Under the guidance of the finding that the tyrosine residues in proteins could undergo three-component Mannich-type reactions with formaldehyde and electron-rich aniline-containing compounds,which forms covalent bondi...Under the guidance of the finding that the tyrosine residues in proteins could undergo three-component Mannich-type reactions with formaldehyde and electron-rich aniline-containing compounds,which forms covalent bonding connections between the protein of interest and the aniline with high levels of selectivity under relatively mild conditions,an orange aromatic primary amine-containing acid dye AMODB was designed and readily synthesized.The molecular structure was characterized by FTIR,^1H NMR,mass spectrometry and elemental analysis.The synthesized dye and a similar control dye（C.I.Acid Yellow 11） without primary amine groups were applied to dye silk fabric by three dyeing processes：Mannich-type dyeing（with and without the addition of formaldehyde） and acidic dyeing.Their washing and rubbing fastness properties with different dyeing methods were examined and compared.It was found that the dyed silk fabric with AMODB by the Mannich-type dyeing showed higher color depth,better anti-stripping ability to DMF and better washing fastness than those of the dyed silk fabric with C.I.Acid Yellow 11 by acidic dyeing due to the covalent bond formation between the dye chromophore of AMODB and silk fiber.In addition,mild Mannich dyeing conditions suitable for silk（AMODB at 3%owf,75：1 liquor-to-goods ratio,dyebath pH 5.5,30℃,10 h） were provided.展开更多
The early RBE of the bone marrow in mice after studied irradiation with fast neutrons(35 MeVp→Be) was studied.60Co-γ ray was used for referent beams.Using the dos.making 50% loss of the nucleated cells of bone marro...The early RBE of the bone marrow in mice after studied irradiation with fast neutrons(35 MeVp→Be) was studied.60Co-γ ray was used for referent beams.Using the dos.making 50% loss of the nucleated cells of bone marrow in mice relative to control group mice to calculated the RBE value which was 2.13±0.18.Meanwhile,the relationship of the RBE values and the dose of neutrons was noted.On log-log plot the RBE values decrease with increasing dose of fast neutrons and it is consistent with a slope of -0.39± 0.10.The α/β ratios were estimated from linear-quadratic model of cell survival,they are 14.4±1.30 Gy for fast neutrons and 0.83±0.10 Gy for γ-ray,respectively.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21106135 and 51173168)Zhejiang Provincial Key Innovation Team(No.2010R50038)+1 种基金Zhejiang Provincial Top Key Academic Discipline of Chemical Engineering and Technology"521" Talent Project of Zhejiang Sci-Tech University
文摘Under the guidance of the finding that the tyrosine residues in proteins could undergo three-component Mannich-type reactions with formaldehyde and electron-rich aniline-containing compounds,which forms covalent bonding connections between the protein of interest and the aniline with high levels of selectivity under relatively mild conditions,an orange aromatic primary amine-containing acid dye AMODB was designed and readily synthesized.The molecular structure was characterized by FTIR,^1H NMR,mass spectrometry and elemental analysis.The synthesized dye and a similar control dye（C.I.Acid Yellow 11） without primary amine groups were applied to dye silk fabric by three dyeing processes：Mannich-type dyeing（with and without the addition of formaldehyde） and acidic dyeing.Their washing and rubbing fastness properties with different dyeing methods were examined and compared.It was found that the dyed silk fabric with AMODB by the Mannich-type dyeing showed higher color depth,better anti-stripping ability to DMF and better washing fastness than those of the dyed silk fabric with C.I.Acid Yellow 11 by acidic dyeing due to the covalent bond formation between the dye chromophore of AMODB and silk fiber.In addition,mild Mannich dyeing conditions suitable for silk（AMODB at 3%owf,75：1 liquor-to-goods ratio,dyebath pH 5.5,30℃,10 h） were provided.
文摘The early RBE of the bone marrow in mice after studied irradiation with fast neutrons(35 MeVp→Be) was studied.60Co-γ ray was used for referent beams.Using the dos.making 50% loss of the nucleated cells of bone marrow in mice relative to control group mice to calculated the RBE value which was 2.13±0.18.Meanwhile,the relationship of the RBE values and the dose of neutrons was noted.On log-log plot the RBE values decrease with increasing dose of fast neutrons and it is consistent with a slope of -0.39± 0.10.The α/β ratios were estimated from linear-quadratic model of cell survival,they are 14.4±1.30 Gy for fast neutrons and 0.83±0.10 Gy for γ-ray,respectively.
