High performance computer is often required by model predictive control(MPC) systems due to the heavy online computation burden.To extend MPC to more application cases with low-cost computation facilities, the impleme...High performance computer is often required by model predictive control(MPC) systems due to the heavy online computation burden.To extend MPC to more application cases with low-cost computation facilities, the implementation of MPC controller on field programmable gate array(FPGA) system is studied.For the dynamic matrix control(DMC) algorithm,the main design idea and the implemental strategy of DMC controller are introduced based on a FPGA’s embedded system.The performance tests show that both the computation efficiency and the accuracy of the proposed controller can be satisfied due to the parallel computing capability of FPGA.展开更多
Taking the formulation of the Daqing Oil. fived five-year development plan as the background, this paper puts forward the concept of dynamic programming with aftereffects and gives the principle of suboptimality as it...Taking the formulation of the Daqing Oil. fived five-year development plan as the background, this paper puts forward the concept of dynamic programming with aftereffects and gives the principle of suboptimality as its approximate solution. By using this principle an oil field development subdynamic programming model has been made and the oil field development program based on this model has achieved obvious economic benefits.展开更多
1996 is the first year for realizing the object of fish culture in 66,600 ha of rice field in Zhejiang Province. The provincial government has appropriated $ 24,000 per ha for starting capital. Starting from this year...1996 is the first year for realizing the object of fish culture in 66,600 ha of rice field in Zhejiang Province. The provincial government has appropriated $ 24,000 per ha for starting capital. Starting from this year, counties with the tradition of fish culture in rice fields as Youngjia and Qingtian have put stress on popularizing the new technique of fish culture in ditches and puddles to raise the yield for per unit area. In areas of Central Zhejiang and North Zhejiang with hilly land and plain area with double—season rice, people have changed traditional fish varieties into special and excellent fish varieties.展开更多
皮肤瘢痕是创面生理修复过程的结果,其中病理性瘢痕(如增生性瘢痕和瘢痕疙瘩)由成纤维细胞的异常活动和细胞外基质过度积累引起,涉及多种细胞和复杂的分子信号通路。针对病理性瘢痕的现有治疗方法包括局部注射激素、放疗、外部治疗、激...皮肤瘢痕是创面生理修复过程的结果,其中病理性瘢痕(如增生性瘢痕和瘢痕疙瘩)由成纤维细胞的异常活动和细胞外基质过度积累引起,涉及多种细胞和复杂的分子信号通路。针对病理性瘢痕的现有治疗方法包括局部注射激素、放疗、外部治疗、激光、冷冻和手术等,但效果有限。纳秒脉冲电场(Nanosecond Pulsed Electric Field,nsPEF)技术作为新兴的非热生物电治疗手段,通过超短脉冲电能激活细胞程序性死亡,对治疗区域有选择性,对周围组织损伤小。nsPEF在皮肤恶性肿瘤和良性病变治疗中显示出安全性和有效性。在瘢痕治疗方面,nsPEF技术理论上可以通过诱导成纤维细胞程序性死亡及软化细胞外基质改善组织愈合并减少瘢痕。此外,nsPEF技术可以通过抗血管生成、免疫调节以及影响相关信号通路减少瘢痕形成,但其具体效果和作用机制需进一步探索。未来研究将聚焦于nsPEF技术的治疗效果、方案优化及治疗参数,验证其在病理性瘢痕治疗中的临床应用价值。展开更多
Summary What is already known about this topic?Trainees in the China Field Epidemiology Training Program(CFETP)constitute a vital workforce in addressing global public health emergencies.Developing intercultural commu...Summary What is already known about this topic?Trainees in the China Field Epidemiology Training Program(CFETP)constitute a vital workforce in addressing global public health emergencies.Developing intercultural communication competence is essential for their future participation in international public health efforts.However,within China’s existing public health training system,this aspect has not yet received adequate attention or been systematically strengthened.展开更多
EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine tar...EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.展开更多
基金the National Science Foundation of China(Nos.60934007 and 61074060)the Postdoctoral Science Foundation of China(No.20090460627)+2 种基金the Postdoctoral Scientific Program of Shanghai (No.10R21414600)the Specialized Research Fund for the Doctoral Program of Higher Education (No.20070248004)the China Postdoctoral Science Foundation Special Support(No.201003272)
文摘High performance computer is often required by model predictive control(MPC) systems due to the heavy online computation burden.To extend MPC to more application cases with low-cost computation facilities, the implementation of MPC controller on field programmable gate array(FPGA) system is studied.For the dynamic matrix control(DMC) algorithm,the main design idea and the implemental strategy of DMC controller are introduced based on a FPGA’s embedded system.The performance tests show that both the computation efficiency and the accuracy of the proposed controller can be satisfied due to the parallel computing capability of FPGA.
文摘Taking the formulation of the Daqing Oil. fived five-year development plan as the background, this paper puts forward the concept of dynamic programming with aftereffects and gives the principle of suboptimality as its approximate solution. By using this principle an oil field development subdynamic programming model has been made and the oil field development program based on this model has achieved obvious economic benefits.
文摘1996 is the first year for realizing the object of fish culture in 66,600 ha of rice field in Zhejiang Province. The provincial government has appropriated $ 24,000 per ha for starting capital. Starting from this year, counties with the tradition of fish culture in rice fields as Youngjia and Qingtian have put stress on popularizing the new technique of fish culture in ditches and puddles to raise the yield for per unit area. In areas of Central Zhejiang and North Zhejiang with hilly land and plain area with double—season rice, people have changed traditional fish varieties into special and excellent fish varieties.
文摘皮肤瘢痕是创面生理修复过程的结果,其中病理性瘢痕(如增生性瘢痕和瘢痕疙瘩)由成纤维细胞的异常活动和细胞外基质过度积累引起,涉及多种细胞和复杂的分子信号通路。针对病理性瘢痕的现有治疗方法包括局部注射激素、放疗、外部治疗、激光、冷冻和手术等,但效果有限。纳秒脉冲电场(Nanosecond Pulsed Electric Field,nsPEF)技术作为新兴的非热生物电治疗手段,通过超短脉冲电能激活细胞程序性死亡,对治疗区域有选择性,对周围组织损伤小。nsPEF在皮肤恶性肿瘤和良性病变治疗中显示出安全性和有效性。在瘢痕治疗方面,nsPEF技术理论上可以通过诱导成纤维细胞程序性死亡及软化细胞外基质改善组织愈合并减少瘢痕。此外,nsPEF技术可以通过抗血管生成、免疫调节以及影响相关信号通路减少瘢痕形成,但其具体效果和作用机制需进一步探索。未来研究将聚焦于nsPEF技术的治疗效果、方案优化及治疗参数,验证其在病理性瘢痕治疗中的临床应用价值。
基金Supported by funds from African countries to enhance their public health capacitybuilding projects[No.OPP1161303(GAT/16/303)].
文摘Summary What is already known about this topic?Trainees in the China Field Epidemiology Training Program(CFETP)constitute a vital workforce in addressing global public health emergencies.Developing intercultural communication competence is essential for their future participation in international public health efforts.However,within China’s existing public health training system,this aspect has not yet received adequate attention or been systematically strengthened.
文摘EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.
