al.2013;Jiang et al.2019).The anthocyanin biosynthetic pathway is conserved across plant species and occurs via the phenylalanine metabolic pathway(Baudry et al.2004).展开更多
BACKGROUND Sodium glucose cotransporter 2(SGLT2)inhibitors use has been associated with toe amputations and non-healing ulcers and gangrene mostly of lower extremities.There are no case reports about association of Em...BACKGROUND Sodium glucose cotransporter 2(SGLT2)inhibitors use has been associated with toe amputations and non-healing ulcers and gangrene mostly of lower extremities.There are no case reports about association of Empagliflozin with finger ulcers or gangrene.This is the first case report of Empagliflozin(Jardiance)an SGLT2 inhibitor causing gangrene of fingers and second case in literature about any SGLT2 inhibitor causing gangrene of upper extremity.CASE SUMMARY A 76-year-old man with type 2 diabetes mellitus sustained minimal trauma to both middle fingers,which started healing.He was started on empagliflozin a week later for management of type 2 diabetes mellitus and started developing gangrene to both middle finger tips along with neuropathic pain which worsened over the course of next four months.Investigations were negative for vascular insufficiency,infection and vasculitis and imaging of hand was normal.Discontinuation of empagliflozin slowed progression of gangrene and caused symptomatic improvement with reduction in neuropathic pain.CONCLUSION This case report suggests possible association of empagliflozin and finger gangrene and recommends that more research and awareness among clinicians is needed in this area.展开更多
基金supported by the National Natural Science Foundation of China(32472684,32102319)Natural Science Foundation of Shandong province(ZR2024MC083,ZR2021QC010)+3 种基金Taishan Scholar Foundation of Shandong Province(tstp20221134)Agricultural Variety Improvement Project of Shandong Province(2023LZGCQY007)the China Agriculture Research System Foundation(CARS-27)Talents of High-level Scientific Research Foundation(665/1121002).
文摘Apple is a most important fruit tree and contains various nutrients and health-promoting compounds.Fruit color is an important factor in terms of consumer preference and determined by anthocyanin content(Winkel-Shirley,2001;Jiang et al.2020).Anthocyanin is synthesized on the cytosolic surface of the endoplasmic reticulum(Gomez et al.2009;Francisco et al.2013;Jiang et al.2019).The anthocyanin biosynthetic pathway is conserved across plant species and occurs via the phenylalanine metabolic pathway(Baudry et al.2004).
文摘BACKGROUND Sodium glucose cotransporter 2(SGLT2)inhibitors use has been associated with toe amputations and non-healing ulcers and gangrene mostly of lower extremities.There are no case reports about association of Empagliflozin with finger ulcers or gangrene.This is the first case report of Empagliflozin(Jardiance)an SGLT2 inhibitor causing gangrene of fingers and second case in literature about any SGLT2 inhibitor causing gangrene of upper extremity.CASE SUMMARY A 76-year-old man with type 2 diabetes mellitus sustained minimal trauma to both middle fingers,which started healing.He was started on empagliflozin a week later for management of type 2 diabetes mellitus and started developing gangrene to both middle finger tips along with neuropathic pain which worsened over the course of next four months.Investigations were negative for vascular insufficiency,infection and vasculitis and imaging of hand was normal.Discontinuation of empagliflozin slowed progression of gangrene and caused symptomatic improvement with reduction in neuropathic pain.CONCLUSION This case report suggests possible association of empagliflozin and finger gangrene and recommends that more research and awareness among clinicians is needed in this area.
