Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disorder characterized by airflow obstruction and progressive damage of lung tissues. As currently more than 3 billion people use biomass fuel for ...Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disorder characterized by airflow obstruction and progressive damage of lung tissues. As currently more than 3 billion people use biomass fuel for cooking and heating worldwide, exposure to biomass smoke(BS) is recognized as a significant risk factor for COPD. Recent clinical data have shown that BS-COPD patients have a Th2-type inflammatory profile significantly different from that in COPD induced by cigarette smoke. As COPD is essentially proinflammatory,however, the mechanism underlying this Th2-type anti-inflammatory profile remains elusive.In this work, a network model is applied to study BS-induced inflammatory dynamics. The network model involves several positive feedback loops, activations of which are responsible for different mechanisms by which clinical phenotypes of COPD are produced. Our modeling study in this work has identified a subset of BS-COPD patients with a mixed M1-and Th2-type inflammatory profile. The model’s prediction is in good agreement with clinical experiments and our in silico knockout simulations have demonstrated several important network components that play an important role in the disease. Our modeling study provides novel insight into BS-COPD progression, offering a rationale for targeted therapy and personalized medicine for treatment of the disease in future.展开更多
This paper is mainly concerned with the model predictive control （MPC） of networked control systems （NCSs） with uncertain time delay and data packets disorder. The network-induced time delay is described as bounde...This paper is mainly concerned with the model predictive control （MPC） of networked control systems （NCSs） with uncertain time delay and data packets disorder. The network-induced time delay is described as bounded and arbitrary process. For the usual state feedback controller, by considering all the possibilities of delays, an augmented state space model of the closed-loop system, which characterizes all the delay cases, is obtained. The stability conditions are given according to the Lyapunov method based on this augmented model. The stability property is inherited in MPC which explicitly considers the physical constraints. A numerical example is given to demonstrate the effectiveness of the proposed MPC.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.21273209).
文摘Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disorder characterized by airflow obstruction and progressive damage of lung tissues. As currently more than 3 billion people use biomass fuel for cooking and heating worldwide, exposure to biomass smoke(BS) is recognized as a significant risk factor for COPD. Recent clinical data have shown that BS-COPD patients have a Th2-type inflammatory profile significantly different from that in COPD induced by cigarette smoke. As COPD is essentially proinflammatory,however, the mechanism underlying this Th2-type anti-inflammatory profile remains elusive.In this work, a network model is applied to study BS-induced inflammatory dynamics. The network model involves several positive feedback loops, activations of which are responsible for different mechanisms by which clinical phenotypes of COPD are produced. Our modeling study in this work has identified a subset of BS-COPD patients with a mixed M1-and Th2-type inflammatory profile. The model’s prediction is in good agreement with clinical experiments and our in silico knockout simulations have demonstrated several important network components that play an important role in the disease. Our modeling study provides novel insight into BS-COPD progression, offering a rationale for targeted therapy and personalized medicine for treatment of the disease in future.
基金supported by National Nature Science Foundation of China (Nos. 60934007 and 60874046)the Fundamental Research Funds for the Central Universities (Nos. CDJZR10175501 and CDJXS10171101)+4 种基金the Program for New Century Excellent Talents in the University of Chinathe Scientific Research Foundation for Returned Overseas Chinese Scholarsthe State Education Ministry of Chinathe Nature Science Foundation of Chongqing(No. 2008BB2049)the Innovative Talent Training Project, the Third Stage of the "211 Project", Chongqing University (No. S-09108)
文摘This paper is mainly concerned with the model predictive control （MPC） of networked control systems （NCSs） with uncertain time delay and data packets disorder. The network-induced time delay is described as bounded and arbitrary process. For the usual state feedback controller, by considering all the possibilities of delays, an augmented state space model of the closed-loop system, which characterizes all the delay cases, is obtained. The stability conditions are given according to the Lyapunov method based on this augmented model. The stability property is inherited in MPC which explicitly considers the physical constraints. A numerical example is given to demonstrate the effectiveness of the proposed MPC.
